Vitamin D regulates microbiome-dependent cancer immunity
Open accessAbstract
A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D–induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis , which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communities, and immune responses to cancer. Collectively, they highlight vitamin D levels as a potential determinant of cancer immunity and immunotherapy success.
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The microbiota produces B-series vitamins that support tissue homeostasis and immunosurveillance.
“The microbiota synthesizes vitamins from the B series [76][77][78][79] that favor tissue homeostasis and immunosurveillance.”
From Impact of the ONCOBIOME network in cancer microbiome research (2025) · cites this paper as [78]
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179 · see citing works
Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
Quan, H., Sundararajan, V., Halfon, P., Fong, A., Burnand, B., Luthi, J.-C., Saunders, L. D., Beck, C. A., Feasby, T. E., & Ghali, W. A. (2005) · Medical Care · doi:10.1097/01.mlr.0000182534.19832.83 · Cited by 10,669 · see citing works
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
Routy, B., Le Chatelier, E., Derosa, L., Duong, C. P. M., Alou, M. T., Daillère, R., Fluckiger, A., Messaoudene, M., Rauber, C., Roberti, M. P., et al. (2018) · Science · doi:10.1126/science.aan3706 · Cited by 5,671 · see citing works
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., et al. (2018) · Science · doi:10.1126/science.aan4236 · Cited by 4,812 · see citing works
Self-citationCommensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888 · see citing works
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., et al. (2015) · Science · doi:10.1126/science.aad1329 · Cited by 3,488 · see citing works
Dendritic cells in cancer immunology and immunotherapy
Wculek, S. K., Cueto, F. J., Mujal, A. M., Melero, I., Krummel, M. F., & Sancho, D. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0210-z · Cited by 2,594 · see citing works
Vitamin D metabolism, mechanism of action, and clinical applications
Bikle, D. D. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.12.016 · Cited by 1,933 · see citing works
Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
Manson, J. E., Cook, N. R., Lee, I.-M. M., Christen, W., Bassuk, S. S., Mora, S., Luttmann‐Gibson, H., Gordon, D., Copeland, T., D’Agostino, D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1809944 · Cited by 1,646 · see citing works
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Deeb, K. K., Trump, D. L., & Johnson, C. S. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2196 · Cited by 1,419 · see citing works
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
Mager, L. F., Burkhard, R., Pett, N., Cooke, N. C. A., Brown, K., Ramay, H., Paik, S., Stagg, J., Groves, R. A., Gallo, M., et al. (2020) · Science · doi:10.1126/science.abc3421 · Cited by 1,407 · see citing works
Gjerstorff, M. L. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810393562 · Cited by 1,356 · see citing works
Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.007 · Cited by 1,158 · see citing works
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., et al. (2019) · Nature · doi:10.1038/s41586-019-0878-z · Cited by 1,145 · see citing works
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
Zelenay, S., van der Veen, A. G., Böttcher, J. P., Snelgrove, K. J., Rogers, N. C., Acton, S. E., Chakravarty, P., Girotti, M. R., Marais, R., Quezada, S. A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.015 · Cited by 1,123 · see citing works
Self-citationCalcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer
Wactawski‐Wende, J., Kotchen, J. M., Anderson, G. L., Assaf, A. R., Brunner, R. L., O’Sullivan, M. J., Margolis, K. L., Ockene, J. K., Phillips, L. S., Pottern, L. M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055222 · Cited by 980 · see citing works
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
Spencer, C. N., McQuade, J. L., Gopalakrishnan, V., McCulloch, J. A., Vetizou, M., Cogdill, A. P., Khan, M. A. W., Zhang, X., White, M. G., Peterson, C. B., et al. (2021) · Science · doi:10.1126/science.aaz7015 · Cited by 966 · see citing works
Self-citationMeta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
Litchfield, K., Reading, J. L., Puttick, C., Thakkar, K., Abbosh, C., Bentham, R., Watkins, T. B. K., Rosenthal, R., Biswas, D., Rowan, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.002 · Cited by 893 · see citing works
Self-citationRamagopalan, S. V., Heger, A., Berlanga‐Taylor, A. J., Maugeri, N., Lincoln, M. R., Burrell, A. M., Handunnetthi, L., Handel, A. E., Disanto, G., Orton, S. M., et al. (2010) · Genome Research · doi:10.1101/gr.107920.110 · Cited by 871 · see citing works
Wang, J., Thingholm, L. B., Skiecevičienė, J., Rausch, P., Kummen, M., Hov, J. R., Degenhardt, F., Heinsen, F.-A., Rühlemann, M. C., Szymczak, S., et al. (2016) · Nature Genetics · doi:10.1038/ng.3695 · Cited by 625 · see citing works
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response
