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Cerebrospinal fluid influx drives acute ischemic tissue swelling
Open accessAbstract
Spreading edema after stroke: The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown to play unexpected roles in neurodegeneration and sleep. Mestre et al. used multimodal in vivo imaging in rodents and found that, after a stroke, an abnormally large volume of CSF rushes into the brain, causing swelling (see the Perspective by Moss and Williams). This influx of CSF is caused by constrictions of arteries triggered by a well-known propagating chemical reaction-diffusion wave called spreading depolarization. CSF transport can thus play a role in brain swelling after stroke. Science , this issue p. eaax7171 ; see also p. 1195
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“Deletion of AQP4 channels reduces both the influx of CSF tracers and the efflux of solutes from the neuropil (24, 30, 31).”
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Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Self-citationSleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Self-citationA reproducible evaluation of ANTs similarity metric performance in brain image registration
Avants, B. B., Tustison, N. J., Song, G., Cook, P. A., Klein, A., & Gee, J. C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.025 · Cited by 4,796
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
Manley, G. T., Fujimura, M., Ma, T., Noshita, N., Filiz, F., Bollen, A. W., Chan, P. H., & Verkman, A. S. (2000) · Nature Medicine · doi:10.1038/72256 · Cited by 1,501
Diffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481
Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study
Feigin, V. L., Krishnamurthi, R., Parmar, P. G. K., Norrving, B., Mensah, G. A., Bennett, D., Barker-Collo, S. L., Moran, A. E., Sacco, R. L., Truelsen, T., et al. (2015) · Neuroepidemiology · doi:10.1159/000441085 · Cited by 1,342
KLATZO, I. (1967) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196701000-00001 · Cited by 1,180
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Iliff, J. J., Lee, H., Yu, M., Feng, T., Logan, J., Nedergaard, M., & Benveniste, H. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67677 · Cited by 1,148
Self-citationDreier, J. P. (2011) · Nature Medicine · doi:10.1038/nm.2333 · Cited by 1,132
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.
Mestre, H., Tithof, J., Du, T., Song, W., Peng, W., Sweeney, A. M., Olveda, G., Thomas, J. H., Nedergaard, M., & Kelley, D. H. (2018) · Nature Communications · doi:10.1038/s41467-018-07318-3 · Cited by 1,110
Self-citationBrain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
Simard, J. M., Kent, T. A., Chen, M., Tarasov, K. V., & Gerzanich, V. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70055-8 · Cited by 799
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Mestre, H., Hablitz, L. M., Xavier, A. L., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Castellanos Rivera, R. M., Simon, M. J., et al. (2018) · eLife · doi:10.7554/elife.40070 · Cited by 738
Self-citationKnowland, D., Arac, A., Sekiguchi, K. J., Hsu, M., Lutz, S. E., Perrino, J., Steinberg, G. K., Barres, B. A., Nimmerjahn, A., & Agalliu, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.003 · Cited by 703
Thorne, R. G., & Nicholson, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509425103 · Cited by 641
Molecular pathophysiology of cerebral edema
Stokum, J. A., Gerzanich, V., & Simard, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15617172 · Cited by 613
Dreier, J. P., Major, S., Manning, A. P., Woitzik, J., Drenckhahn, C., Steinbrink, J. M., Tolias, C. M., Oliveira-Ferreira, A. I., Fabricius, M. E., Hartings, J. A., et al. (2009) · Brain · doi:10.1093/brain/awp102 · Cited by 556
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI.
