The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Microbiome diversity protects against pathogens by nutrient blocking
Open accessAbstract
The human gut microbiome plays an important role in resisting colonization of the host by pathogens, but we lack the ability to predict which communities will be protective. We studied how human gut bacteria influence colonization of two major bacterial pathogens, both in vitro and in gnotobiotic mice. Whereas single species alone had negligible effects, colonization resistance greatly increased with community diversity. Moreover, this community-level resistance rested critically upon certain species being present. We explained these ecological patterns through the collective ability of resistant communities to consume nutrients that overlap with those used by the pathogen. Furthermore, we applied our findings to successfully predict communities that resist a novel target strain. Our work provides a reason why microbiome diversity is beneficial and suggests a route for the rational design of pathogen-resistant communities.
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Cites
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Cited by
Metagenomic symphony of the intestinal ecosystem: How the composition affects the mind
Malan-Müller, S., Martín-Hernández, D., Caso, J. R., Matthijnssens, J., Rodríguez-Urrutia, A., Lowry, C. A., & Leza, J. C. (2025) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2024.09.033 · Cited by 24
Metadata
- Authors
- Spragge, F., Bakkeren, E., Jahn, M. T., B. N. Araujo, E., Pearson, C. F., Wang, X., Pankhurst, L., Cunrath, O., & Foster, K. R.
- Venue
- Science
- Published
- 2023-12-15
- Volume
- 382
- Issue
- 6676
- Pages
- eadj3502-eadj3502
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4389725563
- Cited by
- 435
- References
- 72
- FWCI
- 32.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Spragge, F., Bakkeren, E., Jahn, M. T., B. N. Araujo, E., Pearson, C. F., Wang, X., Pankhurst, L., Cunrath, O., & Foster, K. R. (2023). Microbiome diversity protects against pathogens by nutrient blocking. Science. https://doi.org/10.1126/science.adj3502
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
