Brain cell type–specific enhancer–promoter interactome maps and disease - risk association
Nott, Alexi, Holtman, Inge R., Coufal, Nicole G., Schlachetzki, Johannes C. M., Yu, Miao, Hu, Rong, Han, Claudia Z., Pena, Monique +18 more·2019·Science
Cited by (702)
Items 401–500 of 702
- Single-nucleus transcriptome-wide association study of human brain disordersSanan Venkatesh, Roman Kosoy, Zhenyi Wu, Marios Anyfantakis, Christian Dillard, N. M. Prashant, David Burstein, Deepika Dayal Mathur, Chris Chatzinakos, Bukola Ajanaku et al. · 2026 · Nature
- Cellular specificity is key to deciphering epigenetic changes underlying Alzheimer's diseaseBethany Signal, Thalía Gabriela Pérez Suárez, Phillippa C. Taberlay, Adele Woodhouse · 2023 · Neurobiology of Disease
- Epigenomic and transcriptional determinants of microglial cell identityGosselin, David · 2020 · Glia
- Single-cell multimodal analysis in a case with reduced penetrance of Progranulin-Frontotemporal DementiaKarthick Natarajan, Jesper Eisfeldt, Maria Hammond, Kalicharan Patra, José Miguel Laffita‐Mesa, Yuniesky Andrade‐Talavera, Marcella Birtele, Linn Öijerstedt, André Fisahn, Malin Parmar et al. · 2021 · Acta Neuropathologica Communications
- Single-nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell-type-specific gene regulatory variationYujuan Gui, Kamil Grzyb, Mélanie H. Thomas, Jochen Ohnmacht, Pierre Garcia, Manuel Buttini, Alexander Skupin, Thomas Sauter, Lasse Sinkkonen · 2021 · Epigenetics & Chromatin
- Systems biology approaches to unravel the molecular and genetic architecture of Alzheimer's disease and related tauopathiesMiyoshi, Emily, Morabito, Samuel, Swarup, Vivek · 2021 · Neurobiology of Disease
- A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal DifferentiationSalvatore Martino, Pietro Salvatore Carollo, Viviana Barra · 2023 · Genes
- Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomicsKun Leng, Martin Kampmann · 2022 · Genome Medicine
- Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer’s DementiaKousi, Maria, Boix, Carles, Park, Yongjin P., Mathys, Hansruedi, Sledzieski, Samuel, Peng, Zhuyu, Bennett, David A., Tsai, Li-Huei, Kellis, Manolis · 2022
- Unraveling the three-dimensional (3D) genome architecture in Neurodevelopmental Disorders (NDDs)Pablo Carballo-Pacoret, Ángel Carracedo, Cristina Rodriguez‐Fontenla · 2024 · Neurogenetics
- Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell TypesInge R. Holtman, Christopher K. Glass, Alexi Nott · 2024 · Advances in neurobiology
- Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers ApoB-Containing Lipoproteins in MiceRobert Nathaniel Helsley, Mikala M. Zelows, Victoria P. Noffsinger, Garrett Anspach, Nikitha Dharanipragada, Anna E. Mead, Isidoro Cobo, Abigail Carter, Qinglin Wu, IRINA Y. SHALAUROVA et al. · 2025 · Arteriosclerosis Thrombosis and Vascular Biology
- Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulationEmma Danhash, Anthony C. Verbeck, Daniel Western, Andrea S. Díaz‐Pacheco, Grant Galasso, Shih‐Feng You, Guangming Huang, Emma Starr, Nadia Miller, Collin J. Nadarajah et al. · 2025 · Alzheimer s & Dementia
- Cohesin regulation of genome organization in mature granule neurons in the mouse cerebellumOmar A. Payán Parra, Ziyu Zhao, Tomoko Yamada, Yue Yang · 2025 · Epigenetics & Chromatin
