The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination
Open accessAbstract
High-throughput sequencing suggests age-related differences in the changes in the human antibody repertoire after influenza vaccination.
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“Moreover, elderly individuals have decreased numbers of B-cell lineages but increased pre-vaccination mutation load in their repertoire, resulting in a less efficient response, and the diversity of the lineages is thus greatly reduced as compared with that in young individuals [131].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [131]
In the citing paper
“Furthermore, poor immune responses account for diminished efficacy of vaccines [82,85].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [82]
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“As age advances, the immune system undergoes profound remodelling and decline, with major impact on health and survival [81,82].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [82]
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Cites
Sequences of proteins of immunological interest
Kabat, B. E. A. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90805-4 · Cited by 3,363
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Wrammert, J., Smith, K., Miller, J., Langley, W. A., Kokko, K. E., Larsen, C. P., Zheng, N., Mays, I., Garman, L., Helms, C., et al. (2008) · Nature · doi:10.1038/nature06890 · Cited by 1,026
Self-citationGerminal-Center Organization and Cellular Dynamics
Allen, C. D. C., Okada, T., & Cyster, J. G. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.009 · Cited by 1,025
Systems biology of vaccination for seasonal influenza in humans
Nakaya, H. I., Wrammert, J., Lee, E. K., Racioppi, L., Marie-Kunze, S., Haining, W. N., Means, A. R., Kasturi, S. P., Khan, N., Li, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.2067 · Cited by 812
Wrammert, J., Koutsonanos, D., Li, G., Edupuganti, S., Sui, J., Michael, M., McCausland, M. M., Skountzou, I., Hornig, M., Lipkin, W. I., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101352 · Cited by 777
Self-citationIgH class switching and translocations use a robust non-classical end-joining pathway
Yan, C. T., Boboilă, C., Souza, E. K., Franco, S., Hickernell, T. R., Murphy, M., Gumaste, S., Geyer, M. B., Zarrin, A. A., Manis, J. P., et al. (2007) · Nature · doi:10.1038/nature06020 · Cited by 598
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
Noia, J. M. D., & Neuberger, M. S. (2002) · Nature · doi:10.1038/nature00981 · Cited by 596
Cox, R. J., Brokstad, K. A., & Ogra, P. L. O. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01382.x · Cited by 564
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
Giudicelli, V. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki010 · Cited by 548
Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors
Yu, X., Tsibane, T., McGraw, P. A., House, F. S., Keefer, C. J., Hicar, M. D., Tumpey, T. M., Pappas, C., Perrone, L. A., Martinez, O., et al. (2008) · Nature · doi:10.1038/nature07231 · Cited by 457
Cited by
Sorted by citations
Evolution of the immune system in humans from infancy to old age
Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796
Error filtering, pair assembly and error correction for next-generation sequencing reads
Edgar, R. C., & Flyvbjerg, H. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv401 · Cited by 1,315
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
Ren, X., Wen, W., Fan, X., Hou, W., Su, B., Cai, P., Li, J., Liu, Y., Tang, F., Zhang, F., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.053 · Cited by 865
Self-citationThe evolution of seasonal influenza viruses
Petrova, V. N., & Russell, C. A. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.118 · Cited by 889
Understanding immunosenescence to improve responses to vaccines
Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827
Metadata
- Authors
- Jiang, N., He, J., Weinstein, J. A., Penland, L., Sasaki, S., He, X.-S., Dekker, C. L., Zheng, N.-Y., Huang, M., Sullivan, M., Wilson, P. C., Greenberg, H. B., Davis, M. M., Fisher, D. S., & Quake, S. R.
- Affiliations
- Stanford Medicine (US)
- Stanford University (US)
- VA Palo Alto Health Care System (US)
- University of Chicago (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jiang, Ning
- He, Jiankui
- Weinstein, Joshua A.
- Quake, Stephen R.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2013-02-06
- Volume
- 5
- Issue
- 171
- Pages
- 171ra19-171ra19
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3699344
- OpenAlex
- W2097816699
- Cited by
- 335
- References
- 30
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 16 · 2023: 13 · 2022: 21 · 2021: 26 · 2020: 33 · 2019: 30 · 2018: 23 · 2017: 33 · 2016: 39 · 2015: 39 · 2014: 31 · 2013: 17
- FWCI
- 23.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR001085)
- National Institute on Aging (K99AG040149)
- National Institute of Allergy and Infectious Diseases (U19AI090019, U19AI057229)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- human antibody repertoire, influenza vaccination, immunogenomics, clonal architecture, somatic hypermutation, age-related immune decline, isotype distribution, long-read sequencing
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Antibodies, Viral, Child, Humans, Immunoglobulin M, Immunoglobulin Isotypes, Influenza, Human, Middle Aged, Mutation, Phylogeny, Vaccination, Genetic Variation, Cluster Analysis, Somatic Hypermutation, Immunoglobulin, Young Adult
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