Ding, N., Yu, R. T., Subramaniam, N., Sherman, M. H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.028 · Cited by 622 · see citing works
The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity
Böttcher, J. P., & Reis e Sousa, C. (2018) · Trends in Cancer · doi:10.1016/j.trecan.2018.09.001 · Cited by 607 · see citing works
Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
Lam, K. C., Araya, R. E., Huang, A., Chen, Q., Di Modica, M., Rodrigues, R. R., Lopès, A., Johnson, S. B., Schwarz, B., Bohrnsen, E., et al. (2021) · Cell · doi:10.1016/j.cell.2021.09.019 · Cited by 604 · see citing works
Self-citationExploring vitamin D metabolism and function in cancer
Jeon, S., & Shin, E. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0038-9 · Cited by 554 · see citing works
Estimation of rat mammary tumor volume using caliper and ultrasonography measurements
Faustino‐Rocha, A. I., Oliveira, P. A., Pinho, J. O., Teixeira-Guedes, C., Soares, R. M. M., da Costa, R. M. G., Colaço, B., Pires, M. J., Colaço, J., Ferreira, R. M., et al. (2013) · Lab Animal · doi:10.1038/laban.254 · Cited by 504 · see citing works
Gandini, S., Boniol, M., Haukka, J. K., Byrnes, G. B., Cox, B., Sneyd, M. J., Mullie, P., & Autier, P. (2010) · International Journal of Cancer · doi:10.1002/ijc.25439 · Cited by 500 · see citing works
Amling, M., Priemel, M., Holzmann, T., Chapin, K., Rueger, J. M., Baron, R., & Demay, M. B. (1999) · Endocrinology · doi:10.1210/endo.140.11.7110 · Cited by 497 · see citing works
McCulloch, J. A., Davar, D., Rodrigues, R. R., Badger, J. H., Fang, J. R., Cole, A. M., Balaji, A. K., Vetizou, M., Prescott, S. M., Fernandes, M. R., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01698-2 · Cited by 472 · see citing works
Self-citationEnteric Salmonellosis Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract
Barman, M., Unold, D., Shifley, K., Amir, E., Hung, K.-C., Bos, N. A., & Salzman, N. H. (2007) · Infection and Immunity · doi:10.1128/iai.01432-07 · Cited by 428 · see citing works
Jenab, M., Bueno-de-Mesquita, H. B., Ferrari, P., van Duijnhoven, F. J. B., Norat, T., Pischon, T., Jansen, E. H. J. M., Slimani, N., Byrnes, G. B., Rinaldi, S., et al. (2010) · BMJ · doi:10.1136/bmj.b5500 · Cited by 405 · see citing works
Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein
Safadi, F. F., Thornton, P., Magiera, H., Hollis, B. W., Gentile, M., Haddad, J. G., Liebhaber, S. A., & Cooke, N. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5244 · Cited by 401 · see citing works
Ma, Y., Zhang, P., Wang, F., Yang, J., Liu, Z., & Qin, H. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.7566 · Cited by 383 · see citing works
The Extracellular Actin-Scavenger System and Actin Toxicity
Epstein, F. H., Lee, W. M., & Galbraith, R. M. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205143262006 · Cited by 378 · see citing works
Gut Microbiota in Cancer Immune Response and Immunotherapy
Zhou, C., Zhou, Y., & Fang, J. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.01.010 · Cited by 303 · see citing works
Existing Data Sources in Clinical Epidemiology: Laboratory Information System Databases in Denmark
Arendt, J. F. H., Hansen, A. T., Ladefoged, S. A., Sørensen, H. T., Pedersen, L. H., & Adelborg, K. (2020) · Clinical Epidemiology · doi:10.2147/clep.s245060 · Cited by 296 · see citing works
Newton-Bishop, J. A., Beswick, S., Randerson-Moor, J., Chang, Y.-M., Affleck, P., Elliott, F., Chan, M., Leake, S., Karpavicius, B., Haynes, S., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.1135 · Cited by 295 · see citing works
An update on vitamin D signaling and cancer
Carlberg, C., & Múñoz, A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.018 · Cited by 290 · see citing works
Relationships Between Vitamin D, Gut Microbiome, and Systemic Autoimmunity
Yamamoto, E. A., & Jørgensen, T. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03141 · Cited by 265 · see citing works
New perspectives on the vitamin D binding protein
Chun, R. F. (2012) · Cell Biochemistry and Function · doi:10.1002/cbf.2835 · Cited by 246 · see citing works
The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
Singh, P., Rawat, A., Alwakeel, M., Sharif, E., & Khodor, S. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-77806-4 · Cited by 237 · see citing works
Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications
Medrano, M., Carrillo‐Cruz, E., Montero, I., & Pérez‐Simón, J. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092663 · Cited by 193 · see citing works
Ferrer‐Mayorga, G., Goméz-López, G., Barbáchano, A., Fernández‐Barral, A., Peña, C., Pisano, D. G., Cantero, R., Rojo, F., Múñoz, A., & Larriba, M. J. (2016) · Gut · doi:10.1136/gutjnl-2015-310977 · Cited by 186 · see citing works
Ng, K., Nimeiri, H. S., McCleary, N. J., Abrams, T. A., Yurgelun, M. B. B., Cleary, J. M., Rubinson, D. A., Schrag, D., Miksad, R. A., Bullock, A. J., et al. (2019) · JAMA · doi:10.1001/jama.2019.2402 · Cited by 184 · see citing works
