A CC-SAM, for Coiled Coil–Sterile α Motif, Domain Targets the Scaffold KSR-1 to Specific Sites in the Plasma Membrane
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A previously unknown module that mediates membrane binding is identified in the scaffold KSR.
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MAPK scaffolds such as KSR play a key role in modulating the strength and duration of MAPK activation.
“Recently, MAPK scaffolds (e.g., KSR) have also been shown to play a key role in modulating the strength and duration of MAPK activation.”
From Molecular basis of MAP kinase regulation (2013) · cites this paper as [14]
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Molecular basis of MAP kinase regulation
Peti, W., & Page, R. (2013) · Protein Science · doi:10.1002/pro.2374 · Cited by 302 · see citing works
“, KSR) have also been shown to play a key role in modulating the strength and duration of MAPK activation.(13,14) A comprehensive understanding of how the activity of MAPKs is finely controlled by MAPK regulatory proteins can only be obtained by understanding how these proteins interact at a molecular level.”
BackgroundSelf-citationKSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors
Paniagua, G., Jacob, H. K. C., Brehey, O., García‐Alonso, S., Lechuga, C. G., Pons, T., Musteanu, M., Guerra, C., Drosten, M., & Barbacid, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13213 · Cited by 34 · see citing works
- Authors
- Koveal, D., Schuh-Nuhfer, N., Ritt, D., Page, R., Morrison, D. K., & Peti, W.
- Affiliations
- Brown University (US)
- Frederick National Laboratory for Cancer Research (US)
- Corresponding author
- Morrison, Deborah K.
- Peti, Wolfgang
- Venue
- Science Signaling
- Published
- 2012-12-18
- Volume
- 5
- Issue
- 255
- Pages
- ra94-ra94
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3740349
- OpenAlex
- W2117181640
- Cited by
- 36
- References
- 47
- Citations by year
- 2025: 1 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007601, R01GM098482)
- National Institute of Neurological Disorders and Stroke (R01NS056128)
- National Center for Research Resources (S10RR017269)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- KSR1, coiled coil, sterile alpha motif, membrane targeting, plasma membrane localization, MAPK signaling, scaffold proteins, membrane binding, C1 domain, phospholipid binding
- MeSH terms
- Animals, Cell Membrane, Cells, Cultured, Drosophila melanogaster, Humans, Phospholipids, Protein Binding, Protein Kinases, Protein Structure, Tertiary, Mice, Knockout, Nuclear Magnetic Resonance, Biomolecular, Amino Acid Substitution, Mutation, Missense, Amino Acid Motifs, Extracellular Signal-Regulated MAP Kinases, raf Kinases, Mice
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