Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination

Sequences of proteins of immunological interest

Kabat, B. E. A. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90805-4 · Cited by 3,363

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

Wrammert, J., Smith, K., Miller, J., Langley, W. A., Kokko, K. E., Larsen, C. P., Zheng, N., Mays, I., Garman, L., Helms, C., et al. (2008) · Nature · doi:10.1038/nature06890 · Cited by 1,026

Germinal-Center Organization and Cellular Dynamics

Allen, C. D. C., Okada, T., & Cyster, J. G. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.009 · Cited by 1,025

Systems biology of vaccination for seasonal influenza in humans

Nakaya, H. I., Wrammert, J., Lee, E. K., Racioppi, L., Marie-Kunze, S., Haining, W. N., Means, A. R., Kasturi, S. P., Khan, N., Li, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.2067 · Cited by 812

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

Wrammert, J., Koutsonanos, D., Li, G., Edupuganti, S., Sui, J., Michael, M., McCausland, M. M., Skountzou, I., Hornig, M., Lipkin, W. I., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101352 · Cited by 777

IgH class switching and translocations use a robust non-classical end-joining pathway

Yan, C. T., Boboilă, C., Souza, E. K., Franco, S., Hickernell, T. R., Murphy, M., Gumaste, S., Geyer, M. B., Zarrin, A. A., Manis, J. P., et al. (2007) · Nature · doi:10.1038/nature06020 · Cited by 598

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase

Noia, J. M. D., & Neuberger, M. S. (2002) · Nature · doi:10.1038/nature00981 · Cited by 596

Influenza Virus: Immunity and Vaccination Strategies. Comparison of the Immune Response to Inactivated and Live, Attenuated Influenza Vaccines

Cox, R. J., Brokstad, K. A., & Ogra, P. L. O. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01382.x · Cited by 564

IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes

Giudicelli, V. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki010 · Cited by 548

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

Yu, X., Tsibane, T., McGraw, P. A., House, F. S., Keefer, C. J., Hicar, M. D., Tumpey, T. M., Pappas, C., Perrone, L. A., Martinez, O., et al. (2008) · Nature · doi:10.1038/nature07231 · Cited by 457

Evolution of the immune system in humans from infancy to old age

Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796

Error filtering, pair assembly and error correction for next-generation sequencing reads

Edgar, R. C., & Flyvbjerg, H. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv401 · Cited by 1,315

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Ren, X., Wen, W., Fan, X., Hou, W., Su, B., Cai, P., Li, J., Liu, Y., Tang, F., Zhang, F., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.053 · Cited by 865

The evolution of seasonal influenza viruses

Petrova, V. N., & Russell, C. A. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.118 · Cited by 889

Understanding immunosenescence to improve responses to vaccines

Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827

Human immune system variation

Brodin, P., & Davis, M. M. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.125 · Cited by 730

The promise and challenge of high-throughput sequencing of the antibody repertoire

Georgiou, G., Ippolito, G. C., Beausang, J., Busse, C. E., Wardemann, H., & Quake, S. R. (2014) · Nature Biotechnology · doi:10.1038/nbt.2782 · Cited by 652

B cells, plasma cells and antibody repertoires in the tumour microenvironment

Sharonov, G. V., Serebrovskaya, E. O., Yuzhakova, D. V., Britanova, O. V., & Chudakov, D. M. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0257-x · Cited by 630

Immunosenescence and human vaccine immune responses

Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0164-9 · Cited by 530

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439

Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract

Flerlage, T., Boyd, D. F., Meliopoulos, V., Thomas, P. G., & Schultz‐Cherry, S. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00542-7 · Cited by 419

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

Joyce, M. G., Wheatley, A. K., Thomas, P. V., Chuang, G.-Y., Soto, C., Bailer, R. T., Druz, A., Georgiev, I. S., Gillespie, R. A., Kanekiyo, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.043 · Cited by 333

Predicting evolution

Lässig, M., Mustonen, V., & Walczak, A. M. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0077 · Cited by 352