Canton, J., Blees, H., Henry, C. M., Buck, M. D., Schulz, O., Rogers, N. C., Childs, E., Zelenay, S., Rhys, H. I., Domart, M., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-00824-x · Cited by 184 · see citing works
Self-citationVitamin D and the gut microbiome: a systematic review of in vivo studies
Waterhouse, M., Hope, B., Krause, L., Morrison, M., Protani, M. M., Zakrzewski, M., & Neale, R. E. (2019) · European Journal of Nutrition · doi:10.1007/s00394-018-1842-7 · Cited by 183 · see citing works
Clark, A. P., & Mach, N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00627 · Cited by 168 · see citing works
Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions
Alexander, M., & Turnbaugh, P. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.015 · Cited by 150 · see citing works
Urashima, M., Ohdaira, H., Akutsu, T., Okada, S., Yoshida, M., Kitajima, M., & Suzuki, Y. (2019) · JAMA · doi:10.1001/jama.2019.2210 · Cited by 147 · see citing works
Charoenngam, N., SHIRVANI, A., Kalajian, T. A., Song, A., & Holick, M. F. (2019) · Anticancer Research · doi:10.21873/anticanres.13984 · Cited by 137 · see citing works
Lee, Y. K., Mehrabian, P., Boyajian, S., Wu, W.-L., Selicha, J., Vonderfecht, S. L., & Mazmanian, S. K. (2018) · mSphere · doi:10.1128/msphere.00587-18 · Cited by 135 · see citing works
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
Giampazolias, E., Schulz, O., Lim, K. H. J., Rogers, N. C., Chakravarty, P., Srinivasan, N., Gordon, O., Cardoso, A., Buck, M. D., Poirier, E. Z., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.021 · Cited by 132 · see citing works
Self-citationAnderson, L. N., Cotterchio, M., Cole, D. E. C., & Knight, J. A. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0300 · Cited by 115 · see citing works
Muralidhar, S., Filia, A., Nsengimana, J., Poźniak, J., O'Shea, S. J., Diaz, J. M. S., Harland, M., Randerson‐Moor, J. A., Reichrath, J., Laye, J. P., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3927 · Cited by 113 · see citing works
Key Vitamin D Target Genes with Functions in the Immune System
Koivisto, O., Hänel, A., & Carlberg, C. (2020) · Nutrients · doi:10.3390/nu12041140 · Cited by 111 · see citing works
Primary Vitamin D Target Genes of Human Monocytes
Nurminen, V., Seuter, S., & Carlberg, C. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00194 · Cited by 106 · see citing works
Plasma 25-Hydroxyvitamin D Levels and the Risk of Colorectal Cancer: The Multiethnic Cohort Study
Woolcott, C. G., Wilkens, L. R., Nomura, A. M. Y., Horst, R. L., Goodman, M. T., Murphy, S. P., Henderson, B. E., Kolonel, L. N., & Marchand, L. L. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0475 · Cited by 104 · see citing works
A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD
Sofi, M. H., Wu, Y., Ticer, T. D., Schutt, S. D., Bastian, D. A., Choi, H.-J., Tian, L., Mealer, C., Liu, C., Westwater, C., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.136841 · Cited by 93 · see citing works
Lucas, R. M., Gorman, S., Geldenhuys, S., & Hart, P. H. (2014) · F1000Prime Reports · doi:10.12703/p6-118 · Cited by 89 · see citing works
Lo, C., Wu, D., Jao, S., Wu, C., Lin, C., Chuang, C.-H., Lin, Y.-B., Chen, C.-H., Chen, Y.-T., Chen, J., et al. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00869-0 · Cited by 88 · see citing works
The heightened importance of the microbiome in cancer immunotherapy
Villemin, C., Six, A., Neville, B. A., Lawley, T. D., Robinson, M. J., & Bakdash, G. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.11.002 · Cited by 75 · see citing works
Vitamin D–Binding Protein Deficiency and Homozygous Deletion of the GC Gene
Henderson, C. M., Fink, S. L., Bassyouni, H., Argiropoulos, B., Brown, L. A., Laha, T. J., Jackson, K. J., Lewkonia, R. M., Ferreira, P., Hoofnagle, A. N., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1807841 · Cited by 75 · see citing works
Patrick, S. (2022) · Microbiology · doi:10.1099/mic.0.001156 · Cited by 75 · see citing works
Haddad, J. G., Hu, Y. Z., Kowalski, M. A., Laramore, C., Ray, K., Robzyk, P., & Cooke, N. E. (1992) · Biochemistry · doi:10.1021/bi00146a021 · Cited by 74 · see citing works
Influence of vitamin D on key bacterial taxa in infant microbiota in the KOALA Birth Cohort Study
Talsness, C. E., Penders, J., Jansen, E. H. J. M., Damoiseaux, J. G. M. C., Thijs, C. T., & Mommers, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188011 · Cited by 67 · see citing works
Galus, Ł., Michalak, M., Lorenz, M., Stoińska‐Swiniarek, R., Tusień-Małecka, D., Galus, A., Kolenda, T., Leporowska, E., & Mackiewicz, J. (2023) · Cancer · doi:10.1002/cncr.34718 · Cited by 55 · see citing works
Mondul, A. M., Shui, I. M., Yu, K. F., Travis, R. C., Stevens, V. L., Campa, D., Schumacher, F. R., Ziegler, R. G., Bueno-de-Mesquita, H. B., Berndt, S. I., et al. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0007-t · Cited by 46 · see citing works
The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis
Cardoso, A., Castro, A. G., Martins, A. C. M., Carriche, G. M., Murigneux, V., Castro, I., Cumano, A., Vieira, P., & Saraiva, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00400 · Cited by 46 · see citing works
