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Alzheimer’s Disease: The Challenge of the Second Century
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In the first of our State of the Art Review series, David M. Holtzman, John C. Morris, and Alison M. Goate explore the rapid pace of Alzheimer’s disease research and the challenges to translating research breakthroughs into clinical treatments.
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“Growing evidence suggests that AD pathology, such as cerebral Aβ accumulation, probably begins one to two decades before onset of clinical symptoms (Holtzman et al. 2011, Perrin et al. 2009).”
From miR‐186 is decreased in aged brain and suppresses BACE 1 expression (2016) · cites this paper as Holtzman et al. 2011
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Self-citation
Metadata
- Authors
- Holtzman, D. M., Morris, J. C., & Goate, A. M.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Science Translational Medicine
- Published
- 2011-04-06
- Volume
- 3
- Issue
- 77
- Pages
- 77sr1-77sr1
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3130546
- OpenAlex
- W2005483591
- Cited by
- 1,424
- References
- 225
- Citations by year
- 2026: 53 · 2025: 81 · 2024: 99 · 2023: 102 · 2022: 93 · 2021: 93 · 2020: 100 · 2019: 124 · 2018: 116 · 2017: 101 · 2016: 92 · 2015: 95 · 2014: 95 · 2013: 86 · 2012: 69
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG035083, RC1AG035654, P50AG005681, P01AG003991, R37AG013956, U19AG032438, U01AG032438, R01AG016208, P01AG026276)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, dementia, disease prevalence, pathogenesis, translational research, early detection
- MeSH terms
- Alzheimer Disease, Humans, Amyloid beta-Peptides, tau Proteins, Disease Progression, Presenilins
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