The science and medicine of human immunology

Pulendran, B., & Davis, M. M. (2020) · Science · doi:10.1126/science.aay4014 · Cited by 275

Human Responses to Influenza Vaccination Show Seroconversion Signatures and Convergent Antibody Rearrangements

Jackson, K., Liu, Y., Roskin, K. M., Glanville, J., Hoh, R. A., Seo, K., Marshall, E. L., Gurley, T. C., Moody, M. A., Haynes, B. F., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.05.013 · Cited by 251

Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires

Kovaltsuk, A., Leem, J., Kelm, S., Snowden, J., Deane, C. M., & Krawczyk, K. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800708 · Cited by 247

Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response

Cunha, L. L., Perazzio, S. F., Azzi, J., Cravedi, P., & Riella, L. V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01748 · Cited by 245

Identification and characterization of the constituent human serum antibodies elicited by vaccination

Lavinder, J. J., Wine, Y., Giesecke‐Thiel, C., Ippolito, G. C., Horton, A. P., Lungu, O. I., Hoi, K. H., DeKosky, B. J., Murrin, E. M., Wirth, M. M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317793111 · Cited by 247

Genomic Medicine: A Decade of Successes, Challenges, and Opportunities

McCarthy, J. J., McLeod, H. L., & Ginsburg, G. S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005785 · Cited by 242

Class-switched memory B cells remodel BCRs within secondary germinal centers

McHeyzer‐Williams, L. J., Milpied, P., Okitsu, S. L., & McHeyzer‐Williams, M. G. (2015) · Nature Immunology · doi:10.1038/ni.3095 · Cited by 243

OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs

Sethna, Z. M., Elhanati, Y., Callan, C. G., Walczak, A. M., & Mora, T. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz035 · Cited by 235

B Cell Immunosenescence

Frasca, D., Diaz, A., Romero, M., Garcia, D., & Blomberg, B. B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-011620-034148 · Cited by 232

Accuracy of microbial community diversity estimated by closed- and open-reference OTUs

Edgar, R. C. (2017) · PeerJ · doi:10.7717/peerj.3889 · Cited by 241

tcR: an R package for T cell receptor repertoire advanced data analysis

Nazarov, V. I., Pogorelyy, M. V., Komech, E. A., Zvyagin, I. V., Bolotin, D. A., Shugay, M., Chudakov, D. M., Lebedev, Y. B., & Mamedov, I. Z. (2015) · BMC Bioinformatics · doi:10.1186/s12859-015-0613-1 · Cited by 223

Genetic measurement of memory B-cell recall using antibody repertoire sequencing

Vollmers, C., Sit, R. V., Weinstein, J. A., Dekker, C. L., & Quake, S. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312146110 · Cited by 222

Bioinformatic and Statistical Analysis of Adaptive Immune Repertoires

Greiff, V., Miho, E., Menzel, U., & Reddy, S. T. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.09.006 · Cited by 210

Influenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines

Sridhar, S., Brokstad, K. A., & Cox, R. J. (2015) · Vaccines · doi:10.3390/vaccines3020373 · Cited by 206

Race and ethnicity, gender, and age on perceived threats and fear of COVID-19: Evidence from two national data sources

Niño, M., Harris, C. T., Drawve, G. R., & Fitzpatrick, K. M. (2020) · SSM - Population Health · doi:10.1016/j.ssmph.2020.100717 · Cited by 196

Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility

Strauss‐Albee, D. M., Fukuyama, J., Liang, E. C., Yao, Y., Jarrell, J. A., Drake, A. L., Kinuthia, J., Montgomery, R. R., John-Stewart, G. C., Holmes, S., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac5722 · Cited by 188

Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis

Miller, M. S., Gardner, T. J., Krammer, F., Aguado, L. C., Tortorella, D., Basler, C. F., & Palese, P. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006637 · Cited by 190

High-quality full-length immunoglobulin profiling with unique molecular barcoding

Turchaninova, M. A., Davydov, A., Britanova, O. V., Shugay, M., Bikos, V., Egorov, E. S., Kirgizova, V., Merzlyak, E. M., Staroverov, D. B., Bolotin, D. A., et al. (2016) · Nature Protocols · doi:10.1038/nprot.2016.093 · Cited by 189

Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires

Wang, C., Liu, Y., Xu, L. T., Jackson, K., Roskin, K. M., Pham, T. D., Laserson, J., Marshall, E. L., Seo, K., Lee, J.-Y., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301384 · Cited by 179

ICOS+PD-1+CXCR3+ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

Bentebibel, S.-E., Khurana, S., Schmitt, N., Kurup, P., Mueller, C., Obermoser, G., Palucka, A. K., Albrecht, R. A., García‐Sastre, A., Golding, H., et al. (2016) · Scientific Reports · doi:10.1038/srep26494 · Cited by 171

Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly

Pereira, B. I., Xu, X., & Akbar, A. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583019 · Cited by 190

Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

Herati, R. S., Reuter, M. A., Dolfi, D. V., Mansfield, K. D., Aung, H., Badwan, O. Z., Kurupati, R. K., Kannan, S., Ertl, H., Schmader, K. E., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302503 · Cited by 177

Characterizing immune repertoires by high throughput sequencing: strategies and applications

Calis, J. J. A., & Rosenberg, B. R. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.09.004 · Cited by 190

Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery

Robinson, W. H. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.220 · Cited by 178

PIRD: pan immune repertoire database

Zhang, W., Wang, L., Liu, K., Wei, X., Yang, K., Du, W., Wang, S., Guo, N., Ma, C., Luo, L., et al. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btz614 · Cited by 166

Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics

Horns, F., Dekker, C. L., & Quake, S. R. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.063 · Cited by 160

Estimating the Life Course of Influenza A(H3N2) Antibody Responses from Cross-Sectional Data

Kucharski, A. J., Lessler, J., Read, J. M., Zhu, H., Jiang, C. Q., Guan, Y., Cummings, D. A. T., & Riley, S. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002082 · Cited by 153

Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data

Gupta, N. T., Adams, K., Briggs, A. W., Timberlake, S. C., Vigneault, F., & Kleinstein, S. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601850 · Cited by 159

Understanding immunosenescence and its impact on vaccination of older adults

Allen, J. C., Toapanta, F. R., Chen, W. H., & Tennant, S. M. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.11.002 · Cited by 161

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

Henry, C., Zheng, N., Huang, M., Cabanov, A., Rojas, K. T., Kaur, K., Andrews, S. F., Palm, A.-K. E., Chen, Y.-Q., Li, Y., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.002 · Cited by 142

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events

Sobolev, O., Binda, E., O’Farrell, S., Lorenc, A., Pradines, J., Huang, Y., Duffner, J. L., Schulz, R., Cason, J. W., Zambon, M. C. F. A., et al. (2016) · Nature Immunology · doi:10.1038/ni.3328 · Cited by 149

Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

Horns, F., Vollmers, C., Croote, D., Mackey, S. F., Swan, G. E., Dekker, C. L., Davis, M. M., & Quake, S. R. (2016) · eLife · doi:10.7554/elife.16578 · Cited by 146

Unifying immunology with informatics and multiscale biology

Kidd, B. A., Peters, L. A., Schadt, E. E., & Dudley, J. T. (2014) · Nature Immunology · doi:10.1038/ni.2787 · Cited by 145

Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles

Petrova, V. N., Sawatsky, B., Han, A. X., Laksono, B. M., Walz, L., Parker, E., Pieper, K., Anderson, C. A., de Vries, R. D., Lanzavecchia, A., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aay6125 · Cited by 143

Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves

Adams, R. M., Mora, T., Walczak, A. M., & Kinney, J. B. (2016) · eLife · doi:10.7554/elife.23156 · Cited by 137

Large-scale network analysis reveals the sequence space architecture of antibody repertoires

Miho, E., Roškar, R., Greiff, V., & Reddy, S. T. (2019) · Nature Communications · doi:10.1038/s41467-019-09278-8 · Cited by 138

