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Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients
Open accessAbstract
Alemtuzumab depletes malignant T cells but spares skin resident effector memory T cells, treating L-CTCL without increased risk of infection.
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“Both CD8+ and CD4+ Trm have been identified in the human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes [241, 244, 246, 253-259].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [246]
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“They have been defined as independent populations by tissue retention in parabiosis experiments [239, 240], by distinguishing transcriptional profiles [230, 241-245], by exclusive Ag receptor repertoires and specificities [243, 244, 246], and by exclusive persistence in transplanted tissues [247, 248].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [246]
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Metadata
- Authors
- Clark, R. A., Watanabe, R., Teague, J. E., Schlapbach, C., Tawa, M. C., Adams, N., Dorosario, A. A., Chaney, K. S., Cutler, C. S., LeBoeuf, N. R., Carter, J. B., Fisher, D. C., & Kupper, T. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Dana-Farber Brigham Cancer Center (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Clark, Rachael A.
- Watanabe, Rei
- Kupper, Thomas S.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2012-01-18
- Volume
- 4
- Issue
- 117
- Pages
- 117ra7-117ra7
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3373186
- OpenAlex
- W2076870975
- Cited by
- 367
- References
- 53
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 17 · 2023: 18 · 2022: 25 · 2021: 38 · 2020: 27 · 2019: 27 · 2018: 33 · 2017: 26 · 2016: 31 · 2015: 37 · 2014: 25 · 2013: 20 · 2012: 19
- FWCI
- 40.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (R01 A1025082)
- National Cancer Institute (P50 CA9368305, P50CA093683)
- National Institute of Allergy and Infectious Diseases (R37AI025082, R01AI097128)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056720, R01AR065807)
- Topics
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- cutaneous T-cell lymphoma, alemtuzumab, central memory T cells, effector memory T cells, mycosis fungoides, T cell recirculation, skin-homing T cells, neutrophils, IL-4, interferon-gamma, infection susceptibility, T cell depletion
- MeSH terms
- CD52 Antigen, Alemtuzumab, Aged, Aged, 80 and over, Antigens, Neoplasm, Antineoplastic Agents, Female, Glycoproteins, Humans, Immune System, Immunologic Memory, Male, Middle Aged, Mycosis Fungoides, Neutrophils, Phenotype, Skin, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Antigens, CD, Antibodies, Monoclonal, Humanized
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