Ringstad, G., Valnes, L. M., Dale, A. M., Pripp, A. H., Vatnehol, S.-A. S., Emblem, K. E., Mardal, K.-A., & Eide, P. K. (2018) · JCI Insight · doi:10.1172/jci.insight.121537 · Cited by 533
A quantitative study of three-dimensional Lagrangian particle tracking algorithms
Ouellette, N. T., Xu, H., & Bodenschatz, E. (2005) · Experiments in Fluids · doi:10.1007/s00348-005-0068-7 · Cited by 478
Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI
Gaberel, T., Gakuba, C., Goulay, R., de Lizarrondo, S. M., Hanouz, J., Emery, É., Touzé, E., Vivien, D., & Gauberti, M. (2014) · Stroke · doi:10.1161/strokeaha.114.006617 · Cited by 438
Monai, H., Ohkura, M., Tanaka, M., Oe, Y., Konno, A., Hirai, H., Mikoshiba, K., Itohara, S., Nakai, J., Iwai, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms11100 · Cited by 410
Self-citationKarimy, J. K., Zhang, J., Kurland, D. B., Theriault, B. C., Durán, D., Stokum, J. A., Furey, C. G., Zhou, X., Mansuri, M. S., Montejo, J. D., et al. (2017) · Nature Medicine · doi:10.1038/nm.4361 · Cited by 410
Cytotoxic edema: mechanisms of pathological cell swelling
Liang, D., Bhatta, S., Gerzanich, V., & Simard, J. M. (2007) · Neurosurgical FOCUS · doi:10.3171/foc.2007.22.5.3 · Cited by 409
Stroke research at a crossroad: asking the brain for directions
Iadecola, C., & Anrather, J. (2011) · Nature Neuroscience · doi:10.1038/nn.2953 · Cited by 398
Hartings, J. A., Shuttleworth, C. W., Kirov, S. A., Ayata, C., Hinzman, J. M., Foreman, B. P., Andrew, R. D., Boutelle, M. G., Brennan, K. C., Carlson, A. P., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16654495 · Cited by 384
Iijima, T., Mies, G., & Hossmann, K. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.103 · Cited by 365
The Stroke-Migraine Depolarization Continuum
Dreier, J. P., & Reiffurth, C. (2015) · Neuron · doi:10.1016/j.neuron.2015.04.004 · Cited by 337
Nedergaard, M., & Astrup, J. (1986) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1986.108 · Cited by 330
Self-citationPathophysiological Aspects of Brain Edema
KLATZO, I. (1972) · Springer eBooks · doi:10.1007/978-3-642-65448-0_1 · Cited by 327
Vasoconstrictive Neurovascular Coupling during Focal Ischemic Depolarizations
Shin, H. K., Dunn, A. K., Jones, P., Boas, D. A., Moskowitz, M. A., & Ayata, C. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600252 · Cited by 320
Gotoh, O., Asano, T., Koide, T., & Takakura, K. (1985) · Stroke · doi:10.1161/01.str.16.1.101 · Cited by 303
Dreier, J. P., Körner, K., Ebert, N., Görner, A., Rubin, I., Back, T., Lindauer, U., Wolf, T., Villringer, A., Einhäupl, K. M., et al. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199809000-00007 · Cited by 289
The Effect of Glutamate Receptor Blockade on Anoxic Depolarization and Cortical Spreading Depression
Lauritzen, M., & Hansen, A. J. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.32 · Cited by 285
Pathophysiological aspects of brain edema
KLATZO, I. (1987) · Acta Neuropathologica · doi:10.1007/bf00691095 · Cited by 284
Gill, R., Andiné, P., Hillered, L., Persson, L., & Hagberg, H. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.54 · Cited by 281
Schain, A. J., Melo‐Carrillo, A., Strassman, A. M., & Burstein, R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3390-16.2017 · Cited by 264
The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema
Rungta, R. L., Choi, H. B., Tyson, J. R., Malik, A., Dissing‐Olesen, L., Lin, P. J. C., Cain, S. M., Cullis, P. R., Snutch, T. P., & MacVicar, B. A. (2015) · Cell · doi:10.1016/j.cell.2015.03.029 · Cited by 255
Waxholm Space: An image-based reference for coordinating mouse brain research
