The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis
Open accessAbstract
EpCAM − CTCs isolated from breast cancer patients express markers needed to promote brain metastasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Heterogeneity is observed in the cohort of circulating tumor cells (CTCs).
“Such heterogeneity is observed in the cohort of circulating tumor cells (CTCs) [12,13], which can be isolated from the peripheral bloodstream or cultured for further analyses.”
From Microfluidic modelling of the tumor microenvironment for anti-cancer drug development (2019) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766 · see citing works
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Matera, J., Miller, M. C., Reuben, J. M., Doyle, G. V., Allard, W. J., Terstappen, L. W. M. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040766 · Cited by 4,602 · see citing works
Ginestier, C., Hur, M., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C., Liu, S.-L., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.014 · Cited by 4,121 · see citing works
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476 · see citing works
EMT and Dissemination Precede Pancreatic Tumor Formation
Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136 · see citing works
Genes that mediate breast cancer metastasis to the brain
Bos, P. D., Zhang, X. H.-F., Nadal, C., Shu, W., Gomis, R. R., Nguyen, D. X., Minn, A. J., van de Vijver, M. J., Gerald, W. L., Foekens, J. A., et al. (2009) · Nature · doi:10.1038/nature08021 · Cited by 1,863 · see citing works
Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
Li, X., Lewis, M. T., Huang, J., Gutiérrez, C., Osborne, C. K., Wu, M.-F., Hilsenbeck, S. G., Pavlick, A. C., Zhang, X., Chamness, G. C., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn123 · Cited by 1,794 · see citing works
Detection of Mutations in <i>EGFR</i> in Circulating Lung-Cancer Cells
Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800668 · Cited by 1,617 · see citing works
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective
Talmadge, J. E., & Fidler, I. J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1040 · Cited by 1,172 · see citing works
Circulating tumor cells: approaches to isolation and characterization
Yu, M., Stott, S. L., Toner, M., Maheswaran, S., & Haber, D. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010021 · Cited by 1,085 · see citing works
Charafe-Jauffret, E., Ginestier, C., Iovino, F., Tarpin, C., Diebel, M., Esterni, B., Houvenaeghel, G., Extra, J.-M., Bertucci, F., Jacquemier, J., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1630 · Cited by 732 · see citing works
Circulating Tumor Cells and Circulating Tumor DNA
Alix‐Panabières, C., Schwarzenbach, H., & Pantel, K. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-062310-094219 · Cited by 485 · see citing works
Sieuwerts, A. M., Kraan, J., Bolt, J., van der Spoel, P., Elstrodt, F., Schutte, M. E. M., Martens, J. W. M., Gratama, J.-W. C., Sleijfer, S., & Foekens, J. A. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn419 · Cited by 435 · see citing works
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
Ikediobi, O. N., Davies, H. R., Bignell, G. R., Edkins, S., Stevens, C., O’Meara, S., Santarius, T., Avis, T., Barthorpe, S., Brackenbury, L., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0433 · Cited by 433 · see citing works
<i>HER2</i>Status and Benefit from Adjuvant Trastuzumab in Breast Cancer
Paik, S., Kim, C., & Wolmark, N. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0801440 · Cited by 426 · see citing works
Brain Metastases: The HER2 Paradigm
Lin, N. U., & Winer, E. P. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2478 · Cited by 419 · see citing works
EMT and MET in Metastasis: Where Are the Cancer Stem Cells?
