Coding functions of “noncoding” RNAs

Wei, Lian-Huan; Guo, Junjie U.

doi:10.1126/science.aba6117

Cited by 53RNA Research and SplicingCancer-related molecular mechanisms researchRNA and protein synthesis mechanisms

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Coding functions of “noncoding” RNAs

Wei, Lian-Huan, Guo, Junjie U.·2020·Science

DOI 10.1126/science.aba6117

Open this paper in CoChat — free account

Abstract

Hundreds of RNA regions that encode microproteins are found to regulate cell growth

Integrity signals

Registry

Crossref · 10.1126/science.aba6117

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Noncoding RNAs do not code for peptides or proteins.
“noncoding RNAs (ncRNAs), which do not code for peptides or proteins.213,214”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [214]

lincRNAs: Genomics, Evolution, and Mechanisms
Ulitsky, I., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.06.020 · Cited by 2,652
A micropeptide encoded by a putative long noncoding RNA regulates muscle performance
Anderson, D. M., Anderson, K. M., Chang, C.-L., Makarewich, C. A., Nelson, B. R., McAnally, J. R., Kasaragod, P., Shelton, J. M., Liou, J., Bassel-Duby, R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.009 · Cited by 1,216
Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins
Guttman, M., Russell, P., Ingolia, N. T., Weissman, J. S., & Lander, E. S. (2013) · Cell · doi:10.1016/j.cell.2013.06.009 · Cited by 745
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation
Bazzini, A., Johnstone, T. G., Christiano, R., Mackowiak, S. D., Obermayer, B., Fleming, E. S., Vejnar, C. E., Lee, M. T., Rajewsky, N., Walther, T. C., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201488411 · Cited by 675
Ribosome Profiling Reveals Pervasive Translation Outside of Annotated Protein-Coding Genes
Ingolia, N. T., Brar, G. A., Stern‐Ginossar, N., Harris, M. S., Talross, G. J. S., Jackson, S. E., Wills, M. R., & Weissman, J. S. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.045 · Cited by 670
Pervasive functional translation of noncanonical human open reading frames
Chen, J., Brunner, A., Cogan, J. Z., Nuñez, J. K., Fields, A. P., Adamson, B., Itzhak, D. N., Li, J. Y., Mann, M., Leonetti, M. D., et al. (2020) · Science · doi:10.1126/science.aay0262 · Cited by 654
Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors
Pauli, A., Norris, M. L., Valen, E., Chew, G.-L., Gagnon, J. A., Zimmerman, S., Mitchell, A., Ma, J., Dubrulle, J., Reyon, D., et al. (2014) · Science · doi:10.1126/science.1248636 · Cited by 622
Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins
Ji, Z., Song, R., Regev, A., & Struhl, K. (2015) · eLife · doi:10.7554/elife.08890 · Cited by 592
Translation from the 5′ untranslated region shapes the integrated stress response
Starck, S. R., Tsai, J. C., Chen, K., Shodiya, M., Wang, L., Yahiro, K., Martins‐Green, M. M., Shastri, N., & Walter, P. (2016) · Science · doi:10.1126/science.aad3867 · Cited by 390
Conserved Regulation of Cardiac Calcium Uptake by Peptides Encoded in Small Open Reading Frames
Magny, E. G., Pueyo, J. I., Pearl, F. M. G., Céspedes, M. A., Niven, J. E., Bishop, S. A., & Couso, J. P. (2013) · Science · doi:10.1126/science.1238802 · Cited by 368
Upstream ORFs are prevalent translational repressors in vertebrates
Johnstone, T. G., Bazzini, A. A., & Giraldez, A. J. (2016) · The EMBO Journal · doi:10.15252/embj.201592759 · Cited by 346
Small peptide regulators of actin-based cell morphogenesis encoded by a polycistronic mRNA
Kondo, T., Hashimoto, Y. K., Kato, K., Inagaki, S., Hayashi, S., & Kageyama, Y. (2007) · Nature Cell Biology · doi:10.1038/ncb1595 · Cited by 260
CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins
Kearse, M. G., Green, K. M., Krans, A., Rodriguez, C. M., Linsalata, A. E., Goldstrohm, A. C., & Todd, P. K. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.02.034 · Cited by 178
Distinguishing between "Function" and "Effect" in Genome Biology
Doolittle, W. F., Brunet, T. D. P., Linquist, S., & Gregory, T. R. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu098 · Cited by 101
Rethinking Unconventional Translation in Neurodegeneration
Gao, F., Richter, J. D., & Cleveland, D. W. (2017) · Cell · doi:10.1016/j.cell.2017.10.042 · Cited by 70

