The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging
Abstract
Visualizing neuronal activity in vivo: Imaging the changes in fluorescence of voltage-sensitive reagents would enable monitoring of the activity of neurons in vivo. Abdelfattah et al. created such a voltage indicator by designing a protein that combines the voltage sensor domain from microbial rhodopsin with a domain that captures a dye molecule with exceptional brightness and photostability. When the protein was expressed in mice, flies, or zebrafish, they could monitor single action potentials in dozens of neurons simultaneously for many minutes. Science , this issue p. 699
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Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators
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Metadata
- Authors
- Abdelfattah, A. S., Kawashima, T., Singh, A., Novak, O., Liu, H., Shuai, Y., Huang, Y.-C., Campagnola, L., Seeman, S. C., Yu, J., Zheng, J., Grimm, J. B., Patel, R., Friedrich, J., Mensh, B. D., Paninski, L., Macklin, J. J., Murphy, G. J., Podgorski, K., Lin, B.-J., Chen, T.-W., Turner, G. C., Liu, Z., Koyama, M., Svoboda, K., Ahrens, M. B., Lavis, L. D., & Schreiter, E. R.
- Venue
- Science
- Published
- 2019-08-16
- Volume
- 365
- Issue
- 6454
- Pages
- 699-704
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2964363746
- Cited by
- 455
- References
- 63
- FWCI
- 28.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Abdelfattah, A. S., Kawashima, T., Singh, A., Novak, O., Liu, H., Shuai, Y., Huang, Y.-C., Campagnola, L., Seeman, S. C., Yu, J., Zheng, J., Grimm, J. B., Patel, R., Friedrich, J., Mensh, B. D., Paninski, L., Macklin, J. J., Murphy, G. J., Podgorski, K., . . . Schreiter, E. R. (2019). Bright and photostable chemigenetic indicators for extended in vivo voltage imaging. Science. https://doi.org/10.1126/science.aav6416
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