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Cited by 410MicroRNA in disease regulationCancer-related molecular mechanisms researchPI3K/AKT/mTOR signaling in cancer

Identification of the miR-106b ~ 25 MicroRNA Cluster as a Proto-Oncogenic PTEN -Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

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Poliseno, Laura, Salmena, Leonardo, Riccardi, Luisa, Fornari, Alessandro, Song, Min Sup, Hobbs, Robin M., Sportoletti, Paolo, Varmeh, Shorheh +5 more·2010·Science Signaling
DOI 10.1126/scisignal.2000594PMC PMC2982149
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Abstract

A microRNA network regulates the tumor suppressor PTEN in prostate cancer.

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Crossref · 10.1126/scisignal.2000594

Cites

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  • miR-106b targets several genes implicated in cell cycles, such as p21, E2F, TAF5-like RNA polymerase II, and PTEN.

    “Previous studies have shown that miR-106b targets several genes implicated in cell cycles, such as cyclin-dependent kinase inhibitor 1A (p21), E2F transcription factor, TAF5-like RNA polymerase II, and phosphatase and tensin homolog (Ivanovska et al., 2008; Pichiorri et al., 2008; Poliseno et al., 2010; Trompeter et al., 2011).”

    From miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression (2012) · cites this paper as Poliseno et al., 2010

    The Results section ('Two potentially oncogenic elements—miR-106b∼25 and MCM7—are present in the same locus'; page unavailable) states that all three members of the cluster, including miR-106b, target PTEN. The cited paper does not establish the sentence’s other listed targets—p21, E2F, or TAF5-like RNA polymerase II—so it supports only the PTEN portion of the claim. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 52

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Authors
Poliseno, L., Salmena, L., Riccardi, L., Fornari, A., Song, M. S., Hobbs, R. M., Sportoletti, P., Varmeh, S., Egia, A., Fedele, G., Rameh, L., Loda, M., & Pandolfi, P. P.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • Fondazione Ricerca Molinette (IT)
  • Brigham and Women's Hospital (US)
  • Boston Biomedical Research Institute (US)
Corresponding author
  • Salmena, Leonardo
  • Riccardi, Luisa
  • Pandolfi, Pier Paolo
ORCID
Venue
Science Signaling
Publisher
American Association for the Advancement of Science (AAAS)
Published
2010-04-13
Volume
3
Issue
117
Pages
ra29-ra29
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
DOI
10.1126/scisignal.2000594
PMC
PMC2982149
OpenAlex
W2078576279
Cited by
410
References
2
Citations by year
2026: 2 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 8 · 2021: 11 · 2020: 16 · 2019: 16 · 2018: 23 · 2017: 32 · 2016: 31 · 2015: 29 · 2014: 52 · 2013: 59 · 2012: 42
FWCI
16.52
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders
  • Canadian Institutes of Health Research
  • National Cancer Institute (R01CA082328, R01 CA-82328-0, R01CA102142, P50CA092629)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
PTEN, MCM7, intronic microRNA, miRNA target identification, prostate cancer, prostatic intraepithelial neoplasia, cell transformation, Dicer, miR-22, miR-25, miR-302, tumor suppressor regulation, PI3K/Akt signaling, transgenic mouse model
MeSH terms
Animals, Cell Transformation, Neoplastic, DNA-Binding Proteins, Multigene Family, Humans, Introns, Male, Mice, Transgenic, Nuclear Proteins, Prostatic Neoplasms, Proto-Oncogenes, Cell Cycle Proteins, MicroRNAs, PTEN Phosphohydrolase, Mice, Minichromosome Maintenance Complex Component 7

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