Cited by 214Autophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex

Chan, Edmond Y.·2009·Science Signaling

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Abstract

High nutrient availability stimulates the mammalian target of rapamycin complex 1 (mTORC1) to coordinately activate anabolic processes, such as protein synthesis, while inhibiting the cellular catabolism of autophagy. Positive regulation of protein synthesis through the mTORC1 substrates p70 ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1) has been well characterized. The complementary inhibitory mechanism in which mTORC1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ULK1), the mammalian Atg13 protein, and focal adhesion kinase interacting protein of 200 kD (FIP200) has also been elucidated.

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Authors: Chan, E. Y.
Affiliations: University of Strathclyde (GB)
Corresponding author: Chan, Edmond Y.
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-08-18
Volume: 2
Issue: 84
Pages: pe51-pe51
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.284pe51
OpenAlex: W2165068125
Cited by: 214
References: 25
Citations by year: 2026: 4 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 15 · 2021: 8 · 2020: 16 · 2019: 10 · 2018: 14 · 2017: 13 · 2016: 16 · 2015: 21 · 2014: 15 · 2013: 16 · 2012: 16
FWCI: 10.72
Type: journal article
Language: en
Open access: closed
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mTORC1, ULK1, ATG13, FIP200, autophagy regulation, protein phosphorylation, nutrient signaling, p70S6K, 4E-BP1, anabolic-catabolic balance
MeSH terms: Autophagy-Related Proteins, Autophagy-Related Protein-1 Homolog, Mechanistic Target of Rapamycin Complex 1, Animals, Autophagy, Humans, Models, Biological, Phosphorylation, Protein-Tyrosine Kinases, Proteins, Transcription Factors, Signal Transduction, Protein Serine-Threonine Kinases, Multiprotein Complexes, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, TOR Serine-Threonine Kinases

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mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex

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