Chakraborty, Arup K.

Coactivator condensation at super-enhancers links phase separation and gene control

Sabari, B. R., Dall’Agnese, A., Boija, A., Klein, I. A., Coffey, E. L., Shrinivas, K., Abraham, B. J., Hannett, N. M., Zamudio, A. V., Manteiga, J. C., et al. (2018) · Science

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 2,595

A Phase Separation Model for Transcriptional Control

Hnisz, D., Shrinivas, K., Young, R. A., Chakraborty, A. K., & Sharp, P. A. (2017) · Cell

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 1,753

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

Tam, H. H., Melo, M. B., Kang, M., Pelet, J. M., Ruda, V. M., Foley, M. H., Hu, J. K., Kumari, S., Crampton, J., Baldeon, A. D., et al. (2016) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentImmunotherapy and Immune Responses

Cited by 425

Digital signaling and hysteresis characterize Ras activation in lymphoid cells.

Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A. K., & Roose, J. P. (2009) · Cell

Protein Kinase Regulation and GTPase SignalingGene Regulatory Network Analysis

Cited by 398

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

Artyomov, M. N., Lis, M., Devadas, S., Davis, M. M., & Chakraborty, A. K. (2010) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyImmune Response and Inflammation

Cited by 207

CD45 functions as a signaling gatekeeper in T cells

Courtney, A. H., Shvets, A. A., Lu, W., Griffante, G., Mollenauer, M., Horkova, V., Lo, W.-L., Yu, S., Stepanek, O., Chakraborty, A. K., et al. (2019) · Science Signaling

Protein Tyrosine PhosphatasesT-cell and B-cell Immunology

Cited by 161

Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

Iversen, L., Tu, H.-L., Lin, W.-C., Christensen, S. M., Abel, S. M., Iwig, J., Wu, H.-J., Gureasko, J., Rhodes, C., Petit, R. S., et al. (2014) · Science

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 154

Deconstruction of the Ras switching cycle through saturation mutagenesis

Bandaru, P., Shah, N. H., Bhattacharyya, M., Barton, J. P., Kondo, Y., Cofsky, J. C., Gee, C. L., Chakraborty, A. K., Kortemme, T., Ranganathan, R., et al. (2017) · eLife

Protein Kinase Regulation and GTPase SignalingEvolution and Genetic Dynamics

Cited by 117

Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities.

Artyomov, M. N., Das, J., Kardar, M., & Chakraborty, A. K. (2007) · Proceedings of the National Academy of Sciences

Gene Regulatory Network Analysisstochastic dynamics and bifurcation

Cited by 110

A Model for How Signal Duration Can Determine Distinct Outcomes of Gene Transcription Programs

Fowler, K. D., Kuchroo, V. K., & Chakraborty, A. K. (2012) · PLoS ONE

Cytokine Signaling Pathways and InteractionsGene Regulatory Network Analysis

Cited by 6