Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering

Chemistry and Properties of Nanocrystals of Different Shapes

Burda, C., Chen, X., Narayanan, R., & El-Sayed, M. A. (2005) · Chemical Reviews · doi:10.1021/cr030063a · Cited by 7,230 · see citing works

Nanostructures in Biodiagnostics

Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603 · see citing works

Isolation of rare circulating tumour cells in cancer patients by microchip technology

Nagrath, S., Sequist, L. V. D., Maheswaran, S., Bell, D. W., Irimia, D., Ulkus, L., Smith, M. R., Kwak, E. L., Digumarthy, S. R., Muzikansky, A., et al. (2007) · Nature · doi:10.1038/nature06385 · Cited by 3,565 · see citing works

Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases

Allard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G. J., Uhr, J. W., & Terstappen, L. W. M. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0378 · Cited by 2,542 · see citing works

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476 · see citing works

Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins

Nam, J., Thaxton, C. S., & Mirkin, C. A. (2003) · Science · doi:10.1126/science.1088755 · Cited by 2,391 · see citing works

Microfluidic Large-Scale Integration

Thorsen, T., Maerkl, S. J., & Quake, S. R. (2002) · Science · doi:10.1126/science.1076996 · Cited by 2,223 · see citing works

Electrochemical DNA sensors

Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214 · see citing works

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

Rissin, D. M., Kan, C. W., Campbell, T. G., Howes, S. C., Fournier, D. R., Song, L., Piech, T., Patel, P. P., Chang, L., Rivnak, A. J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1641 · Cited by 2,119 · see citing works

Nanoparticle-Based Bio-Barcodes for the Ultrasensitive Detection of Proteins*

Nam, J., Thaxton, C. S., & Mirkin, C. A. (2020) · Spherical Nucleic Acids · doi:10.1201/9781003056713-94 · Cited by 2,038 · see citing works

Digital PCR

Vogelstein, B., & Kinzler, K. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9236 · Cited by 1,770 · see citing works

High gradient magnetic cell separation with MACS

Miltenyi, S., Müller, W., Weichel, W., & Radbruch, A. (1990) · Cytometry · doi:10.1002/cyto.990110203 · Cited by 1,680 · see citing works

Array-Based Electrical Detection of DNA with Nanoparticle Probes

Park, S., Taton, T. A., & Mirkin, C. A. (2002) · Science · doi:10.1126/science.1067003 · Cited by 1,516 · see citing works

Functionalizing Nanoparticles with Biological Molecules: Developing Chemistries that Facilitate Nanotechnology

Sapsford, K. E., Algar, W. R., Berti, L., Gemmill, K. B., Casey, B. J., Oh, E., Stewart, M. H., & Medintz, I. L. (2013) · Chemical Reviews · doi:10.1021/cr300143v · Cited by 1,429 · see citing works

Direct Ultrasensitive Electrical Detection of DNA and DNA Sequence Variations Using Nanowire Nanosensors

Hahm, J., & Lieber, C. M. (2003) · Nano Letters · doi:10.1021/nl034853b · Cited by 1,304 · see citing works

Spherical Nucleic Acids

Cutler, J. I., Auyeung, E., & Mirkin, C. A. (2012) · Journal of the American Chemical Society · doi:10.1021/ja209351u · Cited by 1,141 · see citing works

Systems Biology and New Technologies Enable Predictive and Preventative Medicine

Hood, L., Heath, J. R., Phelps, M. E., & Lin, B. (2004) · Science · doi:10.1126/science.1104635 · Cited by 1,108 · see citing works

Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells

Emre Özkumur, A., Shah, A. M., Ciciliano, J. C., Emmink, B. L., Miyamoto, D. T., Brachtel, E. F., Yu, M., Chen, P.-I., Morgan, B., Trautwein, J., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005616 · Cited by 1,087 · see citing works

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

Baccelli, I., Schneeweiß, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., Klein, C., Saini, M., Bäuerle, T., Wallwiener, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2576 · Cited by 1,050 · see citing works

Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA

Fan, C., Plaxco, K. W., & Heeger, A. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633515100 · Cited by 1,046 · see citing works