- Systemic mRNA-LNP administration in fetuses improves survival in a mouse model of spinal muscular atrophyMarco D. Carpenter, Nicole Joanne Kus, Rosa B. Choi, Hooda Said, Ana Maria Dumitru, Jackson H. Bauer, Samantha Wang, Valerie L. Luks, Sriya Teerdhala, Aarsha Shah et al. · 2025 · Molecular Therapy — Methods & Clinical Development
- Cell type-specific inference from bulk RNA-sequencing data by integrating single-cell reference profiles via EPIC-unmixChenwei Tang, Quan Sun, Xinyue Zeng, Gang Li, Xiaoyu Yang, Fei Liu, Jinying Zhao, Yin Shen, Boxiang Liu, Jia Wen et al. · 2025 · Genome biology
- CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer’s diseaseNicole F. Oldham Green, Gavin J. Sutton, Javier Pérez‐Burillo, Juli Wang, Samuel Bagot, Hannah G Danon, Kieran Walsh, Akira Gokoolparsadh, Samantha A. Miles, Guang Yang et al. · 2025 · Nature Neuroscience
- An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial functionErica Bello, Kathleen R. Long, Sho Iwama, Juliette Steer, Sarah Cooper, Kaur Alasoo, Natsuhiko Kumasaka, Jeremy Schwartzentruber, Nikolaos I. Panousis, Andrew Roger Bassett · 2026 · iScience
- Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and humanSimone Brioschi, Julia A. Belk, Steffen E. Storck, Yue Wu, Zhuoying Wang, Ziang Feng, Lynn van Olst, Josie L. Emery, Raki Sudan, Junjie Wu et al. · 2026 · Cell
- Single-nucleus atlas of cell-type specific genetic regulation in the human brainBiao Zeng, Hui Yang, N. M. Prashant, Sanan Venkatesh, Deepika Dayal Mathur, Pavan Kumar Auluck, David Alan Bennett, Stefano Marenco, Vahram H. Haroutunian, Aram Hong et al. · 2026 · Nature Genetics
- Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical OutcomesJingxuan Bao, Brian N. Lee, Junhao Wen, Mansu Kim, Shizhuo Mu, Shu Yang, Christos A. Davatzikos, Qi Long, Marylyn DeRiggi Ritchie, Li Shen · 2024 · Annual Review of Biomedical Data Science
- The 3D Genome in Brain Development: An Exploration of Molecular Mechanisms and Experimental MethodsSamir Rahman, Panos Roussos · 2024 · Neuroscience Insights
- Isolation and Molecular Profiling of Nuclei of Specific Neuronal Types from Human Cerebral Cortex and StriatumChristina Pressl, Matthew Baffuto, Paul Darnell, Cuidong Wang, Thomas S. Carroll, Nathaniel Heintz, Kärt Mätlik · 2024 · Current Protocols
- Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseasesChristopher D. Balak, Johannes C. M. Schlachetzki, Addison J. Lana, Elizabeth West, Christine Hong, Jordan DuGal, Yi Zhou, Benjamin Li, Nathanael J. Spann, Payam A. Saisan et al. · 2026 · Immunity
- Translational control in neurovascular brain developmentKleanthi Chalkiadaki, Elpida Statoulla, Μαρία Μάρκου, Sofia Bellou, Eleni Bagli, Theodore Fotsis, Carol Murphy, Christos G. Gkogkas · 2021 · Royal Society Open Science
- Selective isolation of mouse glial nuclei optimized for reliable downstream omics analysesMiguel Ángel Peña-Ortiz, Sarfraz Shafiq, Megan E. Rowland, Nathalie G. Bérubé · 2022 · Journal of Neuroscience Methods
- Regulatory de novo mutations underlying intellectual disabilityMatías G. De Vas, Fanny Boulet, Shweta S Joshi, Myles G. Garstang, Tahir Naeem Khan, Goutham Atla, David Parry, David Moore, Inês Cebola, Shuchen Zhang et al. · 2023 · Life Science Alliance
- High-resolution omics of vascular ageing and inflammatory pathways in neurodegenerationAndrew John Kwok, Jianning Lu, Junzhe Huang, Bonaventure Yiu Ming Ip, Vincent Mok, H. M. Lai, Ho Ko · 2023 · Seminars in Cell and Developmental Biology
- Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variationBrittany A. Baur, Jacob Matthew Schreiber, Junha Shin, Shilu Zhang, Yi Zhang, Mohith Manjunath, Jun S. Song, William Stafford Noble, Sushmita Roy · 2023 · PLoS Computational Biology
- Enhancer RNAs are necessary and sufficient for activity-dependent neuronal gene transcriptionNancy V. N. Carullo, Rhiana C. Simon, Aaron J. Salisbury, Jasmin S. Revanna, Kendra D. Bunner, Katherine E. Savell, Faraz A. Sultan, Gersbach Ca, JJ Day · 2019 · IUScholarWorks Open (Indiana University)
- The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastomaMarla E. Tharp, Claudia Z. Han, Maya Talukdar, Christopher D. Balak, Conor Fitzpatrick, Carolyn O’Connor, Sebastian Preißl, Justin Buchanan, Alexi Nott, Laure Escoubet et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Epigenetic heterogeneity shapes the transcriptional landscape of regional microgliaAlexander V. Margetts, Samara J. Vilca, Florence Bourgain‐Guglielmetti, Luis M. Tuesta · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Rationale and emerging evidence for microglial replacement in Alzheimer’s diseaseJee Yoon Bang, Yongjin Yoo · 2025 · Molecules and Cells
- Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentinJingyan Zhang, Yufei Huang, Yanbing Chen, Yusi Zhang, Jianmin Chen, Yihong Huang, Haizhi Zhong, Haobing He, Xiaoman Dai, Xiaoxin Yan et al. · 2026 · Immunity
- Recent advances in the use of CRISPR/Cas for understanding the early development of molecular gaps in glial cellsCarla P. Barragán-Álvarez, José Miguel Flores-Fernández, Oscar R. Hernández‐Pérez, Daniela Ávila‐González, Néstor Fabián Díaz, Eduardo Padilla‐Camberos, Octavio Dublán‐García, Leobardo Manuel Gómez‐Oliván, Nestor Emmanuel Diaz-Martinez · 2022 · Frontiers in Cell and Developmental Biology
- Integrated genomic analysis identifies novel low-frequency cis-regulatory variant rs2279658 associated with VSD risk in Chinese childrenLihui Jin, Zhenyuan Han, Zhongli Jiang, Jieru Lu, Yizhuo Wu, Bingqian Yan, Weibin Zhang, Xuedong Lin, Lvyan Jiang, Pengjun Zhao et al. · 2022 · Frontiers in Cell and Developmental Biology
- Uncovering oligodendrocyte enhancers that control Cnp expressionChuandong Fan, Hongjoo An, Dongkyeong Kim, Yungki Park · 2023 · Human Molecular Genetics
- Predicting cell population-specific gene expression from genomic sequenceLieke Michielsen, Marcel J. T. Reinders, Ahmed Essam Mahfouz · 2024 · Frontiers in Bioinformatics
- The Promise of Epigenetic Editing for Treating Brain DisordersLuis Alfonso González-Molina, Amalia M. Dolga, Marianne G. Rots, Federica Sarno · 2025 · Sub-cellular biochemistry/Subcellular biochemistry
- Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell–derived microgliaSofia Moura, Luciana Bertholim Nasciben, Aura María Ramírez, Lauren E. Coombs, Joe Rivero, Derek J. Van Booven, Brooke A. DeRosa, Kara L. Hamilton‐Nelson, Patrice L. Whitehead, Larry Deon Adams et al. · 2025 · Alzheimer s & Dementia
- SCOPE-C reveals long-range enhancer networks emerging as key regulators during human cortical neurogenesisLumeng Jia, Yingping Hou, Zejia Cui, Xin Luo, Jiali Duan, Jianbin Guo, Benhui You, Qing Fang, Xiaotian Wang, Minglei Shi et al. · 2025 · Neuron
- Advancements in Genomic and Behavioral Neuroscience Analysis for the Study of Normal and Pathological Brain FunctionAnnalisa M. Baratta, Adam J. Brandner, Sonja L. Plasil, Rachel C. Rice, Sean P. Farris · 2022 · Frontiers in Molecular Neuroscience
