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Cited by 58Surgical Sutures and AdhesivesHydrogels: synthesis, properties, applicationsbiodegradable polymer synthesis and properties

Bioinspired super-strong aqueous synthetic tissue adhesives

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Li, Qing, Song, Wei, Li, Jinghui, Ma, Chuying, Zhao, Xinxiang, Jiao, Jianlin, Mrowczynski, Oliver, Webb, Becky S. +3 more·2022·Matter
DOI 10.1016/j.matt.2021.12.018PMC PMC8896806
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Abstract

Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing biodegradable super-strong aqueous glue (B-Seal) for surgical uses inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super-strong, and elastic adhesive sealant composed of injectable water-borne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal®, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction of designing the next-generation wet tissue adhesives for surgeries.

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  • Compared with clinical sutures, tissue adhesives show advantages in ease of use, sealing of air/fluid leakage, and less pain and scars.

    “Compared with clinical sutures, tissue adhesives show advantages in ease of use, sealing of air/fluid leakage, and less pain and scars [97,98].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [98]

    The Introduction (page unavailable) describes tissue adhesives as alternatives to sutures because of their ease of use, airtight or watertight sealing, and minimal tissue damage. It does not establish that adhesives cause less pain or fewer scars than sutures; the Results’ observation of no excessive scar tissue after B-Seal implantation is not a comparison with sutures. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Li, Q., Song, W., Li, J., Ma, C., Zhao, X., Jiao, J., Mrowczynski, O., Webb, B. S., Rizk, E. B., Lu, D., & Liu, C.
Affiliations
  • Kunming Medical University (CN)
  • Pennsylvania State University (US)
Corresponding author
  • Rizk, Elias B.
  • Liu, Chao
ORCID
Venue
Matter
Publisher
Elsevier BV
Published
2022-03
Volume
5
Issue
3
Pages
933-956
ISSN
2590-2385 (ISSN-L)
DOI
10.1016/j.matt.2021.12.018
PMC
PMC8896806
OpenAlex
W4207030627
Cited by
58
References
2
Citations by year
2026: 16 · 2025: 17 · 2024: 15 · 2023: 7 · 2022: 3
FWCI
10.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Matter (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences
  • Small Business Innovation Research (R43 GM130231)
Topics
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
tissue adhesives, aqueous adhesives, biodegradable polyurethane, nanoparticle dispersion, counterions, burst pressure, lap shear strength, fibrin glue, cerebrospinal fluid leak, surgical sealants, wet tissue adhesion

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