Mitochondrial DNA in innate immune responses and inflammatory pathology

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154 · see citing works

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works

Type I interferons in infectious disease

McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780 · see citing works

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333 · see citing works

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975 · see citing works

Mitochondrial form and function

Friedman, J. R., & Nunnari, J. (2014) · Nature · doi:10.1038/nature12985 · Cited by 1,803 · see citing works

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659 · see citing works

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570 · see citing works

Mitochondria in innate immune responses

West, A. P., Shadel, G. S., & Ghosh, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2975 · Cited by 1,376 · see citing works

Mitochondrial ROS Signaling in Organismal Homeostasis

Shadel, G. S., & Horvath, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.10.001 · Cited by 1,353 · see citing works

STING: infection, inflammation and cancer.

Barber, G. N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3921 · Cited by 1,313 · see citing works

Replication of animal mitochondrial DNA

Clayton, D. A. (1982) · Cell · doi:10.1016/0092-8674(82)90049-6 · Cited by 1,236 · see citing works

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., et al. (2012) · Nature · doi:10.1038/nature10992 · Cited by 1,201 · see citing works

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhong, Z., Umemura, A., Sanchez-Lopez, E., Liang, S., Shalapour, S., Wong, J., He, F., Boassa, D., Perkins, G., Ali, S. R., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.057 · Cited by 1,197 · see citing works

MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES

Shadel, G. S., & Clayton, D. A. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.409 · Cited by 1,059 · see citing works

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

Gao, D., Wu, J., Wu, Y.-T., Du, F., Aroh, C., Yan, N., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1240933 · Cited by 986 · see citing works

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

White, M. J., McArthur, K., Metcalf, D., Lane, R. M., Cambier, J. C., Herold, M. J., van Delft, M. F., Bedoui, S., Lessene, G., Ritchie, M. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.036 · Cited by 983 · see citing works

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

Chen, Q., Boire, A., Jin, X., Valiente, M., Er, E. E., Lopez-Soto, A., S. Jacob, L., Patwa, R., Shah, H., Xu, K., et al. (2016) · Nature · doi:10.1038/nature18268 · Cited by 969 · see citing works

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960 · see citing works

Aicardi–Goutières syndrome and the type I interferonopathies

Crow, Y. J., & Manel, N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3850 · Cited by 925 · see citing works

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

Schoggins, J. W., MacDuff, D. A., Imanaka, N., Gainey, M. D., Shrestha, B., Eitson, J. L., Mar, K. B., Richardson, R. B., Ratushny, A. V., Litvak, V., et al. (2014) · Nature · doi:10.1038/nature12862 · Cited by 896 · see citing works

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., de Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C.-Y., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.037 · Cited by 847 · see citing works

Initiation and perpetuation of <scp>NLRP</scp> 3 inflammasome activation and assembly

Elliott, E. I., & Sutterwala, F. S. (2015) · Immunological Reviews · doi:10.1111/imr.12286 · Cited by 821 · see citing works

Converging roles of caspases in inflammasome activation, cell death and innate immunity

Man, S. M., & Kanneganti, T. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.7 · Cited by 701 · see citing works

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.02.054 · Cited by 675 · see citing works

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

Lewis, S. C., Uchiyama, L. F., & Nunnari, J. (2016) · Science · doi:10.1126/science.aaf5549 · Cited by 673 · see citing works

DNA methylation on N6-adenine in mammalian embryonic stem cells

Wu, T. P., Wang, T., Seetin, M. G., Lai, Y., Zhu, S., Lin, K., Liu, Y., Byrum, S. D., Mackintosh, S. G., Zhong, M., et al. (2016) · Nature · doi:10.1038/nature17640 · Cited by 648 · see citing works

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

Watson, R. O., Bell, S. L., MacDuff, D. A., Kimmey, J. M., Diner, E. J., Olivas, J., Vance, R. E., Stallings, C. L., Virgin, H. W., & Cox, J. S. (2015) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2015.05.004 · Cited by 645 · see citing works

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Carroll, E. C., Jin, L., Mori, A., Muñoz‐Wolf, N., Oleszycka, E., Moran, H. B. T., Mansouri, S., McEntee, C. P., Lambe, E. M., Agger, E. M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.004 · Cited by 599 · see citing works

An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore

Alavian, K. N., Beutner, G., Lazrove, E., Sacchetti, S., Park, H., Licznerski, P., Li, H., Nabili, P., Hockensmith, K., Graham, M. M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401591111 · Cited by 595 · see citing works

The Mitochondrial Proteome and Human Disease

Calvo, S. E., & Mootha, V. K. (2010) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082509-141720 · Cited by 590 · see citing works

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

Bernardi, P., Rasola, A., Forte, M. A., & Lippe, G. (2015) · Physiological Reviews · doi:10.1152/physrev.00001.2015 · Cited by 586 · see citing works

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

Matheoud, D., Sugiura, A., Bellemare-Pelletier, A., Laplante, A., Rondeau, C., Chemali, M., Fazel, A., Bergeron, J. J., Trudeau, L.-E., Burelle, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.039 · Cited by 582 · see citing works

Nucleic acid recognition by the innate immune system

Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577 · see citing works

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

Shock, L. S., Thakkar, P. V., Peterson, E. J., Moran, R. G., & Taylor, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012311108 · Cited by 555 · see citing works

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

Wolf, A. J., Reyes, C. N., Liang, W., Becker, C. A., Shimada, K., Wheeler, M. L., Cho, H. C., Popescu, N. I., Coggeshall, K. M., Arditi, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.076 · Cited by 554 · see citing works

Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins

Parisi, M. A., & Clayton, D. A. (1991) · Science · doi:10.1126/science.2035027 · Cited by 548 · see citing works

