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Cerebrospinal fluid influx drives acute ischemic tissue swelling
Open accessAbstract
Spreading edema after stroke: The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown to play unexpected roles in neurodegeneration and sleep. Mestre et al. used multimodal in vivo imaging in rodents and found that, after a stroke, an abnormally large volume of CSF rushes into the brain, causing swelling (see the Perspective by Moss and Williams). This influx of CSF is caused by constrictions of arteries triggered by a well-known propagating chemical reaction-diffusion wave called spreading depolarization. CSF transport can thus play a role in brain swelling after stroke. Science , this issue p. eaax7171 ; see also p. 1195
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“Deletion of AQP4 channels reduces both the influx of CSF tracers and the efflux of solutes from the neuropil (24, 30, 31).”
From Glymphatic failure as a final common pathway to dementia (2020) · cites this paper as [31]
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Metadata
- Authors
- Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D., Hirase, H., Mori, Y., & Nedergaard, M.
- Affiliations
- University of Rochester Medicine (US)
- University of Copenhagen (DK)
- University of Rochester (US)
- Technical University of Denmark (DK)
- Tel Aviv University (IL)
- University of California San Diego (US)
- Corresponding author
- Mestre, Humberto
- Du, Ting
- Mori, Yuki
- Nedergaard, Maiken
- ORCID
- Mestre, Humberto
- Du, Ting
- Liu, Guojun
- Samson, Andrew J.
- Peng, Weiguo
- Mortensen, Kristian Nygaard
- Stæger, Frederik Filip
- Bork, Peter A. R.
- Bashford, Logan
- Toro, Edna R.
- Tithof, Jeffrey
- Kelley, Douglas H.
- Thomas, John H.
- Hjorth, Poul G.
- Martens, Erik A.
- Mehta, Rupal I.
- Solis, Orestes
- Blinder, Pablo
- Kleinfeld, David
- Hirase, Hajime
- Mori, Yuki
- Nedergaard, Maiken
- Venue
- Science
- Published
- 2020-03-13
- Volume
- 367
- Issue
- 6483
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7375109
- OpenAlex
- W3004007615
- Cited by
- 494
- References
- 83
- Citations by year
- 2026: 59 · 2025: 70 · 2024: 76 · 2023: 80 · 2022: 91 · 2021: 77 · 2020: 40
- FWCI
- 32.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- National Institute on Aging (RF1AG057575)
- National Institute of Neurological Disorders and Stroke (R01NS100366, K08NS089830)
- Army Research Office (MURI W911NF1910280)
- Horizon 2020 Framework Programme (666881)
- Fondation Leducq (16CVD05)
- Lundbeckfonden
- Novo Nordisk Fonden
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- glymphatic system, vasoconstriction, perivascular spaces, stroke
- MeSH terms
- Glymphatic System, Animals, Brain Edema, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Vasoconstriction, Stroke, Mice, Aquaporin 5
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