CHK1 as a therapeutic target to bypass chemoresistance in AML

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

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qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

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Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials

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ATR: an essential regulator of genome integrity

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Chk1 is an essential kinase that is regulated by Atr and required for the G ₂ /M DNA damage checkpoint

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Cdk1 is sufficient to drive the mammalian cell cycle

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Therapeutic Advances in Acute Myeloid Leukemia

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Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

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A competing risks analysis should report results on all cause-specific hazards and cumulative incidence functions

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Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

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High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics

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DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

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DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients

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A ‘DNA replication’ signature of progression and negative outcome in colorectal cancer

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Time from diagnosis to intensive chemotherapy initiation does not adversely impact the outcome of patients with acute myeloid leukemia

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Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias

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An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

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The human bladder carcinoma cell line 5637 constitutively secretes functional cytokines

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Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemiaPreprint

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ATR inhibition preferentially targets homologous recombination-deficient tumor cells

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Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy

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The fork and the kinase: A DNA replication tale from a CHK1 perspective

Besteiro, M. A. G., & Gottifredi, V. (2014) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2014.10.003 · Cited by 71 · see citing works

CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress

Sarmento, L. M., Póvoa, V., Nascimento, R., Real, G., Antunes, I., Martins, L. R., Moita, C. F., Alves, P. M., Abecasis, M., Moita, L. F., et al. (2014) · Oncogene · doi:10.1038/onc.2014.248 · Cited by 64 · see citing works

Targeting the kinase activities of ATR and ATM exhibits therapeutic potential in a mouse model of MLL-rearranged AML

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CDC25B Involvement in the Centrosome Duplication Cycle and in Microtubule Nucleation

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The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions

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Upregulation of Error-Prone DNA Polymerases Beta and Kappa Slows Down Fork Progression Without Activating the Replication Checkpoint

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BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML)

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Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience

LaRochelle, O., Bertoli, S., Vergez, F., et al. (2011) · Oncotarget · doi:10.18632/oncotarget.347 · Cited by 30 · see citing works

E4F1 Is a Master Regulator of CHK1-Mediated Functions

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The clinical relevance of BAALC and ERG expression levels in pediatric AML

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Cytarabine preferentially induces mutation at specific sequences in the genome which are identifiable in relapsed acute myeloid leukaemia

Fordham, S. E., Cole, M. F., Irving, J. A. E., et al. (2014) · Leukemia · doi:10.1038/leu.2014.284 · Cited by 10 · see citing works

Reconciling Theory and Practice Regarding P Values

Savitz, D. A. (2013) · Epidemiology · doi:10.1097/ede.0b013e31829f39d9 · Cited by 4 · see citing works

Untitled work

Harrell, F., Jr. (1996) · doi:10.1002/(sici)1097-0258(19960229)15:4

The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia

Rimmelé, P., Esposito, M., Delestré, L., Guervilly, J.-H., Ridinger-Saison, M., Despras, E., Moreau-Gachelin, F., Rosselli, F., & Guillouf, C. (2017) · Oncotarget · doi:10.18632/oncotarget.16183 · Cited by 11 · see citing works

Effect of cloretazine (VNP40101M) on acute myeloid leukaemia blast cells in vitro as a single agent and combined with cytarabine and daunorubicin

Morris, K. L., Adams, J. A., & Yin, J. A. L. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.01.025 · Cited by 6 · see citing works

Daunorubicin & Cytarabine Liposome (Vyxeos™)

Crain, M. L. (2018) · Oncology Times · doi:10.1097/01.cot.0000534146.30839.ec · Cited by 17 · see citing works

A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia

Lancet, J. E., Baer, M. R., Durán, G. E., et al. (2008) · Leukemia Research · doi:10.1016/j.leukres.2008.09.015 · Cited by 52 · see citing works

DNA damage checkpoint maintenance through sustained Chk1 activity

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Pharmacokinetics, drug metabolism, and tissue distribution of CPX-351 in animals

Wang, Q., Tardi, P. G., Sadowski, N., Xie, S., Heller, D., & Mayer, L. D. (2020) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2020.102275 · Cited by 32 · see citing works