Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

Chang, Che-Wei, Shao, Eric, Mucke, Lennart·2021·Science
DOI 10.1126/science.abb8255

Cited by (265)

Items 201–265 of 265

  1. Targeting tau degradation: a viable therapeutic approach?
    Matthew Mason, Mehtap Bacioglu, Giorgio Vivacqua, Maria Grazia Spillantini, Aviva M. Tolkovsky · 2023 · The Lancet Neurology
  2. In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis
    Christian Behl · 2023 · Springer eBooks
  3. The Importance of Vaccines in Preventing Impending Alzheimer’s Epidemic
    Siddhant Tripathi, Yashika Sharma, Dileep Kumar · 2025 · Reviews on Recent Clinical Trials
  4. Elongation of Fibrils Formed by a Tau Fragment is Inhibited by a Transient Dimeric Intermediate
    Harish Kumar, Jayant B. Udgaonkar · 2022 · The Journal of Physical Chemistry B
  5. Targeted degradation of microtubule-associated protein tau using an engineered nanobody-E3 ubiquitin ligase adapter fusion
    Shiyao Wang, Shaowei Jiang, Guoan Zheng, Yong Ku Cho · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Immunoproteasome deficiency results in accelerated brain aging and epilepsy
    Hanna Leister, Felix F. Krause, Beatriz Gil, Ruslan Prus, Inna Prus, Anne Hellhund, Meghma Mitra, Rogério R. Gerbatin, Norman Delanty, Alan Beausang et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  7. ApoE ε4-dependent alteration of CXCR3+CD127+ CD4+ T cells is associated with elevated plasma neurofilament light chain in Alzheimer’s disease
    Dan Hu, Mei Chen, Xu-Yang Li, Peter Morin, S. Daley, Yuyang Han, M. Hemberg, H. Weiner, Wei-Ming Xia · 2024 · bioRxiv
  8. Tau Aggregation is Altered by Variations in its Projection Domain
    Kayleigh Mason-Chalmers, Aanzan Sachdeva, Gabryelle Kolk, Justin Charles Touchon, Zachary J. Donhauser · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  9. MARK4 enhances stress granule formation and increases tau accumulation
    Sho Nakajima, Kenta Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease
    Chimal-Juárez, Enrique, Patel, Henika, Jury-Garfe, Nur, Dabin, Luke C., Vidal, Ruben, Kim, Jungsu, Lasagna-Reeves, Cristian A. · 2026 · bioRxiv
  11. Tau forms dynamic hot spots that are resistant to microtubule perturbations and cholesterol depletion
    Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Rumelo Amor, Jean‐Baptiste Sibarita, Jürgen Götz · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  12. LTD-inducing low frequency stimulation enhances p-Tau181 and p-Tau217 in an age-dependent manner in live rats
    Yangyang Zhang, Y. Yang, Zhengtao Hu, Manyi Zhu, S. Qin, YU Peng, Bo Li, Ji-Tian Xu, M. Rowan, Neng-Wei Hu · 2022 · bioRxiv
  13. One to Rule Them All: A Unique TAU Therapy for Neurodevelopmental Encephalopathies
    Benito Maffei, Gabriele Lignani · 2022 · Epiliepsy currents/Epilepsy currents
  14. Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy
    Daniel W. Sirkis, Caroline Warly Solsberg, Taylor P. Johnson, Luke W. Bonham, Virginia E. Sturm, Suzee E. Lee, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Epileptiforme activiteit bij de ziekte van Alzheimer
    Amber Nous, Maxime Vande Vyver, Ilse Julia Smolders · 2023 · Epilepsie periodiek voor professionals
  16. Autophagy Regulates Tau Protein Metabolism in Alzheimer’s Disease
    伟壮 夏 · 2023 · Advances in Clinical Medicine
  17. Focus on Tauopathies and Beyond
    Christian Behl · 2023 · Springer eBooks
  18. Expressão dos microRNAs: miR-27a, miR-636, miR-1229 associados a memória em amígdalas, hipocampos e sangue de pacientes com diagnóstico de epilepsia