Making it stick: convection, reaction and diffusion in surface-based biosensors

Squires, T. M., Messinger, R. J., & Manalis, S. R. (2008) · Nature Biotechnology · doi:10.1038/nbt1388 · Cited by 989 · see citing works

Point-of-care nucleic acid testing for infectious diseases

Niemz, A., Ferguson, T. M., & Boyle, D. S. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.01.007 · Cited by 838 · see citing works

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer’s disease

Georganopoulou, D. G., Chang, L., Nam, J.-M., Thaxton, C. S., Mufson, E. J., Klein, W. L., & Mirkin, C. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409336102 · Cited by 835 · see citing works

Target-Responsive Structural Switching for Nucleic Acid-Based Sensors

Li, D., Song, S., & Fan, C. (2010) · Accounts of Chemical Research · doi:10.1021/ar900245u · Cited by 735 · see citing works

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets

Xiang, Y., & Lu, Y. (2011) · Nature Chemistry · doi:10.1038/nchem.1092 · Cited by 679 · see citing works

Spherical Nucleic Acids*

Cutler, J. I., Auyeung, E., & Mirkin, C. A. (2020) · Spherical Nucleic Acids · doi:10.1201/9781003056676-5 · Cited by 678 · see citing works

Quantitation of targets for PCR by use of limiting dilution.

Sykes, P. J., Neoh, S. H., Brisco, M. J., Hughes, E., Condon, J. C., & Morley, A. A. (1992) · PubMed · Cited by 621 · see citing works

Detection Limits for Nanoscale Biosensors

Sheehan, P. E., & Whitman, L. J. (2005) · Nano Letters · doi:10.1021/nl050298x · Cited by 618 · see citing works

Electrochemical Coding Technology for Simultaneous Detection of Multiple DNA Targets

Wang, J., Liu, G., & Merkoçi, A. (2003) · Journal of the American Chemical Society · doi:10.1021/ja029668z · Cited by 612 · see citing works

Point-of-Care Testing for Infectious Diseases: Diversity, Complexity, and Barriers in Low- And Middle-Income Countries

Pai, N. P., Vadnais, C., Denkinger, C. M., Engel, N., & Pai, M. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001306 · Cited by 597 · see citing works

Requirements for high impact diagnostics in the developing world

Urdea, M. S., Penny, L., Olmsted, S. S., Giovanni, M. Y., Kaspar, P., Shepherd, A., Wilson, P. L., Dahl, C. A., Buchsbaum, S., Moeller, G., et al. (2006) · Nature · doi:10.1038/nature05448 · Cited by 589 · see citing works

A DNA Nanostructure‐based Biomolecular Probe Carrier Platform for Electrochemical Biosensing

Pei, H., Lü, N., Wen, Y., Song, S., Liu, Y., Yan, H., & Fan, C. (2010) · Advanced Materials · doi:10.1002/adma.201002767 · Cited by 562 · see citing works

Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer

Stott, S. L., Lee, R. J., Nagrath, S., Yu, M., Miyamoto, D. T., Ulkus, L., Inserra, E. K., Ulman, M. J., Springer, S. U., Nakamura, Z. M., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000403 · Cited by 540 · see citing works

Digital PCR hits its stride

Baker, M. (2012) · Nature Methods · doi:10.1038/nmeth.2027 · Cited by 525 · see citing works

The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis

Zhang, L., Ridgway, L. D., Wetzel, M. D., Ngo, J., Yin, W., Kumar, D., Goodman, J. C., Groves, M. D., & Marchetti, D. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005109 · Cited by 521 · see citing works

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

Strain, M. C., Lada, S. M., Luong, T. Q., Rought, S. E., Gianella, S., Terry, V. H., Spina, C. A., Woelk, C. H., & Richman, D. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055943 · Cited by 505 · see citing works

Hybridization Chain Reaction Amplification of MicroRNA Detection with a Tetrahedral DNA Nanostructure-Based Electrochemical Biosensor

Ge, Z., Lin, M., Wang, P., Pei, H., Yan, J., Shi, J., Huang, Q., He, D., Fan, C., & Zuo, X. (2014) · Analytical Chemistry · doi:10.1021/ac4037262 · Cited by 502 · see citing works

The Role Radius of Curvature Plays in Thiolated Oligonucleotide Loading on Gold Nanoparticles