Recognition of Endogenous Nucleic Acids by the Innate Immune System

Roers, A., Hiller, B., & Hornung, V. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.002 · Cited by 541 · see citing works

Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses

Collins, L. V., Hajizadeh, S., Holme, E., Jonsson, I., & Tarkowski, A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703328 · Cited by 504 · see citing works

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

Caielli, S., Athale, S., Domic, B., Murat, E., Chandra, M., Banchereau, R., Baisch, J., Phelps, K., Clayton, S., Gong, M., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151876 · Cited by 501 · see citing works

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Garcia-Martinez, I., Santoro, N., Chen, Y., Hoque, R., Ouyang, X., Caprio, S., Shlomchik, M. J., Coffman, R. L., Candia, A., & Mehal, W. Z. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83885 · Cited by 498 · see citing works

Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

Yu, J.-J., Nagasu, H., Murakami, T., Hoang, H., Broderick, L., Hoffman, H., & Horng, T. (2014) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1414859111 · Cited by 449 · see citing works

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

Bronner, D. N., Abuaita, B. H., Chen, X., Fitzgerald, K. A., Núñez, G., He, Y. O., Yin, X., & O’Riordan, M. X. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.008 · Cited by 438 · see citing works

Minimizing the damage: repair pathways keep mitochondrial DNA intact

Kazak, L., Reyes, A., & Holt, I. J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3439 · Cited by 412 · see citing works

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

Pinti, M., Cevenini, E., Nasi, M., De Biasi, S., Salvioli, S., Monti, D., Benatti, S., Gibellini, L., Cotichini, R., Stazi, M. A., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201343921 · Cited by 409 · see citing works

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Wassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., Schmid-Burgk, J. L., Schmidt, T., Hornung, V., Cole, S. T., et al. (2015) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2015.05.003 · Cited by 401 · see citing works

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

Gray, E. E., Treuting, P. M., Woodward, J. J., & Stetson, D. B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500969 · Cited by 384 · see citing works

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

Collins, A. C., Cai, H., Li, T., Franco, L. H., Li, X.-D., Nair, V. R., Scharn, C. R., Stamm, C. E., Levine, B., Chen, Z. J., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.005 · Cited by 384 · see citing works

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

Nakahira, K., Hisata, S., & Choi, A. M. K. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6407 · Cited by 363 · see citing works

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

Mankan, A. K., Schmidt, T., Chauhan, D., Goldeck, M., Höning, K., Gaidt, M. M., Kubarenko, A. V., Andreeva, L., Hopfner, K., & Hornung, V. (2014) · The EMBO Journal · doi:10.15252/embj.201488726 · Cited by 359 · see citing works

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

Zhang, Q., Itagaki, K., & Hauser, C. J. (2010) · Shock · doi:10.1097/shk.0b013e3181cd8c08 · Cited by 354 · see citing works

Initiation and Beyond: Multiple Functions of the Human Mitochondrial Transcription Machinery

Bonawitz, N. D., Clayton, D. A., & Shadel, G. S. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.024 · Cited by 337 · see citing works

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

Marques, P. E., Amaral, S. S., Pires, D. A., Nogueira, L. L., Soriani, F. M., Lima, B. H. F., Lopes, G. A. O., Russo, R. C., Ávila, T. V., Melgaço, J. G., et al. (2012) · Hepatology · doi:10.1002/hep.25801 · Cited by 332 · see citing works

Protecting the mitochondrial powerhouse

Scheibye‐Knudsen, M., Fang, E. F., Croteau, D. L., Wilson, D. M., & Bohr, V. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.002 · Cited by 330 · see citing works

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof‐of‐Concept Trial of Metformin

Wang, H., Li, T., Chen, S., Gu, Y., & Ye, S. (2015) · Arthritis &amp; Rheumatology · doi:10.1002/art.39296 · Cited by 325 · see citing works

In D-loop: 40years of mitochondrial 7S DNA

Nicholls, T. J. J., & Minczuk, M. A. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.027 · Cited by 287 · see citing works

Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9

Liu, Y., Yan, W., Tohme, S. T., Chen, M., Fu, Y., Tian, D., Lotze, M. T., Tang, D., & Tsung, A. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.009 · Cited by 269 · see citing works

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern

Bellizzi, D., D’Aquila, P., Scafone, T., Giordano, M., Riso, V., Riccio, A., & Passarino, G. (2013) · DNA Research · doi:10.1093/dnares/dst029 · Cited by 267 · see citing works

Mitochondrial DNA Damage as a Potential Mechanism for Age-Related Macular Degeneration

Karunadharma, P. P., Nordgaard, C. L., Olsen, T. W., & Ferrington, D. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5429 · Cited by 261 · see citing works

Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration

Terluk, M. R., Kapphahn, R. J., Soukup, L. M., Gong, H., Gallardo, C., Montezuma, S. R., & Ferrington, D. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0190-15.2015 · Cited by 253 · see citing works

Mitochondrial DNA Variation in Human Radiation and Disease

Wallace, D. C. (2015) · Cell · doi:10.1016/j.cell.2015.08.067 · Cited by 253 · see citing works

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

Mackenzie, K. J., Carroll, P., Lettice, L., Tarnauskaitė, Ž., Reddy, K., Dix, F., Revuelta, A., Abbondati, E., Rigby, R. E., Rabe, B., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593339 · Cited by 248 · see citing works

The genomic landscape of polymorphic human nuclear mitochondrial insertions

Dayama, G., Emery, S. B., Kidd, J. M., & Mills, R. E. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1038 · Cited by 241 · see citing works

Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

Ding, Z., Liu, S., Wang, X., Khaidakov, M., Dai, Y., & Mehta, J. L. (2013) · Scientific Reports · doi:10.1038/srep01077 · Cited by 204 · see citing works

Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation.