Self-citationYang, L., Chen, H., Zhao, M., & Peng, P. (2017) · Oncotarget · doi:10.18632/oncotarget.16597 · Cited by 43 · see citing works
Smedt, J. D., Kelst, S. V., Boecxstaens, V., Stas, M., Bogaerts, K., Vanderschueren, D., Aura, C. M., Vandenberghe, K., Lambrechts, D., Wolter, P., et al. (2017) · BMC Cancer · doi:10.1186/s12885-017-3538-4 · Cited by 40 · see citing works
Hänel, A., Neme, A., Malinen, M., Hämäläinen, E., Malmberg, H.-R., Etheve, S., Tuomainen, T., Virtanen, J. K., Bendik, I., & Carlberg, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-78288-0 · Cited by 37 · see citing works
Vitamin D binding protein is required to utilize skin-generated vitamin D
Duchow, E. G., Cooke, N. E., Seeman, J., Plum, L. A., & DeLuca, H. F. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915442116 · Cited by 32 · see citing works
Odamaki, T., Xiao, J., Sakamoto, M., Kondo, S., Yaeshima, T., Iwatsuki, K., Togashi, H., Enomoto, T., & Benno, Y. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01106-08 · Cited by 31 · see citing works
Intestinal clock system regulates skeletal homeostasis
Kawai, M., Kinoshita, S., Yamazaki, M., Yamamoto, K., Rosen, C. J., Shimba, S., Ozono, K., & Michigami, T. (2019) · JCI Insight · doi:10.1172/jci.insight.121798 · Cited by 31 · see citing works
Zhou, L., Zhang, X., Chen, X., Liu, L., Lü, C., Tang, X., Shi, J., Li, M., Zhou, M., Zhang, Z., et al. (2012) · Europe PMC (PubMed Central) · Cited by 31 · see citing works
Pesticide Exposure and Inherited Variants in Vitamin D Pathway Genes in Relation to Prostate Cancer
Karami, S., Andreotti, G., Koutros, S., Barry, K. H., Moore, L. E., Han, S. S., Hoppin, J. A., Sandler, D. P., Lubin, J. H., Burdette, L. A., et al. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-1454 · Cited by 28 · see citing works
DNGR-1-mediated cross-presentation of dead cell-associated antigens
Henry, C. M., Castellanos, C. A., & Sousa, C. R. E. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101726 · Cited by 27 · see citing works
Peña-Chilet, M., Ibarrola‐Villava, M., Martín‐González, M., Rodríguez, M. F., Gómez‐Fernández, C., Planelles, D., Carretero, G., Lluch, A. M., Nagore, E., & Ribas, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059607 · Cited by 26 · see citing works
JAMS - A framework for the taxonomic and functional exploration of microbiological genomic dataPreprint
McCulloch, J. A., Badger, J. H., Cannon, N., Rodrigues, R. R., Valencia, M. E., Barb, J. J., Fernandes, M. R., Balaji, A. K., Crowson, L., Ó’hUigín, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.03.531026 · Cited by 14 · see citing works
Self-citationLoss of secreted gelsolin enhances response to anticancer therapies
Lim, K. H. J., Giampazolias, E., Schulz, O., Rogers, N. C., Wilkins, A. C., Sahai, E. A., Strid, J., & Sousa, C. R. E. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005245 · Cited by 11 · see citing works
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Jin, M., Fang, J., Peng, J., Wang, X., Xing, P., Jia, K., Hu, J., Wang, D., Ding, Y., Wang, X., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02176-8 · Cited by 156 · see citing works
Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines
Grant, W. B., Wimalawansa, S. J., Płudowski, P., & Cheng, R. Z. (2025) · Nutrients · doi:10.3390/nu17020277 · Cited by 156 · see citing works
Neuro–immuno–endocrinology of the skin: how environment regulates body homeostasis
Slominski, R. M., Raman, C., Jetten, A. M., & Slominski, A. T. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01107-x · Cited by 133 · see citing works
The gut microbiota in cancer immunity and immunotherapy
Xie, M., Li, X., Lau, H. C.-H., & Yu, J. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01326-2 · Cited by 125 · see citing works
Long-distance microbial mechanisms impacting cancer immunosurveillance
Zitvogel, L., Fidelle, M., & Kroemer, G. (2024) · Immunity · doi:10.1016/j.immuni.2024.07.020 · Cited by 51 · see citing works
Metabolites as agents and targets for cancer immunotherapy
Trefny, M. P., Kroemer, G., Zitvogel, L., & Kobold, S. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01227-z · Cited by 48 · see citing works
Mahat, D. B., Kumra, H., Castro, S. A., Metcalf, E., Nguyen, K. B., Morisue, R., Ho, W. W., Chen, I. X., Sullivan, B., Yim, L., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.06.005 · Cited by 43 · see citing works
Chang, Z., Xu, X., Xu, Y., Wei, X., Yang, G., Guo, P., Jia, J., Chen, Y., Song, X., Zheng, Y., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c05587 · Cited by 39 · see citing works
Lymphatic system regulation of anti-cancer immunity and metastasis
Lei, P., Fraser, C. S., Jones, D., Ubellacker, J. M., & Padera, T. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449291 · Cited by 36 · see citing works
Gamrath, L., Pedersen, T. B., Møller, M. V., Volmer, L. M., Holst-Christensen, L., Vestermark, L. W., & Donskov, F. (2025) · Current Oncology Reports · doi:10.1007/s11912-024-01622-6 · Cited by 30 · see citing works
“This part of the study did unfortunately not correlate outcomes to the microbiome [58].”
