VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus

Hochberg, M. C. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400928 · Cited by 11,409

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX

Gladman, D. D., Ibañez, D., & Urowitz, M. B. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-04434-9.50060-9 · Cited by 2,928

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570

Protein-binding assays in biological liquids using microscale thermophoresis

Wienken, C. J., Baaske, P., Rothbauer, U., Braun, D., & Duhr, S. (2010) · Nature Communications · doi:10.1038/ncomms1093 · Cited by 1,145

Mitochondrial DNA in innate immune responses and inflammatory pathology

West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., San Chin, H., et al. (2018) · Science · doi:10.1126/science.aao6047 · Cited by 1,072

BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death

Yang, S., Kim, H., Liao, G., Ta, N., Tu, H.-C., Ramani, S., Chen, C.-Y., Li, Z.-Y., Tanno, N., Hsieh, J. J.-D., et al. (2026) · Science · doi:10.1126/science.aea2181 · Cited by 3

Suppression of PCK1 attenuates neuronal injury and improves post-resuscitation outcomes

Xu, R., Li, J., Zhu, J. F., Guo, F., Zhang, C., Chen, K., & Xu, J. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167674 · Cited by 2

A C-Terminally Truncated Variant of Neurospora crassa VDAC Assembles Into a Partially Functional Form in the Mitochondrial Outer Membrane and Forms Multimers in vitro

Ferens, F. G., Summers, W. A. T., Bharaj, A., Stetefeld, J., & Court, D. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.739001 · Cited by 2

The Dysfunction of Ca2+ Channels in Hereditary and Chronic Human Heart Diseases and Experimental Animal Models

Шемарова, И. В. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115682 · Cited by 2

Mitoregulin self-associates to form likely homo-oligomeric pore-like complexes

(2024) · doi:10.1016/j.isci.2024.111554 · Cited by 2

An inflammation-associated lncRNA induces neuronal damage via mitochondrial dysfunction

Olazagoitia‐Garmendia, A., Márquez, H. R., Trobisch, T., Moreno‐Castro, C., Etxebarria, A. R., Mentxaka, J., Tripathi, A. K., Yang, B., Ruíz, I. M., Anguíta, J., et al. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102533 · Cited by 2

Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex

Stettler, P., Aeschlimann, S., Schimanski, B., & Schneider, A. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013506 · Cited by 2

Metabolic and mitochondrial dysfunction in SLE

Perl, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820583-9.00014-2 · Cited by 2

Inter-organellar nucleic acid communication by a mitochondrial tRNA regulates nuclear metabolic transcriptionPreprint

Rouya, C., Yambire, K. F., Derbyshire, M. L., Alwaseem, H., & Tavazoie, S. F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.21.558912 · Cited by 2

Voltage-dependent anion channels are mitophagy receptors mediating the recycling of depolarized mitochondria in ArabidopsisPreprint

Ma, W., Ma, J., Zhang, K., Zheng, X., Wang, P., Feng, L., Ming, S., Zhuang, X., Zhou, J., Gao, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.29.656919 · Cited by 2

New Frontiers on Intracellular cGAS Activation: Molecular Mechanisms, Cellular Signaling, and Therapeutic Strategies

Song, X., Ling, X., Liu, H., Zhao, Q., Li, X., Lai, W., & Wang, H. (2024) · Chemical Research in Chinese Universities · doi:10.1007/s40242-024-4120-7 · Cited by 1

Serum starvation induces cytosolic DNA trafficking via exosome and autophagy-lysosome pathway in microglia

Zhou, L., Wu, Z., Yi, X., Xie, D., Wang, J., & Wu, W. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.119905 · Cited by 1

Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS

Cai, D., Chen, C., Meekrathok, P., Zeng, W., Wang, Z., Peng, Z., Mo, Y., Xu, X., Wang, J., & Qiu, J. (2025) · EMBO Reports · doi:10.1038/s44319-025-00614-2 · Cited by 1

The Immunogenic Role of Self-DNA in T Cell Immunity

Lei, J., Liu, M., Huang, X., Zhai, X., Ji, H., & Wen, Z. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09111-9 · Cited by 1

PUMA upregulation promotes the necroptosis of hepatocytes in trichloroethylene-sensitized mice via mtDNA-mediated ZBP1 pathway

