Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association

Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149

Cardiac excitation–contraction coupling

Bers, D., & Despa, S. (2002) · Nature · doi:10.1038/415198a · Cited by 4,927

The epidemiology of heart failure: The Framingham Study

Ho, K. K. L., Pinsky, J. L., Kannel, W. B., & Levy, D. A. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90455-a · Cited by 2,246

Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients

Flather, M. D., Yusuf, S., Køber, L., Pfeffer, M. A., Hall, A. S., Murray, G. D., Torp-Pedersen, C. T., Ball, S. G., Pogue, J. M., Moyé, L. A., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02212-1 · Cited by 1,585

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

Gwathmey, J. K., Copelas, L., MacKinnon, R., Schöen, F. J., Feldman, M. D., Grossman, W., & Morgan, J. P. (1987) · Circulation Research · doi:10.1161/01.res.61.1.70 · Cited by 924

Energy metabolism in heart failure

Ventura‐Clapier, R., Garnier, A., & Veksler, V. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.055095 · Cited by 514

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

Haghighi, K., Kolokathis, F., Pater, L., Lynch, R. A., Asahi, M., Gramolini, A. O., Fan, G.-C., Tsiapras, D., Hahn, H. S., Adamopoulos, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17892 · Cited by 478

Effects of Long-term Enalapril Therapy on Cardiac Structure and Function in Patients With Left Ventricular Dysfunction

Greenberg, B., Quiñones, M. A., Koilpillai, C. J., Limacher, M. C., Shindler, D. M., Benedict, C. R., & Shelton, B. J. (1995) · Circulation · doi:10.1161/01.cir.91.10.2573 · Cited by 473

Systolic Heart Failure

McMurray, J. J. V. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp0909392 · Cited by 464

Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors

Müller, O. J., Kaul, F., Weitzman, M. D., Pasqualini, R., Arap, W., Kleinschmidt, J. A., & Trepel, M. (2003) · Nature Biotechnology · doi:10.1038/nbt856 · Cited by 411

Prospects for gene transfer for clinical heart failure

Tang, T., Gao, M., & Hammond, H. (2012) · Gene Therapy · doi:10.1038/gt.2012.36 · Cited by 26

Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function

Nagai, T., & Komuro, I. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00130.2012 · Cited by 23

Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression

Moulay, G., Ohtani, T., Ogut, O., Guenzel, A. J., Behfar, A., Zakeri, R., Haines, P. G., Storlie, J. R., Bowen, L. A., Pham, L., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.78 · Cited by 23

Cardiac Remodelling in the Era of the Recommended Four Pillars Heart Failure Medical Therapy

Colombo, G., Biering‐Sørensen, T., Ferreira, J. P., Lombardi, C., Bonelli, A., Garascia, A., Metra, M., & Inciardi, R. M. (2024) · ESC Heart Failure · doi:10.1002/ehf2.15095 · Cited by 24

Gene targeting in ischemic heart disease and failure: Translational and clinical studies

Eckhouse, S. R., Jones, J. A., & Spinale, F. G. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.018 · Cited by 22

Cardiomyocytes, Endothelial Cells and Cardiac Fibroblasts: S100A1’s Triple Action in Cardiovascular Pathophysiology

Rohde, D., Busch, M., Volkert, A., Ritterhoff, J., Katus, H. A., Peppel, K., & Most, P. (2015) · Future Cardiology · doi:10.2217/fca.15.18 · Cited by 22

Absence of the calcium-binding protein, S100A1, confers pulmonary hypertension in mice associated with endothelial dysfunction and apoptosis

Teichert-Kuliszewska, K., Tsoporis, J. N., Desjardins, J., Yin, J., Wang, L., Kuebler, W. M., & Parker, T. G. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu241 · Cited by 22

Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution

Yang, L., & Xiao, X. (2013) · Virology Journal · doi:10.1186/1743-422x-10-50 · Cited by 22

Updated and enhanced pig cardiac transcriptome based on long-read RNA sequencing and proteomics