Johnson, G. A., Badea, A., Brandenburg, J., Cofer, G. P., Fubara, B. N., Liu, S., & Nissanov, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.067 · Cited by 253
Cerebral Impedance Changes After Circulatory Arrest
Harreveld, A. V., & Ochs, S. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.187.1.180 · Cited by 229
Drowning stars: reassessing the role of astrocytes in brain edema
Thrane, A. S., Thrane, V. R., & Nedergaard, M. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.010 · Cited by 227
Self-citationPropagation of cortical spreading depolarization in the human cortex after malignant stroke
Woitzik, J., Hecht, N., Pinczolits, A., Sandow, N., Major, S., Winkler, M. K. L., Weber‐Carstens, S., Dohmen, C., Graf, R., Strong, A. J., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182886932 · Cited by 218
Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex
Strong, A. J., Anderson, P. J., Watts, H. R., Virley, D. J., Lloyd, A., Irving, E. A., Nagafuji, T., Ninomiya, M., Nakamura, H., Dunn, A. K., et al. (2006) · Brain · doi:10.1093/brain/awl392 · Cited by 209
High-Resolution In Vivo Imaging of the Neurovascular Unit during Spreading Depression
Chuquet, J., Hollender, L., & Nimchinsky, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0721-07.2007 · Cited by 203
Dreier, J. P., Lemâle, C. L., Kola, V., Friedman, A., & Schoknecht, K. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.027 · Cited by 188
Ischemic Brain Edema and the Osmotic Gradient between Blood and Brain
Hatashita, S., Hoff, J. T., & Salamat, S. M. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.96 · Cited by 185
Topological basis for the robust distribution of blood to rodent neocortex
Blinder, P., Shih, A. Y., Rafie, C., & Kleinfeld, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007239107 · Cited by 182
Self-citationBrain edema and cerebrovascular permeability during cerebral ischemia in rats.
Hatashita, S., & Hoff, J. T. (1990) · Stroke · doi:10.1161/01.str.21.4.582 · Cited by 175
Dynamics of Ionic Shifts in Cortical Spreading Depression
Enger, R., Tang, W., Vindedal, G. F., Jensen, V., Helm, P. J., Sprengel, R., Looger, L. L., & Nagelhus, E. A. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv054 · Cited by 175
Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke
Battey, T. W. K., Karki, M., Singhal, A. B., Wu, O., Sadaghiani, S., Campbell, B. C. V., Davis, S. M., Donnan, G. A., Sheth, K. N., & Kimberly, W. T. (2014) · Stroke · doi:10.1161/strokeaha.114.006884 · Cited by 175
Igarashi, H., Huber, V. J., Tsujita, M., & Nakada, T. (2010) · Neurological Sciences · doi:10.1007/s10072-010-0431-1 · Cited by 160
Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma
Hinzman, J. M., Andaluz, N. O., Shutter, L., Okonkwo, D. O., Pahl, C., Strong, A. J., Dreier, J. P., & Hartings, J. A. (2014) · Brain · doi:10.1093/brain/awu241 · Cited by 159
Albayram, Ö., Kondo, A., Mannix, R., Smith, C., Tsai, C.-Y., Li, C., Herbert, M. K., Qiu, J., Monuteaux, M. C., Driver, J. A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01068-4 · Cited by 154
Young, W., Rappaport, Z. H., Chalif, D. J., & Flamm, E. S. (1987) · Stroke · doi:10.1161/01.str.18.4.751 · Cited by 152
Betz, A. L., Keep, R. F., Beer, M. E., & Ren, X.-D. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.5 · Cited by 145
Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction
Hartings, J. A., York, J., Carroll, C. P., Hinzman, J. M., Mahoney, E., Krueger, B. M., Winkler, M. K. L., Major, S., Horst, V., Jahnke, P., et al. (2017) · Brain · doi:10.1093/brain/awx214 · Cited by 128
Cannula Implantation into the Cisterna Magna of Rodents
