Glymphatic failure as a final common pathway to dementia

Nedergaard, Maiken, Goldman, Steven A.·2020·Science

DOI 10.1126/science.abb8739

Cited by (1,000)

Items 201–300 of 1,000

A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans
Paul Dagum, Laurent Giovangrandi, Swati Rane Levendovszky, Jake J. Winebaum, Tarandeep Singh, Yeilim Cho, Robert M. Kaplan, Michael S. Jaffee, Miranda M. Lim, Carla L. VandeWeerd et al. · 2025 · Nature Biomedical Engineering
ENIGMA‐Sleep: Challenges, opportunities, and the road map
Masoud Tahmasian, André Aleman, Ole A. Andreassen, Zahra Arab, Marion Baillet, Francesco Benedetti, Tom Bresser, Joanna K. Bright, Michael W.L. Chee, Daphné Chylinski et al. · 2021 · Journal of Sleep Research
“Is It Removed During Dialysis?”—Cognitive Dysfunction in Advanced Kidney Failure—A Review Article
Kirsty Crowe, Terence J. Quinn, Patrick Barry Mark, Mark Findlay · 2021 · Frontiers in Neurology
Lights at night: does photobiomodulation improve sleep?
Audrey Valverde, Catherine Hamilton, Cécile Moro, M. Billères, Pierre Julius Magistretti, John Mitrofanis · 2022 · Neural Regeneration Research
Glymphatic system in neurological disorders and implications for brain health
Osman Corbali, Allan I. Levey · 2025 · Frontiers in Neurology
Glymphatic System and Mitochondrial Dysfunction as Two Crucial Players in Pathophysiology of Neurodegenerative Disorders
Kamila Kopeć, Stanisław Szleszkowski, Dariusz Koziorowski, Stanisław Szlufik · 2023 · International Journal of Molecular Sciences
Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Aβ accumulation in mice
Rohan Jagirdar, Chia-Hsuan Fu, Jin Park, Brian F. Corbett, Frederik Seibt, Michael Beierlein, Jeannie Chin · 2021 · Science Translational Medicine
Arterial pulsation dependence of perivascular cerebrospinal fluid flow measured by dynamic diffusion tensor imaging in the human brain
Guangxu Han, Bingjie Jiao, Yifan Zhang, Zejun Wang, Chunjing Liang, Yong Li, Yi‐Cheng Hsu, Ruiliang Bai · 2024 · NeuroImage
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler J. Ward, Susan M. Landau, Suzanne L. Baker, Theresa M. Harrison, William J. Jagust, Alzheimer’s Disease Neuroimaging Initiative · 2024 · Alzheimer s & Dementia
A polysomnography study examining the association between sleep and postoperative delirium in older hospitalized cardiac surgical patients
Reine Ibala, Jennifer Mekonnen, Jacob Gitlin, Eunice Y. Hahm, Breanna R. Ethridge, Katia M. Colon, Sophia Marota, Cristy Ortega, Juan Cristóbal Pedemonte, Marisa Cobanaj et al. · 2021 · Journal of Sleep Research
Assessing cerebral arterial pulse wave velocity using 4D flow MRI
Cecilia Björnfot, Anders Garpebring, Sara Qvarlander, Jan Malm, Anders Eklund, Anders Wåhlin · 2021 · Journal of Cerebral Blood Flow & Metabolism
Mutual Interactions between Brain States and Alzheimer’s Disease Pathology: A Focus on Gamma and Slow Oscillations
Nicole Byron, Anna Semenova, Shuzo Sakata · 2021 · Biology
A New Perspective on the Pathophysiology of Idiopathic Intracranial Hypertension: Role of the Glia-Neuro-Vascular Interface
Per Kristian Eide, Hans‐Arne Hansson · 2022 · Frontiers in Molecular Neuroscience
Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer’s disease mouse model
Shiri Shoob, Nadav Buchbinder, Ortal Shinikamin, Or Gold, Halit Baeloha, Tomer Langberg, Daniel Zarhin, Ilana Shapira, Gabriella Braun, Naomi Habib et al. · 2023 · Nature Communications
Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis
Ruiqing Ni · 2021 · International Journal of Molecular Sciences