Peng, X., Zhu, L., Wan, C., Dong, L., Yang, W., Zhu, Q., Xie, H., & Zhang, J. (2025) · Toxicology Letters · doi:10.1016/j.toxlet.2025.111807 · Cited by 1

Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway

Zhang, H., Chang, A., Xu, X., Peng, H., Zhang, K., Yang, J., Li, W., Wang, X., Wang, W., Yin, X., et al. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48020138 · Cited by 1

The second mitochondrial activator of caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells

Amer, T., Haimovici, A., Kirschnek, S., Vier, J., Moeed, A., Ukachukwu, U., Neugebauer, D., Neubert, P., Helmstädter, M., Kayser, S., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01667-z · Cited by 1

Targeting VDAC1-dependent mtDNA release attenuates fibroblast innate immune activation and vitiligo pathogenesis

Lv, J., Zhang, H., Yu, W., Jiang, P., Yin, C., Xu, W., Cao, Y., & Gao, R. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116411 · Cited by 1

Protective and pathogenic: The Janus-faced role of cGAS–STING in the brain

Corona, C., Kanzlemar, C., Hussaini, S. A., & Ratan, R. R. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261427904 · Cited by 1

Clotting the Gap Between Mitochondria-Mediated Immunity and Mitochondrial Transfer

Tupin, F., González-Chapa, J. A., Chung, J. H., Lood, C., & Boilard, É. (2026) · Circulation Research · doi:10.1161/circresaha.125.326987 · Cited by 1

An engineered viral RNA degrader on mitochondrial surface that mitigates RNA virus infection

Chen, C., Liao, W.-T., Chao, T. H., Chen, Y., Weng, S., Shiao, S.-H., Kao, C.-Y., Li, Y.-J., Cheng, K.-A., & Chang, Z.-F. (2026) · Nature Communications · doi:10.1038/s41467-026-73487-1 · Cited by 1

MTFR2 promotes VDAC1 oligomerization to reprogram BCAA metabolism in tumor cells to polarize TAMs in LUAD

Ge, Y., Yu, T., Yu, S., Sun, A., Zhang, S., Zhang, M., Wang, Q., Liu, J., Zhang, X., Zeng, L., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08871-2 · Cited by 1

SERCA2 deficiency in tubular epithelial cells drives ferroptosis in acute kidney injury regulating endoplasmic reticulum mitochondrial calcium homeostasis via voltage dependent anion channel 1 oligomerization

He, X., Lv, X., Zhang, Y., Huang, H., Cheng, J., Zou, S., Han, Y., Sun, L., Wang, S., Xiong, Y., et al. (2026) · Kidney International · doi:10.1016/j.kint.2026.04.017 · Cited by 1

Rab26 mitigates ferroptosis in airway epithelium induced by cigarette smoke through suppression of VDAC1 oligomerization-mediated cGAS-STING activation

Tian, X., Wen, Z., You, Z., Mao, Y., Huang, Q., Zeng, L., Hu, W., Wei, D., Qian, H., Zhang, M., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.315 · Cited by 1

Glutathione peroxidase 3 preserves hepatocyte mitochondrial quality control to enhance macrophage pro‐regenerative phenotype during liver regeneration

Wang, Y., Xu, J., Zhu, Z., Zhang, Y., Hu, H., Gao, Y., Tao, Y., Yao, F., Zhou, S., Zhong, W., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70695 · Cited by 1

ROS-mitochondria-NLRP3/STING axis mediates the enhanced anti-coronavirus activity of ZIF8 nanoparticles

Ge, H., Liao, M., Shen, Y., Zhao, Y., Fan, B., Li, J., Sun, M., Yang, S., Mao, L., Geng, X., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04618-5 · Cited by 2

VDAC1 mediates LPS-induced T cell inflammation via mtDNA release and cGAS-STING activation

Ren, Y., Zhu, G., Yucai, Z., Yun, C., Jie, G., & Yiping, Z. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112642 · Cited by 1

Copper Exposure Promotes Mitochondrial VDAC Oligomerization and Releases mtDNA to Induce Pyroptosis in Pig Hepatocytes

Qiu, W., Chen, W., Yang, S., Xi, H., Liao, J., Su, R., & Tang, Z. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c03617 · Cited by 1