Müller, T., Boileau, E., Talyan, S., Kehr, D., Varadi, K., Busch, M., Most, P., Krijgsveld, J., & Dieterich, C. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.10.005 · Cited by 21

PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper

Kavita, U., Sun, K., Braun, M., Lembke, W., Mody, H. R., Kamerud, J., Yang, T., Braun, I. V., Fang, X., Gao, W., et al. (2023) · The AAPS Journal · doi:10.1208/s12248-023-00842-1 · Cited by 22

Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

Eden, M., Meder, B., Völkers, M., Poomvanicha, M., Domes, K., Branchereau, M., Marck, P., Will, R., Bernt, A., Rangrez, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11835 · Cited by 7

The Use of Gene Therapy for Ablation of Atrial Fibrillation

Liu, Z., & Donahue, J. K. (2014) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2014.3.3.139 · Cited by 20

Cardiac Gene Therapy

Chaanine, A. H., Kalman, J., & Hajjar, R. J. (2010) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2010.09.009 · Cited by 19

Pathophysiology of Calcium Mediated Ventricular Arrhythmias and Novel Therapeutic Options with Focus on Gene Therapy

Paar, V., Jirak, P., Larbig, R. K., Zagidullin, N. S., Brandt, M. C., Lichtenauer, M., Hoppe, U. C., & Motloch, L. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215304 · Cited by 17

Distribution of cardiomyocyte-selective adeno-associated virus serotype 9 vectors in swine following intracoronary and intravenous infusion

Li, J., Kelly, S. C., Ivey, J. R., Thorne, P. K., Yamada, K. P., Aikawa, T., Mazurek, R., Turk, J. R., Silva, K. A. S., Amin, A. R., et al. (2022) · Physiological Genomics · doi:10.1152/physiolgenomics.00032.2022 · Cited by 19

Bioactive Nanoparticles Improve Calcium Handling in Failing Cardiac Myocytes

Maxwell, J. T., Somasuntharam, I., Gray, W. D., Shen, M., Singer, J., Wang, B., Saafir, T. B., Crawford, B. H., Jiang, R., Murthy, N., et al. (2015) · Nanomedicine · doi:10.2217/nnm.15.126 · Cited by 18

S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction

Ritterhoff, J., Völkers, M., Seitz, A., Spaich, K., Gao, E., Peppel, K., Pleger, S. T., Zimmermann, W., Friedrich, O., Fink, R., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.93 · Cited by 18

Potential targets of gene therapy in the treatment of heart failure

Rosik, J., Szostak, B., Machaj, F., & Pawlik, A. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1514012 · Cited by 18

A Calsequestrin Cis-Regulatory Motif Coupled to a Cardiac Troponin T Promoter Improves Cardiac Adeno-Associated Virus Serotype 9 Transduction Specificity

Chamberlain, K., Riyad, J. M., Garnett, T., Kohlbrenner, E., Mookerjee, A., Elmastour, F., Bénard, L., Chen, J., VandenDriessche, T., Chuah, M., et al. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.188 · Cited by 17

Gene therapy for atrial fibrillation - How close to clinical implementation?

Trivedi, A. D., Hoffman, J. A., & Arora, R. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.07.057 · Cited by 17

Acetylation of SERCA2a, Another Target for Heart Failure Treatment?

Chen, X., Zhang, X., Gross, S., Houser, S. R., & Soboloff, J. (2019) · Circulation Research · doi:10.1161/circresaha.119.315017 · Cited by 17

Liquid jet delivery method featuring S100A1 gene therapy in the rodent model following acute myocardial infarction

Fargnoli, A. S., Katz, M. G., Williams, R. D., Kendle, A. P., Steuerwald, N., & Bridges, C. R. (2015) · Gene Therapy · doi:10.1038/gt.2015.100 · Cited by 16

Beta-3 adrenergic receptor overexpression reverses aortic stenosis–induced heart failure and restores balanced mitochondrial dynamics

