Cited by 289Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsMemory and Neural Mechanisms

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

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Terreros-Roncal, J., Moreno-Jiménez, E. P., Flor-García, M., Rodríguez-Moreno, C. B., Trinchero, M. F., Cafini, F., Rábano, A., Llorens-Martín, M.·2021·Science

Abstract

Disease and hippocampal dysfunction: Impaired function of the brain’s hippocampus can underpin psychiatric symptoms and cognitive impairment. Looking at postmortem brain samples from patients affected by any of several neurodegenerative disorders, Terreros-Roncal et al . investigated whether adult neurogenesis was disrupted (see the Perspective by Gage). Indeed, functions of the neurogenic niche shifted and the cells produced were abnormal in shape and differentiation. The neuronal plasticity characteristic of the hippocampus may make it especially susceptible to the ravages of neurodegenerative disease. —PJH

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Authors
Terreros-Roncal, J., Moreno-Jiménez, E. P., Flor-García, M., Rodríguez-Moreno, C. B., Trinchero, M. F., Cafini, F., Rábano, A., & Llorens-Martín, M.
Affiliations
  • Department of Molecular Neuropathology, Centro de Biología Molecular “Severo Ochoa” (CBMSO), Spanish Research Council (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
  • Consejo Superior de Investigaciones Científicas (ES)
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
  • Universidad Europea de Madrid (ES)
  • Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
Venue
Science
Published
2021-11-26
Volume
374
Issue
6571
Pages
1106-1113
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W3205950297
Cited by
289
References
34
Citations by year
2026: 35 · 2025: 59 · 2024: 66 · 2023: 78 · 2022: 48 · 2021: 3
FWCI
17.70
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion, other-oa)
  • Conicet (submittedVersion, cc-by-nc-sa)
Funders
  • Alzheimer's Association (AARG-17-528125-RAPID, AARG-17-528125, 2015-NIRG-340709)
  • Association for Frontotemporal Degeneration
  • Fundación Ramón Areces
  • Centro de Biología Molecular Severo Ochoa
  • Ministerio de Economía y Competitividad (PRE2018-085233, PEJ2018-001725-A, PID2020-113007RB-I00, SAF-2017-82185-R, RYC-2015-171899)
  • Universidad Autónoma de Madrid (FPI-UAM-2017)
  • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
  • National Institute of Neurological Disorders and Stroke (P01NS083513, R01NS028478)
  • H2020 European Research Council (101001916)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
adult hippocampal neurogenesis, neurodegenerative diseases, dentate gyrus granule cells, neural stem cells, quiescence, neurogenic niche, microglial phagocytosis, astrocyte activation, aging, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, frontotemporal dementia, postmortem brain
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Amyotrophic Lateral Sclerosis, Female, Hippocampus, Humans, Huntington Disease, Male, Middle Aged, Parkinson Disease, Phagocytosis, Microglia, Dentate Gyrus, Neurodegenerative Diseases, Lewy Body Disease, Cell Proliferation, Neurogenesis, Frontotemporal Dementia, Neural Stem Cells

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