    Adriana Lis Pereira · 2023 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  19. Additional file 1 of Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease
    Pieter Jelle Visser, Lianne Maria Reus, Johan Gobom, Iris E. Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R.J. Verhey, Julius Popp, Pablo Martínez‐Lage et al. · 2022 · Figshare
  20. МЕХАНІЗМИ ПЕРВИННОГО І ВТОРИННОГО ПОШКОДЖЕННЯ ГОЛОВНОГО МОЗКУ В УМОВАХ ВПЛИВУ ВИБУХОВОЇ ХВИЛІ
    Юлія Козлова, M. A. Korzachenko, Сергій Агарков, Валентин Родіонов, I. G. Bashta · 2024 · Перспективи та інновації науки
  21. Research Progress on Inhibiting the NLRP3 Inflammasome Activation Pathway in the Treatment of Alzheimer’s Disease
    瑞霞 豆 · 2024 · Advances in Clinical Medicine
  22. Different drugs used as therapeutic targets against AD till date
    Manisha Nahar, Aamir Ghafoor Khan, Ravina Rai, Deepali Jat · 2024 · Elsevier eBooks
  23. Copy number variations of proteins associated with neurodegenerative diseases and rare neurological disorders
    Zhangzhong Yang, Peng Lei · 2024 · Scientia Sinica Vitae
  24. Alzheimer’s Disease: Hypotheses and therapies
    Nanyi Chen · 2025 · Theoretical and Natural Science
  25. Tau controls NMDA receptor trafficking during homeostatic synaptic plasticity
    Xuan Ling Hilary Yong, Kristie Stefanoska, William Chin Kwan, Isabelle Irons, Pranesh Padmanabhan, Evgeniia Samokhina, Andrew Kneynsberg, Nathalie Dehorter, Arne Ittner, Jürgen Götz et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Tau deletion results in sex-dependent modulation of synaptic weakening in rat hippocampus
    Liam T. Ralph, Patrick Tidball, Eric W. Salter, Brian Park, Lijia Zhang, Mengdi Wei, Lauren A. Joe, Jonathan S. Thacker, Sun-Lim Choi, Ashish Kadia et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy
    Jihoon Lee, Su Kim, Hye Yeon Kim, Gee Eun Lee, Dong Won Lee, Eun Hye Jung, Ji Su Lee, Eun Hye Cho, Hong‐Beom Park, Da-ha Park et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Altered brain morphometry and its association with cognitive decline and APOE gene in normal people at risk for Alzheimer's disease
    Min Zhao, Jiaxin Yang, Hewei Cheng, Yong Fan A, Alzheimer’s Disease Neuroimaging Initiative · 2025 · Journal of Alzheimer s Disease
  29. Investigation of three flavonoids as potent tau aggregation inhibitors and In vivo demonstration of myricetin
    Bogdan M. Benin, Trae Hillyer, Bovinari Alistair Csubak, Noah Aguirre, Samuel D. Crish, Chounghun Kang, Woo Shik Shin · 2025 · Pharmacological Research - Natural Products
  30. Tau proteins
    Siddhartha Mondragón‐Rodríguez · 2025 · Elsevier eBooks
  31. Additional file 1 of MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy
    Hadley W. Ressler, Jack Humphrey, Ricardo A. Vialle, Bergan M. Babrowicz, Shrishtee Kandoi, Towfique Raj, Dennis W. Dickson, Ertekin-Taner, Nilüfer, John Crary, Kurt W. Farrell · 2024 · Figshare
  32. Additional file 2 of MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy
    Hadley W. Ressler, Jack Humphrey, Ricardo A. Vialle, Bergan M. Babrowicz, Shrishtee Kandoi, Towfique Raj, Dennis W. Dickson, Ertekin-Taner, Nilüfer, John Crary, Kurt W. Farrell · 2024 · Figshare
  33. Additional file 1 of The therapeutic landscape of tauopathies: challenges and prospects
    Jeffrey L. Cummings, María Isabel González, Martyn C. Pritchard, Patrick C. May, Leticia Toledo‐Sherman, Glenn A. Harris · 2024 · Figshare
  34. Additional file 2 of Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease
    Pieter Jelle Visser, Lianne Maria Reus, Gobom, Johan, Iris E. Jansen, Ellen Dicks, Sven J. van der Lee, Tsolaki, Magda, Frans R.J. Verhey, Julius Popp, Martinez-Lage, Pablo et al. · 2022 · Figshare
  35. Structure‐specific Mini‐prion Model for Alzheimer's Disease Tau Fibrils
    Vishnu Vijay, Gregory E. Merz, Karen Tsay, Andrew P. Longhini, Samuel Lobo, Athena Quddus, K. Nakagawa, Michael P. Vigers, Arthur A. Melo, Eric Tse et al. · 2025 · Alzheimer s & Dementia
  36. Artificial microRNAs targeting tau enable post-symptomatic functional recovery in aged tauopathy mice
    C. Facal, Indiana Páez-Paz, A. Pereyra, Clara Gaguine, Ramiro Clerici-Delville, Rocío B. Foltran, Mariano Soiza-Reilly, M. Avale · 2025 · bioRxiv
  37. Epilepsy and Neurodegeneration
    Maria Thom, Matthias J. Koepp · 2026 · Epilepsy
  38. Radiofrequency electromagnetic fields in Alzheimer’s therapy: emerging evidence and future prospects
    Wenjia Liu, Xin Rao, Wen Sun, Xiaodong Chen, Liyang Yu, J Zhang · 2026 · Electromagnetic Biology and Medicine
  39. The Role of Presynaptic Cytomatrix Protein Bassoon (BSN) in Tau Pathology and Propagation
    Wei Jet Oo, Wei Tong Sia, Jia Yee Lee, C. H. Chen, Wan‐Ling Chang, Soi Moi Chye · 2026 · CNS & Neurological Disorders - Drug Targets
  40. Expanding landscape of tau pathology in neurological disorders: A narrative review guiding diagnostic development and targeted therapeutics
    A. Yakubu, G. Atafo, C. Nwaze, T. Bakare, Temilade Oluwatoyosi Adeniyi, Kehinde P. Alare, Ac Oladele, O. Solagbade · 2026 · NeuroMarkers
  41. Inducing β-hairpin and α-helix folding in peptides : design, synthesis and evaluation of α-synuclein and tau aggregation inhibitors
    Nicolò Bisi · 2023 · theses.fr (ABES)
  42. Fokus auf Tauopathien und mehr
    Christian Behl · 2026 · Springer eBooks
  43. Im Windschatten von Amyloid: die Tau-und-Tangle-Hypothese
    Christian Behl · 2026 · Springer eBooks
  44. Cortical excitability : Prefrontal conditional bistability for parametric working memory in physiological and Alzheimer's Disease conditions & Somatosensory epileptic network activity following neurodevelopmental interneuron mutations
    Morgane Leroux · 2023 · theses.fr (ABES)
  45. The Role of Tubulin Polyglutamylation in Controlling the Binding and Activity of Microtubule-Interacting Proteins
    Mariya Genova · 2023 · theses.fr (ABES)
  46. From Food Additives to Neurodegeneration: The Emerging Role of Polyphosphates in Tauopathies
    Lorenzo Barolo, Maria Vittoria Farina, Giovanna Cimaglia, Ylenia Gigante, Anna Mirone, Lorenza Mautone, Alberto Boffi, Silvia Di Angelantonio, Paola Baiocco · 2026 · ACS Chemical Neuroscience
  47. Ultra-rare variants in LAMA2 are risk factors for frontotemporal dementia and motor neuron disease
    Hiu-Chuen Lok, Carol Dobson-Stone, M. Hallupp, S. Matis, R. Landín-Romero, Boris Guennewig, Hamish D. Mundell, Anthony S. Don, Jennifer A. Fifita, Emily P. McCann et al. · 2026 · Human Molecular Genetics
  48. m6A Modification Genetic Variants Associated with Autism Spectrum Disorder Risks
    Haoxue Wang, Shuai Zhao, Yanlin Chen, Fang Hou, Kaiheng Zhu, Rundong Liu, Zhen Xiang, Qianhui Chen, Hong Fan, Mengyuan Huang et al. · 2026 · Molecular Neurobiology
  49. An integrated in silico approach to identify pyridine-based AChE and BChE inhibitors for Alzheimer's disease
    Shivank Sharma, V. V. Ravi Kumar, Stalin Arulsamy, Shubham Kumar, Pankaj K. Wadhwa · 2026 · Computers in Biology and Medicine