Glymphatic system dysfunction in patients with cluster headache
Jinseung Kim, Dong Ah Lee, Ho‐Joon Lee, Bong Soo Park, Junghae Ko, Si Hyung Park, Yoo Jin Lee, Il Hwan Kim, Jin Han Park, Kang Min Park · 2022 · Brain and Behavior
Ocular Lymphatic and Glymphatic Systems: Implications for Retinal Health and Disease
Mohammad Nasir Uddin, Matt Rutar · 2022 · International Journal of Molecular Sciences
Usefulness of intravoxel incoherent motion MRI for visualizing slow cerebrospinal fluid motion
Shigeki Yamada, Shinnosuke Hiratsuka, Tomohiro Otani, Satoshi Ii, Shigeo Wada, M. Oshima, Kazuhiko Nozaki, Yoshiyuki Watanabe · 2023 · Fluids and Barriers of the CNS
Glymphatic clearance is enhanced during sleep
Kroesbergen, Erik, Riesselmann, Laurence V., Gomolka, Ryszard S., Plá, Virginia, Esmail, Tina, Stenmo, Visti H., Kovács, E. Rebeka, Nielsen, Elise S., Goldman, Steven A., Nedergaard, Maiken et al. · 2024
Brain cerebrospinal fluid flow
Douglas H. Kelley · 2021 · Physical Review Fluids
Structural network efficiency mediates the association between glymphatic function and cognition in mild VCI: a DTI-ALPS study
Hao Song, Zhao Ruan, Lei Gao, Dongwei Lv, Dong Sun, Li Zeng, Ran Zhang, Xiaoli Zhou, Haibo Xu, Junjian Zhang · 2022 · Frontiers in Aging Neuroscience
Preclinical Research on Focused Ultrasound-Mediated Blood–Brain Barrier Opening for Neurological Disorders: A Review
Chanho Kong, Won Seok Chang · 2023 · Neurology International
Immunohistochemical visualization of lymphatic vessels in human dura mater: methodological perspectives
César Luis Vera Quesada, Shreyas Balachandra Rao, Reidun Torp, Per Kristian Eide · 2023 · Fluids and Barriers of the CNS
Atrial fibrillation catheter ablation, brain glymphatic function, and cognitive performance
Jiahuan Guo, Zhe Zhang, Xu Meng, Jing Jing, Yiran Hu, Yan Yao, Ligang Ding, Lihui Zheng, Xingquan Zhao · 2025 · European Heart Journal
The Dopamine System: Insights between Kidney and Brain
Antonio De Donato, Veronica Buonincontri, Gianmarco Borriello, Giuseppe Martinelli, Pasquale Mone · 2022 · Kidney & Blood Pressure Research
Unpacking the Role of Extracellular Vesicles in Ischemic and Hemorrhagic Stroke: Pathophysiology and Therapeutic Implications
Yonatan Hirsch, Joseph R. Geraghty, Cory R. Reiter, Eitan A. Katz, Conner F. Little, Matthew Kyle Tobin, Fernando Daniel Testai · 2022 · Translational Stroke Research
Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain‐wide glymphatic function
Sutton B. Richmond, Swati Rane, Moriah R. Hanson, Sait Albayram, Jeffrey J. Iliff, Dawn Kernagis, Jens T. Rosenberg, Rachael D. Seidler · 2023 · European Journal of Neuroscience
Aging and Cerebral Glucose Metabolism: 18F-FDG-PET/CT Reveals Distinct Global and Regional Metabolic Changes in Healthy Patients
Robert C. Subtirelu, Eric M. Teichner, Yvonne Su, Omar Al‐Daoud, Milan Patel, Shiv Patil, Milo Writer, Thomas J. Werner, Mona-Elisabeth R. Revheim, Poul Flemming Høilund‐Carlsen et al. · 2023 · Life
The aging of glymphatic system in human brain and its correlation with brain charts and neuropsychological functioning
Dai, Zhuozhi, Yang, Zhiqi, Chen, Xiaofeng, Zheng, Wenbin, Zhuang, Zerui, Liao, Yuting, Li, Mu, Chen, Shaoxian, Lin, Daiying, Wu, Xianheng et al. · 2023 · Cerebral Cortex
Sex-specific age-related differences in cerebrospinal fluid clearance assessed by resting-state functional magnetic resonance imaging
Feng Han, Xufu Liu, Yifan Yang, Xiao Liu · 2024 · NeuroImage
The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease
Annibale Antonioni, Alessandro Martorana, Emiliano Santarnecchi, Harald Juergen Hampel, Giacomo Koch · 2025 · Alzheimer s & Dementia
Interstitial Fluidopathy of the Central Nervous System: An Umbrella Term for Disorders with Impaired Neurofluid Dynamics
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Hisashi Kawai, Shinji Naganawa · 2022 · Magnetic Resonance in Medical Sciences
Total sleep duration and daytime napping in relation to dementia detection risk: results from the Million Women Study
Wong, Angel T. Y., Reeves, Gillian K., Floud, Sarah · 2023 · Alzheimer's & Dementia
The Role of the Glymphatic Clearance System in the Mechanisms of the Interactions of the Sleep–Waking Cycle and the Development of Neurodegenerative Processes
Igor V. Shirolapov, Alexander Vladimirovich Zakharov, Daria A. Smirnova, Artem Viktorovich Lyamin, Arseny Gayduk · 2024 · Neuroscience and Behavioral Physiology
Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis
Joji B. Kuramatsu, Stefan T. Gerner, Wendy Ziai, Jürgen Bardutzky, Jochen A. Sembill, Maximilian I. Sprügel, Anne Mrochen, Kathrin Kölbl, Malathi Ram, Radhika Avadhani et al. · 2022 · Stroke
How Do Modifiable Risk Factors Affect Alzheimer’s Disease Pathology or Mitigate Its Effect on Clinical Symptom Expression?
Valentin Ourry, Alexa Pichet Binette, Frédéric St‐Onge, Cherie Strikwerda‐Brown, Audrey Chagnot, Judes Poirier, John C.S. Breitner, Eider M. Arenaza‐Urquijo, Jennifer S. Rabin, Rachel F. Buckley et al. · 2023 · Biological Psychiatry
Gamma Frequency Sensory Stimulation in Probable Mild Alzheimer’s Dementia Patients: Results of a Preliminary Clinical Trial
Diane Chan, Ho‐Jun Suk, Brennan Jackson, Noah Milman, Danielle Stark, Elizabeth B. Klerman, Erin G. Kitchener, Vanesa S. Fernandez Avalos, Arit Banerjee, Sara D. Beach et al. · 2021 · SSRN Electronic Journal
Wasteosomes ( corpora amylacea ) as a hallmark of chronic glymphatic insufficiency
Marta Riba, Jaume del Valle, Laura Molina‐Porcel, Carme Pelegrı́, Jordi Vilaplana · 2022 · Proceedings of the National Academy of Sciences
Increased glymphatic system activity in patients with mild traumatic brain injury
Zhuozhi Dai, Zhiqi Yang, Zhaolin Li, Mu Li, Hongfu Sun, Zerui Zhuang, Weichao Yang, Zehuan Hu, Xiaofeng Chen, Daiying Lin et al. · 2023 · Frontiers in Neurology
Aquaporin-4 as the Main Element of the Glymphatic System for Clearance of Abnormal Proteins and Prevention of Neurodegeneration: A Review
Igor V. Shirolapov, Alexander Vladimirovich Zakharov, Saikat Gochhait, V. F. Pyatin, Mariya Stanislavovna Sergeeva, N. Romanchuk, Yuliya Komarova, Vladimir A. Kalinin, Olga Nikolaevna Pavlova, Elena Khivintseva · 2023 · WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE
Longitudinal assessment of glymphatic changes following mild traumatic brain injury: Insights from perivascular space burden and DTI-ALPS imaging
Jiachen Zhuo, Prashant Raghavan, Jiang Li, Steven Roys, Rosy Linda Njonkou Tchoquessi, Hegang Chen, Emerson M. Wickwire, Gunjan Y. Parikh, Gary Schwartzbauer, Lynn M. Grattan et al. · 2024 · Frontiers in Neurology
Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson’s disease
Ruolan Lin, Guoen Cai, Ying Chen, Jinmei Zheng, Shu Wang, Huinan Xiao, Qinyong Ye, Yunjing Xue, Rifeng Jiang · 2025 · npj Parkinson s Disease
Fatty Acid Binding Protein 3 (FABP3) and Apolipoprotein E4 (ApoE4) as Lipid Metabolism-Related Biomarkers of Alzheimer’s Disease
Maciej Dulewicz, Agnieszka Kulczyńska‐Przybik, Agnieszka Słowik, Renata Borawska, Barbara Mroczko · 2021 · Journal of Clinical Medicine
Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?