Mitochondrial DNA efflux as a potential amplifier of systemic inflammatory network rewiring in heart failure with preserved ejection fraction

Zhao, X., Huang, S., Li, Q., Yang, Y., & Zhang, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1866184 · Cited by 1

Fibroblast Mitochondrial Ca 2+ Overload Drives Skin Fibrosis via Mitochondrial DNA Leakage and Cyclic GMP ‐ AMP Synthase–Stimulator of Interferon Genes Activation in Systemic Sclerosis

Zhang, X., Wang, Y., Huang, H., Guo, X., Ye, W., Cao, L., Wang, Z., Hou, Y., Wang, Y., Yang, J., et al. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70261 · Cited by 1

Mitochondrial DNA in systemic lupus erythematosus: pathogenic mechanisms, clinical biomarkers, and precision therapeutic strategies

Huang, F., Sun, K., Diao, L., Lu, K., Fan, Y., & Xie, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1928003 · Cited by 1

Harnessing cGAS–STING in neurodegeneration: From mitochondrial DNA leakage and microglial reactivity to species-specific translational barriers

Wang, M., Li, J., Wang, X., Chai, X., Luo, J., Zhang, Y., Chang, X., Sun, Y., & Wang, H. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.101537 · Cited by 2

Deoxyarbutin targets mitochondria to trigger p53-dependent senescence of glioblastoma cells

Cai, D., Xu, X., Zeng, W., Wang, Z., Chen, C., Mo, Y., Meekrathok, P., Wang, D., Peng, P., Peng, Z., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.027 · Cited by 1

Mechanisms of fibrinogen trans-activation of the EGFR/Ca2+ signaling axis to regulate mitochondrial transport and energy transfer and inhibit axonal regeneration following cerebral ischemia

Zhou, S., Li, B., Wu, D., Chen, Y., Zeng, W., Huang, J., Tan, L., Mao, G., & Liu, F. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlae114 · Cited by 1

Gelatin enhances bacteria-phagocytosis via a ROS-mitochondria-STING axis in differentiated human macrophage-like U937 cells

Sun, X., Li, M.-L., Ma, Y., Chen, K. G., Jiang, S., Hayashi, T., Itoh, K., Mizuno, K., Hattori, S., Fujisaki, H., et al. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.08.011 · Cited by 1

Mitochondrial genome microhomology-mediated editing by donor DNA delivery into mitochondria in human cells

Maximov, V. N. M., Shebanov, N., Nikitchina, N., Rapoport, R., Maor, Y., Tarassov, I., Pines, O., & Entelis, N. (2026) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2026.102959 · Cited by 1

The mtDNA-ZBP1 axis in alzheimer's disease: Mechanisms, pathogenesis, and therapeutic implications

Chen, Y., Liu, Y., Hu, H., & Li, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115853 · Cited by 1

The cGAS-STING pathway at the crossroads of neuroimmunology: bridging innate immunity to aging and neurodegeneration

Wu, Z., Jia, R., Zhang, Q., Huang, L.-Y., Yan, J.-T., Zhang, Y. H., & Fan, Y. (2026) · Biomarker Research · doi:10.1186/s40364-026-00906-2 · Cited by 2

Mitochondrial homeostasis: the central hub governing the progression of atherosclerosis

Liu, H., Zhao, S., Gao, H., Wang, Y., Gao, J., Guo, P., Yang, Y., Cui, W., Zhang, S. M., Shi, Y., et al. (2026) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbag010 · Cited by 1

Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2

Møhlenberg, M., Jørgensen, S. E., van der Sluis, R. M., Zillinger, T., Hinke, D. M., Hollensen, A. K., Hansen, A. L., Effort, C. H. G., COVID-19 DNABR Group, French COVID Cohort Study Group, et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2522111123 · Cited by 1

Self-assembled nanoparticles from Xiexin Decoction attenuate ulcerative colitis by targeting VDAC1-Mediated NLRP3 inflammasome activation

Chu, Z., Yang, T., Zhang, Y., Zhu, Q., Wang, D., Tang, H., Zhang, G., Jiang, M., Zhou, L., Xu, L., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103078 · Cited by 1

