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Cited by 58Immune Response and InflammationT-cell and B-cell ImmunologyDermatology and Skin Diseases

Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9

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Sawada, Yu, Nakatsuji, Teruaki, Dokoshi, Tatsuya, Kulkarni, Nikhil Nitin, Liggins, Marc C., Sen, George, Gallo, Richard L.·2021·Science Immunology
DOI 10.1126/sciimmunol.abe1935PMC PMC8363943
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Abstract

Inhibition of HDAC8 and HDAC9 impairs keratinocyte tolerance of TLR ligand stimulation, leading to cutaneous inflammation.

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Crossref · 10.1126/sciimmunol.abe1935

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  • For MAP2K3 and KCNJ18, GATK discovered 487 more variants than DRAGEN, which are likely false positives.

    “For MAP2K3, which is related to skin and liver diseases67, and KCNJ18, which is related to other rare diseases68, GATK discovered 487 more variants than DRAGEN, which are likely false positives23 (Supplementary Table 11).”

    From Comprehensive genome analysis and variant detection at scale using DRAGEN (2025) · cites this paper as [67]

    The Results section ('Expression of HDAC8/HDAC9 influences inflammatory responses of the skin'; page unavailable) reports elevated MAP2K3 expression in lesional skin from patients with atopic dermatitis, psoriasis, and acne, supporting the skin-disease portion attached to this citation. The copy does not link MAP2K3 to liver disease. The GATK–DRAGEN comparison and false-positive assessment are attached to a different citation in the printed sentence, not to this source. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Sawada, Y., Nakatsuji, T., Dokoshi, T., Kulkarni, N. N., Liggins, M. C., Sen, G., & Gallo, R. L.
Affiliations
University of California San Diego (US)
Corresponding author
Gallo, Richard L.
ORCID
Venue
Science Immunology
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-05-28
Volume
6
Issue
59
ISSN
2470-9468 (ISSN-L)
DOI
10.1126/sciimmunol.abe1935
PMC
PMC8363943
OpenAlex
W3161328221
Cited by
58
References
2
Citations by year
2026: 6 · 2025: 9 · 2024: 12 · 2023: 6 · 2022: 15 · 2021: 10
FWCI
4.01
Type
journal article
Language
en
Open access
Locations
  • Science Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (R37AI052453, R01AR076082, R01AR074302, R01AR069653, U01AI52038)
  • Geochemical Society
  • Japan Society for the Promotion of Science
  • Universidad Veracruzana
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
innate immune tolerance, epidermis, MAP2K3, HDAC8, HDAC9, histone deacetylase, epigenetic regulation, TLR ligands, skin inflammation, skin barrier
MeSH terms
Imiquimod, Animals, Cells, Cultured, Dendritic Cells, Histone Deacetylases, Humans, Immune Tolerance, Immunity, Innate, Mice, Transgenic, Repressor Proteins, Skin, Staphylococcus aureus, T-Lymphocytes, Ultraviolet Rays, Keratinocytes, Epigenesis, Genetic, MAP Kinase Kinase 3, Toll-Like Receptors

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