Aging and influenza vaccine-induced immunity

Dugan, H. L., Henry, C., & Wilson, P. C. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103998 · Cited by 137

Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging

de Bourcy, C. F. A., Angel, C. J. L., Vollmers, C., Dekker, C. L., Davis, M. M., & Quake, S. R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617959114 · Cited by 132

Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination

Frasca, D., & Blomberg, B. B. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00210-z · Cited by 130

Peanut oral immunotherapy transiently expands circulating Ara h 2–specific B cells with a homologous repertoire in unrelated subjects

Patil, S. U., Ogunniyi, A. O., Calatroni, A., Tadigotla, V. R., Ruiter, B., Ma, A., Moon, J. J., Love, J. C., & Shreffler, W. G. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.026 · Cited by 129

Strength of immune selection in tumors varies with sex and age

Castro, A., Pyke, R. M., Zhang, X., Thompson, W. K., Day, C., Alexandrov, L. B., Zanetti, M., & Carter, H. K. (2020) · Nature Communications · doi:10.1038/s41467-020-17981-0 · Cited by 132

New approaches to understanding the immune response to vaccination and infection

Furman, D., & Davis, M. M. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.06.117 · Cited by 135

Host Factors Impact Vaccine Efficacy: Implications for Seasonal and Universal Influenza Vaccine Programs

Dhakal, S., & Klein, S. L. (2019) · Journal of Virology · doi:10.1128/jvi.00797-19 · Cited by 127

Identification of Antigen-Specific B Cell Receptor Sequences Using Public Repertoire Analysis

Trück, J., Ramasamy, M., Galson, J. D., Rance, R., Parkhill, J., Lunter, G. A., Pollard, A. J., & Kelly, D. F. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401405 · Cited by 119

Advanced Methodologies in High-Throughput Sequencing of Immune Repertoires

Friedensohn, S., Khan, T. A., & Reddy, S. T. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.09.010 · Cited by 118

The Shape of the Lymphocyte Receptor Repertoire: Lessons from the B Cell Receptor

Jackson, K., Kidd, M. J., Wang, Y., & Collins, A. M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00263 · Cited by 114

From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”

Bulati, M., Caruso, C., & Colonna‐Romano, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.04.001 · Cited by 114

Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination

Hoehn, K. B., Heiden, J. A. V., Zhou, J. Q., Lunter, G. A., Pybus, O. G., & Kleinstein, S. H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906020116 · Cited by 114

Co-evolution of immunity and seasonal influenza viruses

Han, A. X., de Jong, S. P. J., & Russell, C. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00945-8 · Cited by 117

Accurate and predictive antibody repertoire profiling by molecular amplification fingerprinting

Khan, T. A., Friedensohn, S., de Vries, A. R. G., Straszewski, J., Ruscheweyh, H., & Reddy, S. T. (2016) · Science Advances · doi:10.1126/sciadv.1501371 · Cited by 103

High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination

Tan, Y., Blum, L. K., Kongpachith, S., Ju, C., Cai, X., Lindström, T. M., Sokolove, J. B., & Robinson, W. H. (2014) · Clinical Immunology · doi:10.1016/j.clim.2013.12.008 · Cited by 103

Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples

Kaplinsky, J., & Arnaout, R. (2016) · Nature Communications · doi:10.1038/ncomms11881 · Cited by 98

Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding

D’Angelo, S., Ferrara, F., Naranjo, L. A., Erasmus, M. F., Hraber, P., & Bradbury, A. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00395 · Cited by 98

Analysis of B cell repertoire dynamics following hepatitis B vaccination in humans, and enrichment of vaccine-specific antibody sequences

Galson, J. D., Trück, J., Fowler, A., Clutterbuck, E. A., Münz, M., Cerundolo, V., Reinhard, C., van der Most, R., Pollard, A. J., Lunter, G., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.11.034 · Cited by 97

Next-generation sequencing and protein mass spectrometry for the comprehensive analysis of human cellular and serum antibody repertoires

Lavinder, J. J., Horton, A. P., Georgiou, G., & Ippolito, G. C. (2014) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2014.11.007 · Cited by 92

