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The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Organoid single-cell genomic atlas uncovers human-specific features of brain development

Kanton, Sabina, Boyle, Michael James, He, Zhisong, Santel, Malgorzata, Weigert, Anne, Sanchís-Calleja, Fátima, Guijarro, Patricia, Sidow, Leila, Fleck, Jonas Simon, Han, Dingding, Qian, Zhengzong, Heide, Michael, Huttner, Wieland B., Khaitovich, Philipp, Pääbo, Svante, Treutlein, Barbara, Camp, J. Gray·2019·Nature
DOI 10.1038/s41586-019-1654-9

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  • Genome editing technologies such as CRISPR-Cas9, pluripotent iPS stem cells and miniaturized organoid systems mimicking simplified organs now offer possibility to investigate functional consequences of virtually any change in sequence of a given genome.

    “Genome editing technologies such as CRISPR-Cas9 344 , pluripotent iPS stem cells 345 and miniaturized organoid systems mimicking simplified organs 346 now offer the possibility to investigate the functional consequences of virtually any change in the sequence of a given genome.”

    From Ancient DNA analysis (2021) · cites this paper as [345]

    The paper’s Abstract describes stem-cell-derived cerebral organoids used to study human brain development and gene-regulatory differences, supporting citation 346’s identification of organoids as a model system. It does not establish that organoids can be used to investigate the functional consequences of virtually any genome-sequence change; the study examines particular differences among primates, not that general capability. (LLM, conf=0.83)

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Research works printed but not linked: 44

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  8. Camp, J. G. et al. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc. Natl Acad. Sci. USA 112, 15672–15677 (2015). · DOI · Paper page
  9. Amiri, A. et al. Transcriptome and epigenome landscape of human cortical development modeled in organoids. Science 362, eaat6720 (2018). · DOI
  10. Mora-Bermúdez, F. et al. Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development. eLife 5, e18683 (2016). · DOI
  11. Pollen, A. A. et al. Establishing cerebral organoids as models of human-specific brain evolution. Cell 176, 743–756 (2019). · DOI · Paper page
  12. Weinreb, C., Wolock, S. & Klein, A. M. SPRING: a kinetic interface for visualizing high dimensional single-cell expression data. Bioinformatics 34, 1246–1248 (2018). · DOI · Paper page
  13. Nowakowski, T. J. et al. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. Science 358, 1318–1323 (2017). · DOI · Paper page
  14. La Manno, G. et al. RNA velocity of single cells. Nature 560, 494–498 (2018). · DOI · Paper page
  15. Renner, M. et al. Self-organized developmental patterning and differentiation in cerebral organoids. EMBO J. 36, 1316–1329 (2017). · DOI · Paper page
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  17. Otani, T., Marchetto, M. C., Gage, F. H., Simons, B. D. & Livesey, F. J. 2D and 3D stem cell models of primate cortical development identify species-specific differences in progenitor behavior contributing to brain size. Cell Stem Cell 18, 467–480 (2016). · DOI · Paper page
  18. Florio, M. et al. Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex. eLife 7, e32332 (2018). · DOI
  19. Visel, A., Minovitsky, S., Dubchak, I. & Pennacchio, L. A. VISTA Enhancer Browser—a database of tissue-specific human enhancers. Nucleic Acids Res. 35, D88–D92 (2007). · DOI · Paper page
  20. Gregorio, I., Braghetta, P., Bonaldo, P. & Cescon, M. Collagen VI in healthy and diseased nervous system. Dis. Model. Mech. 11, dmm032946 (2018). · DOI
  21. Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147 (1998). · DOI
  22. Okita, K. et al. An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. Stem Cells 31, 458–466 (2013). · DOI
  23. Lancaster, M. A. & Knoblich, J. A. Generation of cerebral organoids from human pluripotent stem cells. Nat. Protoc. 9, 2329–2340 (2014). · DOI · Paper page
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Metadata

Authors
Kanton, S., Boyle, M. J., He, Z., Santel, M., Weigert, A., Sanchís-Calleja, F., Guijarro, P., Sidow, L., Fleck, J. S., Han, D., Qian, Z., Heide, M., Huttner, W. B., Khaitovich, P., Pääbo, S., Treutlein, B., & Camp, J. G.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2019-10-16
Volume
574
Issue
7778
Pages
418-422
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/s41586-019-1654-9
Cited by
778
References
31
Language
en
Licence

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