Flagged first, then by citations

Sorted by citations

Review on circular RNAs and new insights into their roles in cancer
Tang, X., Ren, H., Guo, M., Qian, J., Yang, Y., & Gu, C. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.01.018 · Cited by 355
Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
Insect Diapause
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364 · Cited by 187
The Origin and Immune Recognition of Tumor-Specific Antigens
Apavaloaei, A., Hardy, M., Thibault, P., & Perreault, C. (2020) · Cancers · doi:10.3390/cancers12092607 · Cited by 101
Coding, or non-coding, that is the question
Poliseno, L., Lanza, M., & Pandolfi, P. P. (2024) · Cell Research · doi:10.1038/s41422-024-00975-8 · Cited by 98
Long Non-Coding RNAs in Cardiovascular Diseases: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Correia, C. C. M., Rodrigues, L. F., Pelozin, B. R. D. A., de Oliveira, E. M., & Fernandes, T. M. (2021) · Non-Coding RNA · doi:10.3390/ncrna7040065 · Cited by 64
Translational remodeling by RNA ‐binding proteins and noncoding RNAs
Ho, J. J. D., Man, J. H. S., Schatz, J. H., & Marsden, P. A. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1647 · Cited by 45
PROTACs, molecular glues and bifunctionals from bench to bedside: Unlocking the clinical potential of catalytic drugs
Maneiro, M., Vita, E. D., Conole, D., Kounde, C. S., Zhang, Q., & Tate, E. W. (2021) · Progress in medicinal chemistry · doi:10.1016/bs.pmch.2021.01.002 · Cited by 38
From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory
Andjus, S., Morillon, A., & Wéry, M. (2021) · Non-Coding RNA · doi:10.3390/ncrna7030044 · Cited by 38
Eimeria proteins: order amidst disorder
Olajide, J. S., Qu, Z., Yang, S., Oyelade, O. J., & Cai, J. (2022) · Parasites & Vectors · doi:10.1186/s13071-022-05159-0 · Cited by 29
BAALC‐AS1/G3BP2/c‐Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma
Zhang, H., Wang, Y., Zhang, W., Wu, Q., Fan, J., & Zhan, Q. (2021) · 癌症：英文版 · doi:10.1002/cac2.12127 · Cited by 21
LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression
Tang, P. C., Zhang, Y.-Y., Li, J. S.-F., Chan, M. K., Chan, M. K., Tang, Y., Zhou, Y., Zhang, D., Leung, K., To, K., et al. (2022) · Non-Coding RNA · doi:10.3390/ncrna8030036 · Cited by 20
Identification and Validation of an Autophagy-Related lncRNA Signature for Patients With Breast Cancer
Zhang, R., Zhu, Q., Yin, D., Yang, Z., Guo, J., Zhang, J., Zhou, Y., & Yu, J. J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.597569 · Cited by 19
Self-citation
Potential roles of exosome non‑coding RNAs in cancer chemoresistance (Review)
Wang, Y., Liu, Q., & Wang, F. (2020) · Oncology Reports · doi:10.3892/or.2020.7887 · Cited by 17
LncRNA and Protein Expression Profiles Reveal Heart Adaptation to High-Altitude Hypoxia in Tibetan Sheep
He, Z., Li, S., Zhao, F., Sun, H., Hu, J., Wang, J., Liu, X., Li, M., Zhao, Z., & Luo, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010385 · Cited by 15
Non-coding RNAs: The link between maternal malnutrition and offspring metabolism
Zeng, Y., Wu, Y., Zhang, Q., & Xiao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1022784 · Cited by 13
Circular RNAs mediate the regulation of maternal placental nutrient transport and fetal development by sugar-sweetened beverages
He, T., Yuan, Z., Chen, Q., Luo, J., Mao, J., Yang, Y., Cao, K., & Yang, Z. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114856 · Cited by 13
Molecular underpinnings of the early brain developmental response to differential feeding in the honey bee Apis mellifera
Vieira, J., Freitas, F. C. D. P., Cristino, A. S., Pinheiro, D. G., Aguiar, L. R., Laure, M. A. F. B., Moda, L. M. R., Simões, Z. L. P., & Barchuk, A. R. (2021) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2021.194732 · Cited by 13
Computational Analysis Predicts Hundreds of Coding lncRNAs in Zebrafish
Mishra, S. K., & Wang, H. (2021) · Biology · doi:10.3390/biology10050371 · Cited by 11
The miR‐302/367 cluster: Aging, inflammation, and cancer
Li, Z., Duan, Y., Yan, S., Zhang, Y., & Wu, Y. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3836 · Cited by 7
Enhanced bovine genome annotation through integration of transcriptomics and epi-transcriptomics datasets facilitates genomic biology
Beiki, H., Murdoch, B. M., Park, C. A., Kern, C., Konetchy, D. E., Becker, G. M., Rincón, G., Jiang, H., Zhou, H., Thorne, J. W., et al. (2024) · GigaScience · doi:10.1093/gigascience/giae019 · Cited by 7
The roles of epigenetic regulation in graft-versus-host disease
Wang, Y., Liu, Q., Deng, L., Ma, X., Gong, Y., Wang, Y., & Zhou, F. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116652 · Cited by 6
Long Non-coding RNA Linc01224 Regulates Hypopharyngeal Squamous Cell Carcinoma Growth Through Interactions with miR-485-5p and IGF2BP3
Wei, L., Wu, Y., Cai, S., Qin, Y., Xing, S., & Wang, Z. (2023) · Journal of Cancer · doi:10.7150/jca.85019 · Cited by 6
