The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients
Open accessAbstract
Alemtuzumab depletes malignant T cells but spares skin resident effector memory T cells, treating L-CTCL without increased risk of infection.
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“Both CD8+ and CD4+ Trm have been identified in the human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes [241, 244, 246, 253-259].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [246]
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In the citing paper
“They have been defined as independent populations by tissue retention in parabiosis experiments [239, 240], by distinguishing transcriptional profiles [230, 241-245], by exclusive Ag receptor repertoires and specificities [243, 244, 246], and by exclusive persistence in transplanted tissues [247, 248].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [246]
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Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“TEM and TCM are two distinct subsets of memory T cells (9).”
BackgroundWHO-EORTC classification for cutaneous lymphomas
Willemze, R. (2005) · Blood · doi:10.1182/blood-2004-09-3502 · Cited by 3,803
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Reshaping human antibodies for therapy
Riechmann, L., Clark, M., Waldmann, H., & Winter, G. P. (1988) · Nature · doi:10.1038/332323a0 · Cited by 1,565
Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157
The Vast Majority of CLA+ T Cells Are Resident in Normal Skin
Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K.-I., Dowgiert, R. K., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4431 · Cited by 796
Self-citationNaive and memory T cells show distinct pathways of lymphocyte recirculation.
Mackay, C. R., Marston, W. L., & Dudler, L. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.3.801 · Cited by 787
Long-term Outcome of 525 Patients With Mycosis Fungoides and Sézary Syndrome
Kim, Y. H., Liu, H. L., Mraz‐Gernhard, S., Varghese, A., & Hoppe, R. T. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.7.857 · Cited by 652
Campbell, J. J., Clark, R. A., Watanabe, R., & Kupper, T. S. (2010) · Blood · doi:10.1182/blood-2009-11-251926 · Cited by 519
Self-citationThe window of therapeutic opportunity in multiple sclerosis
Coles, A. J., Cox, A., Page, E. L., Jones, J., Trip, S. A., Deans, J., Seaman, S. R., Miller, D. H., Hale, G., Waldmann, H., et al. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0934-5 · Cited by 506
Cited by
Sorted by citations
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Cohen, J. A., Coles, A. J., Arnold, D. L., Confavreux, C., Fox, E. J., Hartung, H.-P., Havrdova, E., Selmaj, K. W., Weiner, H. L., Fisher, E., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61769-3 · Cited by 1,205
Coles, A. J., Twyman, C. L., Arnold, D. L., Cohen, J. A., Confavreux, C., Fox, E. J., Hartung, H.-P., Havrdova, E., Selmaj, K. W., Weiner, H. L., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61768-1 · Cited by 1,198
Tissue-resident memory T cells: local specialists in immune defence
Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897
Metadata
- Authors
- Clark, R. A., Watanabe, R., Teague, J. E., Schlapbach, C., Tawa, M. C., Adams, N., Dorosario, A. A., Chaney, K. S., Cutler, C. S., LeBoeuf, N. R., Carter, J. B., Fisher, D. C., & Kupper, T. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Dana-Farber Brigham Cancer Center (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Clark, Rachael A.
- Watanabe, Rei
- Kupper, Thomas S.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2012-01-18
- Volume
- 4
- Issue
- 117
- Pages
- 117ra7-117ra7
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3373186
- OpenAlex
- W2076870975
- Cited by
- 367
- References
- 53
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 17 · 2023: 18 · 2022: 25 · 2021: 38 · 2020: 27 · 2019: 27 · 2018: 33 · 2017: 26 · 2016: 31 · 2015: 37 · 2014: 25 · 2013: 20 · 2012: 19
- FWCI
- 40.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (R01 A1025082)
- National Cancer Institute (P50 CA9368305, P50CA093683)
- National Institute of Allergy and Infectious Diseases (R37AI025082, R01AI097128)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056720, R01AR065807)
- Topics
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- cutaneous T-cell lymphoma, alemtuzumab, central memory T cells, effector memory T cells, mycosis fungoides, T cell recirculation, skin-homing T cells, neutrophils, IL-4, interferon-gamma, infection susceptibility, T cell depletion
- MeSH terms
- CD52 Antigen, Alemtuzumab, Aged, Aged, 80 and over, Antigens, Neoplasm, Antineoplastic Agents, Female, Glycoproteins, Humans, Immune System, Immunologic Memory, Male, Middle Aged, Mycosis Fungoides, Neutrophils, Phenotype, Skin, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Antigens, CD, Antibodies, Monoclonal, Humanized
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