The DOI matches its Crossref record; 223 of the 225 references it cites were found in a registry or an index.
Alzheimer’s Disease: The Challenge of the Second Century
Open accessAbstract
In the first of our State of the Art Review series, David M. Holtzman, John C. Morris, and Alison M. Goate explore the rapid pace of Alzheimer’s disease research and the challenges to translating research breakthroughs into clinical treatments.
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“Growing evidence suggests that AD pathology, such as cerebral Aβ accumulation, probably begins one to two decades before onset of clinical symptoms (Holtzman et al. 2011, Perrin et al. 2009).”
From miR‐186 is decreased in aged brain and suppresses BACE 1 expression (2016) · cites this paper as Holtzman et al. 2011
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Items 201–223 of 223
Davis, J. A., Naruse, S., Chen, H., Eckman, C., Younkin, S. G., Price, D. L., Borchelt, D., Sisodia, S. S., & Wong, P. C. (1998) · Neuron · doi:10.1016/s0896-6273(00)80998-8 · Cited by 131
Treatment Options in Alzheimer’s Disease: Maximizing Benefit, Managing Expectations
Farlow, M. R., Miller, M. L., & Pejović, V. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000122962 · Cited by 131
Cruchaga, C., Kauwe, J. S. K., Mayo, K., Spiegel, N., Bertelsen, S., Nowotny, P., Shah, A. R., Abraham, R., Hollingworth, P., Harold, D., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001101 · Cited by 128
Self-citationNotch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice
Liu, Z., Turkoz, A., Jackson, E. N., Corbo, J. C., Engelbach, J. A., Garbow, J. R., Piwnica-Worms, D. R., & Kopan, R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43114 · Cited by 119
Young‐Pearse, T. L., Suth, S., Luth, E. S., Sawa, A., & Selkoe, D. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1445-10.2010 · Cited by 104
Areosa, S. A., Sherriff, F., & McShane, R. H. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003154.pub3 · Cited by 103
What the halted phase III γ‐secretase inhibitor trial may (or may not) be telling us
Schor, N. F. (2011) · Annals of Neurology · doi:10.1002/ana.22365 · Cited by 101
Degradation of Amyloid β-Protein by a Serine Protease-α2-Macroglobulin Complex
Qiu, W. Q., Borth, W., Ye, Z., Haass, C., Teplow, D. B., & Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8443 · Cited by 98
Molecular Genetics of Chromosome 17 Tauopathies
HUTTON, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06906.x · Cited by 92
Cloe, A., Orgel, J. P. R. O., Sachleben, J. R., Tycko, R., & Meredith, S. C. (2011) · Biochemistry · doi:10.1021/bi1016217 · Cited by 92
Kauwe, J. S. K., Cruchaga, C., Mayo, K., Fenoglio, C., Bertelsen, S. E., Nowotny, P., Galimberti, D., Scarpini, E. A., Morris, J. C., Fagan, A. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801227105 · Cited by 90
Self-citationKauwe, J. S. K., Jacquart, S., Chakraverty, S., Wang, J., Mayo, K., Fagan, A. M., Holtzman, D. M., Morris, J. C., & Goate, A. M. (2007) · Annals of Neurology · doi:10.1002/ana.21099 · Cited by 84
Self-citationSeizures accelerate anoxia-induced neuronal death in the neonatal rat hippocampus
Dzhala, V. I., Ben‐Ari, Y., & Khazipov, R. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200010)48:4 · Cited by 82
The role of presenilins in Alzheimer’s disease
Thinakaran, G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8728 · Cited by 65
Alzheimer's disease therapeutic research: the path forward
Aisen, P. S. S. (2009) · Alzheimer s Research & Therapy · doi:10.1186/alzrt2 · Cited by 59
Lambert, J., Sleegers, K., González‐Pérez, A., Ingelsson, M., Beecham, G. W., Hiltunen, M. O., Combarros, O., Bullido, M. J., Brouwers, N., Bettens, K., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100933 · Cited by 57
Holtzman, D. M. (2008) · Nature · doi:10.1038/454418a · Cited by 45
Self-citationKauwe, J. S. K., Cruchaga, C., Bertelsen, S. E., Mayo, K., Latu, W., Nowotny, P., Hinrichs, A. L., Fagan, A. M., Holtzman, D. M., Initiative, A. D. N., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091711 · Cited by 44
Self-citationSastre, A. A., Sherriff, F., & McShane, R. H. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003154.pub4 · Cited by 35
Sequestration of Amyloid β‐Peptidea
Goldgaber, D., SCHWARZMAN, A. I., Bhasin, R., Gregori, L. L., Schmechel, D. E., Saunders, A. M., Roses, A. D., & Strittmatter, W. J. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb23042.x · Cited by 34
Hinrichs, A. L., Mintun, M. A., Head, D. M., Fagan, A. M., Holtzman, D. M., Morris, J. C., & Goate, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.012 · Cited by 28
Self-citationGreenberg, S. M., & Frosch, M. P. (2011) · Neurology · doi:10.1212/wnl.0b013e31820e7bce · Cited by 24
Price (1999) · doi:10.1002/1531-8249(199903)45:3
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Sorted by citations
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493
Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606
Self-citationSingle-cell transcriptomic analysis of Alzheimer’s disease
Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1195-2 · Cited by 2,568
Karran, E., Mercken, M., & Strooper, B. D. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3505 · Cited by 2,188
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185
Metadata
- Authors
- Holtzman, D. M., Morris, J. C., & Goate, A. M.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Science Translational Medicine
- Published
- 2011-04-06
- Volume
- 3
- Issue
- 77
- Pages
- 77sr1-77sr1
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3130546
- OpenAlex
- W2005483591
- Cited by
- 1,424
- References
- 225
- Citations by year
- 2026: 53 · 2025: 81 · 2024: 99 · 2023: 102 · 2022: 93 · 2021: 93 · 2020: 100 · 2019: 124 · 2018: 116 · 2017: 101 · 2016: 92 · 2015: 95 · 2014: 95 · 2013: 86 · 2012: 69
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG035083, RC1AG035654, P50AG005681, P01AG003991, R37AG013956, U19AG032438, U01AG032438, R01AG016208, P01AG026276)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, dementia, disease prevalence, pathogenesis, translational research, early detection
- MeSH terms
- Alzheimer Disease, Humans, Amyloid beta-Peptides, tau Proteins, Disease Progression, Presenilins
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