Hill, H. D., Millstone, J. E., Banholzer, M. J., & Mirkin, C. A. (2009) · ACS Nano · doi:10.1021/nn800726e · Cited by 499 · see citing works

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

Yu, M., Ting, D. T., Stott, S. L., Wittner, B. S., Ozsolak, F., Paul, S., Ciciliano, J. C., Smas, M. E., Winokur, D., Gilman, A. J., et al. (2012) · Nature · doi:10.1038/nature11217 · Cited by 484 · see citing works

Quantitative Real-Time Measurements of DNA Hybridization with Alkylated Nonoxidized Silicon Nanowires in Electrolyte Solution

Bunimovich, Y. L., Shin, Y. S., Yeo, W., Amori, M., Kwong, G. A., & Heath, J. R. (2006) · Journal of the American Chemical Society · doi:10.1021/ja065923u · Cited by 482 · see citing works

A Decade of Development in Immunoassay Methodology

Gosling, J. P. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.8.1408 · Cited by 458 · see citing works

Digital PCR for the molecular detection of fetal chromosomal aneuploidy

Lo, Y. M. D., Lun, F. M. F., Chan, K. C. A., Tsui, N. B. Y., Chong, K. C., Lau, T. K., Leung, T. Y., Zee, B. C.-Y., Cantor, C. R., & Chiu, R. W. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705765104 · Cited by 434 · see citing works

Sequence-Specific Detection of Femtomolar DNA via a Chronocoulometric DNA Sensor (CDS):  Effects of Nanoparticle-Mediated Amplification and Nanoscale Control of DNA Assembly at Electrodes

Zhang, J., Song, S., Zhang, L., Wang, L., Wu, H., Pan, D., & Fan, C. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061521a · Cited by 424 · see citing works

Programming the detection limits of biosensors through controlled nanostructuring

Soleymani, L., Fang, Z., Sargent, E. H., & Kelley, S. O. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.276 · Cited by 415 · see citing works

Non-invasive prenatal measurement of the fetal genome

Fan, H. C., Gu, W., Wang, J., Blumenfeld, Y. J., El-Sayed, Y. Y., & Quake, S. R. (2012) · Nature · doi:10.1038/nature11251 · Cited by 393 · see citing works

Nanoparticle-based bio-barcode assay redefines “undetectable” PSA and biochemical recurrence after radical prostatectomy

Thaxton, C. S., Elghanian, R., Thomas, A. D., Stoeva, S. I., Lee, J., Smith, N. D., Schaeffer, A. J., Klocker, H., Horninger, W., Bartsch, G. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904719106 · Cited by 387 · see citing works

Plasma tau levels in Alzheimer's disease

Zetterberg, H., Wilson, D. H., Andréasson, U., Minthon, L., Blennow, K., Randall, J., & Hansson, O. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt163 · Cited by 385 · see citing works

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR

Warren, L. A., Bryder, D., Weissman, I., & Quake, S. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0608512103 · Cited by 373 · see citing works

Risk of prostate carcinoma death in patients with lymph node metastasis

Liang Cheng, C., Zincke, H., Blute, M. L., Bergstralh, E. J., Scherer, B. G., & Bostwick, D. G. (2001) · Cancer · doi:10.1002/1097-0142(20010101)91:1 · Cited by 359 · see citing works

Size-Selective Microcavity Array for Rapid and Efficient Detection of Circulating Tumor Cells

Hosokawa, M., Hayata, T., Fukuda, Y., Arakaki, A., Yoshino, T., Tanaka, T., & Matsunaga, T. (2010) · Analytical Chemistry · doi:10.1021/ac101222x · Cited by 344 · see citing works

Megapixel digital PCR

Heyries, K. A., Tropini, C., VanInsberghe, M. A., Doolin, C., Petriv, O. I., Singhal, A., Leung, K., Hughesman, C. B., & Hansen, C. L. (2011) · Nature Methods · doi:10.1038/nmeth.1640 · Cited by 308 · see citing works

Multiplexed Nanoflares: mRNA Detection in Live Cells

Prigodich, A. E., Randeria, P. S., Briley, W. E., Kim, N. J., Daniel, W. L., Giljohann, D. A., & Mirkin, C. A. (2012) · Analytical Chemistry · doi:10.1021/ac202648w · Cited by 286 · see citing works

