Kleinfeld, David

Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex

Kleinfeld, D., Mitra, P. P., Helmchen, F., & Denk, W. (1998) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesBlood properties and coagulation

Cited by 832

The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

Blinder, P., Tsai, P. S., Kaufhold, J. P., Knutsen, P. M., Suhl, H., & Kleinfeld, D. (2013) · Nature Neuroscience

Barrier Structure and Function StudiesFunctional Brain Connectivity Studies

Cited by 573

Cerebrospinal fluid influx drives acute ischemic tissue swelling

Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., et al. (2020) · Science

Cerebrospinal fluid and hydrocephalusAcute Ischemic Stroke Management

Cited by 494

Chronic optical access through a polished and reinforced thinned skull

Drew, P. J., Shih, A. Y., Driscoll, J. D., Knutsen, P. M., Blinder, P., Davalos, D., Akassoglou, K., Tsai, P. S., & Kleinfeld, D. (2010) · Nature Methods

Optical Imaging and Spectroscopy TechniquesAdvanced Fluorescence Microscopy Techniques

Cited by 406

Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion

Schaffer, C. B., Friedman, B., Nishimura, N., Schroeder, L. F., Tsai, P. S., Ebner, F. F., Lyden, P. D., & Kleinfeld, D. (2006) · PLoS Biology

Blood properties and coagulationBarrier Structure and Function Studies

Cited by 400

Active sensation: Insights from the rodent vibrissa sensorimotor system

Kleinfeld, D., Ahissar, E., & Diamond, M. E. (2006) · Current Opinion in Neurobiology

Tactile and Sensory InteractionsMultisensory perception and integration

Cited by 374

Penetrating arterioles are a bottleneck in the perfusion of neocortex

Nishimura, N., Schaffer, C. B., Friedman, B., Lyden, P. D., & Kleinfeld, D. (2007) · Proceedings of the National Academy of Sciences

Blood properties and coagulationBarrier Structure and Function Studies

Cited by 367

The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit

Shih, A. Y., Blinder, P., Tsai, P. S., Friedman, B., Stanley, G., Lyden, P. D., & Kleinfeld, D. (2013) · Nature Neuroscience

Neurological Disease Mechanisms and TreatmentsAcute Ischemic Stroke Management

Cited by 351

Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke

Nishimura, N., Schaffer, C. B., Friedman, B., Tsai, P. S., Lyden, P. D., & Kleinfeld, D. (2006) · Nature Methods

Acute Ischemic Stroke ManagementOptical Imaging and Spectroscopy Techniques

Cited by 308

Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent “Resting-State” Connectivity

Mateo, C., Knutsen, P. M., Tsai, P. S., Shih, A. Y., & Kleinfeld, D. (2017) · Neuron

Functional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

Cited by 303

A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale

Bohland, J. W., Wu, C., Barbas, H., Bokil, H., Bota, M., Breiter, H. C., Cline, H. T., Doyle, J. C., Freed, P. J., Greenspan, R. J., et al. (2009) · PLoS Computational Biology

Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and Applications

Cited by 261

The capillary bed offers the largest hemodynamic resistance to the cortical blood supply

Gould, I. G., Tsai, P., Kleinfeld, D., & Linninger, A. (2017) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesBlood properties and coagulation

Cited by 252

Invited Review Anatomical loops and their electrical dynamics in relation to whisking by rat

KLEINFELD, D., BERG, R. W., & O'CONNOR, S. M. (1999) · Somatosensory & Motor Research

Tactile and Sensory InteractionsMotor Control and Adaptation

Cited by 191

Topological basis for the robust distribution of blood to rodent neocortex

Blinder, P., Shih, A. Y., Rafie, C., & Kleinfeld, D. (2010) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesNeurological Disease Mechanisms and Treatments

Cited by 182

Neuronal Basis for Object Location in the Vibrissa Scanning Sensorimotor System

Kleinfeld, D., & Deschênes, M. (2011) · Neuron

Tactile and Sensory InteractionsMultisensory perception and integration

Cited by 153

Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex

Muller, A., Joseph, V., Slesinger, P. A., & Kleinfeld, D. (2014) · Nature Methods

Advanced Fluorescence Microscopy TechniquesNeuroscience and Neuropharmacology Research

Cited by 139

Active Dilation of Penetrating Arterioles Restores Red Blood Cell Flux to Penumbral Neocortex after Focal Stroke

Shih, A. Y., Friedman, B., Drew, P. K., Tsai, P. S., Lyden, P. D., & Kleinfeld, D. (2009) · Journal of Cerebral Blood Flow & Metabolism

Acute Ischemic Stroke ManagementTraumatic Brain Injury and Neurovascular Disturbances

Cited by 127

Reversibly Modulating the Blood–Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles

Li, X., Vemireddy, V., Cai, Q., Xiong, H., Kang, P., Li, X., Giannotta, M., Hayenga, H. N., Pan, E., Sirsi, S. R., et al. (2021) · Nano Letters

Barrier Structure and Function StudiesNanoparticle-Based Drug Delivery

Cited by 105

Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions

McElvain, L. E., Friedman, B., Karten, H. J., Svoboda, K., Wang, F., Deschênes, M., & Kleinfeld, D. (2018) · Neuroscience

Tactile and Sensory InteractionsMotor Control and Adaptation

Cited by 82

Acute Vascular Disruption and Aquaporin 4 Loss After Stroke

Friedman, B., Schachtrup, C., Tsai, P. S., Shih, A. Y., Akassoglou, K., Kleinfeld, D., & Lyden, P. D. (2009) · Stroke

Ion Transport and Channel RegulationAcute Ischemic Stroke Management

Cited by 71