The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids
Open accessAbstract
In mice, ω-3 fatty acids in the diet are converted by 5-lipoxygenase to a metabolite that inhibits destructive vessel growth similar to diabetic retinopathy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
The Opposing Effects of N-3 and n-6 Fatty Acids
Schmitz, G., & Ecker, J. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.12.004 · Cited by 1,245
Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189
Self-citationHong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000
Self-citationLeesnitzer, L. M., Parks, D. J., Bledsoe, R. K., Cobb, J. E., Collins, J. L., Consler, T. G., Davis, R. G., Hull-Ryde, E. A., Lenhard, J. M., Patel, L., et al. (2002) · Biochemistry · doi:10.1021/bi0159581 · Cited by 566
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
Sapieha, P., Sirinyan, M., Hamel, D., Zaniolo, K., Joyal, J.-S., Cho, J.-H., Honoré, J.-C., Kermorvant-Duchemin, E., Varma, D. R., Tremblay, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1873 · Cited by 359
Self-citation(2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.5.671 · Cited by 283
Bazan, N. G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800068-jlr200 · Cited by 256
Cited by
Lam, S. M., Tong, L., Duan, X., Petznick, A., Wenk, M. R., & Shui, G. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m044826 · Cited by 310
Fish oil — How does it reduce plasma triglycerides?
Shearer, G. C., Savinova, O. V., & Harris, W. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.011 · Cited by 285
Oral Docosahexaenoic Acid in the Prevention of Exudative Age-Related Macular Degeneration
Souied, E. H., Delcourt, C., Querques, G., Bassols, A., Merle, B., Zourdani, A., Smith, T., & Benlian, P. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2013.01.005 · Cited by 157
Unlocking the health potential of microalgae as sustainable sources of bioactive compounds
Saide, A., Martínez, K. A., Ianora, A., & Lauritano, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094383 · Cited by 105
Fu, Z., Lofqvist, C. A., Shao, Z., Sun, Y., Joyal, J.-S., Hurst, C. G., Cui, R. Z., Evans, L. P., Tian, K., SanGiovanni, J. P., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.099291 · Cited by 76
Self-citation
Metadata
- Authors
- Sapieha, P., Stahl, A., Chen, J., Seaward, M. R., Willett, K. L., Krah, N. M., Dennison, R. J., Connor, K. M., Aderman, C. M., Liclican, E., Carughi, A., Perelman, D., Kanaoka, Y., SanGiovanni, J. P., Gronert, K., & Smith, L. E. H.
- Venue
- Science Translational Medicine
- Published
- 2011-02-09
- Volume
- 3
- Issue
- 69
- Pages
- 69ra12-69ra12
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2032147202
- Cited by
- 252
- References
- 10
- FWCI
- 18.85
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: 5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids. https://app.cochat.ai/papers/10.1126/scitranslmed.3001571
- The paper
- Sapieha, P., Stahl, A., Chen, J., Seaward, M. R., Willett, K. L., Krah, N. M., Dennison, R. J., Connor, K. M., Aderman, C. M., Liclican, E., Carughi, A., Perelman, D., Kanaoka, Y., SanGiovanni, J. P., Gronert, K., & Smith, L. E. H. (2011). 5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.3001571
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.