The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
Open accessAbstract
SARS-CoV-2 from alpha to epsilon: As battles to contain the COVID-19 pandemic continue, attention is focused on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that have been deemed variants of concern because they are resistant to antibodies elicited by infection or vaccination or they increase transmissibility or disease severity. Three papers used functional and structural studies to explore how mutations in the viral spike protein affect its ability to infect host cells and to evade host immunity. Gobeil et al . looked at a variant spike protein involved in transmission between minks and humans, as well as the B1.1.7 (alpha), B.1.351 (beta), and P1 (gamma) spike variants; Cai et al . focused on the alpha and beta variants; and McCallum et al . discuss the properties of the spike protein from the B1.1.427/B.1.429 (epsilon) variant. Together, these papers show a balance among mutations that enhance stability, those that increase binding to the human receptor ACE2, and those that confer resistance to neutralizing antibodies. —VV
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Cited by
The biological and clinical significance of emerging SARS-CoV-2 variants
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Mannar, D., Saville, J. W., Zhu, X., Srivastava, S. S., Berezuk, A. M., Tuttle, K. S., Marquez, A. C., Sekirov, I., & Subramaniam, S. (2022) · Science · doi:10.1126/science.abn7760 · Cited by 630
Free energy perturbation calculations of mutation effects on SARS-CoV-2 RBD::ACE2 binding affinity
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Metadata
- Authors
- Gobeil, S. M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Stalls, V., Kopp, M. F., Manne, K., Li, D., Wiehe, K., Saunders, K. O., Edwards, R. J., Korber, B., Haynes, B. F., Henderson, R., & Acharya, P.
- Venue
- Science
- Published
- 2021-08-06
- Volume
- 373
- Issue
- 6555
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3174731125
- Cited by
- 394
- References
- 91
- FWCI
- 27.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gobeil, S. M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Stalls, V., Kopp, M. F., Manne, K., Li, D., Wiehe, K., Saunders, K. O., Edwards, R. J., Korber, B., Haynes, B. F., Henderson, R., & Acharya, P. (2021). Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science. https://doi.org/10.1126/science.abi6226
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