Brabletz, T. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.11.009 · Cited by 405 · see citing works
Fehm, T. N., Müller, V., Aktas, B., Janni, W., Schneeweiß, A., Stickeler, E., Lattrich, C., Löhberg, C. R., Solomayer, E. F., Rack, B. K., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1163-x · Cited by 354 · see citing works
Her-2 Overexpression Increases the Metastatic Outgrowth of Breast Cancer Cells in the Brain
Palmieri, D., Bronder, J. L., Herring, J. M., Yoneda, T., Weil, R. J., Stark, A. M., Kurek, R., Vega-Valle, E., Feigenbaum, L., Halverson, D. O., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3316 · Cited by 333 · see citing works
Königsberg, R., Obermayr, E., Bises, G., Pfeiler, G., Gneist, M., Wrba, F., Santis, M. D., Zeillinger, R., Hudec, M., & Dittrich, C. (2011) · Acta Oncologica · doi:10.3109/0284186x.2010.549151 · Cited by 241 · see citing works
Molecular mechanisms of metastasis in breast cancer—clinical applications
Mego, M., Mani, S. A., & Cristofanilli, M. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.171 · Cited by 235 · see citing works
HER2 and Chromosome 17 Effect on Patient Outcome in the N9831 Adjuvant Trastuzumab Trial
Perez, E. A., Reinholz, M. M., Hillman, D. W., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.2154 · Cited by 233 · see citing works
Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse
Harrell, J. C., Prat, A., Parker, J. S., Fan, C., He, X., Carey, L., Anders, C. K., Ewend, M. G., & Perou, C. M. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1619-7 · Cited by 228 · see citing works
Mammalian heparanase: what is the message?
Vreys, V., & David, G. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00039.x · Cited by 217 · see citing works
A Novel Platform for Detection of CK+ and CK− CTCs
Pecot, C. V., Bischoff, F. Z., Mayer, J. A., Wong, K. L., Pham, T., Bottsford-Miller, J. N., Stone, R. L., Lin, Y. G., Jaladurgam, P., Roh, J., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0215 · Cited by 217 · see citing works
Rimawi, M. F., Shetty, P. B., Weiss, H. L., Schiff, R., Osborne, C. K., Chamness, G. C., & Elledge, R. M. (2010) · Cancer · doi:10.1002/cncr.24816 · Cited by 215 · see citing works
Yatim, A., Benne, C., Sobhian, B., Laurent‐Chabalier, S., Déas, O., Judde, J., Lelièvre, J., Lévy, Y., & Benkirane, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.022 · Cited by 207 · see citing works
MicroRNA-1258 Suppresses Breast Cancer Brain Metastasis by Targeting Heparanase
Zhang, L., Sullivan, P. S., Goodman, J. C., Gunaratne, P. H., & Marchetti, D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1910 · Cited by 180 · see citing works
Self-citationJoosse, S. A., Hannemann, J., Spötter, J., Bauche, A., Andreas, A., Müller, V., & Pantel, K. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2100 · Cited by 155 · see citing works
McGowan, P. M., Simedrea, C., Ribot, E. J., Foster, P. J., Palmieri, D., Steeg, P. S., Allan, A. L., & Chambers, A. F. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0457 · Cited by 150 · see citing works
Romano, P., Manniello, A., Aresu, O., Armento, M., Cesaro, M., & Parodi, B. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn730 · Cited by 147 · see citing works
Fonsatti, E., Jekunen, A. P., Kairemo, K., et al. (2000) · PubMed · Cited by 135 · see citing works
Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype
Ameri, K., Luong, R. H., Zhang, H., Powell, A. A., Montgomery, K. D., Espinosa, Í., Bouley, D. M., Harris, A. L., & Jeffrey, S. S. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605491 · Cited by 132 · see citing works
Rethinking the metastatic cascade as a therapeutic target
Mina, L. A., & Sledge, G. W. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.59 · Cited by 123 · see citing works
Characterization of metastatic breast cancer patients with nondetectable circulating tumor cells
Mego, M., Giorgi, U. D., Dawood, S., Wang, X., Valero, V., Andreopoulou, E., Handy, B. C., Ueno, N. T., Reuben, J. M., & Cristofanilli, M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25690 · Cited by 115 · see citing works
Cohen‐Kaplan, V., Doweck, I., Naroditsky, I., Vlodavsky, I., & Ilan, N. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2910 · Cited by 86 · see citing works
Katz, R. L., He, W., Khanna, A., Fernandez, R. L., Zaidi, T. M., Krebs, M., Caraway, N. P., Zhang, H.-Z., Jiang, F., Spitz, M. R., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3358 · Cited by 63 · see citing works
Zhang, L., Sullivan, P., Suyama, J. A., & Marchetti, D. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0375 · Cited by 55 · see citing works
Self-citationRidgway, L. D., Wetzel, M. D., Ngo, J. A., Erdreich‐Epstein, A., & Marchetti, D. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0534 · Cited by 41 · see citing works
Self-citationProstate cancer and other xenografts from cells in peripheral blood of patients.