Self-citation
Conceptual breakthroughs of the long noncoding RNA functional system and its endogenous regulatory role in the cancerous regime
Wang, A. (2024) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2024.00211 · Cited by 6
Distinctive functional regime of endogenous lncRNAs in dark regions of human genome
Wang, A., & Hai, R. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.05.020 · Cited by 5
Molecular Signaling Pathways that Regulate Diapause
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.010 · Cited by 5
Compilation of resources on subcellular localization of lncRNA
Choudhury, S., Rathore, A. S., & Raghava, G. P. S. (2024) · Frontiers in RNA Research · doi:10.3389/frnar.2024.1419979 · Cited by 4
Interpreting Seasonal Cues to Program Diapause Entry
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.006 · Cited by 4
Circular RNA Vv‐circCOR27 modulates thermotolerance through attenuating VvHSP90 .2b‐ VvHsfA7a interaction in grapevine
Ren, Y., Xu, Y., Liu, M., Zhang, L., Song, Y., Li, J., Liu, J., Fan, D., Zhang, Z., He, J., et al. (2026) · New Phytologist · doi:10.1111/nph.70962 · Cited by 3
The Diapause State
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.008 · Cited by 3
Confronting the Challenges of a Seasonal Environment
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.002 · Cited by 3
Preparing for Diapause
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.007 · Cited by 2
Chroniques génomiques
Jordan, B. (2020) · médecine/sciences · doi:10.1051/medsci/2020108 · Cited by 2
Which Seasons Are Being Avoided?
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.003 · Cited by 1
Molecular Diagnosis of Genetic Diseases of the Kidney: Primer for Pediatric Nephrologists
Waters, A. M., & Lemaire, M. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-11665-0_4 · Cited by 1
Ending Diapause and Reinitiating Development
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.009 · Cited by 1
References
(2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.014
Evolution of Diapause
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.012
The Cost of Diapause and Some Diapause Alternatives
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.005
Subject Index
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.016
Genetic Control of Diapause
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.011
Variation in the Diapause Response
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.004
Wider Implications
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.013
Species Index
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.015
Preface
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.001
Plate Section (PDF Only)
Denlinger, D. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108609364.017
Tumor antigenicity and cancer as non-self
Niederhuber, J. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-87763-3.00014-9
mRNPs biogenesis perturbation by the bacterial Rho factor : genomic analysis of the recrutment of the THO complex and its subunits
Beauvais, V. (2023) · theses.fr (ABES) · doi:10.70675/55ea0070zdf29z46fcz9dfezfa066fbaece7
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
Luo, X., Shi, J., Wang, S., & Jin, X. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02488-8
Exploration de génomes par analyse de données omiques.
Foissac, S. (2024) · HAL
Caractérisation fonctionnelle de longs ARNs non codants induits par l’hypoxie et impliqués dans l’agressivité des cancers pulmonaires non à petites cellules
Gautier‐Isola, M. (2020) · theses.fr (ABES) · doi:10.70675/b7e26a71za1e0z48e7za416z5e837ae7e8ef
Role of translation in the degradation of antisense long non-coding RNAs in yeast
Andjus, S. (2022) · theses.fr (ABES) · doi:10.70675/94fafd42zc6b0z48cdz8e96zef86e8977d4a
Emerging Hallmarks of Functional Proteins Encoded by Non‐Canonical ORFs
Zhou, F., Jiang, J., Lei, T., Chang, Y., & Zhang, H. (2026) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.70063

Authors: Wei, L.-H., & Guo, J. U.
Affiliations: Yale University (US)
ORCID: Wei, Lian-Huan
Guo, Junjie U.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-03-06
Volume: 367
Issue: 6482
Pages: 1074-1075
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aba6117
OpenAlex: W3010473795
Cited by: 52
References: 15
Citations by year: 2026: 2 · 2024: 7 · 2023: 6 · 2022: 24 · 2021: 9 · 2020: 4
Type: journal article
Language: en
Open access: closed
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor)
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (DP2GM132930)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: microproteins, microRNA, non-coding RNA, cell growth regulation
MeSH terms: Humans, Open Reading Frames, RNA, Untranslated, RNA, Long Noncoding

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Coding functions of “noncoding” RNAs

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks