Weissman, Irving L.

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature

Cancer Cells and MetastasisDevelopmental Biology and Gene Regulation

Cited by 9,738

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell

Signaling Pathways in DiseaseCalpain Protease Function and Regulation

Cited by 4,116

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 2,617

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature

Cancer Cells and MetastasisRedox biology and oxidative stress

Cited by 2,555

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine

Mesenchymal stem cell researchHematopoietic Stem Cell Transplantation

Cited by 2,314

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature

Genetics, Aging, and Longevity in Model OrganismsMesenchymal stem cell research

Cited by 2,287

Wnt proteins are lipid-modified and can act as stem cell growth factors

Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 2,257

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell

Hematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

Cited by 2,253

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Gordon, S. R., Maute, R. L., Dulken, B. W., Hutter, G., George, B. M., McCracken, M. N., Gupta, R., Tsai, J. M., Sinha, R., Corey, D., et al. (2017) · Nature

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 2,247

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature

Hematopoietic Stem Cell TransplantationWnt/β-catenin signaling in development and cancer

Cited by 2,159

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 1,871

New tools for studying microglia in the mouse and human CNS

Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,804

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell

Phagocytosis and Immune RegulationAcute Myeloid Leukemia Research

Cited by 1,752

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

Jamieson, C. H. M., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., et al. (2004) · New England Journal of Medicine

Chronic Myeloid Leukemia TreatmentsHematopoietic Stem Cell Transplantation

Cited by 1,485

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

Berlin, C., Berg, E. L., Briskin, M. J., Andrew, D. P., Kilshaw, P. J., Holzmann, B., Weissman, I. L., Hamann, A., & Butcher, E. C. (1993) · Cell

Cell Adhesion Molecules ResearchT-cell and B-cell Immunology

Cited by 1,453

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 1,247

Cell intrinsic alterations underlie hematopoietic stem cell aging

Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 1,152

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 1,115

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 991

Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations

Weissman, I. L., Anderson, D. J., & Gage, F. (2001) · Annual Review of Cell and Developmental Biology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 948

Physiological Migration of Hematopoietic Stem and Progenitor Cells

Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L., & Weissman, I. L. (2001) · Science

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 933

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

Ootani, A., Li, X., Sangiorgi, E., Ho, Q. T., Ueno, H., Toda, S., Sugihara, H., Fujimoto, K., Weissman, I. L., Capecchi, M. R., et al. (2009) · Nature Medicine

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 906

Stems Cells and the Pathways to Aging and Cancer

Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L. (2008) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 895

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

Cheshier, S. H., Morrison, S. J., Liao, X., & Weissman, I. L. (1999) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 858