Cited by 36Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK PathwaysLipid Membrane Structure and Behavior

A CC-SAM, for Coiled Coil–Sterile α Motif, Domain Targets the Scaffold KSR-1 to Specific Sites in the Plasma Membrane

Open access
Koveal, Dorothy, Schuh-Nuhfer, Natasha, Ritt, Daniel, Page, Rebecca, Morrison, Deborah K., Peti, Wolfgang·2012·Science Signaling

Abstract

A previously unknown module that mediates membrane binding is identified in the scaffold KSR.

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Crossref · 10.1126/scisignal.2003289

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47 of 47 references verified0 citation errors · 0 not checkable

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  • MAPK scaffolds such as KSR play a key role in modulating the strength and duration of MAPK activation.

    “Recently, MAPK scaffolds (e.g., KSR) have also been shown to play a key role in modulating the strength and duration of MAPK activation.”

    From Molecular basis of MAP kinase regulation (2013) · cites this paper as [14]

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Authors
Koveal, D., Schuh-Nuhfer, N., Ritt, D., Page, R., Morrison, D. K., & Peti, W.
Affiliations
  • Brown University (US)
  • Frederick National Laboratory for Cancer Research (US)
Corresponding author
  • Morrison, Deborah K.
  • Peti, Wolfgang
Venue
Science Signaling
Published
2012-12-18
Volume
5
Issue
255
Pages
ra94-ra94
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2117181640
Cited by
36
References
47
Citations by year
2025: 1 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3
FWCI
0.90
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (T32GM007601, R01GM098482)
  • National Institute of Neurological Disorders and Stroke (R01NS056128)
  • National Center for Research Resources (S10RR017269)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
KSR1, coiled coil, sterile alpha motif, membrane targeting, plasma membrane localization, MAPK signaling, scaffold proteins, membrane binding, C1 domain, phospholipid binding
MeSH terms
Animals, Cell Membrane, Cells, Cultured, Drosophila melanogaster, Humans, Phospholipids, Protein Binding, Protein Kinases, Protein Structure, Tertiary, Mice, Knockout, Nuclear Magnetic Resonance, Biomolecular, Amino Acid Substitution, Mutation, Missense, Amino Acid Motifs, Extracellular Signal-Regulated MAP Kinases, raf Kinases, Mice

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