Androgen Receptor Signaling in Circulating Tumor Cells as a Marker of Hormonally Responsive Prostate Cancer

Miyamoto, D. T., Lee, R. J., Stott, S. L., Ting, D. T., Wittner, B. S., Ulman, M. J., Smas, M. E., Lord, J. B., Brannigan, B. W., Trautwein, J., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0222 · Cited by 272 · see citing works

DNA Nanostructure-Decorated Surfaces for Enhanced Aptamer-Target Binding and Electrochemical Cocaine Sensors

Wen, Y., Pei, H., Wan, Y., Su, Y. L., Huang, Q., Song, S., & Fan, C. (2011) · Analytical Chemistry · doi:10.1021/ac201491p · Cited by 265 · see citing works

Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector

Issadore, D., Chung, J., Shao, H., Liong, M., Ghazani, A. A., Castro, C. M., Weissleder, R., & Lee, H. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003747 · Cited by 247 · see citing works

Multiplexed Quantification of Nucleic Acids with Large Dynamic Range Using Multivolume Digital RT-PCR on a Rotational SlipChip Tested with HIV and Hepatitis C Viral Load

Shen, F., Sun, B., Kreutz, J. E., Davydova, E. K., Du, W., Reddy, P. L., Joseph, L. J., & Ismagilov, R. F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2060116 · Cited by 231 · see citing works

Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: Results of a pilot study

Randall, J., Mörtberg, E., Provuncher, G. K., Fournier, D. R., Duffy, D. C., Rubertsson, S., Blennow, K., Zetterberg, H., & Wilson, D. H. (2013) · Resuscitation · doi:10.1016/j.resuscitation.2012.07.027 · Cited by 230 · see citing works

DNA Nanostructure-based Interfacial engineering for PCR-free ultrasensitive electrochemical analysis of microRNA

Wen, Y., Pei, H., Shen, Y., Xi, J., Lin, M., Lü, N., Shen, X., Li, J., & Fan, C. (2012) · Scientific Reports · doi:10.1038/srep00867 · Cited by 222 · see citing works

Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device

Kirby, B. J., Jodari‐Karimi, M., Loftus, M. S., Gakhar, G., Pratt, E. D., Chanel‐Vos, C., Gleghorn, J. P., Santana, S. M., Liu, H., Smith, J. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035976 · Cited by 212 · see citing works

Use of Electrochemical DNA Biosensors for Rapid Molecular Identification of Uropathogens in Clinical Urine Specimens

Liao, J. C., Mastali, M., Gau, V., Suchard, M. A., Møller, A. K., Bruckner, D. A., Babbitt, J. T., Li, Y., GORNBEIN, J. A., Landaw, E. M., et al. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.2.561-570.2006 · Cited by 211 · see citing works

Metagenomics and Personalized Medicine

Virgin, H. W., & Todd, J. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.009 · Cited by 203 · see citing works

An ultrasensitive universal detector based on neutralizer displacement

Das, J., Cederquist, K. B., Zaragoza, A. A., Lee, P. E., Sargent, E. H., & Kelley, S. O. (2012) · Nature Chemistry · doi:10.1038/nchem.1367 · Cited by 199 · see citing works

Digital Concentration Readout of Single Enzyme Molecules Using Femtoliter Arrays and Poisson Statistics

Rissin, D. M., & Walt, D. R. (2006) · Nano Letters · doi:10.1021/nl060227d · Cited by 196 · see citing works

Digital LAMP in a sample self-digitization (SD) chip

Gansen, A., Herrick, A. M., Dimov, I. K., Lee, L. P., & Chiu, D. T. (2012) · Lab on a Chip · doi:10.1039/c2lc21247a · Cited by 187 · see citing works

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

Zetterberg, H., Mörtberg, E., Song, L., Chang, L., Provuncher, G. K., Patel, P. P., Ferrell, E. P., Fournier, D. R., Kan, C. W., Campbell, T. G., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028263 · Cited by 173 · see citing works

Nanostructuring of Sensors Determines the Efficiency of Biomolecular Capture

Bin, X., Sargent, E. H., & Kelley, S. O. (2010) · Analytical Chemistry · doi:10.1021/ac101164n · Cited by 147 · see citing works

Hierarchical Nanotextured Microelectrodes Overcome the Molecular Transport Barrier To Achieve Rapid, Direct Bacterial Detection

Soleymani, L., Fang, Z., Lam, B., Bin, X., Vasilyeva, E., Ross, A. J., Sargent, E. H., & Kelley, S. O. (2011) · ACS Nano · doi:10.1021/nn200586s · Cited by 141 · see citing works

Miniature Analytical Methods for Medical Diagnostics

Walt, D. R. (2005) · Science · doi:10.1126/science.1108161 · Cited by 135 · see citing works

Charge Transport within a Three-Dimensional DNA Nanostructure Framework

Lü, N., Pei, H., Ge, Z., Simmons, C. R., Yan, H., & Fan, C. (2012) · Journal of the American Chemical Society · doi:10.1021/ja302447r · Cited by 131 · see citing works

Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma

Neselius, S., Zetterberg, H., Blennow, K., Randall, J., Wilson, D. M., Marcusson, J. O., & Brisby, H. (2013) · Brain Injury · doi:10.3109/02699052.2012.750752 · Cited by 130 · see citing works

Direct, electronic microRNA detection for the rapid determination of differential expression profiles.

Yang, H., Hui, A., Pampalakis, G., Soleymani, L., Liu, F.-F., Sargent, E., & Kelley, S. (2009) · Angewandte Chemie · doi:10.1002/anie.200902577 · Cited by 130 · see citing works

Solution-based circuits enable rapid and multiplexed pathogen detection

Lam, B., Das, J., Holmes, R. D., Live, L. S., Sage, A. T., Sargent, E. H., & Kelley, S. O. (2013) · Nature Communications · doi:10.1038/ncomms3001 · Cited by 129 · see citing works

Direct, Electronic MicroRNA Detection for the Rapid Determination of Differential Expression Profiles

Yang, H. Y., Hui, A. B., Pampalakis, G., Soleymani, L., Liu, F., Sargent, E. H., & Kelley, S. O. (2009) · Angewandte Chemie · doi:10.1002/ange.200902577 · Cited by 127 · see citing works

Electrocatalytic Detection of Pathogenic DNA Sequences and Antibiotic Resistance Markers

Lapierre-Devlin, M. A., O’Keefe, M., Taft, B. J., & Kelley, S. O. (2003) · Analytical Chemistry · doi:10.1021/ac0349429 · Cited by 120 · see citing works

Deformability considerations in filtration of biological cells

Kuo, J. S., Zhao, Y., Schiro, P. G., Ng, L., Lim, D. S. W., Shelby, J. P., & Chiu, D. T. (2010) · Lab on a Chip · doi:10.1039/b922301k · Cited by 118 · see citing works

Regenerable electrochemical immunological sensing at DNA nanostructure-decorated gold surfaces

Pei, H., Wan, Y., Li, J., Hu, H., Su, Y. L., Huang, Q., & Fan, C. (2011) · Chemical Communications · doi:10.1039/c1cc11660f · Cited by 110 · see citing works

Organophosphonate-Based PNA-Functionalization of Silicon Nanowires for Label-Free DNA Detection

Cattani‐Scholz, A., Pedone, D., Dubey, M. K., Neppl, S., Nickel, B. A., Feulner, P., Schwartz, J., Abstreiter, G., & Tornow, M. (2008) · ACS Nano · doi:10.1021/nn800136e · Cited by 110 · see citing works

Microfluidic digital PCR enables rapid prenatal diagnosis of fetal aneuploidy

Fan, H. C., Blumenfeld, Y. J., El-Sayed, Y. Y., Chueh, J. T., & Quake, S. R. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.03.002 · Cited by 108 · see citing works

Molecular Methods and Platforms for Infectious Diseases Testing

Emmadi, R., Boonyaratanakornkit, J., Selvarangan, R., Shyamala, V., Zimmer, B. A., Williams, L. O., Bryant, B. R., Schutzbank, T. E., Schoonmaker, M. M., Amos, J. A., et al. (2011) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2011.05.011 · Cited by 105 · see citing works

Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay

Goh, H., Lin, M., Fukushima, T., Saglio, G. N., Kim, D., Choi, S.-Y., Kim, S., Lee, J. E., Lee, Y., Oh, S.-M., et al. (2011) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2011.555569 · Cited by 102 · see citing works

Studying copy number variations using a nanofluidic platform

Qin, J., Jones, R. C., & Ramakrishnan, R. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn518 · Cited by 102 · see citing works

Digital PCR provides absolute quantitation of viral load for an occult RNA virus

White, R. A., III, Quake, S. R., & Curr, K. A. (2011) · Journal of Virological Methods · doi:10.1016/j.jviromet.2011.09.017 · Cited by 96 · see citing works

Digital Readout of Target Binding with Attomole Detection Limits via Enzyme Amplification in Femtoliter Arrays

Rissin, D. M., & Walt, D. R. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058425e · Cited by 95 · see citing works

Mechanistic Evaluation of the Pros and Cons of Digital RT-LAMP for HIV-1 Viral Load Quantification on a Microfluidic Device and Improved Efficiency via a Two-Step Digital Protocol

Sun, B., Shen, F., McCalla, S. E., Kreutz, J. E., Karymov, M. A., & Ismagilov, R. F. (2013) · Analytical Chemistry · doi:10.1021/ac3037206 · Cited by 95 · see citing works

Direct Profiling of Cancer Biomarkers in Tumor Tissue Using a Multiplexed Nanostructured Microelectrode Integrated Circuit

Fang, Z., Soleymani, L., Pampalakis, G., Yoshimoto, M., Squire, J. A., Sargent, E. H., & Kelley, S. O. (2009) · ACS Nano · doi:10.1021/nn900733d · Cited by 93 · see citing works

Direct Detection of Bacterial Genomic DNA at Sub-Femtomolar Concentrations Using Single Molecule Arrays

Song, L., Shan, D., Zhao, M., Pink, B. A., Minnehan, K. A., York, L., Gardel, M., Sullivan, S., Phillips, A. F., Hayman, R. B., et al. (2013) · Analytical Chemistry · doi:10.1021/ac303426b · Cited by 88 · see citing works

Increased Robustness of Single-Molecule Counting with Microfluidics, Digital Isothermal Amplification, and a Mobile Phone versus Real-Time Kinetic Measurements

Selck, D. A., Karymov, M. A., Sun, B., & Ismagilov, R. F. (2013) · Analytical Chemistry · doi:10.1021/ac4030413 · Cited by 80 · see citing works

Efficient Isolation and Accurate In Situ Analysis of Circulating Tumor Cells Using Detachable Beads and a High‐Pore‐Density Filter

Lee, H. J., Oh, J. H., Oh, J. M., Park, J., Lee, J., Kim, M. S., Kim, Y. J., Kang, H. J., Jeong, J., Kim, S. I., et al. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201302278 · Cited by 80 · see citing works

Detection of HIV-1 P24 Gag in Plasma by a Nanoparticle-Based Bio-Barcode-Amplification Method

Kim, E., Stanton, J., Korber, B., Krebs, K. C., Bogdan, D., Kunstman, K., Wu, S., Phair, J., Mirkin, C. A., & Wolinsky, S. M. (2008) · Nanomedicine · doi:10.2217/17435889.3.3.293 · Cited by 75 · see citing works

Direct Genetic Analysis of Ten Cancer Cells: Tuning Sensor Structure and Molecular Probe Design for Efficient mRNA Capture

Vasilyeva, E., Lam, B., Fang, Z., Minden, M. D., Sargent, E. H., & Kelley, S. O. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006793 · Cited by 71 · see citing works

Detection of Single-Molecule DNA Hybridization Using Enzymatic Amplification in an Array of Femtoliter-Sized Reaction Vessels

Li, Z., Hayman, R. B., & Walt, D. R. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8053018 · Cited by 69 · see citing works

An Automated High-Throughput Counting Method for Screening Circulating Tumor Cells in Peripheral Blood

Zhao, M., Schiro, P. G., Kuo, J. S., Koehler, K. M., Sabath, D. E., Popov, V., Feng, Q., & Chiu, D. T. (2013) · Analytical Chemistry · doi:10.1021/ac400193b · Cited by 68 · see citing works