History, applications, and challenges of immune repertoire research

Liu, X., & Wu, J. (2018) · Cell Biology and Toxicology · doi:10.1007/s10565-018-9426-0 · Cited by 91

A spectral clustering-based method for identifying clones from high-throughput B cell repertoire sequencing data

Nouri, N., & Kleinstein, S. H. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty235 · Cited by 88

Studying the antibody repertoire after vaccination: practical applications

Galson, J. D., Pollard, A. J., Trück, J., & Kelly, D. F. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.005 · Cited by 94

Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements

Hormoz, S., Singer, Z. S., Linton, J. M., Antebi, Y. E., Shraiman, B. I., & Elowitz, M. B. (2016) · Cell Systems · doi:10.1016/j.cels.2016.10.015 · Cited by 94

The Diversity and Molecular Evolution of B-Cell Receptors during Infection

Hoehn, K. B., Fowler, A., Lunter, G. A., & Pybus, O. G. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw015 · Cited by 89

Integrating high‐throughput screening and sequencing for monoclonal antibody discovery and engineering

Parola, C., Neumeier, D., & Reddy, S. T. (2017) · Immunology · doi:10.1111/imm.12838 · Cited by 94

UNCROSS2: identification of cross-talk in 16S rRNA OTU tablesPreprint

Edgar, R. C. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/400762 · Cited by 88

Quantitative Profiling of Immune Repertoires for Minor Lymphocyte Counts Using Unique Molecular Identifiers

Egorov, E. S., Merzlyak, E. M., Shelenkov, A. A., Britanova, O. V., Sharonov, G. V., Staroverov, D. B., Bolotin, D. A., Davydov, A. N., Barsova, E. A., Lebedev, Y. B., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500215 · Cited by 86

Clonal and cellular dynamics in germinal centers

Victora, G. D., & Mesin, L. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.02.010 · Cited by 89

High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis

Bernat, N. V., Corcoran, M., Hardt, U., Kaduk, M., Phad, G. E., Martin, M., & Hedestam, G. B. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00660 · Cited by 83

A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

Fu, Y., Zhang, Z., Sheehan, J., Avnir, Y., Ridenour, C. A., Sachnik, T., Sun, J., Hossain, M. J., Chen, L.-M., Zhu, Q. K., et al. (2016) · Nature Communications · doi:10.1038/ncomms12780 · Cited by 83

In-Depth Assessment of Within-Individual and Inter-Individual Variation in the B Cell Receptor Repertoire

Galson, J. D., Trück, J., Fowler, A., Münz, M., Cerundolo, V., Pollard, A. J., Lunter, G. A., & Kelly, D. F. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00531 · Cited by 79

Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing

Tsioris, K., Gupta, N. T., Ogunniyi, A. O., Zimnisky, R. M., Qian, F., Yao, Y., Wang, X., Stern, J. N. H., Chari, R., Briggs, A. W., et al. (2015) · Integrative Biology · doi:10.1039/c5ib00169b · Cited by 74

The Impact of Immunosenescence on Humoral Immune Response Variation after Influenza A/H1N1 Vaccination in Older Subjects

Haralambieva, I. H., Painter, S. D., Kennedy, R. B., Ovsyannikova, I. G., Lambert, N. D., Goergen, K. M., Oberg, A. L., & Poland, G. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122282 · Cited by 76

BCR repertoire sequencing: different patterns of B‐cell activation after two Meningococcal vaccines

Galson, J. D., Clutterbuck, E., Trück, J., Ramasamy, M., Münz, M., Fowler, A., Cerundolo, V., Pollard, A. J., Lunter, G. A., & Kelly, D. F. (2015) · Immunology and Cell Biology · doi:10.1038/icb.2015.57 · Cited by 74

Autoreactive B Cell Differentiation in Diffuse Ectopic Lymphoid-Like Structures of Inflamed Pemphigus Lesions

Zhou, S., Liu, Z., Yuan, H., Zhao, X., Zou, Y., Zheng, J., & Pan, M. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.07.717 · Cited by 72

