The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance
Open accessAbstract
Turning down tolerance: Persister cells, which are found in abundance in biofilms, adopt a quiescent state and survive antimicrobial treatments, seeding disease recurrence and incubating new resistance mutations. Building on work implicating the reactive small-molecule hydrogen sulfide in bacterial defense against antibiotics, Shatalin et al. conducted a structure-based screen for inhibitors of a bacterial hydrogen sulfide–producing enzyme and found a group of inhibitors that act through an allosteric mechanism (see the Perspective by Mah). These inhibitors potentiated bactericidal antibiotics in vitro and in mouse infection models. They also suppressed persister bacteria and disrupted biofilm formation. This strategy of taking out persister cells may be promising for treating recalcitrant infections and holding the line against drug-resistant bacteria. Science , abd8377, this issue p. 1169 ; see also abj3062, p. 1153
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Metadata
- Authors
- Shatalin, K., Nuthanakanti, A., Kaushik, A., Shishov, D., Peselis, A., Shamovsky, I., Pani, B., Lechpammer, M., Vasilyev, N., Shatalina, E., Rebatchouk, D., Mironov, A., Fedichev, P., Serganov, A., & Nudler, E.
- Venue
- Science
- Published
- 2021-06-11
- Volume
- 372
- Issue
- 6547
- Pages
- 1169-1175
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3170819454
- Cited by
- 259
- References
- 92
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Shatalin, K., Nuthanakanti, A., Kaushik, A., Shishov, D., Peselis, A., Shamovsky, I., Pani, B., Lechpammer, M., Vasilyev, N., Shatalina, E., Rebatchouk, D., Mironov, A., Fedichev, P., Serganov, A., & Nudler, E. (2021). Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science. https://doi.org/10.1126/science.abd8377
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