The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Species-specific pace of development is associated with differences in protein stability
Open accessAbstract
Setting the tempo for development: Many animals display similarities in their organization (body axis, organ systems, and so on). However, they can display vastly different life spans and thus must accommodate different developmental time scales. Two studies now compare human and mouse development (see the Perspective by Iwata and Vanderhaeghen). Matsuda et al. studied the mechanism by which the human segmentation clock displays an oscillation period of 5 to 6 hours, whereas the mouse period is 2 to 3 hours. They found that biochemical reactions, including protein degradation and delays in gene expression processes, were slower in human cells compared with their mouse counterparts. Rayon et al. looked at the developmental tempo of mouse and human embryonic stem cells as they differentiate to motor neurons in vitro. Neither the sensitivity of cells to signals nor the sequence of gene-regulatory elements could explain the differing pace of differentiation. Instead, a twofold increase in protein stability and cell cycle duration in human cells compared with mouse cells was correlated with the twofold slower rate of human differentiation. These studies show that global biochemical rates play a major role in setting the pace of development. Science , this issue p. 1450 , p. eaba7667 ; see also p. 1431
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Cited by
Species-specific segmentation clock periods are due to differential biochemical reaction speeds
Matsuda, M., Hayashi, H., Garcia-Ojalvo, J., Yoshioka-Kobayashi, K., Kageyama, R., Yamanaka, Y., Ikeya, M., Toguchida, J., Alev, C., & Ebisuya, M. (2020) · Science · doi:10.1126/science.aba7668 · Cited by 254
An epigenetic barrier sets the timing of human neuronal maturation
Ciceri, G., Baggiolini, A., Cho, H. S., Kshirsagar, M., Benito-Kwiecinski, S., Walsh, R. M., Aromolaran, K. A., Gonzalez-Hernandez, A. J., Munguba, H., Koo, S. Y., et al. (2024) · Nature · doi:10.1038/s41586-023-06984-8 · Cited by 240
Developmental mechanisms underlying the evolution of human cortical circuits
Vanderhaeghen, P., & Polleux, F. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00675-z · Cited by 173
Human neuronal maturation comes of age: cellular mechanisms and species differences
Wallace, J. L., & Pollen, A. A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00760-3 · Cited by 82
Cellular and Molecular Mechanisms Linking Human Cortical Development and Evolution
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Metadata
- Authors
- Rayon, T., Stamataki, D., Perez-Carrasco, R., Garcia-Perez, L., Barrington, C., Melchionda, M., Exelby, K., Lazaro, J., Tybulewicz, V. L. J., Fisher, E. M. C., & Briscoe, J.
- Venue
- Science
- Published
- 2020-09-18
- Volume
- 369
- Issue
- 6510
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3087046884
- Cited by
- 268
- References
- 65
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- green
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