Reis, R. J. S., & Goldstein, S. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44633-3 · Cited by 203 · see citing works

Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication.

Albring, M., Griffith, J. D., & Attardi, G. M. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.4.1348 · Cited by 197 · see citing works

Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis

Hajizadeh, S., DeGroot, J., TeKoppele, J. M., Tarkowski, A., & Collins, L. V. (2003) · Arthritis Res Ther · doi:10.1186/ar787 · Cited by 196 · see citing works

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

McCarthy, C. G., Wenceslau, C. F., Goulopoulou, S., Ogbi, S. N., Baban, B., Sullivan, J. C., Matsumoto, T., & Webb, R. C. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv137 · Cited by 193 · see citing works

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

Itagaki, K., Kaczmarek, E., Lee, Y. T., Tang, I. T., Isal, B., Adibnia, Y., Sandler, N., Grimm, M. J., Segal, B. H., Otterbein, L. E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120549 · Cited by 193 · see citing works

Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery

McIlroy, D. J., Jarnicki, A. G., Au, G. G., Lott, N., Smith, D. W., Hansbro, P. M., & Balogh, Z. J. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2014.07.013 · Cited by 187 · see citing works

cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection

Storek, K. M., Talmor, N., Ohlson, M. B., & Monack, D. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402764 · Cited by 184 · see citing works

Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA

Hong, E. E., Okitsu, C. Y., Smith, A. D., & Hsieh, C.-L. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00220-13 · Cited by 175 · see citing works

The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent

Wiens, K. E., & Ernst, J. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005809 · Cited by 173 · see citing works

High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcytosine in Mouse Embryonic Stem Cells

Sun, Z., Terragni, J., Borgaro, J. G., Liu, Y., Yu, L., Guan, S., Wang, H., Sun, D., Cheng, X., Zhu, Z., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.001 · Cited by 170 · see citing works

Mitochondrial permeability transition triggers the release of mtDNA fragments

Patrushev, M., Kasymov, V., Patrusheva, V., Ushakova, T., Gogvadze, V., & Gaziev, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4424-1 · Cited by 168 · see citing works

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

Pouwels, S. D., Zijlstra, G. J., van der Toorn, M., Hesse, L., Gras, R., ten Hacken, N. H. T., Krysko, D. V., Vandenabeele, P., de Vries, M., van Oosterhout, A. J. M., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00174.2015 · Cited by 168 · see citing works

Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

Leo, M. G. D., Staiano, L., Vicinanza, M., Luciani, A., Carissimo, A., Mutarelli, M., Campli, A. D., Polishchuk, E., Tullio, G. D., Morra, V., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3386 · Cited by 167 · see citing works

Mitochondrial damage contributes toPseudomonas aeruginosaactivation of the inflammasome and is downregulated by autophagy

Jabir, M. S., Hopkins, L., Ritchie, N. D., Ullah, I., Bayes, H. K., Li, D., Tourlomousis, P., Lupton, A., Puleston, D. J., Simon, A. K., et al. (2015) · Autophagy · doi:10.4161/15548627.2014.981915 · Cited by 164 · see citing works

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

Tumurkhuu, G., Shimada, K., Dagvadorj, J., Crother, T., Zhang, W., Luthringer, D., Gottlieb, R., Chen, S., & Arditi, M. (2016) · Circulation Research · doi:10.1161/circresaha.116.308362 · Cited by 164 · see citing works

Methylation pattern of mouse mitochondrial DNA

Pollack, Y., Kasir, J., Shemer, R., Metzger, S., & Moshe Szyf, A. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.12.4811 · Cited by 161 · see citing works

Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9

Tsuji, N., Tsuji, T., Ohashi, N., Kato, A., Fujigaki, Y., & Yasuda, H. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015040376 · Cited by 158 · see citing works

Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model

Yao, X., Carlson, D., Sun, Y., Ma, L., Wolf, S. E., Minei, J. P., & Zang, Q. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139416 · Cited by 145 · see citing works

Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells In vivo and in vitro methylation

Nass, M. M. K. (1973) · Journal of Molecular Biology · doi:10.1016/0022-2836(73)90239-8 · Cited by 141 · see citing works

Herpes simplex virus eliminates host mitochondrial DNA

Saffran, H. A., Pare, J. M., Corcoran, J. A., Weller, S. K., & Smiley, J. R. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400878 · Cited by 141 · see citing works

Membrane-associated DNA Transport MachinesPreprint

Burton, B., & Dubnau, D. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000406 · Cited by 124 · see citing works

Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition

Zhang, Z., Meng, P., Han, Y., Shen, C., Li, B., Hakim, M. A., Zhang, X., Lu, Q., Rong, M., & Lai, R. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.018 · Cited by 124 · see citing works

Fidelity of capture-enrichment for mtDNA genome sequencing: influence of NUMTs

Li, M., Schröeder, R., Ko, A. M., & Stoneking, M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks499 · Cited by 122 · see citing works

Mitochondrial Dysfunction Due to Oxidative Mitochondrial DNA Damage Is Reduced through Cooperative Actions of Diverse Proteins

O'Rourke, T. W., Doudican, N. A., Mackereth, M. D., Doetsch, P. W., & Shadel, G. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4086-4093.2002 · Cited by 121 · see citing works

Ambiguities in NLRP3 inflammasome regulation: Is there a role for mitochondria?

Lawlor, K. E., & Vince, J. E. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.08.014 · Cited by 120 · see citing works

Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA

JULIAN, M. W., Shao, G., Bao, S., Knoell, D. L., Papenfuss, T. L., VanGundy, Z., & Crouser, E. D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101375 · Cited by 112 · see citing works

Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

Reyes, A., Kazak, L., Wood, S., Yasukawa, T., Jacobs, H. T., & Holt, I. J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt196 · Cited by 110 · see citing works

Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors

Crouser, E. D., Shao, G., JULIAN, M. W., Macre, J. E., Shadel, G. S., Tridandapani, S., Huang, Q., & Wewers, M. D. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a001ae · Cited by 108 · see citing works

Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions

Kenney, M. C., Chwa, M., Atilano, S. R., Falatoonzadeh, P., Ramírez, C., Malik, D., Tarek, M., Cáceres‐del‐Carpio, J., Nesburn, A. B., Boyer, D. S., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu065 · Cited by 108 · see citing works

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions

Rebelo, A. P., Williams, S. L., & Moraes, C. T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp727 · Cited by 108 · see citing works

Preventing the pollution of mitochondrial datasets with nuclear mitochondrial paralogs (numts)

Calvignac‐Spencer, S., Konecny‐Dupré, L., Malard, F., & Douady, C. J. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.10.004 · Cited by 106 · see citing works

Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

Gerhold, J. M., Cansız-Arda, Ş., Lõhmus, M., Engberg, O., Reyes, A., van Rennes, H., Sanz, A., Holt, I. J., Cooper, H. M., & Spelbrink, J. N. (2015) · Scientific Reports · doi:10.1038/srep15292 · Cited by 106 · see citing works

Mitochondrial DNA fragments released through the permeability transition pore correspond to specific gene size

Garcı́a, N., & Chávez, E. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.08.019 · Cited by 94 · see citing works

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

van der Burgh, R., Nijhuis, L., Pervolaraki, K., Compeer, E. B., Jongeneel, L. H., van Gijn, M. E., Coffer, P. J., Murphy, M. P., Mastroberardino, P. G., Frenkel, J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536920 · Cited by 92 · see citing works

5-Methylcytidylic Acid: Absence from Mitochondrial DNA of Frogs and HeLa Cells

Dawid, I. B. (1974) · Science · doi:10.1126/science.184.4132.80 · Cited by 87 · see citing works

Accessorizing the human mitochondrial transcription machinery

Bestwick, M. L., & Shadel, G. S. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.03.006 · Cited by 82 · see citing works

Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs

Kuck, J. L., Obiako, B. O., Gorodnya, O. M., Pastukh, V. M., Kua, J., Simmons, J. D., & Gillespie, M. N. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00015.2015 · Cited by 80 · see citing works

Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells

Pázmándi, K., Agod, Z., Kumar, B. V., Szabó, A., Fekete, T., Sógor, V., Veres, Á. N., Boldogh, I. R., Rajnavölgyi, É., Lányi, Á., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.09.028 · Cited by 76 · see citing works

Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F1FO ATP synthase

Jonas, E. A., Porter, G. A., Beutner, G., Mnatsakanyan, N., & Alavian, K. N. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.04.013 · Cited by 76 · see citing works

Induction of Type I IFN Is a Physiological Immune Reaction to Apoptotic Cell-Derived Membrane Microparticles

Schiller, M. R., Parčina, M., Heyder, P., Foermer, S., Ostrop, J., Leo, A., Heeg, K. M., i, M. H., Lorenz, H., & Bekeredjian‐Ding, I. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100631 · Cited by 74 · see citing works

Mitochondrial DNA

Schäfer, S. T., Franken, L., Adamzik, M., Schumak, B., Scherag, A., Engler, A., Schönborn, N., Walden, J., Koch, S., Baba, H. A., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001008 · Cited by 70 · see citing works

Mitochondrial DNA has a pro-inflammatory role in AMD

Dib, B., Lin, H., Maidana, D. E., Tian, B., Miller, J. B., Bouzika, P., Miller, J. W., & Vavvas, D. G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.08.012 · Cited by 66 · see citing works

Herpes Simplex Virus UL12.5 Targets Mitochondria through a Mitochondrial Localization Sequence Proximal to the N Terminus

Corcoran, J. A., Saffran, H. A., Duguay, B. A., & Smiley, J. R. (2009) · Journal of Virology · doi:10.1128/jvi.02087-08 · Cited by 66 · see citing works

Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly

Verschoor, C. P., Loukov, D., Naidoo, A., Puchta, A., Johnstone, J., Millar, J., Lelic, A., Novakowski, K. E., Dorrington, M. G., Loeb, M. B., et al. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.01.015 · Cited by 62 · see citing works

Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation

Ries, M., Schuster, P., Thomann, S., Donhauser, N., Vollmer, J., & Schmidt, B. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0612278 · Cited by 61 · see citing works

Methylation of Mitochondrial DNA Is Not a Useful Marker for Cancer Detection

Maekawa, M., Taniguchi, T., Higashi, H., Sugimura, H., Sugano, K., & Kanno, T. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.035139 · Cited by 59 · see citing works

Cyclosporine and tacrolimus have inhibitory effects on toll-like receptor signaling after liver transplantation

Howell, J. A., Sawhney, R., Testro, A., Skinner, N. A., Gow, P. J., Angus, P., Ratnam, D. T., & Visvanathan, K. (2013) · Liver Transplantation · doi:10.1002/lt.23712 · Cited by 55 · see citing works

Innate Immune Recognition of mtDNA—An Undercover Signal?