MSC-derived exosomes ameliorate systemic lupus erythematosus by reprogramming macrophage mitochondrial homeostasis via the CMPK2-cGAS-STING axis

Zang, J., Chu, J., Sun, W., Yang, C., Qu, Z., Bie, H., Wang, Y., Guo, J., & Xu, D. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04320-6 · Cited by 1

Lipid nanoparticle used in mRNA vaccine promotes tumor metastasis in mouse model via mtDNA-induced neutrophil activation and NETosis

Wang, B., Hao, Y., Hong, W., Bai, Z., Qin, F., Ai, J., Liu, J., Alu, A., Gao, Z., Wu, Y., et al. (2026) · Nano Today · doi:10.1016/j.nantod.2026.103039 · Cited by 1

Small but mighty: mitochondrial DNA at the centre of retrograde signalling

Harding, E., Bazzani, V., & Vascotto, C. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02858-4 · Cited by 1

Viral Mimicry of Alzheimer’s Disease: Innate Sensing of Self-Nucleic Acids as a Driver of Glial Senescence

Abuhassan, Q., Saeed, T. N., Al-Hussainy, A. F., Roopashree, R., Mishra, S., Nanda, A., Mukherjee, G., Rizaev, J., Taher, S. G., Alwan, M., et al. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02532-x · Cited by 1

NOX2 inhibitor baicalein alleviates rheumatoid arthritis and inactivating mitochondrial oxidative stress-mediated cGAS-STING signaling in fibroblast-like synoviocytes

Wang, R., Fang, W., Qiao, Y., Zhang, X., Gao, Y., Gao, Z., Guo, Y., & Wei, L. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158268 · Cited by 1

Mitochondrial Stress Orchestrates Tumor Immune Evasion and Immunotherapy Resistance

Bılır, A., Yıldırım, B., & Karalök, M. H. (2026) · Cells · doi:10.3390/cells15100890 · Cited by 1

Mitochondrial permeability transition in redox homeostasis and ferroptosis

Guo, L. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113244 · Cited by 1

Neurovascular unit senescence as a driver of blood–brain barrier dysfunction in Alzheimer’s disease：Mechanisms, consequences, and therapeutic implications

Yao, M., Liu, A., Xing, L., Song, J., Yang, Y., Yue, X., & Li, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103260 · Cited by 1

cGAS/STING Signaling in Ulcerative Colitis: Mechanism and Therapeutic Opportunities

Dai, X., Zhang, J., & Tang, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146513 · Cited by 1

Mitochondrial Distress Signals at the Heart–Liver Interface: Molecular Links Between MASLD and Heart Failure

Yang, X., Cheng, K., Chen, C., Zhang, Y., & Wang, D. W. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177734 · Cited by 1

Pannexin1 promotes cellular senescence by triggering mtDNA release to activate the cGAS-STING pathway

Li, J., Zhao, X., Shen, Y., Huang, L., Guo, J., & Wang, J. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168388 · Cited by 1

The double-edged sentinel: cGAS-STING as a context-dependent regulator of microglial senescence and neuronal genotoxic stress in neurodegeneration

Zhang, C., & Yang, Z. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112118 · Cited by 1

Dopamine-induced mitochondrial dysfunction activates cGAS-sTING to drive IL-6 secretion in macrophages

Daniali, M., Channer, B., Curley, E. O., Amirfallah, A., Kist, T., Montilla, J., Kosashvili, S., Sheldon, L., Stauch, K. L., Jackson, J. G., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.118118 · Cited by 1

Nucleic Acid Sensing and Systemic Lupus Erythematosus: The Danger of Self

Zou, Y.-R., & Davidson, A. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200129 · Cited by 1

Casting a Wide NET

Kaplan, M. J. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200173 · Cited by 1

Effect of erastin and G3139 on rat liver mitochondria in chronic alcoholic intoxication

Baburina, Y. L., Zvyagina, A. I., Odinokova, I. V., & Krestinina, O. V. (2023) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20236901062 · Cited by 1

Mitochondrial DNA release mediates metabolic-associated steatohepatitis via activation of inflammatory pathways

Liu, Y., Hu, Y., & Shan, Z. (2025) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v33.i5.344 · Cited by 1