Polymerase Chain Reaction-Free, Sample-to-Answer Bacterial Detection in 30 Minutes with Integrated Cell Lysis

Lam, B., Fang, Z., Sargent, E. H., & Kelley, S. O. (2011) · Analytical Chemistry · doi:10.1021/ac202599b · Cited by 65 · see citing works

Chip-Based Nanostructured Sensors Enable Accurate Identification and Classification of Circulating Tumor Cells in Prostate Cancer Patient Blood Samples

Ivanov, I., Stojcic, J., Stanimirovic, A., Sargent, E. H., Nam, R. K., & Kelley, S. O. (2012) · Analytical Chemistry · doi:10.1021/ac3029739 · Cited by 53 · see citing works

A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells

Casavant, B. P., Mosher, R., Warrick, J. W., Maccoux, L. J., Berry, S. M., Becker, J. T., Chen, V., Lang, J. M., McNeel, D. G., & Beebe, D. J. (2013) · Methods · doi:10.1016/j.ymeth.2013.05.027 · Cited by 51 · see citing works

Simple diffusion-constrained immunoassay for p24 protein with the sensitivity of nucleic acid amplification for detecting acute HIV infection

Chang, L., Song, L., Fournier, D. R., Kan, C. W., Patel, P. P., Ferrell, E. P., Pink, B. A., Minnehan, K. A., Hanlon, D., Duffy, D. C., et al. (2012) · Journal of Virological Methods · doi:10.1016/j.jviromet.2012.08.017 · Cited by 49 · see citing works

Single molecule measurements of tumor necrosis factor α and interleukin-6 in the plasma of patients with Crohn's disease

Song, L., Hanlon, D., Chang, L., Provuncher, G. K., Kan, C. W., Campbell, T. G., Fournier, D. R., Ferrell, E. P., Rivnak, A. J., Pink, B. A., et al. (2011) · Journal of Immunological Methods · doi:10.1016/j.jim.2011.07.015 · Cited by 47 · see citing works

The Effect of Rapid Screening for Methicillin-ResistantStaphylococcus aureus(MRSA) on the Identification and Earlier Isolation of MRSA-Positive Patients

Creamer, E., Dolan, A., Sherlock, O., Thomas, T., Walsh, J. J., Moore, J., Smyth, E. G., O’Neill, E., Shore, A. C., Sullivan, D. J., et al. (2010) · Infection Control and Hospital Epidemiology · doi:10.1086/651093 · Cited by 43 · see citing works

A portable, pressure driven, room temperature nucleic acid extraction and storage system for point of care molecular diagnostics

Byrnes, S. A., Fan, A., Trueb, J. T., Jareczek, F. J., Mazzochette, M., Sharon, A., Sauer-Budge, A. F., & Klapperich, C. M. (2013) · Analytical Methods · doi:10.1039/c3ay40162f · Cited by 31 · see citing works

Clinical evaluation of a novel method for the measurement of prostate‐specific antigen, AccuPSA TM , as a predictor of 5‐year biochemical recurrence‐free survival after radical prostatectomy: results of a pilot study

Lepor, H., Cheli, C. D., Thiel, R. P., Taneja, S. S., Laze, J., Chan, D. W., Sokoll, L. J., Mangold, L. A., & Partin, A. W. (2011) · British Journal of Urology · doi:10.1111/j.1464-410x.2011.10568.x · Cited by 19 · see citing works

Ultra-sensitive protein detection using single molecule arrays (SiMoA): the potential for detecting single molecules of botulinum toxin

Duffy, D. C. (2012) · The Botulinum J · doi:10.1504/tbj.2012.050200 · Cited by 2 · see citing works

Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules

Labib, M., Sargent, E. H., & Kelley, S. O. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00220 · Cited by 981 · see citing works

A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors

Krishnan, S. K., Singh, E. J., Singh, P., Meyyappan, M., & Nalwa, H. S. (2019) · RSC Advances · doi:10.1039/c8ra09577a · Cited by 793 · see citing works

Ultrasensitive surface-enhanced Raman scattering detection in common fluids

Yang, S., Dai, X., Stogin, B. B., & Wong, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518980113 · Cited by 703 · see citing works