Pun-García, A., Clemente‐Moragón, A., Villena-Gutiérrez, R., Gómez, M., Sanz‐Rosa, D., Díaz-Guerra, A., Prados, B., Medina, J. P., Montó, F., Ivorra, M. D., et al. (2022) · Basic Research in Cardiology · doi:10.1007/s00395-022-00966-z · Cited by 15

Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Prakoso, D., Tate, M., Blasio, M. J. D., & Ritchie, R. H. (2021) · Clinical Science · doi:10.1042/cs20210052 · Cited by 15

Structural insights into the regulation of RyR1 by S100A1

Weninger, G., Miotto, M., Tchagou, C., Reiken, S. R., Dridi, H., Brandenburg, S., Riedemann, G. C., Yuan, Q., Liu, Y., Chang, A., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400497121 · Cited by 14

CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice

Lerchenmüller, C., Hastings, M. H., Rabolli, C. P., Betge, F., Roshan, M., Liu, L. X., Liu, X., Hess, C., Roh, J. D., Platt, C., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.07.018 · Cited by 14

Myocardial Regeneration for Humans ― Modifying Biology and Manipulating Evolution ―

Broughton, K. M., & Sussman, M. A. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-1228 · Cited by 14

Emerging molecular therapies targeting myocardial infarction-related arrhythmias

Driessen, H. E., van Veen, T. A. B., & Boink, G. J. J. (2016) · EP Europace · doi:10.1093/europace/euw198 · Cited by 14

Gene therapy for heart failure: A novel treatment for the age old disease.

Vora, N., Patel, P., Gajjar, A., Ladani, P., Konat, A., Bhanderi, D., Gadam, S., Prajjwal, P., Sharma, K., & Arunachalam, S. P. (2023) · Disease-a-month : DM · doi:10.1016/j.disamonth.2023.101636 · Cited by 12

S100A1ct: A Synthetic Peptide Derived From S100A1 Protein Improves Cardiac Performance and Survival in Preclinical Heart Failure Models

Kehr, D., Ritterhoff, J., Glaser, M., Jarosch, L., Salazar, R. E., Spaich, K., Varadi, K., Birkenstock, J., Egger, M., Gao, E., et al. (2024) · Circulation · doi:10.1161/circulationaha.123.066961 · Cited by 12

Model‐specific selection of molecular targets for heart failure gene therapy

Katz, M. G., Fargnoli, A. S., Tomasulo, C. E., Pritchette, L. A., & Bridges, C. R. (2011) · The Journal of Gene Medicine · doi:10.1002/jgm.1610 · Cited by 11

Comprehensive cardiac phenotyping in large animals: comparison of pressure–volume analysis and cardiac magnetic resonance imaging in pig post-myocardial infarction systolic heart failure

Raake, P. W. J., Barthelmes, J., Krautz, B., Buss, S. J., Huditz, R., Schlegel, P., Weber, C., Stangassinger, M., Haberkorn, U., Katus, H. A., et al. (2019) · International journal of cardiac imaging · doi:10.1007/s10554-019-01610-z · Cited by 9

Locally Targeted Cardiac Gene Delivery by AAV Microbubble Destruction in a Large Animal Model

Schlegel, P., Huditz, R., Meinhardt, E., Rapti, K., Geis, N. A., Most, P., Katus, H. A., Müller, O. J., Bekeredjian, R., & Raake, P. W. J. (2016) · Human Gene Therapy Methods · doi:10.1089/hgtb.2015.120 · Cited by 11

Enhanced Cardiac S100A1 Expression Improves Recovery from Global Ischemia-Reperfusion Injury

Jungi, S., Fu, X., Segiser, A., Busch, M., Most, P., Fiedler, M., Carrel, T. P., Stahel, H. T. T., Longnus, S., & Most, H. (2018) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-018-9788-y · Cited by 11

Advancements in gene therapy approaches for atrial fibrillation: Targeted delivery, mechanistic insights and future prospects

Khawajakhail, R., Khan, R. U., Gondal, M. U. R., Toru, H. K., Malik, M., Iqbal, A., Malik, J., Faraz, M., & Awais, M. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102431 · Cited by 10