In Silico Exploration of Alternative Conformational States of VDAC

Mannella, C. A. (2023) · Molecules · doi:10.3390/molecules28083309 · Cited by 1

Longitudinal diffusion barriers imposed by myofilaments and mitochondria in murine cardiac myocytes

Deisl, C., Chung, J. H., & Hilgemann, D. W. (2023) · The Journal of General Physiology · doi:10.1085/jgp.202213329 · Cited by 1

POS0109 IDENTIFICATION OF PRIMARY SJOGREN'S SYNDROME SUBTYPES BY MACHINE LEARNING

Qiu, M. T., Zhang, S. X., Qiao, J., Zhang, J. Q., Song, S., Zhao, R., Chang, M., Zhang, Y., Liu, G., He, P. F., et al. (2021) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-eular.2402 · Cited by 1

STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the Nan (EKLF/E339D) mouse model of neonatal anemiaPreprint

Arif, T., Mukherjee, K., Li, X., Catrow, J. L., Cox, J., & Bieker, J. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.11.693792 · Cited by 1

Ceramides disrupt hexokinase HKI-VDAC complex assembly and modulate VDAC tiltingPreprint

Timme, M., Holthuis, J. C. M., & Melo, M. N. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.25.720789 · Cited by 1

Cell autonomous inflammation in VEXAS is mediated by cGAS-STINGPreprint

Magaziner, S. J., Collins, J. C., Miller, B., Zheng, P., Wang, A. K., Hadjadj, J., Balandrán, J. C., Sirenko, M., English, M., Bertlin, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.26.727520 · Cited by 1

Is COVID 19, a beginning of new entity called chronic viral systemic inflammatory syndrome?

Gurusamy, D. S., Selvamurugesan, V., Kalyanasundaram, S., & Kalyanaraman, S. (2021) · AIMS Allergy and Immunology · doi:10.3934/allergy.2021010

POS0108 PLASMA MITOCHONDRIAL DNA AS A BIOMARKER IN DIAGNOSIS AND FOLLOW-UP OF SYSTEMIC LUPUS ERYTHEMATOSUS

Giaglis, S., Daoudlarian, D., Kyburz, D., Venhoff, N., & Walker, U. A. (2021) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-eular.1833

Type I Interferons and the Perpetuation of a Loss of Tolerance

Connelly, K., & Hoi, A. Y.-B. (2021) · Springer eBooks · doi:10.1007/978-3-030-85161-3_4

Angeborene autoinflammatorische Störungen der cGAS-STING- und OASRNase-L-vermittelten Nukleinsäure-Immunität

Hauck, F. H. (2021) · Trillium Immunologie · doi:10.47184/ti.2021.03.04

Faculty Opinions recommendation of Mitonuclear genomics and aging.

Osiewacz, H. D. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737293312.793571684

Lupus eritematoso sistémico

Rojas, G. A. S., Gonzalez, M. A., Farfán-Cano, H. R., Farfán-Cano, G. G., & Rojas, K. J. S. (2021) · Revista Ecuatoriana de Ciencia Tecnología e Innovación en Salud Pública · doi:10.31790/inspilip.v5i1.45

Molecular Basis of Mitochondrial Diseases Exemplified by Mutation of the Translation Factor Cox14

Witte, S. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10162

Metabolic control of immunopathogenesis in systemic lupus erythematosus

Perl, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93232-5.00023-x

Effect of TRO19622 (Olesoxime) on the Functional Activity of Isolated Mitochondria and Cell Viability

Ilzorkina, A. I., Belosludtseva, N. V., Semenova, A. A., Dubinin, M. V., & Belosludtsev, K. N. (2024) · Биофизика · doi:10.31857/s0006302924040068

From Hypoxia to Buoyancy: Serotonin and Oxygen Deprivation Rewire NeutrophilsPreprint

Blanco, L. P., Romo‐Tena, J., Wang, X., Lightfoot, Y. L., & Kaplan, M. J. (2024) · Research Square · doi:10.21203/rs.3.rs-5349113/v1

Mitochondria-derived vesicles: from quality control to inflammation and extracellular vesicles

Todkar, K. J., Amari, L., & Germain, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00007-7

Targeting Mtch2 Stimulates Immunotherapy Response in Aggressive Breast Cancer Via Mtdna-Cgas-Sting PathwayPreprint

