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CD45 functions as a signaling gatekeeper in T cells
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CD45 promotes strong but suppresses weak antigen-induced T cell receptor activation.
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CD45 is expressed in microglia, albeit not to the extent of its expression in T-cells, where it is one of the most abundant proteins in the plasma membrane.
“It is known to be expressed in microglia [67], albeit not to the extent of its expression in T-cells, where it is one of the most abundant proteins in the plasma membrane (PM) [68].”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [68]
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Digital signaling and hysteresis characterize Ras activation in lymphoid cells.
Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A. K., & Roose, J. P. (2009) · Cell · doi:10.1016/j.cell.2008.11.051 · Cited by 398 · cited 1×
“We previously reported that Ras/SOS/ERK pathway behavior in T cells can be recapitulated computationally (41).”
BackgroundSelf-citationThe cytotoxic T cell proteome and its shaping by the kinase mTOR
Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Murillo, A. B., Hawkins, P. T., Stephens, L. R., Lamond, A. I., & Cantrell, D. A. (2016) · Nature Immunology · doi:10.1038/ni.3314 · Cited by 249
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Research works printed but not linked: 66
- 10.1038/357161a0 · DOI
- 10.1016/0092-8674(92)90428-F · DOI
- 10.1016/j.tibs.2017.11.008 · DOI
- 10.1146/annurev.immunol.021908.132706 · DOI · Paper page
- 10.1038/s41577-018-0020-8 · DOI
- 10.1038/385602a0 · DOI
- 10.1038/385595a0 · DOI
- 10.1073/pnas.86.16.6302 · DOI
- 10.1073/pnas.86.22.8959 · DOI
- 10.1002/j.1460-2075.1993.tb05659.x · DOI
- 10.1038/384484a0 · DOI
- 10.1002/j.1460-2075.1992.tb05361.x · DOI
- 10.1016/j.cell.2008.05.051 · DOI
- 10.1016/0092-8674(93)90302-7 · DOI
- 10.1016/0092-8674(89)90504-7 · DOI
- 10.1038/346066a0 · DOI
- 10.1016/0092-8674(93)90642-4 · DOI
- 10.1038/29802 · DOI
- 10.1016/j.immuni.2010.05.011 · DOI
- 10.1126/scisignal.2003607 · DOI
- 10.7554/eLife.08088 · DOI
- 10.4049/jimmunol.1600178 · DOI
- 10.1038/nsmb.2762 · DOI
- 10.1073/pnas.91.23.10928 · DOI
- 10.1006/smim.2000.0203 · DOI
- 10.1146/annurev.immunol.19.1.375 · DOI
- 10.1038/ni.3392 · DOI
- 10.1038/nature03843 · DOI
- 10.1016/j.immuni.2010.03.006 · DOI
- 10.1016/j.cell.2014.08.042 · DOI
- 10.1126/scisignal.2001893 · DOI
- 10.1038/ni.2772 · DOI
- 10.1016/0092-8674(94)90169-4 · DOI
- 10.1038/nature05269 · DOI
- 10.1084/jem.20110308 · DOI
- 10.7554/eLife.35074 · DOI
- 10.1126/science.1231143 · DOI · Paper page
- 10.1126/science.1225829 · DOI · Paper page
- 10.1016/j.immuni.2007.07.015 · DOI
- 10.1038/s41590-018-0131-1 · DOI
- 10.1038/nature07657 · DOI
- 10.1038/nature08944 · DOI
- 10.1016/j.cell.2018.06.017 · DOI
- 10.1074/jbc.M109.052712 · DOI
- 10.1016/j.it.2018.05.005 · DOI
- 10.1016/j.cell.2014.02.053 · DOI
- 10.1038/s41590-018-0259-z · DOI
- 10.1073/pnas.92.11.5042 · DOI
- 10.1038/nri3728 · DOI
- 10.1128/MCB.00168-06 · DOI
- 10.1083/jcb.125.3.639 · DOI
- 10.1034/j.1600-065X.2003.00015.x · DOI
- 10.1016/j.coi.2013.04.001 · DOI
- 10.1038/ni.2958 · DOI
- 10.1016/j.coi.2004.03.001 · DOI
- 10.1038/365156a0 · DOI
- 10.1016/j.molcel.2017.06.024 · DOI
- 10.1126/scisignal.2005596 · DOI
- 10.3389/fimmu.2016.00076 · DOI
- 10.4049/jimmunol.1303187 · DOI
- 10.1038/ni.2710 · DOI
- 10.3389/fimmu.2018.00713 · DOI
- 10.1016/j.immuni.2008.06.014 · DOI
- 10.1038/ni1272 · DOI
- 10.1038/nature11311 · DOI
- 10.4049/jimmunol.1601453 · DOI
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Magno, L., Bunney, T. D., Mead, E., Svensson, F., & Bictash, M. N. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00436-5 · Cited by 64
Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy
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Metadata
- Authors
- Courtney, A. H., Shvets, A. A., Lu, W., Griffante, G., Mollenauer, M., Horkova, V., Lo, W.-L., Yu, S., Stepanek, O., Chakraborty, A. K., & Weiss, A.
- Affiliations
- University of California, San Francisco (US)
- Massachusetts Institute of Technology (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Howard Hughes Medical Institute (US)
- Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague 4, Czech Republic.
- Ragon Institute of MGH, MIT and Harvard (US)
- Corresponding author
- Courtney, Adam H.
- Weiss, Arthur
- ORCID
- Venue
- Science Signaling
- Published
- 2019-10-22
- Volume
- 12
- Issue
- 604
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC6948007
- OpenAlex
- W2981470547
- Cited by
- 161
- References
- 2
- Citations by year
- 2026: 28 · 2025: 32 · 2024: 23 · 2023: 24 · 2022: 23 · 2021: 21 · 2020: 10
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health (P01 AI091580)
- Howard Hughes Medical Institute
- Cancer Research Institute
- Czech Science Foundation (16-09208Y)
- German research Foundation (GRK1660)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- CD45, T cell receptor signaling, Lck, Csk, protein tyrosine phosphatase, negative regulation of T cell activation, antigen discrimination, graded signaling
- MeSH terms
- CSK Tyrosine-Protein Kinase, Animals, Humans, Mice, Transgenic, Receptors, Antigen, T-Cell, T-Lymphocytes, Signal Transduction, Leukocyte Common Antigens, Jurkat Cells, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Mice
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