Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies
Open accessAbstract
The many faces of tau: The protein tau is implicated in several brain disorders, including Alzheimer's disease, suggesting that it could be a target of therapeutics. However, because it is unclear how the pleiotropic roles of tau lead to neural pathology in different brain diseases, drug development remains challenging. Chang et al. review the possible mechanisms of tau in brain diseases and possible paths forward to improving research and drug development. Science , this issue p. eabb8255
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Because tau is eliminated from all cell types in the global knockout, glial transcriptional remodeling may reflect both cell-autonomous and non-cell-autonomous mechanisms whereby relief of neuronal stress reduces maladaptive signaling and enables glia to re-engage adaptive programs.
“Because tau is eliminated from all cell types in the global knockout, glial transcriptional remodeling may reflect both cell-autonomous and non-cell-autonomous mechanisms whereby relief of neuronal stress reduces maladaptive signaling and enables glia to re-engage adaptive programs [143].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [143]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredHyperphosphorylation of Tau is linked to synaptic dysfunctions and subsequent neurodegeneration in AD.
“Hyperphosphorylation of Tau is linked to synaptic dysfunctions and subsequent neurodegeneration in AD [9].”
From Elevated SGK1 increases Tau phosphorylation and microtubule instability in Alzheimer’s patient-derived cortical neurons (2026) · cites this paper as [9]
The “Pathogenic mechanisms of abnormal tau” section (page not supplied) says acetylated, hyperphosphorylated FTLD-tau may contribute to neural dysfunction. It does not establish that tau hyperphosphorylation leads from synaptic dysfunction to neurodegeneration in AD; it also cautions that hyperphosphorylation can be pathogenic or protective depending on the sites involved. (LLM, conf=0.85)
Experimental — accuracy not yet measuredTau can regulate PI3K-Akt-mTOR signaling, but under pathological stress such as in ASD or amyloid accumulation, it can promote network dysfunction.
“Tau can regulate this pathway [56], but under pathological stress such as in conditions such as ASD or amyloid accumulation, it can promote network dysfunction [22, 143].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [143]
α-Synuclein and tau are both intrinsically disordered proteins with distinct conformations that probably drive their respective pathologies and for which induced proteolytic degradation could be disease-modifying.
“α-Synuclein and tau are both intrinsically disordered proteins with distinct conformations that probably drive their respective pathologies and for which induced proteolytic degradation could be disease-modifying184.”
From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [184]
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“ASOs can also be used to modulate alternative splicing, a strategy that could help lower the abundance of the most pathogenic isoforms of tau (140), which may differ across tauopathies (1, 15).”
BackgroundCryo-EM structures of tau filaments
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Dietary salt promotes cognitive impairment through tau phosphorylation
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Human secreted tau increases amyloid-beta production
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Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains
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Tau deletion promotes brain insulin resistance
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Regulation of human MAPT gene expression
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Tau reduction prevents disease in a mouse model of <scp>D</scp> ravet syndrome
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Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo
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Ordered Assembly of Tau Protein and Neurodegeneration
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Tau misfolding efficiently propagates between individual intact hippocampal neurons
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Tau is not necessary for amyloid-β–induced synaptic and memory impairments
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Pitavastatin decreases tau levels via the inactivation of Rho/ROCK
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Tau Protein Role in Sleep-Wake Cycle
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Genetic Ablation of Tau Mitigates Cognitive Impairment Induced by Type 1 Diabetes
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Neuronal levels and sequence of tau modulate the power of brain rhythms
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PROTAC targeted protein degraders: the past is prologue
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Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials
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- Authors
- Chang, C.-W., Shao, E., & Mucke, L.
- Affiliations
- Gladstone Institutes (US)
- Corresponding author
- Mucke, Lennart
- Venue
- Science
- Published
- 2021-02-26
- Volume
- 371
- Issue
- 6532
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8118650
- OpenAlex
- W3129727567
- Cited by
- 263
- References
- 152
- Citations by year
- 2026: 42 · 2025: 53 · 2024: 42 · 2023: 47 · 2022: 57 · 2021: 22
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (R01 MH115679, R56 AG060631, UH3 AG054304)
- Alzheimer's Association
- Tau Consortium
- Cure Network Dolby Acceleration Partners
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- tau protein, tauopathy, Alzheimer's disease, neurodegenerative diseases, autism spectrum disorder, epilepsy, microtubule binding, neuronal dysfunction, disease models
- MeSH terms
- Animals, Brain, Brain Diseases, Humans, Microtubules, Neurons, tau Proteins, Tauopathies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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