Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
Open accessAbstract
Disease and hippocampal dysfunction: Impaired function of the brain’s hippocampus can underpin psychiatric symptoms and cognitive impairment. Looking at postmortem brain samples from patients affected by any of several neurodegenerative disorders, Terreros-Roncal et al . investigated whether adult neurogenesis was disrupted (see the Perspective by Gage). Indeed, functions of the neurogenic niche shifted and the cells produced were abnormal in shape and differentiation. The neuronal plasticity characteristic of the hippocampus may make it especially susceptible to the ravages of neurodegenerative disease. —PJH
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The authors' group and others have shown evidence of neurogenesis throughout adulthood using double immunofluorescence, in situ hybridization, and 14C decay-defined neuronal age.
“However, our group and others have shown evidence of neurogenesis throughout adulthood using double immunofluorescence98-101, in situ hybridization102 and 14C decay-defined neuronal age103.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [99]
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Self-citationComment on “Impact of neurodegenerative diseases on human adult hippocampal neurogenesis”
Álvarez-Buylla, A., Cebrián‐Silla, A., Sorrells, S. F., Nascimento, M. A., Paredes, M. F., García‐Verdugo, J. M., Yang, Z., & Huang, E. J. (2022) · Science · doi:10.1126/science.abn8861 · Cited by 15 · see citing works
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Self-citation
- Authors
- Terreros-Roncal, J., Moreno-Jiménez, E. P., Flor-García, M., Rodríguez-Moreno, C. B., Trinchero, M. F., Cafini, F., Rábano, A., & Llorens-Martín, M.
- Affiliations
- Department of Molecular Neuropathology, Centro de Biología Molecular “Severo Ochoa” (CBMSO), Spanish Research Council (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
- Consejo Superior de Investigaciones Científicas (ES)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Europea de Madrid (ES)
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
- ORCID
- Venue
- Science
- Published
- 2021-11-26
- Volume
- 374
- Issue
- 6571
- Pages
- 1106-1113
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7613437
- OpenAlex
- W3205950297
- Cited by
- 289
- References
- 34
- Citations by year
- 2026: 35 · 2025: 59 · 2024: 66 · 2023: 78 · 2022: 48 · 2021: 3
- FWCI
- 17.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion, other-oa)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- Alzheimer's Association (AARG-17-528125-RAPID, AARG-17-528125, 2015-NIRG-340709)
- Association for Frontotemporal Degeneration
- Fundación Ramón Areces
- Centro de Biología Molecular Severo Ochoa
- Ministerio de Economía y Competitividad (PRE2018-085233, PEJ2018-001725-A, PID2020-113007RB-I00, SAF-2017-82185-R, RYC-2015-171899)
- Universidad Autónoma de Madrid (FPI-UAM-2017)
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- National Institute of Neurological Disorders and Stroke (P01NS083513, R01NS028478)
- H2020 European Research Council (101001916)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult hippocampal neurogenesis, neurodegenerative diseases, dentate gyrus granule cells, neural stem cells, quiescence, neurogenic niche, microglial phagocytosis, astrocyte activation, aging, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, frontotemporal dementia, postmortem brain
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Amyotrophic Lateral Sclerosis, Female, Hippocampus, Humans, Huntington Disease, Male, Middle Aged, Parkinson Disease, Phagocytosis, Microglia, Dentate Gyrus, Neurodegenerative Diseases, Lewy Body Disease, Cell Proliferation, Neurogenesis, Frontotemporal Dementia, Neural Stem Cells
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