Cited by 637Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyGut microbiota and health

Shaping the Future of Probiotics and Prebiotics

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Cunningham, Marla, Azcarate-Peril, M. Andrea, Barnard, Alan, Benoit, Valerie, Grimaldi, Roberta, Guyonnet, Denis, Holscher, Hannah D., Hunter, Kirsty +8 more·2021·Trends in Microbiology

Abstract

Recent and ongoing developments in microbiome science are enabling new frontiers of research for probiotics and prebiotics. Novel types, mechanisms, and applications currently under study have the potential to change scientific understanding as well as nutritional and healthcare applications of these interventions. The expansion of related fields of microbiome-targeted interventions, and an evolving landscape for implementation across regulatory, policy, prescriber, and consumer spheres, portends an era of significant change. In this review we examine recent, emerging, and anticipated trends in probiotic and prebiotic science, and create a vision for broad areas of developing influence in the field.

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Crossref · 10.1016/j.tim.2021.01.003

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Authors
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., Petrova, M. I., Steinert, R. E., Swanson, K. S., van Sinderen, D., Vulevic, J., & Gibson, G. R.
Affiliations
  • General Mills (United States) (US)
  • GlaxoSmithKline (United Kingdom) (GB)
  • University of Illinois Urbana-Champaign (US)
  • Nottingham Trent University (GB)
  • Danone (France) (FR)
  • Winclove Probiotics (Netherlands) (NL)
  • University Hospital Zurich (CH)
  • University of Reading (GB)
Corresponding author
Cunningham, Marla
Venue
Trends in Microbiology
Publisher
Elsevier BV
Published
2021-08
Volume
29
Issue
8
Pages
667-685
ISSN
0966-842X (ISSN-L)
OpenAlex
W3126245112
Cited by
637
References
162
Citations by year
2026: 77 · 2025: 141 · 2024: 132 · 2023: 124 · 2022: 125 · 2021: 38
FWCI
9.57
Type
journal article
Language
en
Open access
Locations
  • Trends in Microbiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc-nd)
  • Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
probiotics, prebiotics, microbiome, microbiota-targeted interventions, probiotic mechanisms of action, probiotic applications, probiotic regulation, consumer acceptance, dietary intervention, medical applications
MeSH terms
Gastrointestinal Microbiome, Bacteria, Humans, Probiotics, Prebiotics, Precision Medicine

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