- Hooked Up from a Distance: Charting Genome-Wide Long-Range Interaction Maps in Neural Cells Chromatin to Identify Novel Candidate Genes for Neurodevelopmental DisordersSara Mercurio, Giorgia Pozzolini, Roberta Baldi, Sara E. Barilà, Mattia Pitasi, Orazio Catona, Romina D’Aurizio, Silvia K. Nicolis · 2023 · International Journal of Molecular Sciences
- Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissuesXingzhong Zhao, Liting Song, Anyi Yang, Jinglong Zhang, Jinglong Zhang, Yucheng Yang, Xing‐Ming Zhao · 2023 · Genome Medicine
- Protocol for the purification and transcriptomic analysis of mouse astrocytes using GFATLara Labarta-Bajo, James Deng, Minerva Contreras, Nicola J. Allen · 2023 · STAR Protocols
- Leveraging functional annotations to map rare variants associated with Alzheimer disease with gruyereAnjali Das, Chirag M. Lakhani, Chloé Terwagne, Jui-Shan T Lin, Tatsuhiko Naito, Towfique Raj, David A. Knowles · 2025 · The American Journal of Human Genetics
- In search of lost time: Enhancers as modulators of timing in lymphocyte development and differentiationJonathan Chu, Nicholas A. Pease, Hao Yuan Kueh · 2021 · Immunological Reviews
- Deciphering the functional impact of Alzheimer’s Disease-associated variants in resting and proinflammatory immune cellsMarielle L. Bond, Ivana Yoseli Quiroga, Susan D’Costa, Yijia Wu, Jessica L. Bell, Jessica C. McAfee, Nicole E. Kramer, Sool Lee, Mary Patrucco, Douglas H. Phanstiel et al. · 2024 · medRxiv
- Genome-wide association studies identify 77 loci for suicidality and provide novel biological insightsSarah M. C. Colbert, Maria Koromina, Alexander S Hatoum, Mallory Stephenson, Alexis C. Edwards, Emma C. Johnson, Xuejun Qin, Andrey A Shabalin, Lucas T Ito, Kevin S O’Connell et al. · 2025 · medRxiv
- Lysosomes cell autonomously regulate myeloid cell states and immune responsesTejwani, Leon, Balak, Christopher, Skuja, Lukas L., Tatarakis, David, Rana, Anil, Fitzgerald, Gabriel A., Ha, Connie, Lunkes de Melo, Gabrielly, Sun, Elizabeth W., Heffner, Catherine M. et al. · 2024
- Lipid Droplet-Accumulating Microglia as a Therapeutic Node in Neurodegenerative DiseaseSiqi Guo, Q Y Zhang, Rui Guo, Liyuan Fu, Huaxu Zhu, Qichun Zhang · 2026 · ACS Chemical Neuroscience
- Network Analysis of Enhancer–Promoter Interactions Highlights Cell-Type-Specific Mechanisms of Transcriptional Regulation VariationJustin Koesterich, Jiayi Liu, Sarah Williams, Nan Yang, Anat Kreimer · 2024 · International Journal of Molecular Sciences
- Microglia endotoxin tolerance is retained after enforced repopulationTiago Medeiros-Furquim, Anneke Miedema, Edwin Schilder, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. Eggen · 2025 · Brain Behavior and Immunity
- Proteomic Characterization of the Alzheimer’s Disease Risk Factor BIN1 InteractomeJoseph D. McMillan, Shuai Wang, Jessica Wohlfahrt, Jennifer Guergues, Stanley M. Stevens, Gopal Thinakaran · 2025 · Molecular & Cellular Proteomics
- Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1Jennifer E Palmer, Claudia Puri, Ryan O’Rourke, Sung Min Son, Chun Sang, Yu‐Wen Alvin Huang, David Chaim Rubinsztein · 2025 · Cell Reports
- Can classical statistics and deep learning converge on explainable, causally driven target discovery?Liyin Chen · 2025 · DNA Research