Alicia García‐Culebras, María Isabel Cuartero, Carolina Peña‐Martínez, Ana Moraga, Sandra Vázquez‐Reyes, Francisco Javier Castro-Millán, Marta Cortés‐Canteli, Ignacio Lizasoaín, María Ángeles Moro · 2023 · British Journal of Pharmacology
Sleep features and long-term incident neurodegeneration: a polysomnographic study
Abubaker Ibrahim, Matteo Cesari, Anna Heidbreder, Michaela Defrancesco, Elisabeth Brandauer, Klaus Seppi, Stefan Julia Kiechl, Birgit Högl, Ambra Stefani · 2023 · SLEEP
Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease
Zhengyun Han, Xingmao Yang, Shuiqing Huang · 2024 · Heliyon
Glymphatic dysfunction mediates the influence of choroid plexus enlargement on information processing speed in patients with white matter hyperintensities
Yanan Xu, Mengxue Wang, Xiaoli Li, Tong Lu, Yanjuan Wang, X.L. Zhang, Zan Wang, Fuling Yan · 2024 · Cerebral Cortex
Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage
Changkai Hou, Jian Li, Bangyue Wang, Quanlei Liu, Yan Zhao, Hao Zhang, Weihan Wang, Wen Ren, Xiaopeng Cui, Xinyu Yang · 2022 · Frontiers in Neurology
Migraine Pharmacological Treatment and Cognitive Impairment: Risks and Benefits
Mirella Russo, Matteo Alessandro De Rosa, Dario Calisi, Stefano Consoli, Giacomo Evangelista, Fedele Dono, Matteo Santilli, Alberto Granzotto, MARCO C. ONOFRJ, Stefano Luca Sensi · 2022 · International Journal of Molecular Sciences
Phototherapy of Alzheimer’s Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review
Oxana V. Semyachkina-Glushkovskaya, Thomas Penzel, Mikhail Gur'evich Poluektov, Ivan V. Fedosov, Maria O. Tsoy, Andrey V. Terskov, Inna Blokhina, В. В. Сидоров, Jürgen Kurths · 2023 · International Journal of Molecular Sciences
Continuous Theta-Burst Stimulation Promotes Paravascular CSF-Interstitial Fluid Exchange through Regulation of Aquaporin-4 Polarization in APP/PS1 Mice
Cheng Wu, Tuo Lin, Qian Ding, Ni Zhang, Zi-tong Ou, Guiyuan Cai, Hongying Chen, Jia-yue Xu, Ge Li, Zhong Pei et al. · 2022 · Mediators of Inflammation
The glymphatic system and Amyotrophic lateral sclerosis
Andrew Eisen, Maiken Nedergaard, Emma Gray, Matthew C. Kiernan · 2024 · Progress in Neurobiology
Development and validation of a perivascular space segmentation method in multi-center datasets
Peiyu Huang, Lingyun Liu, Yao Zhang, Siyan Zhong, Peng Liu, Hui Hong, Shuyue Wang, Linyun Xie, Lin Miao, Yeerfan Jiaerken et al. · 2024 · NeuroImage
Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau
Kai Chen, Yosuke M. Morizawa, Tal Nuriel, Osama Al‐Dalahmah, Zhongcong Xie, Guang Yang · 2025 · Neuron
A systematic review and meta-analysis on glymphatic flow dysfunction in Parkinson’s disease and Parkinsonism spectrum