Kanneganti, T., Kundu, M., & Green, D. R. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.019 · Cited by 35 · see citing works

Mutation in cytochrome b gene of mitochondrial DNA in a family with fibromyalgia is associated with NLRP3-inflammasome activation

Cordero, M. D., Alcocer‐Gómez, E., Marín‐Aguilar, F., Rybkina, T., Cotán, D., Pérez‐Pulido, A. J., Álvarez-Suárez, J. M., Battino, M. A., Sánchez-Alcázar, J. A., Carrión, Á. M., et al. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103392 · Cited by 35 · see citing works

The Conjugative DNA Translocase TrwB Is a Structure-specific DNA-binding Protein

Matilla, I., Alfonso, C., Rivas, G., Bolt, E. L., de la Cruz, F., & Cabezón, E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.084137 · Cited by 34 · see citing works

Hydroxymethyl cytosine marks in the human mitochondrial genome are dynamic in nature

Ghosh, S., Sengupta, S., & Scaria, V. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.01.003 · Cited by 33 · see citing works

Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication

Duguay, B. A., Saffran, H. A., Ponomarev, A., Duley, S. A., Eaton, H. E., & Smiley, J. R. (2013) · Journal of Virology · doi:10.1128/jvi.03129-13 · Cited by 32 · see citing works

Cyclosporin A inhibits the early phase of NF-κB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells

Nishiyama, S., Manabe, N., Kubota, Y., Ohnishi, H., Kitanaka, A., Tokuda, M., Taminato, T., Ishida, T., Takahara, J., & Tanaka, T. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.11.018 · Cited by 27 · see citing works

Severe Septic Patients with Mitochondrial DNA Haplogroup JT Show Higher Survival Rates: A Prospective, Multicenter, Observational Study

Lorente, L., Iceta, R., Martin, M. M. I. D. O., López‐Gallardo, E., Solé‐Violán, J., Blanquer, J., Labarta, L., Díaz, C., Borreguero-León, J. M., Jiménez, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073320 · Cited by 20 · see citing works

Targeted and Robust Amplification of Mitochondrial DNA in the Presence of Nuclear-Encoded Mitochondrial Pseudogenes Using Φ29 DNA Polymerases

Wolff, J. N. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0835-6_17 · Cited by 6 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death &amp; Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Mitochondrial TCA cycle metabolites control physiology and disease

Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813 · see citing works

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Singh, R., Letai, A., & Sarosiek, K. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0089-8 · Cited by 2,111 · see citing works

Inflammation and immune dysfunction in Parkinson disease

Tansey, M. G., Wallings, R. L., Houser, M. C., Herrick, M. K., Keating, C. E., & Joers, V. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00684-6 · Cited by 1,382 · see citing works

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255 · see citing works

Mitochondrial dysfunction: mechanisms and advances in therapy

Yao, Z., Li, H., Liao, P., Chen, L., Pan, Y., Zheng, Y., Zhang, C., Liu, D., Zheng, M., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01839-8 · Cited by 1,274 · see citing works

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., San Chin, H., et al. (2018) · Science · doi:10.1126/science.aao6047 · Cited by 1,072 · see citing works

Detection of immunogenic cell death and its relevance for cancer therapy

Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020) · Cell Death &amp; Disease · doi:10.1038/s41419-020-03221-2 · Cited by 1,138 · see citing works

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

Zindel, J., & Kubes, P. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032847 · Cited by 874 · see citing works

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Xian, H., Watari, K., Sanchez-Lopez, E., Offenberger, J., Onyuru, J., Sampath, H., Ying, W., Hoffman, H. M., Shadel, G. S., & Karin, M. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.007 · Cited by 850 · see citing works

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

Kim, J., Gupta, R., Blanco, L. P., Yang, S., Shteinfer-Kuzmine, A., Wang, K., Zhu, J., Yoon, H. E., Wang, X., Kerkhofs, M., et al. (2019) · Science · doi:10.1126/science.aav4011 · Cited by 793 · see citing works

Liquid–liquid phase separation in human health and diseases

Wang, B., Zhang, L., Dai, T., Qin, Z.-R., Lu, H.-S., Zhang, L., & Zhou, F.-F. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00678-1 · Cited by 634 · see citing works

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Shpilka, T., & Haynes, C. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.110 · Cited by 716 · see citing works

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

Dhir, A., Dhir, S., Borowski, L. S., Jimenez, L., Teitell, M., Rötig, A., Crow, Y. J., Rice, G. I., Duffy, D., Tamby, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0363-0 · Cited by 631 · see citing works

Mitochondrial signal transduction

Picard, M. A., & Shirihai, O. S. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.10.008 · Cited by 666 · see citing works

Mitochondria in health, disease, and aging

Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 622 · see citing works

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

Riley, J. S., Quarato, G., Cloix, C., Lopez, J., O'Prey, J., Pearson, M., Chapman, J., Sesaki, H., Carlin, L. M., Passos, J. F., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201899238 · Cited by 551 · see citing works

Mitochondrial fusion, fission, and mitochondrial toxicity

Meyer, J. N., Leuthner, T. C., & Luz, A. L. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.019 · Cited by 521 · see citing works

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate

Chakrabarty, R. P., & Chandel, N. S. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.011 · Cited by 490 · see citing works

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

Garg, A. D., & Agostinis, P. (2017) · Immunological Reviews · doi:10.1111/imr.12574 · Cited by 448 · see citing works

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., Kidane, Y., Rathi, K. S., Smith, S. M., Stear, B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.002 · Cited by 402 · see citing works

Mitochondria in innate immune signaling

Banoth, B., & Cassel, S. L. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.014 · Cited by 410 · see citing works

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

Weindel, C. G., Martinez, E. L., Zhao, X. L., Mabry, C. J., Bell, S. L., Vail, K. J., Coleman, A. K., VanPortfliet, J. J., Zhao, B., Wagner, A. R., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.038 · Cited by 404 · see citing works

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

Yu, Y., Liu, Y., An, W., Song, J., Zhang, Y., & Zhao, X. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121842 · Cited by 384 · see citing works

