Shaping the Future of Probiotics and Prebiotics
Open accessAbstract
Recent and ongoing developments in microbiome science are enabling new frontiers of research for probiotics and prebiotics. Novel types, mechanisms, and applications currently under study have the potential to change scientific understanding as well as nutritional and healthcare applications of these interventions. The expansion of related fields of microbiome-targeted interventions, and an evolving landscape for implementation across regulatory, policy, prescriber, and consumer spheres, portends an era of significant change. In this review we examine recent, emerging, and anticipated trends in probiotic and prebiotic science, and create a vision for broad areas of developing influence in the field.
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A. muciniphila is one of the most promising candidates for next-generation probiotics despite difficulties in transforming such species into industrially viable probiotics.
“A. muciniphila is one of the most promising candidates despite all these difficulties [3].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [3]
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Estevinho, M. M., Yuan, Y., Rodríguez‐Lago, I., Sousa‐Pimenta, M., Dias, C. C., Barreiro‐de Acosta, M., Jairath, V., & Magro, F. (2024) · United European gastroenterology journal · doi:10.1002/ueg2.12636 · Cited by 74 · see citing works
“Microbiota ‐ based treatments 88 are promising strategies to complement the IBD drug armamentarium.”
Bilal, M., Ashraf, S., & Zhao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931458 · Cited by 58 · see citing works
Understanding the Functionality of Probiotics on the Edge of Artificial Intelligence (AI) Era
Asar, R., Erenler, S., Devecioglu, D., Ispirli, H., Karbancioglu-Guler, F., Ozturk, H. I., & Dertli, E. (2025) · Fermentation · doi:10.3390/fermentation11050259 · Cited by 37 · see citing works
Exploring the genomic traits of infant-associated microbiota members from a Zimbabwean cohort
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Lee, Y.-S., Noh, D.-I., Lee, S.-J., Jeon, M.-H., Kim, Y.-R., Jang, W. J., & Lee, E.-W. (2025) · Journal of Applied Microbiology · doi:10.1093/jambio/lxaf256 · Cited by 3 · see citing works
- Authors
- Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., Petrova, M. I., Steinert, R. E., Swanson, K. S., van Sinderen, D., Vulevic, J., & Gibson, G. R.
- Affiliations
- General Mills (United States) (US)
- GlaxoSmithKline (United Kingdom) (GB)
- University of Illinois Urbana-Champaign (US)
- Nottingham Trent University (GB)
- Danone (France) (FR)
- Winclove Probiotics (Netherlands) (NL)
- University Hospital Zurich (CH)
- University of Reading (GB)
- Corresponding author
- Cunningham, Marla
- ORCID
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 29
- Issue
- 8
- Pages
- 667-685
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W3126245112
- Semantic Scholar
- 5c15fbf50ba603e66993a896cd650a9d80b256e2
- Cited by
- 637
- References
- 162
- Citations by year
- 2026: 77 · 2025: 141 · 2024: 132 · 2023: 124 · 2022: 125 · 2021: 38
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Microbiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc-nd)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, prebiotics, microbiome, microbiota-targeted interventions, probiotic mechanisms of action, probiotic applications, probiotic regulation, consumer acceptance, dietary intervention, medical applications
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Humans, Probiotics, Prebiotics, Precision Medicine
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