Xavier, A. L. R., Hauglund, N. L., von Holstein‐Rathlou, S., Li, Q., Sanggaard, S., Lou, N., Lundgaard, I., & Nedergaard, M. (2018) · Journal of Visualized Experiments · doi:10.3791/57378 · Cited by 127
Self-citationBrain ion homeostasis in cerebral ischemia
Hansen, A. J., & Nedergaard, M. (1988) · Neurochemical Pathology · doi:10.1007/bf03160362 · Cited by 125
Self-citationYao, X., Derugin, N., Manley, G. T., & Verkman, A. S. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.10.040 · Cited by 112
Multivariate Analysis of Structural and Diffusion Imaging in Traumatic Brain Injury
Avants, B., Duda, J., Kim, J., Zhang, H. G., Pluta, J. B., Gee, J. C., & Whyte, J. (2008) · Academic Radiology · doi:10.1016/j.acra.2008.07.007 · Cited by 112
The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex
Lückl, J., Lemâle, C. L., Kola, V., Horst, V., Khojasteh, U., Oliveira-Ferreira, A. I., Major, S., Winkler, M. K. L., Kang, E., Schoknecht, K., et al. (2018) · Brain · doi:10.1093/brain/awy102 · Cited by 107
Plog, B. A., Mestre, H., Olveda, G. E., Sweeney, A. M., Kenney, H. M., Cove, A., Dholakia, K. Y., Tithof, J., Nevins, T. D., Lundgaard, I., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120922 · Cited by 102
Self-citationPirici, I., Balsanu, T. A., Cătălin, B., Mărgăritescu, C., Divan, T., Văcăraș, V., Mogoantă, L., Pirici, D. N., Carare, R. O., & Muresanu, D. F. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010046 · Cited by 100
Using particle tracking to measure flow instabilities in an undergraduate laboratory experiment
Kelley, D. H., & Ouellette, N. T. (2011) · American Journal of Physics · doi:10.1119/1.3536647 · Cited by 94
Self-citationActive role of capillary pericytes during stimulation-induced activity and spreading depolarization
Khennouf, L., Gesslein, B., Brazhe, A., Octeau, J. C., Kutuzov, N. P., Khakh, B. S., & Lauritzen, M. (2018) · Brain · doi:10.1093/brain/awy143 · Cited by 89
Glibenclamide in Cerebral Ischemia and Stroke
Simard, J., Sheth, K. N., Kimberly, W. T., Stern, B., del Zoppo, G. D., Jacobson, S., & Gerzanich, V. (2014) · Neurocritical Care · doi:10.1007/s12028-013-9923-1 · Cited by 88
Brain distribution spaces of mannitol-3H, inulin-14C, and dextran-14C in the rat
Wb, S., & Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.1.214 · Cited by 82
Ito, U., Hakamata, Y., Kawakami, E., & Oyanagi, K. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.97 · Cited by 81
Kang, E.-J., Major, S., Jorks, D., Reiffurth, C., Offenhauser, N., Friedman, A., & Dreier, J. P. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.007 · Cited by 81
Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats
Dreier, J. P., Petzold, G. C., Tille, K., Lindauer, U., Arnold, G., Heinemann, U., Einhäupl, K. M., & Dirnagl, U. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0515i.x · Cited by 78
McBride, D. W., Klebe, D. W., Tang, J., & Zhang, J. H. (2015) · Translational Stroke Research · doi:10.1007/s12975-015-0400-3 · Cited by 71
A novel method to study cerebrospinal fluid dynamics in rats
Karimy, J. K., Kahle, K. T., Kurland, D. B., Yu, E., Gerzanich, V., & Simard, J. M. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.12.015 · Cited by 69
Changes in the Diameter of Apical Dendrites During Spreading Depression
Harreveld, A. V. (1958) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1958.192.3.457 · Cited by 67
Susceptibility of Primary Sensory Cortex to Spreading Depolarizations
Bogdanov, V. B., Middleton, N. A., Theriot, J. J., Parker, P. D., Abdullah, O., Ju, Y. S., Hartings, J. A., & Brennan, K. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3694-15.2016 · Cited by 65
Transport of sodium from blood to brain in ischemic brain edema.