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

Torralba, D., Baixauli, F., Villarroya‐Beltri, C., Fernández‐Delgado, I., Latorre, A., Acín‐Pérez, R., Martin-Cofreces, N. B., Jaso-Tamame, A. L., Iborra, S., Jorge, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05077-9 · Cited by 376 · see citing works

New frontiers in the cGAS-STING intracellular DNA-sensing pathway

Dvorkin, S., Cambier, S., Volkman, H. E., & Stetson, D. B. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.019 · Cited by 377 · see citing works

Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

Kuo, C., Babuharisankar, A. P., Lin, Y.-C., Lien, H.-W., Lo, Y.-K., Chou, H.-Y., Tangeda, V., Cheng, L.-C., Cheng, A., & Lee, A. (2022) · Journal of Biomedical Sciences · doi:10.1186/s12929-022-00859-2 · Cited by 316 · see citing works

Mitochondrial DNA Release in Innate Immune Signaling

Newman, L. E., & Shadel, G. S. (2023) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-104401 · Cited by 331 · see citing works

The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

Kang, I., Chu, C. T., & Kaufman, B. A. (2018) · FEBS Letters · doi:10.1002/1873-3468.12989 · Cited by 325 · see citing works

Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

Puhm, F., Afonyushkin, T., Resch, U., Obermayer, G., Rohde, M., Penz, T., Schuster, M., Wagner, G., Rendeiro, A. F., Melki, I., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314601 · Cited by 306 · see citing works

cGAS-STING–mediated DNA sensing maintains CD8 ⁺ T cell stemness and promotes antitumor T cell therapy

Li, W., Lu, L., Lu, J., Wang, X., Yang, C., Jin, J., Wu, L., Hong, X., Li, F., Cao, D., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay9013 · Cited by 305 · see citing works

Mitochondrial DNA variation and cancer

Kopinski, P. K., Singh, L. N., Zhang, S., Lott, M. T., & Wallace, D. C. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00358-w · Cited by 301 · see citing works

Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

Porter, R. J., Kalla, R., & Ho, G. (2020) · F1000Research · doi:10.12688/f1000research.20805.1 · Cited by 299 · see citing works

Type I Interferons in Autoimmune Disease

Crow, M. K., Olferiev, M., & Kirou, K. A. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043952 · Cited by 297 · see citing works

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Lei, Y., VanPortfliet, J. J., Chen, Y., Bryant, J. D., Li, Y., Fails, D., Torres-Odio, S., Ragan, K. B., Deng, J., Mohan, A., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.039 · Cited by 292 · see citing works

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Benmerzoug, S., Rose, S., Bounab, B., Gosset, D., Duneau, L., Chenuet, P., Mollet, L., Bert, M. L., Lambers, C., Geleff, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07425-1 · Cited by 282 · see citing works

Oxidative stress and the role of redox signalling in chronic kidney disease

Kishi, S., Nagasu, H., Kidokoro, K., & Kashihara, N. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00775-0 · Cited by 283 · see citing works

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

Dela Cruz, C. S., & Kang, M.-J. (2018) · Mitochondrion · doi:10.1016/j.mito.2017.12.001 · Cited by 255 · see citing works

Mitochondrial function in immune cells in health and disease

Faas, M. M., & de Vos, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165845 · Cited by 246 · see citing works

Mitocellular communication: Shaping health and disease

Mottis, A., Herzig, S., & Auwerx, J. H. (2019) · Science · doi:10.1126/science.aax3768 · Cited by 238 · see citing works

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Yambire, K. F., Rostosky, C. M., Watanabe, T., Pacheu‐Grau, D., Torres-Odio, S., Sanchez-Guerrero, A., Senderovich, O., Meyron‐Holtz, E. G., Milošević, I., Frahm, J., et al. (2019) · eLife · doi:10.7554/elife.51031 · Cited by 229 · see citing works

Mitochondrial DNA-triggered innate immune response: mechanisms and diseases

Hu, M.-M., & Shu, H. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01086-x · Cited by 247 · see citing works

Molecular Mechanisms of mtDNA-Mediated Inflammation

Gaetano, A. D., Solodka, K., Zanini, G., Selleri, V., Mattioli, A. V., Nasi, M., & Pinti, M. (2021) · Cells · doi:10.3390/cells10112898 · Cited by 235 · see citing works

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

Willemsen, J., Neuhoff, M., Hoyler, T., Noir, E., Tessier, C., Sarret, S., Thorsen, T. N., Littlewood-Evans, A. J., Zhang, J., Hasan, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109977 · Cited by 228 · see citing works

Mitochondrial diseases: from molecular mechanisms to therapeutic advances

Wen, H., Deng, H., Li, B., Chen, J., Zhu, J., Zhang, X., Yoshida, S., & Zhou, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02044-3 · Cited by 250 · see citing works

Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

Tyrrell, D. J., Blin, M. G., Song, J., Wood, S. C., Zhang, M., Beard, D. A., & Goldstein, D. R. (2019) · Circulation Research · doi:10.1161/circresaha.119.315644 · Cited by 228 · see citing works

The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy

Ge, Z., & Ding, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.590941 · Cited by 224 · see citing works

Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation

Drury, B., Hardisty, G. R., Gray, R. D., & Ho, G. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.03.002 · Cited by 222 · see citing works

Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver

Mihm, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103104 · Cited by 232 · see citing works

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Jauhari, A., Baranov, S. V., Suofu, Y., Kim, J., Singh, T., Yablonska, S., Li, F., Wang, X., Oberly, P. J., Minnigh, M. B., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135026 · Cited by 215 · see citing works

Mitochondria and Critical Illness

Supinski, G. S., Schroder, E. A., & Callahan, L. A. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.08.2182 · Cited by 208 · see citing works

