Cited by 146Protein Structure and DynamicsProtein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets

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Kaneko, Tomonori, Huang, Haiming, Zhao, Bing, Li, Lei, Liu, Huadong, Voss, Courtney K., Wu, Chenggang, Schiller, Martin R. +1 more·2010·Science Signaling

Abstract

Selective blocking of binding pockets by surface loops defines the specificity of a phosphotyrosine-binding domain.

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Authors
Kaneko, T., Huang, H., Zhao, B., Li, L., Liu, H., Voss, C. K., Wu, C., Schiller, M. R., & Li, S. S.-C.
Affiliations
  • Western University (CA)
  • University of Nevada, Las Vegas (US)
Corresponding author
  • Huang, Haiming
  • Li, Shawn Shun-Cheng
Venue
Science Signaling
Published
2010-05-04
Volume
3
Issue
120
Pages
ra34-ra34
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2023799737
Cited by
146
References
89
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 16 · 2020: 17 · 2019: 7 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 11 · 2014: 14 · 2013: 7 · 2012: 14
FWCI
4.95
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Scholarship - UNLV (University of Nevada Reno) (submittedVersion)
  • Scholarship@Western (Western University) (submittedVersion)
Funders
National Institute of General Medical Sciences (R01GM079689)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords
SH2 domain, protein-protein interaction, phosphotyrosine binding, sequence specificity, peptide binding
MeSH terms
Amino Acid Sequence, Binding Sites, Humans, Ligands, Models, Molecular, Genome, Human, src Homology Domains, Adaptor Proteins, Signal Transducing

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