Dekker, Cornelia L.

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., et al. (2015) · Cell

Genetic Associations and EpidemiologyImmune responses and vaccinations

Cited by 1,065

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Sayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 572

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

Alpert, A., Pickman, Y., Leipold, M., Rosenberg-Hasson, Y., Ji, X., Gaujoux, R., Rabani, H., Starosvetsky, E., Kveler, K., Schaffert, S., et al. (2019) · Nature Medicine

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 513

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

Furman, D., Chang, J., Lartigue, L., Bolen, C. R., Haddad, F., Gaudilliere, B., Ganio, E. A., Fragiadakis, G. K., Spitzer, M. H., Douchet, I., et al. (2017) · Nature Medicine

Inflammasome and immune disordersGenetics, Aging, and Longevity in Model Organisms

Cited by 389

Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination

Jiang, N., He, J., Weinstein, J. A., Penland, L., Sasaki, S., He, X.-S., Dekker, C. L., Zheng, N.-Y., Huang, M., Sullivan, M., et al. (2013) · Science Translational Medicine

T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies Research

Cited by 335

Cytomegalovirus infection enhances the immune response to influenza

Furman, D., Jojic, V., Sharma, S., Shen-Orr, S. S., L. Angel, C. J., Onengut-Gumuscu, S., Kidd, B. A., Maecker, H. T., Concannon, P., Dekker, C. L., et al. (2015) · Science Translational Medicine

Cytomegalovirus and herpesvirus researchImmune responses and vaccinations

Cited by 332

Single-cell chromatin modification profiling reveals increased epigenetic variations with aging

Cheung, P., Vallania, F., Warsinske, H. C., Donato, M., Schaffert, S., Chang, S. E., Dvorak, M., Dekker, C. L., Davis, M. M., Utz, P. J., et al. (2018) · Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 323

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

Sasaki, S., Sullivan, M., Narvaez, C. F., Holmes, T. H., Furman, D., Zheng, N.-Y., Nishtala, M., Wrammert, J., Smith, K., James, J. A., et al. (2011) · Journal of Clinical Investigation

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 300

KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

Li, J., Zaslavsky, M., Su, Y., Guo, J., Sikora, M. J., van Unen, V., Christophersen, A., Chiou, S.-H., Chen, L., Li, J., et al. (2022) · Science

T-cell and B-cell ImmunologyImmune Cell Function and Interaction

Cited by 249

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

Furman, D., Jojic, V., Kidd, B., Shen‐Orr, S., Price, J., Jarrell, J., Tse, T., Huang, H., Lund, P., Maecker, H. T., et al. (2013) · Molecular Systems Biology

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 184

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

Christophersen, A., Lund, E. G., Snir, O., Solà, E., Kanduri, C., Dahal-Koirala, S., Zühlke, S., Molberg, Ø., Utz, P. J., Rohani-Pichavant, M., et al. (2019) · Nature Medicine

Celiac Disease Research and ManagementT-cell and B-cell Immunology

Cited by 164

Defective signaling in the JAK-STAT pathway tracks with chronic inflammation and cardiovascular risk in aging humans

Shen-Orr, S. S., Furman, D., Kidd, B. A., Hadad, F., Lovelace, P., Huang, Y.-W., Rosenberg-Hasson, Y., Mackey, S., Grisar, F. A. G., Pickman, Y., et al. (2016) · Cell Systems

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 154

Expression of CD39 on activated T cells impairs their survival in older individuals

Fang, F., Yu, M., Cavanagh, M. M., Hutter Saunders, J., Qi, Q., Ye, Z., Le Saux, S., Sultan, W., Turgano, E., Dekker, C. L., et al. (2016) · Cell Reports

T-cell and B-cell ImmunologyAdenosine and Purinergic Signaling

Cited by 138

Consensus summary report for CEPI/BC March 12–13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines

Lambert, P.-H., Ambrosino, D. M., Andersen, S. R., Baric, R. S., Black, S. B., Chen, R. T., Dekker, C. L., Didierlaurent, A. M., Graham, B. S., Martin, S. D., et al. (2020) · Vaccine

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 119