Promise of adeno-associated virus as a gene therapy vector for cardiovascular diseases

Bera, A., & Sen, D. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9622-7 · Cited by 11

Intracavernosal Adeno-Associated Virus-Mediated S100A1 Gene Transfer Enhances Erectile Function in Diabetic Rats by Promoting Cavernous Angiogenesis via VEGF-A/VEGFR2 Signaling

Yu, Z., Zhang, Y., Tang, Z., Song, J., Gao, X., Sun, T., Liu, Y., Yang, J., Wang, T., & Liu, J. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.06.011 · Cited by 10

Elevated serum levels of S100A1 and zinc α2-glycoprotein in patients with heart failure

Soltani, L., Kheirouri, S., & Enamzadeh, E. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.07.029 · Cited by 10

Gene transfer for congestive heart failure: update 2013

Tang, T., & Hammond, H. K. (2012) · Translational research · doi:10.1016/j.trsl.2012.11.004 · Cited by 9

Cardiac regenerative medicine: At the crossroad of microRNA function and biotechnology

Raso, A., & Dirkx, E. (2017) · Non-coding RNA Research · doi:10.1016/j.ncrna.2017.03.001 · Cited by 9

Basic and Clinical Application of Adeno-Associated Virus–Mediated Genome Editing

He, X., Xie, H., Liu, X., & Gu, F. (2018) · Human Gene Therapy · doi:10.1089/hum.2018.190 · Cited by 7

S100A1 Gene Therapy in Small and Large Animals

Most, P., Raake, P. W. J., Weber, C., Katus, H. A., & Pleger, S. T. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-230-8_25 · Cited by 9

Translational Aspects of Adeno-Associated Virus–Mediated Cardiac Gene Therapy

Ziegler, T., Ishikawa, K., Hinkel, R., & Kupatt, C. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.229 · Cited by 9

Analysis of recombinant adeno-associated viral vector shedding in sheep following intracoronary delivery

Farraha, M., Barry, M. A., Lu, J., Pouliopoulos, J., Le, T. Y. L., Igoor, S., Rao, R., Kok, C., Chong, J. J. H., & Kizana, E. (2019) · Gene Therapy · doi:10.1038/s41434-019-0097-0 · Cited by 8

Identification of novel drug targets for the treatment of heart failure

Moilanen, A. (2012) · Cited by 8

A Titratable Two-Step Transcriptional Amplification Strategy for Targeted Gene Therapy Based on Ligand-Induced Intramolecular Folding of a Mutant Human Estrogen Receptor

Chen, I. Y., Paulmurugan, R., Nielsen, C. H., Wang, D. S., Chow, V. W. K., Robbins, R. C., & Gambhir, S. S. (2013) · Molecular Imaging and Biology · doi:10.1007/s11307-013-0673-4 · Cited by 8

LCZ696 Ameliorates Tachycardia-Induced Cardiac Calcium Dyshomeostasis in the SERCA2α-Dependent Pathway

Liu, L., Sun, S.-J., Yang, Z., Zhu, S., & Zou, C. (2023) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2023.j043 · Cited by 8

Gene therapy for heart disease: molecular targets, vectors and modes of delivery to myocardium

Scimia, M. C., Cannavò, A., & Koch, W. J. (2013) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2013.818813 · Cited by 8

S100A1 transgenic treatment of acute heart failure causes proteomic changes in rats

Guo, Y., Cui, L., Jiang, S.-L., Wang, D., Jiang, S., Xie, C., & Jia, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5440 · Cited by 8

AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration

Wang, J., Jonker, T., Cervera-Barea, A., Dong, Z., Visser, R. N., Birza, E. E., Boender, A., Klerk, M., Yang, Y., Visser, J., et al. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101532 · Cited by 8

Evaluation of AAV vectors with tissue-specific or ubiquitous promoters in a mouse model of mucopolysaccharidosis type IVA