Xu, Q., Jiang, Z., Li, S., Pan, Y., Cao, Z., Hua, S., Yang, R., He, X., Wu, H., Wen, H., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5029678

Mitochondrial damage triggers therapy-induced senescencePreprint

Baltira, C., Alkan, F., Mayayo‐Peralta, I., Navarro, M. G., Thijssen, B., Lempers, R., Pello, K., Fedorushkova, D. M., Their, A., Jochems, F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.20.629667

The Effect of TRO19622 (Olesoxime) on the Functional Activity of Isolated Mitochondria and Cell Viability

Ilzorkina, A. I., Belosludtseva, N. V., Semenova, A. A., Dubinin, M. V., & Belosludtsev, K. N. (2024) · BIOPHYSICS · doi:10.1134/s0006350924700714

Apoptotic caspases silence spontaneous innate immune signals by specifically cleaving activated mitochondrial antiviral signalling protein (MAVS)Preprint

Gradzka-Boberda, S., Parui, I., Chakraborty, P., Anthony, D. P., Puthussery, B. K., Weber, A., Brokatzky, D., Giansanti, P., Mergner, J., Öllinger, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.25.640042

Chronic lysosome damage boosts interferon responses to Palbociclib dependent upon the mitochondrionPreprint

Božić, M., Lim, T. E., Salomo-Coll, C., Karageorgiou, A., Kemp, A. J., Winnington-Ingram, K., Murphy, L. C., Dhir, A., Wheeler, A. P., Jiménez-Moreno, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.13.642980

Complex I Governs Iron Levels in Bat Mitochondria to Couple Respiration with Lipid MetabolismPreprint

Zeng, W., Peng, P., Chen, C., Wang, D., Cao, L., Wang, Z., Xia, Y., & Qiu, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.10.658522

Shedding of mitochondrial Voltage-Dependent Anion Channel-1 (VDAC1) Reflects COVID-19 Severity and Reveals Macrophage DysfunctionPreprint

Sjögren, M., Dunér, P., Marinis, Y. Z. D., Neumann, A., Leandersson, K., Rasmussen, M., Wollheim, C. B., & Salehi, A. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.07.663218

Radiation-dependent Nucleic Acid Sensing, and Its Possible Impact on Radiotherapy

Pickering, R. J., & Zierhut, C. (2025) · The Cancer Journal · doi:10.1097/ppo.0000000000000775

Oxidative Stress-Induced Mitochondrial Damage Aggravates M1 Macrophage Polarization by Activating the Cgas–Sting-Nf-Κb Signaling Axis in Autoimmune UveitisPreprint

Guo, D., Xu, S., Feng, J., Peng, Y., Xu, F., Liu, Y., Liu, B., Yin, X., Wei, H., Tian, Q., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5384578

Structural characterization of intra- and intermolecular disulfide bonds in voltage-dependent anion channel 3 (VDAC3) protein from Rattus norvegicus by high-resolution mass spectrometry

Pittalà, M. G. G., Cucina, A., Nibali, S. C., Cunsolo, V., Francesco, A. D., Battiato, G., Reina, S., Foti, S., Pinto, V. D., & Saletti, R. (2025) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-025-06074-w

VDAC activation inhibits hippocampal plasticity via NLRP3 inflammasome & caspase-1: modulation by allopregnanolone enantiomersPreprint

Izumi, Y., O'Dell, K. M. C., Covey, D. F., Qian, M., Mennerick, S. J., & Zorumski, C. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.24.684242

Additional file 1 of Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

Zhang, W. Z., Hoffman, K. L., Schiffer, K. T., Oromendia, C., Rice, M. C., Barjaktarevic, I., Peters, S. P., Putcha, N., Bowler, R. P., Wells, J. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14490545

Additional file 1 of Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway

Li, Y., Chen, H., Yang, Q., Wan, L., Zhao, J., Wu, Y., Wang, J., Yang, Y., Niu, M., Liu, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19234345

Additional file 1 of SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes

Chang, Y., Wang, C., Zhu, J., Zheng, S., Sun, S., Wu, Y., Jiang, X., Li, L., Ma, R., & Li, G. (2024) · Figshare · doi:10.6084/m9.figshare.26605984