- Super enhancers as key drivers of gene regulatory networks in normal and malignant hematopoiesisYing Cheng, Guangxin Pei, Hengchao Zhang, Yan Hou, Lei Sun, H. Xu, Yuning Lv, Xiuyun Wu · 2025 · Frontiers in Cell and Developmental Biology
- Integrated phenotypic and proteomic screening identifies top‐tier Alzheimer's disease therapeutic targetsGregory A. Cary, Qianjin Li, Jesse C. Wiley, Carolyn A. Paisie, Yuhong Du, Elizabeth L. Zoeller, Duc Minh Duong, Haian Fu, Nicholas T. Seyfried, Allan I. Levey et al. · 2025 · Alzheimer s & Dementia
- Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signaturesValentin Laroche, Rachel Cavill, Morteza P Kouhsar, Joshua Müller, Rick A. Reijnders, Joshua Harvey, Adam R. Smith, Jennifer L. Imm, Jarno Koetsier, Luke Stephen Weymouth et al. · 2026 · Acta Neuropathologica
- Making of BDNF: role of promoters, enhancers, and untranslated regionsEli‐Eelika Esvald, Annela Avarlaid, Indrek Koppel, Jürgen Tuvikene, Tõnis Timmusk · 2026 · Trends in Neurosciences
- Cell-type-aware transcriptome-wide association studies identify 91 independent risk genes for Alzheimer’s disease dementiaQiang Liu, Randy L. Parrish, Shizhen Tang, Shinya Tasaki, David A. A Bennett, Nicholas T. Seyfried, Philip L. De Jager, Vilas Menon, Aron S. Buchman, Jingjing Yang · 2026 · Communications Biology
- Non-coding structural variants disrupt FOXG1 transcriptional regulation in early neurodevelopmentLisa Hamerlinck, Eva D’haene, Michael Vaughan, Nore Van Loon, María del Rocío Pérez Baca, Sebastian Leimbacher, Michael Kosicki, Lara Colombo, Lukas Genbrugge, Lies Vantomme et al. · 2026 · Nature Communications
- Biomedical Data Commons (BMDC) prioritizes B-lymphocyte non-coding genetic variants in Type 1 DiabetesSamantha N. Piekos, Sadhana Gaddam, Pranav Bhardwaj, Prashanth Radhakrishnan, Ramanathan V. Guha, Anthony E. Oro · 2021 · PLoS Computational Biology
- SCN1A: bioinformatically informed revised boundaries for promoter and enhancer regionsSusanna Pagni, Helena Martins Custodio, Adam Frankish, Jonathan M. Mudge, James Dominic Mills, Sanjay M. Sisodiya · 2023 · Human Molecular Genetics
- 3D Genome Reconstruction from Partially Phased Hi-C DataDiego Cifuentes, Jan Draisma, Oskar Henriksson, Annachiara Korchmaros, Kaie Kubjas · 2024 · Bulletin of Mathematical Biology
- Neuroimmune Dysfunction in Alzheimer’s Disease and Other Forms of DementiaTakuya Yamane, Takeshi Yoshioka, Yusuke Shimo · 2024 · Chemical and Pharmaceutical Bulletin
- Regression convolutional neural network models implicate peripheral immune regulatory variants in the predisposition to Alzheimer’s diseaseEaswaran Ramamurthy, Snigdha Agarwal, Noelle Toong, Heather H. Sestili, Irene M. Kaplow, Ziheng Chen, BaDoi N. Phan, Andreas R. Pfenning · 2024 · PLoS Computational Biology
- sTREM2 Mediates the Correlation Between BIN1 Gene Polymorphism and Tau Pathology in Alzheimer’s DiseaseFan Guo, Meng‐Shan Tan, Hao Hu, Ya‐Nan Ou, Ming‐Zhan Zhang, Ze-Hu Sheng, Hao‐Chen Chi, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative · 2024 · Journal of Alzheimer s Disease
- Exploring the feasibility of using mice as a substitute model for investigating microglia in aging and Alzheimer’s disease though single cell analysisRong He, Qiang Zhang, Limei Wang, Yiwen Hu, Yue Qiu, Jia Liu, Dingyun You, Jishuai Cheng, Xue Cao · 2024 · PLoS ONE
- Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulationLiduo Yin, Xiguang Xu, Benjamin Conacher, Lin Yu, Gabriela L. Carrillo, Yupeng Cun, Michael A. Fox, Xuemei Lu, Hehuang Xie · 2025 · BMC Biology
- Identification of a functional SNP rs7304782 at schizophrenia risk locus 12q24.31 and validation of its association with schiz ophrenia in Chinese populationsChangguo Ma, Yifan Li, Xiaoyan Li, Jiewei Liu, Xiong‐Jian Luo · 2020 · Psychiatry Research
- Genomics at cellular resolution: insights into cognitive disorders and their evolutionStefano Berto, Yuxiang Liu, Geneviève Konopka · 2020 · Human Molecular Genetics
- scMAPA: Identification of cell-type–specific alternative polyadenylation in complex tissuesYulong Bai, Yidi Qin, Zhenjiang Fan, Robert M. Morrison, Kyong Nyon Nam, Hassane M. Zarour, Radosveta P. Koldamova, Quasar Saleem Padiath, Soyeon Kim, Hyun Jung Park · 2022 · GigaScience
- Spatially and temporally distinct patterns of expression for VPS10P domain receptors in human cerebral organoidsFabia Febbraro, H. H. Andersen, Meagan M. Kitt, Thomas E. Willnow · 2023 · Frontiers in Cell and Developmental Biology
- Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human BrainYang Xie, Lei Chang, Guojie Zhong, Jonathan A. Rink, Tatiana Baez-Becerra, Ethan J. Armand, Wubin Ding, Kai Li, Éric Bonne, Anita Lie et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Variant-to-function mapping of late-onset Alzheimer’s disease GWAS signals in human microglial cell models implicates
<i>RTFDC1</i>
at the
<i>CASS4</i>
locusBurton, Elizabeth A., Argenziano, Mariana, Cook, Kieona, Ridler, Molly, Lu, Sumei, Su, Chun, Manduchi, Elisabetta, Littleton, Sheridan H., Leonard, Michelle E., Hodge, Kenyaita M. et al. · 2024
- Bayesian colocalization of GWAS and eQTL signals reveals cell type-specific genes and regulatory variants for susceptibility to subtypes of ischemic strokeYunji Seo, Hojin Bae, Chaeyoung Lee · 2024 · Computational Biology and Chemistry
- Discovery of oligodendrocyte enhancers that regulate Sox10 expressionHongjoo An, Chuandong Fan, Dongkyeong Kim, Huy Bui, Yungki Park · 2025 · PLoS Genetics
- Cell-weighted polygenic risk scores are associated with β-amyloid and tau biomarkers in Alzheimer’s diseaseAtul Kumar, Alexa Pichet Binette, Divya Bali, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Jacob W. Vogel, Oskar Hansson, Niklas Mattsson · 2025 · Brain Communications
- Developing a comprehensive database and search tool for single-cell ATAC-seq dataArrian Gibson-Khademi, Jonathan Wang, Erik Christensen, Parisa Shooshtari · 2026 · Scientific Reports
- Genetic risk in Alzheimer’s diseaseYining Pan, Hwayoung Cho, Qian Lou, Wei Zhang, Breton Michael Asken, Qianqian Song · 2026 · npj Systems Biology and Applications
- Genetic modifiers of APOE-ε4-associated cognitive declineAlex G. Contreras, Skylar Walters, Jaclyn M. Eissman, Derek B. Archer, Alexandra N. Regelson, Alaina Durant, Michelle J. Clifton, Shubhabrata Mukherjee, Michael L. Lee, Seo-Eun Choi et al. · 2026 · Nature Communications
- Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver diseaseBiying Zhu, Na He, Yang Xiao, Bin Chen, C Li, Ravi Mandla, Yifan Liu, Jiayu Zhang, Xiao Chang, Fulong Yu et al. · 2026 · Nature Genetics
- Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer’s diseaseYang Zhang, Xinyue Lu, Alexander K. Kunisky, Shahul Alam, Junjie Tang, Ruochi Zhang, Shike Wang, H H Zhang, Jude K. Baroudi, Walid Ichcho et al. · 2026 · Science
- Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescenceXin Yan, Christina Georgopoulou, Hang‐Mao Lee, Ala Ahrari, Jenny Russ, Vijay Chandrasekar, Tim Ducksch, Giuliano Crispatzu, Valentina Talevi, Liang Qiao et al. · 2026 · Nature Neuroscience
- A systems biology-based identification and in vivo functional screening of Alzheimer’s disease risk genes reveal modulators of memory functionAdam D. Hudgins, Shiyi Zhou, Rachel N. Arey, Michael G. Rosenfeld, Coleen T. Murphy, Yousin Suh · 2024 · Neuron
- FANS Unfixed: Isolation and Proteomic Analysis of Mouse Cell Type-Specific Brain NucleiLucy Bedwell, Myrto Mavrotas, Nikita Demchenko, Reuben M Yaa, Brittannie Willis, Zuzana Demianová, Nelofer Syed, Harry J. Whitwell, Alexi Nott · 2024 · Journal of Proteome Research
- Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease riskYuk Yee Leung, Pavel P. Kuksa, Luke Carter, Jeffrey Cifello, Emily Greenfest‐Allen, Otto Valladares, Louisa Boateng, Shannon Laub, Natalia M. Tulina, Sofia Moura et al. · 2025 · npj Dementia
- Silencer variants are key drivers of gene up-regulation in Alzheimer’s diseaseDi Huang, Ivan Ovcharenko · 2026 · Science Advances
- Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14Shannon Laub, Natalia M. Tulina, Matthew Hoffman, Joe Faryean, Sandhya Ramachandran, Bao Khanh Trang, Stephanie M. Lewkiewicz, Alessandra Chesi · 2026 · The American Journal of Human Genetics
- Chromatin accessibility in neuropsychiatric disordersGabor Egervári · 2021 · Neurobiology of Learning and Memory
- Genetic mapping of developmental trajectories for complex traits and diseasesEldad David Shulman, Ran Elkon · 2021 · Computational and Structural Biotechnology Journal
- Deep learning predicts the impact of regulatory variants on cell-type-specific enhancers in the brainAn Zheng, Zeyang Shen, Christopher K. Glass, Melissa Gymrek · 2023 · Bioinformatics Advances
- SnapHiC-G: identifying long-range enhancer–promoter interactions from single-cell Hi-C data via a global background modelWeifang Liu, Wujuan Zhong, Paola Giusti‐Rodríguez, Zhiyun Jiang, Geoffery W. Wang, Huaigu Sun, Ming Hu, Yun Li · 2024 · Briefings in Bioinformatics
- Genetic variants associated with age‐related episodic memory decline implicate distinct memory pathologiesAmanat Ali, Sofiya Milman, Erica F Weiss, Tina Gao, Valerio Napolioni, Nir Barzilai, Zhengdong D. Zhang, Jhih-Rong Lin · 2024 · Alzheimer s & Dementia
- Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal developmentYaoyu Sun, Min Li, Chao Ning, Lei Gao, Zhenbo Liu, Suijuan Zhong, Junjie Lv, Yuwen Ke, Xinxin Wang, Qiang Ma et al. · 2025 · Cell Discovery
- Cell Type–Specific Nuclei Markers: The Need for Human Brain Research to Go NuclearJames A. Wiseman, Mike Dragunow, Thomas Park · 2021 · The Neuroscientist
- DeCOOC Deconvoluted Hi‐C Map Characterizes the Chromatin Architecture of Cells in Physiologically Distinctive TissuesJunmei Wang, Lu Lu, Shiqi Zheng, Danyang Wang, Long Guo Jin, Qing Zhang, Mingzhou Li, Zhihua Zhang · 2023 · Advanced Science
- Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's diseaseViola Volpato · 2021 · Biochemical Society Transactions
- Genome-wide profiling of angiogenic cis-regulatory elements unravels cis-regulatory SNPs for vascular abnormalityLihui Jin, Zhenyuan Han, Xiao‐Tong Mao, Jieru Lu, Bingqian Yan, Yiwen Lu, Lili Liang, Lin Wang, Yu Yu, Kun Sun · 2024 · Scientific Data