Tang, Y., Cai, Q., Tian, Z., Chen, W., & Tang, H. (2025) · Research · doi:10.34133/research.0600 · Cited by 27 · see citing works
Clinical Evidence for Microbiome-Based Strategies in Cancer Immunotherapy: A State-of-the-Art Review
Petrelli, F., Ghidini, A., Dottorini, L., Ghidini, M., Zaniboni, A., & Tomasello, G. (2025) · Medicina · doi:10.3390/medicina61091595 · Cited by 28 · see citing works
Impact of the ONCOBIOME network in cancer microbiome research
Zitvogel, L., Derosa, L., Routy, B., Loibl, S., Heinzerling, L., de Vries, I. J. M., Engstrand, L., ONCOBIOME Network, Silva, C. A. C., Barbieri, D., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03608-8 · Cited by 23 · see citing works
Interactions between the tumor microbiota and breast cancer
Guo, H. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1499203 · Cited by 21 · see citing works
Harnessing the microbiome for cancer therapy
Hajjar, R., Mars, R. A. T., & Kashyap, P. (2026) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01268-6 · Cited by 28 · see citing works
Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease
Theis, B. F., Park, J. S., Kim, J. S., Zeydabadinejad, S., Vijay–Kumar, M., Yeoh, B. S., & Saha, P. (2025) · Biomedicines · doi:10.3390/biomedicines13061357 · Cited by 24 · see citing works
The Mediating Role of Bioactive Molecules in Gut Microbiota–Bone Metabolism Crosstalk
Liang, X., & Wang, L. (2025) · Nutrients · doi:10.3390/nu17213421 · Cited by 17 · see citing works
Xu, J., Tian, Y., Zhao, B., Hu, D., Wu, S., Ma, J., & Yang, L. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00200-3 · Cited by 16 · see citing works
The role of the intestinal microbiome in cognitive decline in patients with kidney disease
Wagner, C. A., Frey-Wagner, I. M., Ortíz, A., Unwin, R. J., Liabeuf, S., Suzumoto, Y., Iervolino, A., Stasi, A., Marzo, V. D., Gesualdo, L., et al. (2025) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae253 · Cited by 16 · see citing works
Zhang, H., Lee, B. J. Y., Wang, T., Xiang, X., Tan, Y., Han, Y., Bi, Y., Zhi, F., Wang, X., He, F., et al. (2025) · hLife · doi:10.1016/j.hlife.2025.04.004 · Cited by 16 · see citing works
The multi-kingdom cancer microbiome
Dohlman, A. B., Pan, X., Zitvogel, L., & Iliev, I. D. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02103-7 · Cited by 14 · see citing works
Next‐Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy
Bautista, J., Echeverría, C. E., Maldonado-Noboa, I., Adatty-Molina, J., Urresta, S. S., Coral-Riofrio, E. C., Araujo‐Abad, S., Kyriakidis, N. C., & López-Cortés, A. (2026) · Journal of Immunology Research · doi:10.1155/jimr/7864229 · Cited by 15 · see citing works
Dalamaga, Μ., Emfietzoglou, R., Petropoulou, D., Kypraiou, M., Kounatidis, D. C., Vallianou, N. G., Karras, S. Ν., Magkos, F., & Karampela, Ι. (2026) · Current Nutrition Reports · doi:10.1007/s13668-026-00748-2 · Cited by 13 · see citing works
The therapeutic promise of probiotic Bacteroides fragilis (BF839) in cancer immunotherapy
Peng, K., Li, Y., Yang, Q., Yu, P., Zeng, T., Lin, C., Deng, Y., & Chen, J. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1523754 · Cited by 15 · see citing works
Stone, S., McPherson, J. P., Kulkarni, R. P., & Young, A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00890-z · Cited by 13 · see citing works
Vitamin D: What role in obesity-related cancer?
Martinez, P., & Grant, W. B. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.03.007 · Cited by 12 · see citing works
Nutrition and Diet Patterns as Key Modulators of Metabolic Reprogramming in Melanoma Immunotherapy
Grafanaki, K., Maniatis, A., Anastogianni, A., Bania, A., Pasmatzi, E., & Stathopoulos, C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124193 · Cited by 12 · see citing works
Microbial metabolites for cancer immunotherapy: Current evidence and future directions
Wang, X., Liang, J.-J., Duan, X., & Chen, G. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.10.005 · Cited by 10 · see citing works
Cholesterol metabolism: a new checkpoint in cancer immunity
Zhao, L., Zheng, R., Liu, W., Li, X., Liu, H., Yin, H., Zhang, R., & Yang, A. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.11.003 · Cited by 12 · see citing works
Jia, K., Chen, Y., Dai, D., Xie, Y., Peng, H., Cao, Y., Zou, H., Qiu, C., Tan, Y., zhang, X., et al. (2026) · BMC Medicine · doi:10.1186/s12916-025-04575-0 · Cited by 10 · see citing works
Exploring micronutrients and microbiome synergy: pioneering new paths in cancer therapy
Bhatnagar, K., Jha, K., Dalal, N., Patki, N., Gupta, G., Kumar, A., Kumar, A., & Chaudhary, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1442788 · Cited by 11 · see citing works
Zhang, Y., Xu, Y., Zhong, W., Zhao, J., Liu, X., Gao, X., Chen, M., & Wang, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104511 · Cited by 11 · see citing works
Vitamin D, Gut Microbiota, and Cancer Immunotherapy—A Potentially Effective Crosstalk
Yan, Y., Mao, S., Guo, Y., Chenhang, Y., Jiang, Q., Zhao, L. R., & Zhao, L. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157052 · Cited by 10 · see citing works
Yang, Q., Shu, C., Li, H., Xie, X., Wu, H., Zhou, Y., Hu, H., Zhao, J., Xu, C., & He, Y. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.08.003 · Cited by 12 · see citing works
Lin, X.-Y., Ye, T., Duan, X., Wang, B., Zhou, D., & Li, H. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c04801 · Cited by 9 · see citing works
