Cited by 251Genomics and Chromatin DynamicsNeurogenesis and neuroplasticity mechanismsEpigenetics and DNA Methylation

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Chromatin accessibility dynamics in a model of human forebrain development

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Abstract

Organoids recapitulate brain development: Gene expression changes and their control by accessible chromatin in the human brain during development is of great interest but limited accessibility. Trevino et al. avoided this problem by developing three-dimensional organoid models of human forebrain development and examining chromatin accessibility and gene expression at the single-cell level. From this analysis, they matched developmental profiles between the organoid and fetal samples, identified transcription factor binding profiles, and predicted how transcription factors are linked to cortical development. The researchers were able to correlate the expression of neurodevelopmental disease risk loci and genes with specific cell types during development. Science , this issue p. eaay1645

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Metadata

Authors
Trevino, A. E., Sinnott-Armstrong, N., Andersen, J., Yoon, S.-J., Huber, N., Pritchard, J. K., Chang, H. Y., Greenleaf, W. J., & Pașca, S. P.
Affiliations
  • Stanford University (US)
  • Stanford Medicine (US)
  • Howard Hughes Medical Institute (US)
  • Chan Zuckerberg Biohub San Francisco (US)
Corresponding author
  • Trevino, Alexandro E.
  • Sinnott-Armstrong, Nasa
  • Andersen, Jimena
  • Greenleaf, William J.
  • Pașca, Sergiu P.
Venue
Science
Published
2020-01-24
Volume
367
Issue
6476
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W3000751841
Cited by
251
References
78
Citations by year
2026: 23 · 2025: 30 · 2024: 39 · 2023: 36 · 2022: 56 · 2021: 42 · 2020: 22
FWCI
12.64
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Mental Health (R01MH107800, U01MH115745)
  • National Human Genome Research Institute (RM1HG007735, P50HG007735, UM1HG009442)
  • National Institute of Allergy and Infectious Diseases (U19AI090023, U19AI057266)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
chromatin accessibility, forebrain development, cortical development, three-dimensional organoids, glial lineage, neuronal lineage, transcription factors, neuropsychiatric disorders, genetic risk, evolutionary conservation, gene regulatory dynamics
MeSH terms
Animals, Mental Disorders, Chromatin, Humans, Nervous System Diseases, Organoids, Prosencephalon, Gene Expression Regulation, Developmental, Cell Lineage, Pluripotent Stem Cells, Chromatin Assembly and Disassembly, Mice, Neurogenesis, Transcriptome

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