Pretlow, T. G., Schwartz, S. H., Giaconia, J. M., et al. (2000) · PubMed · Cited by 38 · see citing works
Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors
Mori (2009) · Oncology Reports · doi:10.3892/or_00000603 · Cited by 37 · see citing works
Ostapkowicz, A., Inai, K., Smith, L. M., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0226 · Cited by 25 · see citing works
Tarin, D. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9326-8 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Liquid biopsy and minimal residual disease - latest advances and implications for cure
Pantel, K., & Alix-Panabières, C. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0187-3 · Cited by 1,110 · see citing works
Mechanisms Governing Metastatic Dormancy and Reactivation
Giancotti, F. G. (2013) · Cell · doi:10.1016/j.cell.2013.10.029 · Cited by 586 · see citing works
Precision medicine for cancer with next-generation functional diagnostics
Friedman, A. A., Letai, A., Fisher, D. E., & Flaherty, K. T. (2015) · Nature Reviews Cancer · doi:10.1038/nrc4015 · Cited by 570 · see citing works
Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications
Ishiguro, T., Ohata, H., Sato, A., Yamawaki, K., Enomoto, T., & Okamoto, K. (2017) · Cancer Science · doi:10.1111/cas.13155 · Cited by 530 · see citing works
Kelley, S. O., Mirkin, C. A., Walt, D. R., Ismagilov, R. F., Toner, M., & Sargent, E. H. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.261 · Cited by 398 · see citing works
Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Shang, M., Soon, R. H., Lim, C. T., Khoo, B. L., & Han, J. (2019) · Lab on a Chip · doi:10.1039/c8lc00970h · Cited by 227 · see citing works
Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model
Zhang, Z., Shiratsuchi, H., Lin, J., Chen, G., Reddy, R. M., Azizi, E., Fouladdel, S., Chang, A. C., Lin, L., Jiang, H., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2592 · Cited by 207 · see citing works
Khoo, B. L., Grenci, G., Lim, Y. B., Lee, S. C., Han, J., & Lim, C. T. (2018) · Nature Protocols · doi:10.1038/nprot.2017.125 · Cited by 172 · see citing works
Khoo, B. L., Grenci, G., Jing, T., Lim, Y. B., Lee, S. C., Thiery, J. P., Han, J., & Lim, C. T. (2016) · Science Advances · doi:10.1126/sciadv.1600274 · Cited by 147 · see citing works
De Angelis, M. L., Francescangeli, F., Nicolazzo, C., Signore, M., Giuliani, A., Colace, L., Boe, A., Magri, V., Baiocchi, M., Ciardi, A., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02263-y · Cited by 75 · see citing works
- Authors
- Zhang, L., Ridgway, L. D., Wetzel, M. D., Ngo, J., Yin, W., Kumar, D., Goodman, J. C., Groves, M. D., & Marchetti, D.
- Affiliations
- Baylor College of Medicine (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Marchetti, Dario
- Venue
- Science Translational Medicine
- Published
- 2013-04-10
- Volume
- 5
- Issue
- 180
- Pages
- 180ra48-180ra48
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3863909
- OpenAlex
- W2097849024
- Cited by
- 521
- References
- 43
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 23 · 2023: 37 · 2022: 44 · 2021: 33 · 2020: 49 · 2019: 48 · 2018: 35 · 2017: 56 · 2016: 57 · 2015: 60 · 2014: 39 · 2013: 10
- FWCI
- 29.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 016672, R01CA216991, R01CA160335, P30CA016672, P30CA125123)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Brain Metastases and Treatment
- Keywords
- breast cancer, brain metastases, circulating tumor cells, HER2, EGFR, heparanase, Notch1, xenografts, cell invasion, lung metastasis, CellSearch
- MeSH terms
- Animals, Brain Neoplasms, Breast Neoplasms, Female, Humans, Mice, Nude, Neoplastic Cells, Circulating, Erb-b2 Receptor Tyrosine Kinases, Cell Line, Tumor, Mice, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