Friedberg, J. W., Brady, M. T., Strawderman, M., Kahl, B. S., Lossos, I. S., Cohen, J. B., Reagan, P. M., Casulo, C., Averill, B. L., Baran, A. M., et al. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102959 · Cited by 9 · see citing works
Exploring the microbiome-gut-testis axis in testicular germ cell tumors
Čierniková, S., Ševčíková, A., & Mego, M. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1529871 · Cited by 9 · see citing works
Wang, S., He, C., Li, N., Zhu, D., Wang, Z., Qiao, X., & Duan, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-05693-8 · Cited by 9 · see citing works
Jia, R. F., Xiao, C., Zhang, Y., Hu, L.-Y., Jun-jun, Y., Zuo, R., Hu, Y., Xie, Y.-H., Ma, X., Li, Q., et al. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101311 · Cited by 8 · see citing works
CYP24A1 in Small Intestinal Vitamin D Metabolism and Clinical Implications
Nowacka, A., Śniegocki, M., Bożiłow, D., & Ziółkowska, E. (2025) · Nutrients · doi:10.3390/nu17213348 · Cited by 8 · see citing works
Fang, X., Zhao, J., Wu, S., Liao, P., & Guan, G. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126396 · Cited by 7 · see citing works
Microbiota and cancer immunotherapy: Mechanisms, clinical implications, and precision therapeutics
Wei, D., Sun, Y., Han, J., & Liu, J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.12.002 · Cited by 7 · see citing works
Nutritional intervention alleviates T cell exhaustion and empowers anti-tumor immunity
Xu, Y., Yuan, W., Li, K., & Li, P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1689317 · Cited by 8 · see citing works
Leveraging intratumoral probiotics for pancreatic cancer immunotherapy via xenophagy
Li, B., Liu, G., Zhu, Y., Chen, L., Zhang, N., Zhu, X., Sun, Y., Liu, X., Liu, W., Ma, Y., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.02.010 · Cited by 7 · see citing works
Microbes and vitamin D aid immunotherapy
Franco, F., & McCoy, K. D. (2024) · Science · doi:10.1126/science.adp1309 · Cited by 7 · see citing works
High-performance coaxial 3D printing towards emulsion-Vitamin D formability
Hu, H., Yao, S., Niu, R., Huang, Z., Wan, B., Zhu, Q., Zhou, J., Liu, D., & Xu, E. (2024) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2024.112453 · Cited by 7 · see citing works
Huang, W., Jiang, T., He, J., Ruan, J., Wu, B., Tao, R., Xu, P., Wang, Y., Chen, R., Wang, H., et al. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10471-z · Cited by 7 · see citing works
Key genes of vitamin D metabolism and their roles in the risk and prognosis of cancer
Zheng, S., Zhu, L., Wang, Y., Hua, Y., Ying, J., & Chen, J. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1598525 · Cited by 6 · see citing works
Merino, J. J., Rey, N. B., & García, R. F. (2025) · Life · doi:10.3390/life15091412 · Cited by 6 · see citing works
Yuan, S., Bremmer, A., Yang, X., & Hu, Q. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.11.023 · Cited by 6 · see citing works
Microbiota mechanisms in cancer progression and therapy
Zhang, X., Fam, K. T., Dai, T., & Hang, H. C. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.04.005 · Cited by 7 · see citing works
Healthy food design based on gut microbiota metabolic flux
Yan, F., Xiang, S., Ying, J., Chen, J., Shi, L., Zhang, Y., Han, J., & Zhu, X. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104790 · Cited by 5 · see citing works
Microbial metabolite ammonia disrupts TGF-β signaling to promote colon cancer
Bhowmick, K., Yang, X., Mohammad, T., Xiang, X., Molmenti, C. L. S., Mishra, B., Dasarathy, S., Krainer, A. R., Hassan, M. I., Crandall, K. A., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108559 · Cited by 5 · see citing works
Perez, K. J., Costa, A. D., Jordan, A., Karasic, T. B., Elganainy, D., Kim, S., Yuan, C., Gui, D. Y., Tan, R., Hong, S. C., et al. (2026) · Nature Cancer · doi:10.1038/s43018-026-01165-8 · Cited by 6 · see citing works
In vitro validation of colon delivery of vitamin B2 through a food grade multi-unit particle system
Steinert, R. E., Sybesma, W., Duss, R., Rehman, A., Watson, M., van den Ende, T. C., & Funda, E. (2024) · Beneficial Microbes · doi:10.1163/18762891-bja00045 · Cited by 5 · see citing works
Knuth, M. M., Campos, C. V., Smith, K., Hutchins, E. K., Lewis, S., York, M., Coghill, L. M., Franklin, C. L., MacFarlane, A. J., Ericsson, A. C., et al. (2024) · Lab Animal · doi:10.1038/s41684-024-01477-1 · Cited by 5 · see citing works
Vitamin D, Calcium to Magnesium Ratio, and the Gut Microbiome
Chambers, P. W. (2025) · Medical & Clinical Research · doi:10.33140/mcr.10.02.04 · Cited by 5 · see citing works
Immunomodulatory role of vitamin D and emerging immunotherapies in hepatocellular carcinoma
Chiriva-Internati, M., Grizzi, F., Monari, M., Taverna, G., Figueroa, J. A., Wei, D.-Y., & Bresalier, R. S. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1611829 · Cited by 6 · see citing works
Lin, Z., Mu, S., Zhang, W., Guo, Y., Dong, C., Song, L., Zhang, H., Wu, R., Luo, P., & Liang, L. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102428 · Cited by 4 · see citing works
Hu, Y., Zhu, C., Qin, Y., Zhu, Y., Zhang, J., Tong, Q., & Cai, S. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1617565 · Cited by 4 · see citing works
Bringing Vitamin D and the Vitamin D Receptor into the Limelight
Sun, J. (2024) · Biomolecules · doi:10.3390/biom14091094 · Cited by 4 · see citing works
