Cited by 1,062Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismUbiquitin and proteasome pathways

The role of the Atg1/ULK1 complex in autophagy regulation

Mizushima, Noboru·2010·Current Opinion in Cell Biology

Abstract

The Atg1/ULK complex plays an essential role in the initiation of autophagy: receiving signals of cellular nutrient status, recruiting downstream Atg proteins to the autophagosome formation site, and governing autophagosome formation. Recent studies of mammalian Atg1 homologs (ULK1 and ULK2) have identified several novel interacting proteins, FIP200, mAtg13, and Atg101. FIP200 and Atg101 are not conserved in Saccharomyces cerevisiae, despite the high conservation rates of other downstream Atg proteins between the yeast and mammals. Furthermore, through studies of the Atg1/ULK1 complex, the molecular mechanism by which (m)TORC1 regulates autophagy is now being clarified in detail.

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Crossref · 10.1016/j.ceb.2009.12.004

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Authors
Mizushima, N.
Affiliations
Tokyo Medical and Dental University (JP)
Corresponding author
Mizushima, Noboru
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2010-04
Volume
22
Issue
2
Pages
132-139
ISSN
0955-0674 (ISSN-L)
OpenAlex
W2065592028
Cited by
1,062
References
78
Citations by year
2026: 19 · 2025: 47 · 2024: 58 · 2023: 45 · 2022: 64 · 2021: 61 · 2020: 73 · 2019: 66 · 2018: 61 · 2017: 61 · 2016: 88 · 2015: 86 · 2014: 79 · 2013: 85 · 2012: 65
FWCI
9.22
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Takeda Science Foundation
  • Korea Toray Science Foundation
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
autophagy initiation, autophagosome formation, ULK1, ULK2, FIP200, ATG101, TORC1 signaling, nutrient sensing, autophagy regulation
MeSH terms
Animals, Autophagy, Neurons, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases

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