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A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

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Decoding myofibroblast origins in human kidney fibrosis

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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

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Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

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Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

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Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases

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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

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Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction

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Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

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Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses

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Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

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Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

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Chromatin accessibility dynamics in a model of human forebrain development

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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

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Xist ribonucleoproteins promote female sex-biased autoimmunity

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Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

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An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

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FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer

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Decoding gene regulation in the fly brain

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The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes

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High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer

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Precise modulation of transcription factor levels identifies features underlying dosage sensitivity

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Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag

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Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis

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Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1

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Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy

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Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma

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FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer

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A homeostatic Arid1a-dependent permissive chromatin state licenses hepatocyte responsiveness to liver-injury-associated YAP signaling

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Induction of mouse totipotent stem cells by a defined chemical cocktail.

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Cross-species analysis of enhancer logic using deep learning

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Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

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Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

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Association of a common genetic variant with Parkinson’s disease is mediated by microglia

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Novel insights from a multiomics dissection of the Hayflick limit

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Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain

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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

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Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation

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Outer Membrane Vesicle‐Based Nanohybrids Target Tumor‐Associated Macrophages to Enhance Trained Immunity‐Related Vaccine‐Generated Antitumor Activity

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Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration

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Time-resolved single-cell RNA-seq using metabolic RNA labelling

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Functional characterization of Alzheimer’s disease genetic variants in microglia

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A plate-based single-cell ATAC-seq workflow for fast and robust profiling of chromatin accessibility

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Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs

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