Photodynamic therapy of cancer‐associated infections
Kassab, G., Chen, J., & Zheng, G. (2024) · Photochemistry and Photobiology · doi:10.1111/php.14038 · Cited by 4 · see citing works
Wang, J., Hu, Q., Wang, J., Lang, L., Wei, S., Li, H., Jing, M., Ma, X., Zhao, Y., & Zhou, X. (2025) · Current Research in Food Science · doi:10.1016/j.crfs.2025.100990 · Cited by 4 · see citing works
COVID-19 and our understanding of vitamin D and immune function
Hewison, M. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106710 · Cited by 4 · see citing works
Liu, C., Zheng, H., Xu, W., Zhu, X., Li, M., & Liu, L. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1588700 · Cited by 3 · see citing works
Microenvironment of Solid Tumors
Korneenko, T. V., Pestov, N. B., Shakhparonov, M. I., & Barlev, N. A. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl36940 · Cited by 3 · see citing works
Gong, F., Liu, N., Miao, J., Wang, C., Lin, M., Luan, B., Chen, J., Chen, Y., Chen, X., Ge, F., et al. (2025) · Gene · doi:10.1016/j.gene.2025.149872 · Cited by 3 · see citing works
Resonance frequency analysis of dental implants in patients with vitamin D deficiency
Toy, V. E., & Sabancı, A. (2024) · Clinical Oral Investigations · doi:10.1007/s00784-024-06085-4 · Cited by 3 · see citing works
Zheng, J., Gao, H., Zhang, Y., Sun, M., Sun, H., & Pei, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1578191 · Cited by 3 · see citing works
Zhang, H., Dou, B., Sun, X., & Chen, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-95931-w · Cited by 3 · see citing works
Zhu, B., Yang, J., Fan, R., Song, H., Zhong, L., Zeng, T., Long, R., Wan, X., Li, Q., Liu, L., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115857 · Cited by 4 · see citing works
Li, J., Hou, Y., Ding, H., Wang, P., & Li, B. (2024) · Steroids · doi:10.1016/j.steroids.2024.109488 · Cited by 2 · see citing works
Self-citationLi, H., Li, W., & Hu, X.-R. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03747-9 · Cited by 2 · see citing works
Dietary Intake of Phytochemicals, Gut Microbiota, and Appetite Control
Al‐Dujaili, E. A. S. (2025) · Nutrients · doi:10.3390/nu17162646 · Cited by 2 · see citing works
Feng, X. G., Li, J., Meng, Y., Jing, Y., Qian, H., Zhang, W., Liu, R., Wang, D., Zhang, W., Hao, Y., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c07085 · Cited by 2 · see citing works
Yang, S., & Yang, W. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05890-4 · Cited by 2 · see citing works
He, Z., & Du, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1688910 · Cited by 2 · see citing works
Ye, Z., Li, G., Zhang, Y., Li, Z., & Lei, J. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000004003 · Cited by 2 · see citing works
The role of vitamin D in gastrointestinal cancer prevention and management: a narrative review
Khan, N., Shehzadi, T., Hasan, Z. W., Panezai, A., Naqash, M., Rehman, A. U., Mohan, A., Tanush, D., Karimi, H., Aminpoor, H., et al. (2025) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000004114 · Cited by 2 · see citing works
Shaping the Tumor Microenvironment: Insights from Host–Microbiota Interactions
Lam, K. C., & Goldszmid, R. S. (2026) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-1350 · Cited by 2 · see citing works
Self-citationQian, Z.-Y., Deng, Y., Xi, M., Zhang, X. M., Sun, H., Mao, M., Luo, X.-J., Li, M., Zhang, Q., Chen, B., et al. (2026) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-1449 · Cited by 2 · see citing works
The lethal symbiont: exploring the pathophysiology of cancer
Nolan, E., Li, L., Giampazolias, E., Ombrato, L., & Malanchi, I. (2026) · Physiological Reviews · doi:10.1152/physrev.00019.2025 · Cited by 2 · see citing works
Self-citationTumor-associated bacterial effectors: novel frontiers in tumor biology and immunity
Dai, J.-H., Lu, Y.-Q., Feng, S.-Y., Tan, X.-R., Li, L., Zeng, Y.-C., Chen, J., Ma, J., & Liu, N. (2026) · 中国科学通报:英文版 · doi:10.1016/j.scib.2026.04.034 · Cited by 2 · see citing works
Cheng, H., & Wong, C. C. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02698-3 · Cited by 2 · see citing works
Vitamin D-dependent microbiota-enhancing tumor immunotherapy
Izquierdo, J. M. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01184-4 · Cited by 2 · see citing works
CYP 24 A 1 Binding to FUS Maintains Tumor Properties by Regulating the mi R ‐200c/ ZEB 1/ EMT Axis
Wang, P., Xu, J., You, W., Li, J., Yu, J., Jiang, F., Zhang, Z., Hu, W., & Li, B. (2025) · Cancer Science · doi:10.1111/cas.16445 · Cited by 2 · see citing works
Self-citationXu, N., Lin, H., Ding, X., Wang, P., & Lin, J. (2025) · Talanta · doi:10.1016/j.talanta.2025.127754 · Cited by 2 · see citing works
Self-citationZhang, H., Qin, L., Li, Q., Wu, T., Zhang, L., Wang, K., Cheng, S.-B., Shi, Y., Feng, Y.-Q., Han, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.30.555532 · Cited by 2 · see citing works
Disruption of The Spinal Cord-Gut Axis Alters Gut Microbial Dynamics and Carbohydrate Cross-feedingPreprint
Mohssen, M., Zayed, A. A., Kigerl, K. A., Du, J., Smith, G. J., Schwab, J. M., Sullivan, M. B., & Popovich, P. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.27.656368 · Cited by 2 · see citing works
Li, H., Leaman, A. A., & Zheng, Q. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.04.001 · Cited by 1 · see citing works