Damage-associated molecular patterns in trauma

Relja, B., & Land, W. G. (2019) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-019-01235-w · Cited by 218 · see citing works

Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

Ma, X. M., Geng, K., Law, B. Y. K., Wang, P., Pu, Y. L., Chen, Q., Xu, H. W., Tan, X. Z., Jiang, Z. Z., & Xu, Y. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09692-z · Cited by 208 · see citing works

Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles

Cheng, A. N., Cheng, L.-C., Kuo, C., Lo, Y. K., Chou, H.-Y., Chen, C., Wang, Y., Chuang, T., Cheng, S., & Lee, A. Y. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001372 · Cited by 209 · see citing works

Mitochondrial dysfunction as a trigger of innate immune responses and inflammation

West, A. P. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.016 · Cited by 199 · see citing works

Cell Death and Inflammation: The Role of Mitochondria in Health and Disease

Picca, A., Calvani, R., Coelho‐Júnior, H. J., & Marzetti, E. (2021) · Cells · doi:10.3390/cells10030537 · Cited by 203 · see citing works

Mitochondria as Cellular and Organismal Signaling Hubs

Shen, K., Pender, C. L., Bar‐Ziv, R., Zhang, H., Wickham, K., Willey, E., Durieux, J., Ahmad, Q., & Dillin, A. G. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-015303 · Cited by 203 · see citing works

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

Borsche, M., König, I. R., Delcambre, S., Petrucci, S., Balck, A., Brüggemann, N., Zimprich, A. A., Wasner, K., Pereira, S. L., Avenali, M., et al. (2020) · Brain · doi:10.1093/brain/awaa246 · Cited by 197 · see citing works

Mitochondria—Striking a balance between host and endosymbiont

Youle, R. J. (2019) · Science · doi:10.1126/science.aaw9855 · Cited by 192 · see citing works

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

Guarnieri, J. W., Dybas, J. M., Fazelinia, H., Kim, M. S., Frere, J. J., Zhang, Y., Albrecht, Y. E. S., Murdock, D. G., Angelin, A., Singh, L. N., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abq1533 · Cited by 191 · see citing works

Mitochondrial function in development and disease

Rossmann, M. P., Dubois, S. M., Agarwal, S., & Zon, L. I. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048912 · Cited by 191 · see citing works

The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

Hu, Q., Ren, J., Li, G., Wu, J., Wu, X., Wang, G., Gu, G., Ren, H., Hong, Z., & Li, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0436-x · Cited by 182 · see citing works

Roles of neutrophil granule proteins in orchestrating inflammation and immunity

Othman, A., Sekheri, M., & Filep, J. G. (2021) · FEBS Journal · doi:10.1111/febs.15803 · Cited by 184 · see citing works

Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations

Trumpff, C., Michelson, J., Lagranha, C. J., Taleon, V., Karan, K. R., Sturm, G., Lindqvist, D., Fernström, J., Moser, D., Kaufman, B. A., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.04.002 · Cited by 181 · see citing works

Blood mitochondrial DNA copy number: What are we counting?

Picard, M. A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.06.010 · Cited by 183 · see citing works

Apoptosis in Cancer Biology and Therapy

Moyer, A. F., Tanaka, K., & Cheng, E. H. Y. (2025) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-115023 · Cited by 202 · see citing works

TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA

Liu, H., Zhen, C., Xie, J., Luo, Z., Zeng, L., Zhao, G., Lu, S., Zhuang, H., Fan, H., Li, X., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01419-6 · Cited by 185 · see citing works

DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways

Huang, Y., Jiang, W., & Zhou, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01027-3 · Cited by 189 · see citing works

The World Goes Bats: Living Longer and Tolerating Viruses

Gorbunova, V., Seluanov, A., & Kennedy, B. K. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.013 · Cited by 162 · see citing works

Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

Lai, P., Liu, L., Bancaro, N., Troiani, M., Calì, B., Li, Y., Chen, J., Singh, P. K., Arzola, R. A., Attanasio, G., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.03.005 · Cited by 174 · see citing works

KDM5 histone demethylases repress immune response via suppression of STING

Wu, L., Cao, J. P., Cai, W. L., Lang, S. M., Horton, J. R., Jansen, D. J., Liu, Z. Z., Chen, J. F.-Y., Zhang, M., Mott, B. T., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006134 · Cited by 175 · see citing works

Understanding the Physiological Links Between Physical Frailty and Cognitive Decline

Ma, L., & Chan, P. (2020) · Aging and Disease · doi:10.14336/ad.2019.0521 · Cited by 175 · see citing works

Host mitochondria influence gut microbiome diversity: A role for ROS

Yardeni, T., Tanes, C., Bittinger, K. L., Mattei, L. M., Schaefer, P. M., Singh, L. N., Wu, G. D., Murdock, D. G., & Wallace, D. C. (2019) · Science Signaling · doi:10.1126/scisignal.aaw3159 · Cited by 171 · see citing works

Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

Sprenger, H., MacVicar, T., Bahat, A., Fiedler, K. U., Hermans, S., Ehrentraut, D., Ried, K., Milenkovic, D., Bonekamp, N. A., Larsson, N., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00385-9 · Cited by 165 · see citing works

Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway

Li, Y., Chen, H., Yang, Q., Wan, L., Zhao, J., Wu, Y., Wang, J., Yang, Y., Niu, M., Liu, H., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02262-z · Cited by 170 · see citing works

Untangling “NETosis” from NETs

Yousefi, S., Stojkov, D., Germič, N., Simon, D., Wang, X., Benarafa, C., & Simon, H. (2019) · European Journal of Immunology · doi:10.1002/eji.201747053 · Cited by 160 · see citing works

