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Microbiome Alterations and Alzheimer’s Disease: Modeling Strategies with Transgenic Mice

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Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer's disease

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Neuroinflammation and nutrition in Alzheimer’s disease

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Correlation between APOE4 gene and gut microbiota in Alzheimer’s disease

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Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response

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The gut microbiota–oligodendrocyte axis: A promising pathway for modulating oligodendrocyte homeostasis and demyelination-associated disorders

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The microbiota-gut-brain axis: a potential target in the small-molecule compounds and gene therapeutic strategies for Parkinson’s disease

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The Alzheimer’s risk gene APOE modulates the gut–brain axis

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ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

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Gut-brain axis interacts with immunomodulation in inflammatory bowel disease

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Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition?

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Gut microbiome‐derived metabolites in Alzheimer's disease: Regulation of immunity and potential for therapeutics

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Plasma and feces multiomics unveil cognition‐associated perturbations of chronic inflammatory pathways of the gut‐microbiota–brain axis

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Host–gut microbiota interactions in health and disease: mechanisms and intervention strategies

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The Effects of Antimicrobial Mouthwashes on Systemic Disease: What Is the Evidence?

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Restorative Effects of Short-Chain Fatty Acids on Corneal Homeostasis Disrupted by Antibiotic-Induced Gut Dysbiosis

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Association between the dietary index for gut microbiota and atherosclerotic cardiovascular disease risk among US elderly adults: a cross‑sectional study

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Prognostic Value of Gut Microbiome for Conversion from Mild Cognitive Impairment to Alzheimer’s Disease Dementia within 4 Years: Results from the AlzBiom Study

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Overview of the Gut Microbiome

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The synergistic interplay between vitamin A, dietary fiber, and the microbiota-gut-brain axis: a potential mechanism for preventing Alzheimer’s disease

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Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice

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Alzheimer's Disease Has Its Origins in Early Life via a Perturbed Microbiome

Ginsberg, S. D., & Blaser, M. J. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae200 · Cited by 10

Lactobacillus plantarum LP104 improved intestinal and brain inflammation by modulating TLR4 pathway and gut flora in alcohol liver injury mice

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Intermittent Fasting Ameliorates β‐Amyloid Deposition and Cognitive Impairment Accompanied by Decreased Lipid Droplet Aggregation Within Microglia in an Alzheimer's Disease Model

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The microbiota-brain connection in neurological diseases: the ubiquitous short-chain fatty acids

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Gut microbes modulate neurodegeneration

Jain, T., & Li, Y. (2023) · Science · doi:10.1126/science.adf9548 · Cited by 10

ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers

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Hallmarks of aging in age-related macular degeneration and age-related neurological disorders: novel insights into common mechanisms and clinical relevance

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Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases

Olajide, T. S., & Ijomone, O. M. (2025) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70000 · Cited by 11

The Role of the Gut-Brain Axis in Diseases

Chen, J. W., Xu, Y., & Cao, P. (2025) · Physiology · doi:10.1152/physiol.00016.2025 · Cited by 13

Rodent models of Alzheimer's disease: Critical analysis of current hypotheses and pathways for future research

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Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice

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The current state of apolipoprotein E in dyslipidemia

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Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease

Trojan, E., Curzytek, K., Cieślik, P., Wierońska, J. M., Gräff, J., Lasoń, W., Saito, T., Saido, T. C., & Basta‐Kaim, A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106219 · Cited by 9

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

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Longitudinal microbiome investigation throughout prion disease course reveals pre- and symptomatic compositional perturbations linked to short-chain fatty acid metabolism and cognitive impairment in mice

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Evaluation of the protective bioactivity and molecular mechanism verification of lactoferrin in an Alzheimer's mouse model with ulcerative enteritis

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The role of the gut microbiome in the regulation of astrocytes in Alzheimer's disease

Chandra, S., & Vassar, R. J. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00425 · Cited by 7

Research Trends in the Comorbidity Between Periodontitis and Neurodegenerative Diseases

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Knowledge Mapping of Macrophage in Spinal Cord Injury: A Bibliometric Analysis

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Acetylcholinesterase inhibitors considerably affect the salivary microbiome in patients with Alzheimer’s disease

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Gut Microbiome Alterations in Mild Cognitive Impairment: Findings from the ALBION Greek Cohort

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Cutting-Edge iPSC-Based Approaches in Studying Host—Microbe Interactions in Neuropsychiatric Disorders

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Extending genetic risk for Alzheimer’s disease from host to holobiont

