The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Host monitoring of quorum sensing during Pseudomonas aeruginosa infection
Abstract
Spying on bacterial signals: Many bacteria produce small molecules for monitoring population density and thus regulating their collective behavior, a process termed quorum sensing. Pathogens like Pseudomonas aeruginosa , which complicates cystic fibrosis disease, produce different quorum-sensing ligands at different stages of infection. Moura-Alves et al. used experiments in human cells, zebrafish, and mice to show that a host organism can eavesdrop on these bacterial conversations. A host sensor responds differentially to bacterial quorum-sensing molecules to activate or repress different response pathways. The ability to “listen in” on bacterial signaling provides the host with the capacity to fine-tune physiologically costly immune responses. Science , this issue p. eaaw1629
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The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909
The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology
Esser, C., & Rannug, A. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009001 · Cited by 501
Pandini, A., Denison, M. S., Song, Y., Soshilov, A. A., & Bonati, L. (2007) · Biochemistry · doi:10.1021/bi061460t · Cited by 160 · cited 1×
“In this model, all residues previously found to interact with the bona fide AhR ligand 2,3,7,8tetrachlorodibenzodioxin (TCDD) by mutagenesis experiments (23, 24) are predicted to be involved in forming the binding pocket.”
BackgroundPandini, A., Soshilov, A. A., Song, Y., Zhao, J., Bonati, L., & Denison, M. S. (2009) · Biochemistry · doi:10.1021/bi900259z · Cited by 124
Cited by
Deciphering the quorum-sensing lexicon of the gut microbiota
Oliveira, R. A., Cabral, V., Torcato, I., & Xavier, K. B. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.015 · Cited by 74
Iron Acquisition by Bacterial Pathogens: Beyond Tris‐Catecholate Complexes
Zhang, Y., Sen, S., & Giedroc, D. P. (2020) · ChemBioChem · doi:10.1002/cbic.201900778 · Cited by 30
Metadata
- Authors
- Moura-Alves, P., Puyskens, A., Stinn, A., Klemm, M., Guhlich-Bornhof, U., Dorhoi, A., Furkert, J., Kreuchwig, A., Protze, J., Lozza, L., Pei, G., Saikali, P., Perdomo, C., Mollenkopf, H. J., Hurwitz, R., Kirschhoefer, F., Brenner-Weiss, G., Weiner, J., Oschkinat, H., Kolbe, M., Krause, G., & Kaufmann, S. H. E.
- Venue
- Science
- Published
- 2019-12-20
- Volume
- 366
- Issue
- 6472
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2996221411
- Cited by
- 166
- References
- 4
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moura-Alves, P., Puyskens, A., Stinn, A., Klemm, M., Guhlich-Bornhof, U., Dorhoi, A., Furkert, J., Kreuchwig, A., Protze, J., Lozza, L., Pei, G., Saikali, P., Perdomo, C., Mollenkopf, H. J., Hurwitz, R., Kirschhoefer, F., Brenner-Weiss, G., Weiner, J., Oschkinat, H., . . . Kaufmann, S. H. E. (2019). Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. Science. https://doi.org/10.1126/science.aaw1629
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