Sadegh Ghaderi, Sana Mohammadi, Ali Fathi Jouzdani, Amir Mahmoud Ahmadzadeh, Farzad Fatehi · 2025 · npj Parkinson s Disease
Glymphatic imaging and modulation of the optic nerve
Anisha Kasi, Crystal Liu, Muneeb A. Faiq, Kevin C. Chan · 2021 · Neural Regeneration Research
Glymphatic Dysfunction in Patients With End-Stage Renal Disease
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park · 2022 · Frontiers in Neurology
Effects of sleep on brain perivascular space in a cognitively healthy population
Nien‐Chu Shih, Giuseppe Barisano, Karen D. Lincoln, Wendy Jean Mack, Farshid Sepehrband, Jeiran Choupan · 2023 · Sleep Medicine
Glymphatic system dysfunction correlated with gut dysbiosis and cognitive impairment in schizophrenia
Hui Wu, Bingdong Liu, Weiyin Vivian Liu, Zhi Wen, Wen‐Bin Yang, Huaguang Yang, Jianbo Li, Yunfei Zha · 2025 · Schizophrenia
Contrasting Metabolic Insufficiency in Aging and Dementia
Dennis A. Turner · 2021 · Aging and Disease
KATP channels in lymphatic function
Michael John Davis, Hae Jin Kim, Colin G. Nichols · 2022 · American Journal of Physiology-Cell Physiology
Dementia Prevention in Clinical Practice
Kellyann Niotis, Kiarra Akiyoshi, Caroline Carlton, Richard Isaacson · 2022 · Seminars in Neurology
Fluid dynamics in aging-related dementias
Thierno Madjou Bah, Dominic Aaron Siler, Aseel H. Ibrahim, Justin Schultz Cetas, Nabil J. Alkayed · 2023 · Neurobiology of Disease
Higher order diffusion imaging as a putative index of human sleep-related microstructural changes and glymphatic clearance
Balázs Örzsik, Marco Palombo, Iris Asllani, Derk‐Jan Dijk, Neil Andrew Harrison, Mara Cercignani · 2023 · NeuroImage
Unlocking the enigma: unraveling multiple cognitive dysfunction linked to glymphatic impairment in early Alzheimer’s disease
Jiayi Zhong, Xiaochen Zhang, Huanyu Xu, Xiaoran Zheng, Luyao Wang, Jiehui Jiang, Yunxia Li · 2023 · Frontiers in Neuroscience
Glymphatic system dysfunction in restless legs syndrome: evidenced by diffusion tensor imaging along the perivascular space
Kang Min Park, Keun Tae Kim, Dong Ah Lee, Gholam K. Motamedi, Yong Won Cho · 2023 · SLEEP
Clinically accessible neuroimaging predictors of post-stroke neurocognitive disorder: a prospective observational study
Till Schellhorn, Eva Birgitte Aamodt, Stian Lydersen, Stina Aam, Torgeir Bruun Wyller, Ingvild Tina Saltvedt, Mona Kristiansen Beyer · 2021 · BMC Neurology
Maintaining brain health across the lifespan
Isabel García‐García, Olga Donica, Armand Aaron Cohen, Semira Gonseth, Adrian F. Heini, Sébastien C. Nusslé, Claude Pichard, Ernst Rietschel, Goranka Tanačković, Silvio Folli et al. · 2023 · Neuroscience & Biobehavioral Reviews
Non-canonical pathways associated to Amyloid beta and tau protein dyshomeostasis in Alzheimer’s disease: A narrative review