  50. A Biomarker Out of Context: Understanding High p-tau217 in the Developing Brain
    Akansha Pal, Himanshu Yadav, Deepak Yadav, Falguni Goel, Mithun Singh Rajput · 2026 · Molecular Neurobiology
  51. At the forefront of gene-based therapies in Dravet syndrome
    Antonella Riva, Sara Di Gioacchino, Greta Volpedo, Beatrice Risso, Antonella De Lillo, Federico Zara, Antonio Falace, Pasquale Striano · 2026 · Expert Opinion on Emerging Drugs
  52. De novo design of microprotein in neurodegenerative diseases
    Ajoy Kumar Das, Maina Borah · 2026 · Discover Molecules
  53. Tau knockout mitigates long-term cognitive impairment following neonatal sepsis via mechanisms involving dendritic structural remodelling and adult hippocampal neurogenesis
    Hongchun Li, Bin Yu, Bingqiao Wang, Luqiang Sun, Chenhao Zhao, Linlin Hu, Mengqi Yuan, Haichuan Wang · 2026 · Journal of Neuroinflammation
  54. Patient‐derived forebrain cortical organoids reveal biphasic tau–MAP6–microtubule axis dysfunction in tauopathy
    Xiaohuan Sun, Skandha Ramakrishnan, Victor C. Ogbolu, Nicholas M. Kanaan, Celeste M M. Karch, Peter W. Baas, Qiang Liang · 2026 · Alzheimer s & Dementia
  55. Menopause and Alzheimer’s disease: can hormone replacement therapy modify the risk? A narrative review
    Jenny Y Wang, Olaf Ansorage · 2026 · BMC Women s Health
  56. Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model
    Sara J. Knowles, Cathrine Sant, Pranav Nambiar, Rafaella Araujo Gonçalves, Kaitlyn Ho, Gui-Qiu Yu, Reuben Thomas, Megumi Mori, Lane Domke, Victor Huang et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Reduced Microtubule Polyglutamylation Perturbs Neuronal Function and Accelerates Tau-Induced Neurodegeneration
    Shreyangi Chakraborty, Silvia Poggini, Michaela Rusková, Isabelle Lavenir, Davide Boido, Adela Karhanova, Laetitia Besse, Naomi Ciano Albanese, Yana Al-Inaya, Laura Lebrun et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Tau-targeting pharmacological strategies in neurodegenerative disease
    Hanyuan Zheng, Jie Zheng · 2026 · Trends in Pharmacological Sciences
  59. Challenges in Studying Synapses in Alzheimer's Disease
    Thomas Christian Südhof · 2026 · Annals of Neurology
  60. Mid-life candidate vascular plasma biomarkers are associated with MRI markers of vascular brain injury and amyloid- and tau-PET in cognitively healthy adults
    Martin D. Mulligan, Ruiqi Wang, Qiong Yang, Alexa Beiser, Pauline Maillard, Claudia Liliana Satizábal, Saptaparni Ghosh, Jeremy A. Tanner, Keith A. Johnson, Charles S DeCarli et al. · 2026 · Journal of Alzheimer s Disease
  61. Rationally Designed Peptides and Peptoids as Inhibitors of Amyloid-β (Aβ) Aggregation
    Xiaoping Huang, Sijie Ma, Xiang Li, Jie Pan · 2026 · Bioconjugate Chemistry
  62. Shared genetic architecture between DTI‐ALPS traits and neurodegenerative diseases
    Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, 唐北沙, Xinhua Wei, Lu He et al. · 2026 · Alzheimer s & Dementia
  63. Tau Overexpression Causes Cardiac Hypertrophy by Disrupting Mitochondrial Homeostasis
    Jingping Xu, Yujia Xing, Qiqi Liu, Tianle Wang, Wenjia Liu, Xiao Yang, Zhenhua Li, Jian Wang · 2026 · International Journal of Molecular Sciences
  64. Advances in the treatment of Alzheimer's disease upon nanozymes
    Yuxing Yan, Qingshan Liu, Yuxuan Huo, Hao Wang, Yifeng Cheng, Huanhuan Qiao, Ruiping Zhang · 2026 · Nano Today
  65. Running in reverse: Tau redirects mitochondrial electron flow toward neurodegeneration
    Ahmed Atwa, Marco A. Perez, Nicholas M. Kanaan · 2026 · Neuron