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

Tezel, G. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100998 · Cited by 172 · see citing works

Roles of reactive oxygen species in inflammation and cancer

Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 170 · see citing works

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation

Li, S., Li, H., Zhang, Y.-L., Xin, Q., Guan, Z., Chen, X., Zhang, X., Li, X., Xiao, G., Lozach, P., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.105 · Cited by 163 · see citing works

Mitochondrial DNA in liver inflammation and oxidative stress

Zhang, X., Wu, X., Hu, Q., Wu, J., Wang, G., Hong, Z., & Ren, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.020 · Cited by 163 · see citing works

Mitochondria and Inflammatory Bowel Diseases: Toward a Stratified Therapeutic Intervention

Ho, G., & Theiss, A. L. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060821-083306 · Cited by 162 · see citing works

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

Nakayama, H., & Otsu, K. (2018) · Biochemical Journal · doi:10.1042/bcj20170714 · Cited by 160 · see citing works

Cardiolipin in Immune Signaling and Cell Death

Pizzuto, M., & Pelegrı́n, P. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.09.004 · Cited by 157 · see citing works

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

Szczęsny, B., Marcatti, M., Ahmad, A., Montalbano, M., Brunyánszki, A., Bibli, S., Papapetropoulos, A., & Szabó, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-19216-1 · Cited by 155 · see citing works

Mitochondrial Metabolism Regulation of T Cell–Mediated Immunity

Steinert, E. M., Vasan, K., & Chandel, N. S. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-082015 · Cited by 153 · see citing works

The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity

Liu, N., Pang, X., Zhang, H., & Ji, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.814709 · Cited by 152 · see citing works

Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis

Borrajo, A., Spuch, C., Penedo, M. A., Olivares, J. M., & Agís‐Balboa, R. C. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1814962 · Cited by 150 · see citing works

Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells

Guo, Y., Gu, R., Gan, D., Hu, F., Li, G., & Xu, G. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00637-3 · Cited by 151 · see citing works

HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy

Thangaraj, A., Periyasamy, P., Liao, K., Bendi, V. S., Callen, S. E., Pendyala, G., & Buch, S. J. (2018) · Autophagy · doi:10.1080/15548627.2018.1476810 · Cited by 147 · see citing works

Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD

Boyapati, R. K., Dorward, D. A., Tamborska, A., Kalla, R., Ventham, N. T., Doherty, M. K., Whitfield, P. D., Gray, M., Loane, J. F., Rossi, A. G., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy095 · Cited by 146 · see citing works

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C. C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.12.001 · Cited by 145 · see citing works

Mitochondrial DNA stress signalling protects the nuclear genome

Wu, Z., Oeck, S., West, A. P., Mangalhara, K. C., Sainz, A. G., Newman, L. E., Zhang, X.-O., Wu, L., Yan, Q., Bosenberg, M., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0150-8 · Cited by 146 · see citing works

Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway

Zhou, L., Zhang, Y.-F., Yang, F.-H., Mao, H., Chen, Z., & Zhang, L. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00738-7 · Cited by 143 · see citing works

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

Balsa, E., Perry, E. A., Bennett, C. F., Jedrychowski, M. P., Gygi, S. P., Doench, J. G., & Puigserver, P. (2020) · Nature Communications · doi:10.1038/s41467-020-16423-1 · Cited by 138 · see citing works

Nanocatalytic Innate Immunity Activation by Mitochondrial DNA Oxidative Damage for Tumor‐Specific Therapy

Jiang, H., Guo, Y., Wei, C., Hu, P., & Shi, J. (2021) · Advanced Materials · doi:10.1002/adma.202008065 · Cited by 141 · see citing works

Suramin Potently Inhibits cGAMP Synthase, cGAS, in THP1 Cells to Modulate IFN-β Levels

Wang, M., Sooreshjani, M. A., Mikek, C. G., Opoku‐Temeng, C., & Sintim, H. O. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0322 · Cited by 142 · see citing works

Reactive Oxygen Species Interact With NLRP3 Inflammasomes and Are Involved in the Inflammation of Sepsis: From Mechanism to Treatment of Progression

Zhao, S., Chen, F., Yin, Q., Wang, D., Han, W., & Zhang, Y. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.571810 · Cited by 141 · see citing works

Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition

Vercesi, A. E., Castilho, R. F., Kowaltowski, A. J., Oliveira, H. C. F., de Souza-Pinto, N. C., Figueira, T. R., & Busanello, E. N. B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.034 · Cited by 141 · see citing works

Forms of extracellular mitochondria and their impact in health

Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138 · see citing works

Mitochondrial DNA in inflammation and immunity

Riley, J. S., & Tait, S. W. G. (2020) · EMBO Reports · doi:10.15252/embr.201949799 · Cited by 876 · see citing works

Mitochondrial DNA release and sensing in innate immune responses

VanPortfliet, J. J., Chute, C., Lei, Y., Shutt, T. E., & West, A. P. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae031 · Cited by 67 · see citing works

Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity

Kausar, S., Yang, L., Abbas, M. N., Hu, X., Zhao, Y., Zhu, Y., & Cui, H. (2020) · Genes · doi:10.3390/genes11010086 · Cited by 40 · see citing works

Mitochondrial DNA in the regulation of innate immune responses

Fang, C., Wei, X., & Wei, Y. (2015) · Protein & Cell · doi:10.1007/s13238-015-0222-9 · Cited by 169 · see citing works

Advances in crosstalk among innate immune pathways activated by mitochondrial DNA

Tao, G., Liao, W., Hou, J., Jiang, X., Deng, X., Chen, G., & Ding, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24029 · Cited by 44 · see citing works