Anna Maggiore, Valentina Latina, Maria D’Erme, Giuseppina Amadoro, Roberto Coccurello · 2024 · Ageing Research Reviews
Loss of glymphatic homeostasis in heart failure
Marios Kritsilis, Lotte Vanherle, Marko Rosenholm, René in ‘t Zandt, Yuan Yao, Kelley M. Swanberg, Pia Weikop, Michael Gottschalk, Nagesh C. Shanbhag, Jiebo Luo et al. · 2024 · Brain
Genome-wide association study unravels mechanisms of brain glymphatic activity
Shu‐Yi Huang, Yi‐Jun Ge, Peng Ren, Bang‐Sheng Wu, Weikang Gong, Jing Du, Shi-Dong Chen, Jujiao Kang, Qing Ma, Arun L.W. Bokde et al. · 2025 · Nature Communications
Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer's disease: A DTI-ALPS study
Cuiping Bao, Hongbin Luo, Jiao Wang, Xuehuan Liu, Yiming Li, Jun Yang, Chong Chen, Rongrong Yang, Weili Ba, Xinying Lian et al. · 2025 · The Journal of Prevention of Alzheimer s Disease
Pericytes: Intrinsic Transportation Engineers of the CNS Microcirculation
Ahmed M. Eltanahy, Yara A. Koluib, Albert Louis Gonzales · 2021 · Frontiers in Physiology
Cerebrovascular alterations in NAFLD: Is it increasing our risk of Alzheimer's disease?
Anna Hadjihambi · 2021 · Analytical Biochemistry
Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound
Seung‐Schik Yoo, Evgenii Kim, Kavin Kowsari, Jared Van Reet, Hyun‐Chul Kim, Kyungho Yoon · 2023 · Scientific Reports
Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability
Enrico Pracucci, R. Graham, Laura Alberio, Gabriele Nardi, Olga Cozzolino, Vinoshene Pillai, Giacomo Pasquini, Luciano Saieva, Darren A. Walsh, Silvia Landi et al. · 2023 · Nature Communications
Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation
Per Kristian Eide, Aslan Lashkarivand, Are Hugo Pripp, Lars Magnus Valnes, Markus Herberg Hovd, Geir André Ringstad, Kaj Blennow, Henrik Zetterberg · 2023 · Brain Communications
Does Sleep Flush Wastes From the Brain?
Anthony L. Komaroff · 2021 · JAMA
Emergence of the brain-border immune niches and their contribution to the development of neurodegenerative diseases
Li Yang Tan, Grace Cunliffe, Michael Patrick Hogan, Xin Yi Yeo, Chansik Oh, Bohwan Jin, Junmo Kang, Junho Park, Min‐Soo Kwon, MinYoung Kim et al. · 2024 · Frontiers in Immunology
Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases
Sephira G. Ryman, Andrei A. Vakhtin, Andrew R. Mayer, Harm Jan van der Horn, Nicholas A. Shaff, Stephanie R. Nitschke, Kayla R. Julio, Rawan M. Tarawneh, Gary A. Rosenberg, Shanna V. Diaz et al. · 2024 · Movement Disorders
Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution
Keith A. Wafford · 2021 · Cerebral Circulation - Cognition and Behavior
Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?