Kazmi, S. A., & Hsiao, E. Y. (2023) · Cell · doi:10.1016/j.cell.2023.01.004 · Cited by 6

Signatures of HIV and Major Depressive Disorder in the Plasma Microbiome

Taylor, B. C., Andalibi, M. S. S., Wandro, S., Weldon, K. C., Sepich‐Poore, G. D., Carpenter, C. S., Fraraccio, S., Franklin, D., Iudicello, J. E., Letendre, S. L., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11041022 · Cited by 6

An emerging role for the gut microbiome in tauopathy

Zhu, Y., Self, W. K., & Holtzman, D. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00423 · Cited by 6

The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gutPreprint

Zhang, Y., Noya, S. B., Li, Y., Fang, J., & Sehgal, A. (2024) · eLife · doi:10.7554/elife.97130 · Cited by 6

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia

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Unlocking the therapeutic potential of gut microbiota for preventing and treating aging-related neurological disorders

Garg, G., Trisal, A., & Singh, A. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.020 · Cited by 6

Selective changes in vasopressin neurons and astrocytes in the suprachiasmatic nucleus of Prader–Willi syndrome subjects

Corrêa‐da‐Silva, F., Berkhout, J. B., Schouten, P., Sinnema, M., Schrander-Stumpel, C. T. R. M., Curfs, L., Höybye, C., Mahfouz, A. E., Meijer, O. C., Pereira, A. M., et al. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70015 · Cited by 5

Amyloid-related imaging abnormalities (ARIA) in Alzheimer’s disease: from pathophysiology to individualized risk assessment

Merkel, J., Perneczky, R., Jessen, F., Frölich, L., Jansen, O., Peters, S., Berg, D., Schulz, J. B., & Bartsch, T. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-02022-7 · Cited by 5

Effects of Freshwater Acidification on the Gut Microbial Community of Trachemys scripta elegans

Niu, X., Dang, Z., Hong, M., Shi, H., & Ding, L. (2024) · Animals · doi:10.3390/ani14131898 · Cited by 5

Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?

Capocchi, J. K., Figueroa‐Romero, C., Dunham, S. J. B., Faraci, G., Rothman, J. A., Whiteson, K., Seo, D.-O., Holtzman, D. M., Grabrucker, S., Nolan, Y. M., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1295-24.2024 · Cited by 6

In silico metabolic modelling links microbiome-derived metabolites to risk factors of Alzheimer’s disease

Hensen, T., Ahmad, S., Kastenmüller, G., Kraaij, R., Ghanbari, M., Ikram, M. A., Kaddurah‐Daouk, R., & Thiele, I. (2024) · Gut Microbes Reports · doi:10.1080/29933935.2024.2443171 · Cited by 5

Probiotic treatment with Bifidobacterium animalis subsp. lactis LKM512 + arginine improves cognitive flexibility in middle-aged mice

Joho, D., Takahashi, M., Suzuki, T., Ikuta, K., Matsumoto, M., & Kakeyama, M. (2023) · Brain Communications · doi:10.1093/braincomms/fcad311 · Cited by 7

Gut dysbacteriosis induces expression differences in the adult head transcriptome of Spodoptera frugiperda in a sex-specific manner

Junrui-Fu, Rong, Z., Huang, X., Wang, J., Long, X., Feng, Q., & Deng, H. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03089-0 · Cited by 4

Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus

Brandt, E., Koivisto, A. M., Pereira, P. A. B., Mustanoja, E., Auvinen, P., Saari, T. T., Lehtola, J.-M., Hannonen, S., Rusanen, M., Leinonen, V., et al. (2024) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000613 · Cited by 5

APOE genotype and sex drive microbiome divergence after microbiome standardization in APOE -humanized mice

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Progress and Perspectives on the Estrogen–Microbiota–Brain Axis in Alzheimer’s Disease

Wang, M., Zeng, Y., Jin, Y., Wu, J., & Li, J. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04613-6 · Cited by 4

Microbiota-derived IPA mitigates post-stroke neuroinflammation by inhibiting TREM2-dependent pyroptosis

Chen, J., Zhang, C., Yu, L.-L., Sun, J.-X., Zhang, J.-H., Chen, L., Zhu, F., Shi, G., Yang, L., Guo, A., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03660-8 · Cited by 6

The Gut-Brain Axis (GBA): Implications for Brain Longevity

Gautam, P., Vishwakarma, R. K., & Pathak, A. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-2790-8_9 · Cited by 4

Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility

Blackmer‐Raynolds, L., Lipson, L. D., Kozlov, A., Yang, A., Hill, E. J., Sampson, M. M., Hamilton, A. M., Fraccaroli, I., Kelly, S. D., Chopra, P., et al. (2026) · Cell Systems · doi:10.1016/j.cels.2025.101481 · Cited by 5

Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

Ávila, J., Pérez, M., Ávila‐Villanueva, M., Santa‐María, I., & Hernández, F. (2023) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2023.00044 · Cited by 4

Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes

Pachado, M. P., Casas, A. I., Elbatreek, M. H., Nogales, C., Güney, E., Espay, A. J., & Schmidt, H. H. H. W. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230694 · Cited by 4

Multi-site investigation of gut microbiota in CDKL5 deficiency disorder mouse models: Targeting dysbiosis to improve neurological outcomes

Damiani, F., Giuliano, M. G., Cornuti, S., Putignano, E., Tognozzi, A., Suckow, V., Kalscheuer, V. M., Pizzorusso, T., & Tognini, P. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115546 · Cited by 4

Inflammatory bowel disease linked to accelerated cognitive decline in individuals with dementia: a nationwide cohort study

Mo, M., Sun, J., Mikulic, I., Ludvigsson, J. F., Ptacek, S. G., Eriksdotter, M., & Xu, H. (2025) · Gut · doi:10.1136/gutjnl-2025-335370 · Cited by 4

Multifactorial glial responses and their contributions to Alzheimer's disease continuum

Hijioka, M., Manabe, T., & Saito, T. (2023) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12745 · Cited by 4

A pseudo-circular DNA walker-mediated electrochemical biosensor for sensitive detection of the apolipoprotein E4 gene

Xu, Y., Lv, X., Dong, H., Wang, T., Sun, Y., Hao, B., Yu, M., Xu, M., Liu, Z., & Zhou, Y. (2025) · Chemical Communications · doi:10.1039/d5cc04197j · Cited by 3

The role of microbiota modulation in preventing Alzheimer’s disease- a review

Strzępa, A., & Szczepanik, M. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00796-5 · Cited by 3

The gut microbiota-brain axis in Alzheimer’s disease model mice

Li, N., Peng, X., Xiong, W., Chen, C., & Wang, W. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115178 · Cited by 4

Single-nucleus transcriptomics of an engineered pig model reveals microglia–T cell interactions driving Huntington’s disease neurodegeneration

Li, J., Lin, Y., Gao, J., Yang, F., Li, C., Chen, Y., Huang, C., Song, X., Song, Z., Wu, J., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-026-01621-x · Cited by 3

Constructing Neuroinflammation‐On‐A‐Chip for Traditional Chinese Medicine Extracts Evaluation

Wang, X., Lin, X., Zhi, Y., Shang, L., Luo, Y., & Wang, Y. F. (2026) · Smart Medicine · doi:10.1002/smmd.70032 · Cited by 3

Gut microbiota and ALS: cause, consequence or correlation? - a systematic review

Chakraborty, D. K., Roy, T., Ngo, S. T., Al‐Chalabi, A., & Khleifat, A. A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1774417 · Cited by 3

The role of Gut-Microbiome-Brain-axis in Alzheirmer's disease

Rocha, V. M. N., Rocha, V. M. N., Gomes, G. F., Galvão, S. L., de Paula, L. Z. M., Oliveira, M. E., Oliveira, I. D., da Silva, L. A., Freitas, V. H. M., Sales, C. R., et al. (2024) · Brazilian Journal of Clinical Medicine and Review · doi:10.52600/2965-0968.bjcmr.2023.2.3.22-28 · Cited by 3

ISMRM Clinical Focus Meeting 2023: “Imaging the Fire in the Brain”

Agarwal, N., Fan, A. P., Huang, X., Dehkharghani, S., & van der Kolk, A. G. (2024) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29587 · Cited by 3

Isovaleric acid alleviates food allergy-related constipation in mice via repairing serotonin synthesis in serotonergic neurons

Wang, S., Huang, J., He, F., He, H., Lin, J., Zhang, N., He, Y., & Tao, A. (2025) · Pediatric Research · doi:10.1038/s41390-025-04222-7 · Cited by 3

The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the gutPreprint

Zhang, Y., Li, Y., Noya, S. B., & Sehgal, A. (2024) · eLife · doi:10.7554/elife.97130.1 · Cited by 3

Gut Microbiome Transplants and Their Health Impacts across Species

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