Lo, W. D., Betz, A. L., Schielke, G. P., & Hoff, J. T. (1987) · Stroke · doi:10.1161/01.str.18.1.150 · Cited by 50
Bere, Z., Obrenovitch, T. P., Bari, F., & Farkas, E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.032 · Cited by 43
Enger, R., Dukefoss, D. B., Tang, W., Pettersen, K. H., Bjørnstad, D. M., Helm, P. J., Jensen, V., Sprengel, R., Vervaeke, K., Ottersen, O. P., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw359 · Cited by 36
Thrane, A. S., Takano, T., Thrane, V. R., Wang, F., Peng, W., Ottersen, O. P., Nedergaard, M., & Nagelhus, E. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.63 · Cited by 29
Self-citationAquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice
Yao, X., Smith, A. J., Jin, B., Zador, Z. E., Manley, G. T., & Verkman, A. S. (2015) · Glia · doi:10.1002/glia.22853 · Cited by 28
Transitions from Trees to Cycles in Adaptive Flow Networks
Martens, E. A., & Klemm, K. (2017) · Frontiers in Physics · doi:10.3389/fphy.2017.00062 · Cited by 24
Self-citationPeri-infarct flow transients predict outcome in rat focal brain ischemia
Lückl, J., Dreier, J. P., Szabados, T., Wiesenthal, D., Bari, F., & Greenberg, J. H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.049 · Cited by 20
Front tracking for quantifying advection-reaction-diffusion
Nevins, T. D., & Kelley, D. H. (2017) · Chaos An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/1.4979668 · Cited by 15
Self-citationInoue, Y., Aoki, I., Mori, Y., Kawai, Y., Ebisu, T., Osaka, Y., Houri, T., Mineura, K., Higuchi, T., & Tanaka, C. (2009) · NMR in Biomedicine · doi:10.1002/nbm.1464 · Cited by 9
Self-citationIshimaru, S., & Hossmann, K. ‐. (1990) · Springer eBooks · doi:10.1007/978-3-7091-9115-6_73 · Cited by 8
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Metadata
- Authors
- Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D., Hirase, H., Mori, Y., & Nedergaard, M.
- Affiliations
- University of Rochester Medicine (US)
- University of Copenhagen (DK)
- University of Rochester (US)
- Technical University of Denmark (DK)
- Tel Aviv University (IL)
- University of California San Diego (US)
- Corresponding author
- Mestre, Humberto
- Du, Ting
- Mori, Yuki
- Nedergaard, Maiken
- ORCID
- Mestre, Humberto
- Du, Ting
- Liu, Guojun
- Samson, Andrew J.
- Peng, Weiguo
- Mortensen, Kristian Nygaard
- Stæger, Frederik Filip
- Bork, Peter A. R.
- Bashford, Logan
- Toro, Edna R.
- Tithof, Jeffrey
- Kelley, Douglas H.
- Thomas, John H.
- Hjorth, Poul G.
- Martens, Erik A.
- Mehta, Rupal I.
- Solis, Orestes
- Blinder, Pablo
- Kleinfeld, David
- Hirase, Hajime
- Mori, Yuki
- Nedergaard, Maiken
- Venue
- Science
- Published
- 2020-03-13
- Volume
- 367
- Issue
- 6483
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7375109
- OpenAlex
- W3004007615
- Cited by
- 494
- References
- 83
- Citations by year
- 2026: 59 · 2025: 70 · 2024: 76 · 2023: 80 · 2022: 91 · 2021: 77 · 2020: 40
- FWCI
- 32.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- National Institute on Aging (RF1AG057575)
- National Institute of Neurological Disorders and Stroke (R01NS100366, K08NS089830)
- Army Research Office (MURI W911NF1910280)
- Horizon 2020 Framework Programme (666881)
- Fondation Leducq (16CVD05)
- Lundbeckfonden
- Novo Nordisk Fonden
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- glymphatic system, vasoconstriction, perivascular spaces, stroke
- MeSH terms
- Glymphatic System, Animals, Brain Edema, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Vasoconstriction, Stroke, Mice, Aquaporin 5
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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