The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Phase separation provides a mechanism to reduce noise in cells
Open accessAbstract
Keeping the noise down: Protein concentrations in a cell fluctuate considerably because of stochasticity in gene expression and variations in the cell's microenvironment. How cells cope with concentration fluctuations when precision is important is unclear. Klosin et al. used a combination of theoretical and experimental work to demonstrate that phase-separated compartments can effectively reduce protein concentration noise in cells (see the Perspective by Riback and Brangwynne). The results suggest that phase separation provides a mechanism to enhance the robustness of biological systems. Science , this issue p. 464 ; see also p. 364
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Self-citationStochastic Gene Expression in a Single Cell
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Self-citationLiquid-Liquid Phase Separation in Biology
Hyman, A. A., Weber, C. A., & Jülicher, F. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013325 · Cited by 3,155
Self-citationA subcellular map of the human proteome
Thul, P. J., Åkesson, L., Wiking, M., Mahdessian, D., Geladaki, A., Ait Blal, H., Alm, T., Asplund, A., Björk, L., Breckels, L. M., et al. (2017) · Science · doi:10.1126/science.aal3321 · Cited by 2,813
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Self-citationA framework for understanding the functions of biomolecular condensates across scales
Lyon, A. S., Peeples, W. B., & Rosen, M. K. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00303-z · Cited by 895
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Kar, M., Dar, F., Welsh, T. J., Vogel, L. T., Kühnemuth, R., Majumdar, A., Krainer, G., Franzmann, T. M., Alberti, S., Seidel, C. A. M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202222119 · Cited by 270
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Metadata
- Authors
- Klosin, A., Oltsch, F., Harmon, T., Honigmann, A., Jülicher, F., Hyman, A. A., & Zechner, C.
- Venue
- Science
- Published
- 2020-01-24
- Volume
- 367
- Issue
- 6476
- Pages
- 464-468
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3002736232
- Cited by
- 361
- References
- 39
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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