Li Ba, Lifang Huang, Ziyu He, Saiyue Deng, Yi Xie, Min Zhang, Cornelius Jacob, Emanuele Antonecchia, Yuqing Liu, Wenchang Xiao et al. · 2021 · Frontiers in Aging Neuroscience
Association study of brain structure–function coupling and glymphatic system function in patients with mild cognitive impairment due to Alzheimer’s disease
Yong‐Wen Sun, Xinyue Lyu, Xiaoyang Lei, Mingming Huang, Zhenmin Wang, Bo Gao · 2024 · Frontiers in Neuroscience
Clearance mechanisms of the glymphatic/lymphatic system in the brain: new therapeutic perspectives for cognitive impairment
Zhidong He, Jing Sun · 2025 · Cognitive Neurodynamics
Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets
Pingjing Zheng, Wendi Yan, Yang-Nan Ding, Yang Zhang, Zhangwei Chen, Juying Qian, Junbo Ge · 2026 · Signal Transduction and Targeted Therapy
Risk of neurodegenerative diseases in patients with sleep disorders: A nationwide population-based case-control study
Wei Lin, Yu‐Kai Lin, Fu‐Chi Yang, Chi‐Hsiang Chung, Je‐Ming Hu, Chang‐Huei Tsao, Zi‐Xeng Weng, Chien-An Ko, Wu‐Chien Chien · 2023 · Sleep Medicine
Glymphatic dysfunction in the pathogenesis of neurodegenerative diseases and pathological aging
Igor V. Shirolapov, Alexander Vladimirovich Zakharov, Svetlana Viktorovna Bulgakova, Elena Khivintseva, Mariya Stanislavovna Sergeeva, N. Romanchuk, Olga Nikolaevna Pavlova, Victor Kazantsev · 2023 · Genes and Cells
Nervous System-Systemic Crosstalk in SARS-CoV-2/COVID-19: A Unique Dyshomeostasis Syndrome
Harnadar Anand, Victoria Ende, Gurinder K. Singh, Irfan Qureshi, Timothy Q. Duong, Mark F. Mehler · 2021 · Frontiers in Neuroscience
Glymphatic-System Function Is Associated with Addiction and Relapse in Heroin Dependents Undergoing Methadone Maintenance Treatment
Lei Wang, Yue Qin, Xiaoshi Li, Xin Li, Yuwei Liu, Wei Li, Yarong Wang · 2023 · Brain Sciences
Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease
Sydney M. Ragsdale, John M. Radovich, Isabel I. Coiduras, William Vaughn McCall, Samuel C. Grant, Christopher Seungkyu Lee, Aaron A. Wilber · 2025 · npj Biological Timing and Sleep
Glymphatic dysfunction evidenced by DTI-ALPS is related to obstructive sleep apnea intensity in newly diagnosed Parkinson’s disease
Jiří Nepožitek, Stanislav Mareček, Veronika Rottová, Simona Dostálová, Tomáš Krajča, Jiří Keller, Karel Šonka, Petr Dušek · 2025 · npj Parkinson s Disease
Does Impaired Glymphatic Drainage Cause Glymphedema? A Review Tailored to Neurocritical Care and Neurosurgery
Paul Taylor Akins, Kern H. Guppy · 2021 · Neurocritical Care
Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment
Antonio Ladrón-de-Guevara, Jessica K. Shang, Maiken Nedergaard, Douglas H. Kelley · 2020 · Journal of Theoretical Biology
MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau
Ming-Liang Wang, Dianxu Yang, Zheng Sun, Wenbin Li, Qiaoqiao Zou, Pengyang Li, Xue Wu, Yuehua Li · 2022 · Frontiers in Psychiatry
Vascular endothelial cells: a fundamental approach for brain waste clearance
Huimin Wei, Huimin Jiang, Yifan Zhou, Xuechun Xiao, Chen Zhou, Xunming Ji · 2022 · Brain
Mechanisms of Activation of Brain’s Drainage during Sleep: The Nightlife of Astrocytes
Dmitry Engelevich Postnov, Oxana V. Semyachkina-Glushkovskaya, Elena Litvinenko, Jürgen Kurths, Thomas Penzel · 2023 · Cells
History of ALS and the competing theories on pathogenesis: IFCN handbook chapter
Andrew Eisen, Steve Vucic, Hiroshi Mitsumoto · 2023 · Clinical Neurophysiology Practice
Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment
Lin Zhang, Dongna Li, Pengrong Yi, Jiangwei Shi, Mengqing Guo, Qingsheng Yin, Dingbin Liu, Pengwei Zhuang, Yanjun Zhang · 2023 · Acta Pharmaceutica Sinica B
Therapeutic approaches to CNS diseases via the meningeal lymphatic and glymphatic system: prospects and challenges
Rui Zhang, Jiuhong Li, Xueying Li, Si Zhang · 2024 · Frontiers in Cell and Developmental Biology
Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity
Fayaz Ahmad Mir, Arianna R. S. Lark, Christa J. Nehs · 2025 · Frontiers in Aging