Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets
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Selective blocking of binding pockets by surface loops defines the specificity of a phosphotyrosine-binding domain.
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A coherent structural model of SH2 domain binding specificity has been suggested.
“This is in contrast to the systematically studied interactions between SH2 domains and linear motifs for which a coherent structural model of SH2 domain binding specificity has been suggested (17-18).”
From Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove (2012) · cites this paper as [17]
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Self-citation
- Authors
- Kaneko, T., Huang, H., Zhao, B., Li, L., Liu, H., Voss, C. K., Wu, C., Schiller, M. R., & Li, S. S.-C.
- Affiliations
- Western University (CA)
- University of Nevada, Las Vegas (US)
- Corresponding author
- Huang, Haiming
- Li, Shawn Shun-Cheng
- ORCID
- Venue
- Science Signaling
- Published
- 2010-05-04
- Volume
- 3
- Issue
- 120
- Pages
- ra34-ra34
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC6590088
- OpenAlex
- W2023799737
- Cited by
- 146
- References
- 89
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 16 · 2020: 17 · 2019: 7 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 11 · 2014: 14 · 2013: 7 · 2012: 14
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Scholarship - UNLV (University of Nevada Reno) (submittedVersion)
- Scholarship@Western (Western University) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM079689)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- SH2 domain, protein-protein interaction, phosphotyrosine binding, sequence specificity, peptide binding
- MeSH terms
- Amino Acid Sequence, Binding Sites, Humans, Ligands, Models, Molecular, Genome, Human, src Homology Domains, Adaptor Proteins, Signal Transducing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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