Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

Chang, Che-Wei, Shao, Eric, Mucke, Lennart·2021·Science

DOI 10.1126/science.abb8255

Cited by (265)

Items 101–200 of 265

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Phenotypic Differences between the Alzheimer’s Disease-Related hAPP-J20 Model and HeterozygousZbtb20Knock-Out Mice
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Jiedu Yizhi Formula Improves Cognitive Function by Regulating the Gut Dysbiosis and TLR4/NF-κB Signaling Pathway
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Current progress in aptamer-based sensors for the detection of protein biomarkers in neurodegenerative diseases
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Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model
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Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease
Marcel Victor Alavi · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNS
Ergina Vourkou, Vassilis Paspaliaris, Anna Bourouliti, Maria-Christina Zerva, Engie Prifti, Katerina Papanikolopoulou, Efthimios M. C. Skoulakis · 2022 · International Journal of Molecular Sciences
Focus on Alzheimer’s Disease: The Role of Fibroblast Growth Factor 21 and Autophagy
Lan Yang, Jianfei Nao · 2022 · Neuroscience
Spreading of Tau Protein Does Not Depend on Aggregation Propensity
Sara Rodrigues, Marta Anglada‐Huguet, Katja Hochgräfe, Senthilvelrajan Kaniyappan, Susanne Wegmann, Eva‐Maria Mandelkow · 2023 · Journal of Molecular Neuroscience
Acetylated tau exacerbates apoptosis by disturbing mitochondrial dynamics in HEK293 cells
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Dynamic-Inspired Perspective on the Molecular Inhibitor of Tau Aggregation by Glucose Gallates Based on Human Neurons
Yuan Hu, Danjing Yang, Ying Tu, Keke Chai, Lei Chu, Shuo Shi, Tianming Yao · 2021 · ACS Chemical Neuroscience
Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement
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Elevated SGK1 increases Tau phosphorylation and microtubule instability in Alzheimer’s patient-derived cortical neurons
Saleem, Komal, Xiao, Zichun, Zhu, Binglin, Ren, Yong, Yan, Zhen, Feng, Jian · 2026 · Molecular Psychiatry
Combating multiple aetiologies of Alzheimer's disease to rescue behavioural deficits
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TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy
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Melissa officinalis extract suppresses endoplasmic reticulum stress-induced apoptosis in the brain of hypothyroidism-induced rats exposed to γ-radiation
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Interaction Between a High-Fat Diet and Tau Pathology in Mice: Implications for Alzheimer’s Disease
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A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia
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Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice
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Tau post-translational modifications in Alzheimer's disease: Insights into pathogenesis, therapeutic strategies, and diagnostic advances
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