Pathogen evolution and the immunological niche

Cobey, S. E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12493 · Cited by 72

Molecular and genetic inflammation networks in major human diseases

Zhao, Y., Forst, C. V., Sayegh, C. E., Wang, I., Yang, X., & Zhang, B. (2016) · Molecular BioSystems · doi:10.1039/c6mb00240d · Cited by 72

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Linterman, M. A. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2013.77 · Cited by 69

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Knight, M., Changrob, S., Li, L., & Wilson, P. C. (2020) · Immunological Reviews · doi:10.1111/imr.12900 · Cited by 69

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Scherer, E. M., Smith, R. A. J., Simonich, C. A. L., Niyonzima, N., Carter, J. J., & Galloway, D. A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004461 · Cited by 68

Overlapping hotspots in CDRs are critical sites for V region diversification

Wei, L., Chahwan, R., Wang, S., Wang, X. H., Pham, P., Goodman, M. F., Bergman, A., Scharff, M. D., & MacCarthy, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500788112 · Cited by 69

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Schramm, C. A., Sheng, Z., Zhang, Z., Mascola, J. R., Kwong, P. D., & Shapiro, L. S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00372 · Cited by 65

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Marks, C., & Deane, C. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.010181 · Cited by 69

Signatures of selection in the human antibody repertoire: Selective sweeps, competing subclones, and neutral drift

Horns, F., Vollmers, C., Dekker, C. L., & Quake, S. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814213116 · Cited by 69

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Arnaout, R., Prak, E. T. L., Schwab, N., Rubelt, F., & Community, T. A. I. R. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626793 · Cited by 66

Quantitative assessment of the robustness of next-generation sequencing of antibody variable gene repertoires from immunized mice

Greiff, V., Menzel, U., Haessler, U., Cook, S. C., Friedensohn, S., Khan, T. A., Pogson, M., Hellmann, I., & Reddy, S. T. (2014) · BMC Immunology · doi:10.1186/s12865-014-0040-5 · Cited by 64

The ageing human B cell repertoire: a failure of selection?

Dunn‐Walters, D. K. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12700 · Cited by 63

Human lymphocyte repertoires in ageing

Boyd, S. D., Liu, Y., Wang, C., Martin, V., & Dunn‐Walters, D. K. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.007 · Cited by 61

Variability in the immune system: of vaccine responses and immune states

Shen-Orr, S. S., & Furman, D. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.009 · Cited by 61

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Appanna, R., Srinivasan, K. G., Xu, M. H., Toh, Y.-X., Velumani, S., Carbajo, D., Lee, C. Y., Züst, R., Balakrishnan, T., Xu, W., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.003 · Cited by 59

Remote immune processes revealed by immune-derived circulating cell-free DNA

Fox-Fisher, I., Piyanzin, S., Ochana, B.-L., Klochendler, A., Magenheim, J., Peretz, A., Loyfer, N., Moss, J., Cohen, D., Drori, Y., et al. (2021) · eLife · doi:10.7554/elife.70520 · Cited by 58

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Jiang, N. J., He, J., Weinstein, J. A., Penland, L., Saaki, S., He, X.-S., Dekker, C. L., Wilson, P., Greenberg, H. B., Davis, M. M., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.188.supp.58.14 · Cited by 1

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Wu, Y.-C. B., Kipling, D., & Dunn‐Walters, D. K. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00193 · Cited by 101

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Ju, C., Blum, L. K., Kongpachith, S., Lingampalli, N., Mao, R., Brodin, P., Dekker, C. L., Davis, M. M., & Robinson, W. H. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.01.011 · Cited by 21

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Jung, J., Le, J., Horton, A. P., Boutz, D. R., McDaniel, J. R., King, G., Tanno, Y., Ippolito, G. C., Georgiou, G., Park, D., et al. (2018)

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

Lee, J., Boutz, D. R., Chromikova, V., Joyce, M. G., Vollmers, C., Leung, K., Horton, A. P., DeKosky, B. J., Lee, C., Lavinder, J. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4224 · Cited by 278