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Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody
Open accessPublished version of a preprint
Abstract
A steric block to SARS-CoV-2: In response to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the immune system makes antibodies, many of which target the spike protein, a key player in host cell entry. Antibodies that potently neutralize the virus hold promise as therapeutics and could inform vaccine design. Lv et al. report a humanized monoclonal antibody that protected against SARS-CoV-2 in a mouse model. The cryo–electron microscopy structure, together with biochemical, cellular, and virological studies, showed that the antibody acts by binding to the receptor-binding domain of the spike and blocking its attachment to the host receptor. Science , this issue p. 1505
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Metadata
- Authors
- Lv, Z., Deng, Y.-Q., Ye, Q., Cao, L., Sun, C.-Y., Fan, C., Huang, W., Sun, S., Sun, Y., Zhu, L., Chen, Q., Wang, N., Nie, J., Cui, Z., Zhu, D., Shaw, N., Li, X.-F., Li, Q., Xie, L., Wang, Y., Rao, Z., Qin, C.-F., & Wang, X.
- Venue
- Science
- Published
- 2020-09-18
- Volume
- 369
- Issue
- 6510
- Pages
- 1505-1509
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3044050454
- Cited by
- 386
- References
- 43
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Funders
- Ministry of Science and Technology of the People's Republic of China (2020YFA0707500, 2018YFA0900801)
- National Science Fund for Distinguished Young Scholars (No. 81925025)
- Beijing Municipal Science and Technology Project (Z201100005420017)
- the Strategic Priority Research Program (XDB29010000)
- Innovation Fund for Medical Sciences (No.2019-I2M-5-049)
- Innovative Research Group from the NSFC (No. 81621005)
- Ten Thousand Talent Program and the NSFS Innovative Research Group (No. 81921005)
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- Lv, Z., Deng, Y.-Q., Ye, Q., Cao, L., Sun, C.-Y., Fan, C., Huang, W., Sun, S., Sun, Y., Zhu, L., Chen, Q., Wang, N., Nie, J., Cui, Z., Zhu, D., Shaw, N., Li, X.-F., Li, Q., Xie, L., . . . Wang, X. (2020). Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody. Science. https://doi.org/10.1126/science.abc5881
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