Khan, S. A., Álvarez, J. V., Nidhi, F., Benincore-Flórez, E., & Tomatsu, S. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101447 · Cited by 7

Determination of Anti-Adeno-Associated Viral Vector Neutralizing Antibodies in Patients With Heart Failure in the Cardiovascular Foundation of Colombia (ANVIAS): Study Protocol

Rincón, M. Y., Prada, C. E., López, M., Castillo, V., Echeverría, L. E., & Serrano, N. C. (2016) · JMIR Research Protocols · doi:10.2196/resprot.5535 · Cited by 7

Recent advances in gene therapy for atrial fibrillation

Yoo, S., Geist, G. E., Pfenniger, A., Rottmann, M., & Arora, R. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15116 · Cited by 8

AAV-mediated gene therapy for heart failure: enhancing contractility and calcium handling

Zouein, F. A., & Booz, G. W. (2013) · F1000Prime Reports · doi:10.12703/p5-27 · Cited by 7

Status of Therapeutic Gene Transfer to Treat Cardiovascular Disease in Dogs and Cats

Sleeper, M. M. (2017) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2017.04.005 · Cited by 7

Adeno-associated virus vectors for human gene therapy

Chen, H. (2015) · World Journal of Medical Genetics · doi:10.5496/wjmg.v5.i3.28 · Cited by 8

Fusion expression of the two soluble viral receptors of porcine reproductive and respiratory syndrome virus with a single adeno-associated virus vector

Liu, X., Xia, W., Zhang, X., Xia, X., & Sun, H. (2021) · Research in Veterinary Science · doi:10.1016/j.rvsc.2020.12.026 · Cited by 7

Beta Adrenergic Receptors

Makaritsis, K. P., & Triposkiadis, F. K. (2014) · Springer eBooks · doi:10.1007/978-3-319-08798-6_5 · Cited by 7

Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease

Hinkel, R., & Kupatt, C. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6588-5_18 · Cited by 7

Advances and Challenges in Adeno-Associated Virus Gene Therapy Applications of Localized Delivery Strategies

Chen, J.-H., Zhan, L.-J., Lv, C.-M., Teng, J.-B., & Cao, C. (2025) · Current Medical Science · doi:10.1007/s11596-025-00084-6 · Cited by 7

Nrf2 de-SUMOylation alleviates myocardial ischemia-reperfusion injury (MIRI) by attenuating myocardial ferroptosis in mice

Shi, Q., Yao, W., Zhang, W., Xu, J., Wang, X., Wei, X., Hu, S., Fan, Q., Yang, H., Wu, X., et al. (2026) · Redox Report · doi:10.1080/13510002.2026.2624946 · Cited by 6

Gene Therapy “Made in Germany”: A Historical Perspective, Analysis of the Status Quo, and Recommendations for Action by the German Society for Gene Therapy

Büning, H., Fehse, B., Ivics, Z., Kochanek, S., Koehl, U., Kupatt, C., Mussolino, C., Nettelbeck, D. M., Schambach, A., Uckert, W., et al. (2021) · Human Gene Therapy · doi:10.1089/hum.2021.29178.hbu · Cited by 6

SERCA2a: its role in the development of heart failure and as a potential therapeutic target

Zarain‐Herzberg, Á., & Fragoso-Medina, J. A. (2014) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s38614 · Cited by 6

The new biology: a bridge to clinical cardiology.

Louridas, G. L. G., & Lourida, K. G. (2012) · Europe PMC (PubMed Central) · Cited by 6

Gene Therapy for the Treatment of Cardiac Arrhythmias: Current and Emerging Applications

Trivedi, A. D., & Arora, R. (2018) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2018.091204 · Cited by 6

AAV viral vectors as therapeutic interventions for inherited or non-inherited cardiac disorders: current aspects and future prospects

Kumar, V., Kalishwaralal, K., Chauhan, C., Singh, G., Barnwal, R. P., & Sharma, S. K. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1678325 · Cited by 6

LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy

Sleczka, B. G., Lévesque, P., Adam, L. P., Olah, T. V., & Shipkova, P. A. (2020) · Analytical Biochemistry · doi:10.1016/j.ab.2020.113766 · Cited by 5

Gene Therapy in Heart Failure

Fargnoli, A. S., Katz, M. G., Bridges, C. R., & Hajjar, R. J. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_81 · Cited by 6

S100A1: a promising therapeutic target for heart failure

Noll, D., Kehr, D., Most, P., & Ritterhoff, J. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2345746 · Cited by 5

Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors

Rapti, K., Hajjar, R. J., & Weber, T. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-891-7_12 · Cited by 4

Novel Strategies for the Treatment of Heart Failure

Kehat, I. (2012) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10078 · Cited by 4

Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to the injured heart

Brun, M. J., Song, K., Kang, B., Lueck, C., Chen, W., Thatcher, K., Gao, E., Koch, W. J., Lincoln, J., Rajan, S., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.058 · Cited by 4

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI

Baritello, O., Sündermann, S., Espinosa-Garnica, K., Kempfert, J., Jähnert, M., Beetz, N. L., Geisel, D., Gaugel, J., Rominger, J., Müller‐Werdan, U., et al. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13846 · Cited by 3

Cardiac-Targeted AAV5-S100A1 Gene Therapy Protects Against Adverse Remodeling and Contractile Dysfunction in Postischemic Hearts

Kehr, D., Salatzki, J., Seger, B., Varadi, K., Birkenstock, J., Schlegel, P., Gao, E., Koch, W. J., Riffel, J., André, F., et al. (2025) · Circulation Heart Failure · doi:10.1161/circheartfailure.124.012479 · Cited by 5

Cardiomyopathies associated with the DES gene mutations: molecular pathogenesis and gene therapy approaches

Kochergin-Nikitsky, K. S., Zaklyazminskaya, E. V., Лавров, А. В., & Smirnikhina, S. (2019) · Almanac of Clinical Medicine · doi:10.18786/2072-0505-2019-47-025 · Cited by 3

Cardiac Gene Therapy

Hajjar, R. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00046-6 · Cited by 3

Gene and protein-based therapies for improving cardiac performance and regeneration

Katz, M. G., Gubara, S. M., Bridges, C. R., Hajjar, R. J., & Fargnoli, A. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813706-2.00016-6 · Cited by 3

Therapeutic Potential of Heme Oxygenase 1 in Ischemia Reperfusion Injury

Bozoglu, T. M., & Hinkel, R. (2016) · Journal of Transplantation Technologies & Research · doi:10.4172/2161-0991.1000162 · Cited by 3

Gene Transfer in Cardiomyocytes Derived from ES and iPS Cells

Stillitano, F., Karakikes, I., & Hajjar, R. J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6588-5_12 · Cited by 3

Design and Production of Heart Chamber-Specific AAV9 Vectors

Bilal, A. S., Thuerauf, D. J., Blackwood, E. A., & Glembotski, C. C. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2707-5_8 · Cited by 3

Gene Transfer for Clinical Congestive Heart Failure

Tang, T., & Hammond, H. K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800563-7.00014-2 · Cited by 3

Cardiac gene therapy makes a comeback

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Chen, C., Seeger, T., Termglinchan, V., & Karakikes, I. (2017) · Continuing Cardiology Education · doi:10.1002/cce2.68 · Cited by 2

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López, A. E., Bauzá, M. D. R., Cuniberti, L. A., Crottogini, A., Olea, F. D., & Locatelli, P. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001072 · Cited by 2

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Lyu, D., Yan, H., Chen, L., Zhang, L., Du, Y., Ding, L., & Lu, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.593955 · Cited by 2

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Weber, T., Zangi, L., & Hajjar, R. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801888-0.00029-1 · Cited by 1

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Kehr, D., Salatzki, J., Seger, B., Varadi, K., Birkenstock, J., Schlegel, P., Gao, E., Koch, W. J., Riffel, J., André, F., et al. (2025) · Circulation Heart Failure · doi:10.1161/circheartfailure.124.012479 · Cited by 5