Additional file 2 of SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes

Chang, Y., Wang, C., Zhu, J., Zheng, S., Sun, S., Wu, Y., Jiang, X., Li, L., Ma, R., & Li, G. (2024) · Figshare · doi:10.6084/m9.figshare.26605987

Additional file 1 of IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis

Sun, K., Lü, F., Hou, L., Zhang, X., Pan, C., Liu, H., Zheng, Z., Guo, Z., Ruan, Z., Hou, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26333322

Additional file 1 of Nanoplastics causes heart aging/myocardial cell senescence through the Ca2+/mtDNA/cGAS-STING signaling cascade

Wang, K., Du, Y., Li, P., Guan, C., Zhou, M., Wu, L., Liu, Z., & Huang, Z. (2024) · Figshare · doi:10.6084/m9.figshare.25357851

Additional file 2 of IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis

Sun, K., Lü, F., Hou, L., Zhang, X., Pan, C., Liu, H., Zheng, Z., Guo, Z., Ruan, Z., Hou, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26333416

Additional file 1 of Analysis of cellular and cell free mitochondrial DNA content and reactive oxygen species levels in maternal blood during normal pregnancy: a pilot study

Srivastava, A., Srivastava, P., Mathur, S., Mishra, S., Abbas, S., Gupta, A., Mishra, P., Tiwari, M., & Sharma, L. K. (2022) · Figshare · doi:10.6084/m9.figshare.21582319

Targeting ST18-mediated pathomechanism in pemphigus vulgaris through voltage-dependent anion channel inhibition

Assaf, S., Sarig, O., Ishtewy, R., Zoabi, Y., Feller, Y., Malovitski, K., Mohamad, J., Bergson, S., Bilu, C., Shoshan‐Barmatz, V., et al. (2025) · Skin Health and Disease · doi:10.1093/skinhd/vzaf107

Deletion of Glaesserella parasuis nanA promotes apoptosis by inhibiting PINK1/Parkin pathway

Liu, Y., Tan, Y., Huan, S., Wu, Z., & Lei, Z. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150472

Neutrophils impair B cell differentiation via mitochondrial and lipid metabolism in lupusPreprint

Bradford, H. F., Montamat, G., Barrenechea, L. G., Spinazzola, A., Lowe, D. M., Salama, A. D., Mauri, C., & Antonelou, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.03.703615

The complex role of mitochondrial dysfunction in the development of obese asthma

Jiang, P., & Zhang, Z. (2026) · Journal of Asthma · doi:10.1080/02770903.2026.2633350

Host mitochondrial DNA in bacterial pathogenesis: Friend, Foe, or Both?

Ahmadian, M., Shoraka, S., Elahi, Y., Abdollahi, A. K., Karimi-Jashni, A., & Hassani, Z. (2026) · Archives of Microbiology · doi:10.1007/s00203-026-04784-y

Context-Specific Innate Immune Evasion via VDAC1 Gate-Jamming in Microsatellite-Stable Colorectal CancerPreprint

Vasquez, A. J. (2026) · Research Square · doi:10.21203/rs.3.rs-8935902/v1

Oligomerization of VDAC1 promotes mtDNA release and lupus‐like disease

Kim, J. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.09093

VDAC oligomer pores: A mechanism in disease triggered by mtDNA release

Yan, J., Liu, W., Feng, F., & Chen, L. (2020) · Cell Biology International · doi:10.1002/cbin.11427 · Cited by 30

The role of the mitochondrial voltage‐dependent anion channel in obesity and inflammation

Kim, J., Yoon, H., & Chung, J. H. (2021) · The FASEB Journal · doi:10.1096/fasebj.2021.35.s1.02749

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Xian, H., Watari, K., Sanchez-Lopez, E., Offenberger, J., Onyuru, J., Sampath, H., Ying, W., Hoffman, H. M., Shadel, G. S., & Karin, M. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.007 · Cited by 850

FEN1-Generated Oxidized DNA Fragments Escape Mitochondria via mPTP- and VDAC-Dependent Channels to License NLRP3 Inflammasome and STING ActivationPreprint

Xian, H., Watari, K., Sánchez‐López, E., Shadel, G. S., & Karin, M. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4022698 · Cited by 6