The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
Open accessAbstract
Defining tumor cell immune evasion: Mouse models used to study cancer often lack a full immune system, allowing implantation of human tumors into the mice. By contrast, naturally evolving tumors must contend with a fully functional immune system and its destruction of some of the cells (see the Perspective by Ho and Wood). Two groups now report studies on mouse models with a fully intact immune system. Martin et al . started with preexisting murine tumor cell lines and examined their continued evolution in vivo, whereas Del Poggetto et al . examined the development of new pancreatic tumors in the context of inflammation, as is often seen in human patients. In each study, the authors found that the immune system exerted a selective pressure on cells that would give rise to tumors, promoting the survival of those that had lost expression of tumor suppressor genes or activated a specific oncogene. The findings suggest a major role for the immune system in driving tumor evolution across multiple types of cancer. —YN
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Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 399
Self-citationMultifaceted role for p53 in pancreatic cancer suppression
Mello, S. S., Flowers, B. M., Mazur, P. K., Lee, J. J., Müller, F., Denny, S. K., Ferreira, S., Hanson, K., Kim, S. K., Greenleaf, W. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211937120 · Cited by 55
Dong, H., Zhang, X., Duan, Y., He, Y., Zhao, J., Wang, Z., Wang, J., Li, Q., Fan, G., Liu, Z., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03070-2 · Cited by 49
Singh, I., Fernandez-Perez, D., Sanchez, P. S., & Rodriguez-Fraticelli, A. E. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.01.012 · Cited by 25
Metadata
- Authors
- Del Poggetto, E., Ho, I.-L., Balestrieri, C., Yen, E.-Y., Zhang, S., Citron, F., Shah, R., Corti, D., Diaferia, G. R., Li, C.-Y., Loponte, S., Carbone, F., Hayakawa, Y., Valenti, G., Jiang, S., Sapio, L., Jiang, H., Dey, P., Gao, S., Deem, A. K., Rose-John, S., Yao, W., Ying, H., Rhim, A. D., Genovese, G., Heffernan, T. P., Maitra, A., Wang, T. C., Wang, L., Draetta, G. F., Carugo, A., Natoli, G., & Viale, A.
- Venue
- Science
- Published
- 2021-09-17
- Volume
- 373
- Issue
- 6561
- Pages
- eabj0486-eabj0486
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3200323540
- Cited by
- 253
- References
- 88
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Del Poggetto, E., Ho, I.-L., Balestrieri, C., Yen, E.-Y., Zhang, S., Citron, F., Shah, R., Corti, D., Diaferia, G. R., Li, C.-Y., Loponte, S., Carbone, F., Hayakawa, Y., Valenti, G., Jiang, S., Sapio, L., Jiang, H., Dey, P., Gao, S., . . . Viale, A. (2021). Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science. https://doi.org/10.1126/science.abj0486
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