Mohssen, M., Zayed, A. A., Kigerl, K. A., Du, J., Smith, G. J., Schwab, J. M., Sullivan, M. B., & Popovich, P. G. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-026-01107-3 · Cited by 3 · see citing works
Yu, Y., & Zhou, Y. (2025) · Acta Odontologica Scandinavica · doi:10.2340/aos.v84.44053 · Cited by 1 · see citing works
Liu, C., Wu, R., Wu, Y., Li, C., & Zhang, X. (2025) · Comparative Immunology Reports · doi:10.1016/j.cirep.2025.200253 · Cited by 1 · see citing works
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Yu, K., Sun, X., Ma, W., Yang, J., Sun, X., Zhang, L., Liu, Y., Ren, T., Wang, Q., Wang, J., et al. (2026) · Advanced Science · doi:10.1002/advs.202520095 · Cited by 1 · see citing works
Ahn, E. R., Iyer, N., & Cothran, S. B. (2026) · Nutrients · doi:10.3390/nu18081253 · Cited by 1 · see citing works
Romeo, M., Basile, C., Martinelli, G., Nardo, F. D., Napolitano, C., Gregorio, A. D., Vaia, P., Puorto, L. D., Indipendente, M., Federico, A., et al. (2026) · Cancers · doi:10.3390/cancers18081316 · Cited by 1 · see citing works
Luo, Z., Xu, D., Wang, Z., Wu, L., Ou, C., & Ou, Z. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102270 · Cited by 1 · see citing works
The immunomodulatory role of vitamins in tumor: Mechanisms and therapeutic implications
Wen, L., Liu, H., Liao, X., Liu, Y., Liu, Y., 姬颖华, Chen, S., Zhang, L., Yang, W., & Jiang, J. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108309 · Cited by 2 · see citing works
Immunotherapy in cancer: Mechanisms and strategies to overcome resistance
Yang, H., Yang, Z., Wang, X., Patel, H. H., Wu, Z., Ashby, C. R., Wang, W., & Chen, Z. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101447 · Cited by 1 · see citing works
- Authors
- Giampazolias, E., Pereira da Costa, M., Lam, K. C., Lim, K. H. J., Cardoso, A., Piot, C., Chakravarty, P., Blasche, S., Patel, S., Biram, A., Castro-Dopico, T., Buck, M. D., Rodrigues, R. R., Poulsen, G. J., Palma-Duran, S. A., Rogers, N. C., Koufaki, M. A., Minutti, C. M., Wang, P., Vdovin, A., Frederico, B., Childs, E., Lee, S., Simpson, B., Iseppon, A., Omenetti, S., Kelly, G., Goldstone, R., Nye, E., Suárez-Bonnet, A., Priestnall, S. L., MacRae, J. I., Zelenay, S., Patil, K. R., Litchfield, K., Lee, J. C., Jess, T., Goldszmid, R. S., & Reis e Sousa, C.
- Affiliations
- The Francis Crick Institute (GB)
- Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- National Cancer Institute (US)
- University of Cambridge (GB)
- University of Manchester (GB)
- Frederick National Laboratory for Cancer Research (US)
- Aalborg University Hospital (DK)
- University College London (GB)
- Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.
- Royal Veterinary College (GB)
- Corresponding author
- Giampazolias, Evangelos
- Lam, Khiem C.
- Lim, Kok Haw Jonathan
- Cardoso, Ana
- Piot, Cécile
- ORCID
- Giampazolias, Evangelos
- Pereira da Costa, Mariana
- Lam, Khiem C.
- Lim, Kok Haw Jonathan
- Cardoso, Ana
- Piot, Cécile
- Chakravarty, Probir
- Blasche, Sonja
- Patel, Swara
- Biram, Adi
- Castro-Dopico, Tomas
- Buck, Michael D.
- Rodrigues, Richard R.
- Poulsen, Gry Juul
- Palma-Duran, Susana A.
- Rogers, Neil C.
- Koufaki, Maria A.
- Minutti, Carlos M.
- Wang, Pengbo
- Vdovin, Alexander
- Frederico, Bruno
- Childs, Eleanor
- Lee, Sonia
- Iseppon, Andrea
- Omenetti, Sara
- Kelly, Gavin
- Goldstone, Robert
- Nye, Emma
- Suárez-Bonnet, Alejandro
- Priestnall, Simon L.
- MacRae, James I.
- Zelenay, Santiago
- Patil, Kiran Raosaheb
- Litchfield, Kevin
- Lee, James C.
- Jess, Tine
- Goldszmid, Romina S.
- Reis e Sousa, Caetano
- Venue
- Science
- Published
- 2024-04-26
- Volume
- 384
- Issue
- 6694
- Pages
- 428-437
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7615937
- OpenAlex
- W4395447498
- Cited by
- 151
- References
- 80
- Citations by year
- 2026: 49 · 2025: 77 · 2024: 24 · 2023: 1
- FWCI
- 45.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Science (publishedVersion, cc-by)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (publishedVersion, other-oa)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- The Francis Crick Institute (cc-by)
- Funders
- Wellcome Trust (CC2090, 216327, 106973/Z/15/Z, AdG 268670, 106973, 268670, /Z/15/Z, 216327/Z/19/Z)
- Francis Crick Institute (CC2090, 106973/Z/15/Z, CC1061, 216327/Z/19/Z, CC2016, AdG 268670, CC1107, CC2219)
- Frederick National Laboratory for Cancer Research
- Cancer Research UK (A27412, 216327/Z/19/Z, C5759, 106973/Z/15/Z, CC2090, AdG 268670, C5759/A27412, 100001)
- National Research Foundation (DNRF148)
- Boehringer Ingelheim Fonds
- Louis-Jeantet Foundation
- Danmarks Grundforskningsfond (DNRF-148)
- National Institutes of Health
- Medical Research Council (MC_PC_24010, MC_UU_00025, 106973/Z/15/Z, 216327/Z/19/Z, MC_UU_00025/11, CC2090, AdG 268670)
- National Cancer Institute
- H2020 European Research Council (866028)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- vitamin D, gut microbiota, antitumor immunity, immune checkpoint inhibitors, Bacteroides fragilis, intestinal epithelial cells, transplantable tumors, immunomodulation, overall survival, commensal bacteria
- MeSH terms
- Gastrointestinal Microbiome, Immune Checkpoint Inhibitors, Animals, Bacteroides fragilis, Calcifediol, Diet, Female, Humans, Immunotherapy, Intestinal Mucosa, Male, Mice, Inbred C57BL, Neoplasms, Vitamin D, Vitamin D-Binding Protein, Cell Line, Tumor, Mice
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