Exploring the Trans‐Cleavage Activity of CRISPR‐Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

Dai, Y., Somoza, R. A., Wang, L., Welter, J. F., Li, Y., Caplan, A. I., & Liu, C.-C. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201910772 · Cited by 660 · see citing works

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

Zhang, P., Zhou, X. M., He, M., Shang, Y., Tetlow, A. L., Godwin, A. K., & Zeng, Y. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0356-9 · Cited by 550 · see citing works

Recent progress on highly sensitive perovskite photodetectors

Miao, J., & Zhang, F. (2019) · Journal of Materials Chemistry C · doi:10.1039/c8tc06089d · Cited by 439 · see citing works

Electrochemical detection of nucleic acids, proteins, small molecules and cells using a DNA-nanostructure-based universal biosensing platform

Lin, M., Song, P., Zhou, G., Zuo, X., Aldalbahi, A. K., Lou, X., Shi, J., & Fan, C. (2016) · Nature Protocols · doi:10.1038/nprot.2016.071 · Cited by 390 · see citing works

Highly Narrowband Photomultiplication Type Organic Photodetectors

Wang, W., Zhang, F., Du, M., Li, L., Zhang, M., Wang, K., Wang, Y., Hu, B., Fang, Y. Z., & Huang, J. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b05418 · Cited by 378 · see citing works

Advances in the Application of Magnetic Nanoparticles for Sensing

Gloag, L., Mehdipour, M., Chen, D., Tilley, R. D., & Gooding, J. J. (2019) · Advanced Materials · doi:10.1002/adma.201904385 · Cited by 364 · see citing works

Metal-Polydopamine Framework: An Innovative Signal-Generation Tag for Colorimetric Immunoassay

Ren, R., Cai, G., Yu, Z., Zeng, Y., & Tang, D. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03538 · Cited by 360 · see citing works

Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences

Chiu, D. T., deMello, A. J., Carlo, D. D., Doyle, P. S., Hansen, C. L., Maceiczyk, R. M., & Wootton, R. C. R. (2017) · Chem · doi:10.1016/j.chempr.2017.01.009 · Cited by 343 · see citing works

Challenges and Solutions in Developing Ultrasensitive Biosensors

Wu, Y., Tilley, R. D., & Gooding, J. J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b09397 · Cited by 307 · see citing works

Quantitative and Sensitive SERS Platform with Analyte Enrichment and Filtration Function

Ding, Q., Wang, J., Chen, X., Liu, H., Li, Q., Wang, Y., & Yang, S. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c02683 · Cited by 294 · see citing works

Rationally Engineered Nucleic Acid Architectures for Biosensing Applications

Xiao, M., Lai, W., Man, T., Chang, B., Li, L., Chandrasekaran, A. R., & Pei, H. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00121 · Cited by 289 · see citing works

Reaction–diffusion processes at the nano- and microscales

Epstein, I. R., & Xu, B. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.41 · Cited by 285 · see citing works

Recent Progress on Photomultiplication Type Organic Photodetectors

Miao, J., & Zhang, F. (2018) · Laser & Photonics Review · doi:10.1002/lpor.201800204 · Cited by 284 · see citing works

An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum

Das, J., Ivanov, I., Montermini, L., Rak, J. W., Sargent, E. H., & Kelley, S. O. (2015) · Nature Chemistry · doi:10.1038/nchem.2270 · Cited by 274 · see citing works

Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells

Yu, R., Ying, Y., Gao, R., & Long, Y. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201803229 · Cited by 255 · see citing works

Artificial intelligence aids in development of nanomedicines for cancer management

Tan, P., Chen, X., Zhang, H., Wei, Q., & Luo, K. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.01.005 · Cited by 254 · see citing works

CRISPR Mediated Biosensing Toward Understanding Cellular Biology and Point‐of‐Care Diagnosis

Dai, Y., Wu, Y., Liu, G., & Gooding, J. J. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202005398 · Cited by 243 · see citing works

Recent advances in lab-on-a-chip for biosensing applications

Lafleur, J., Jönsson, A., Senkbeil, S., & Kutter, J. P. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.08.003 · Cited by 241 · see citing works

Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review

Liao, Z., Zhang, Y., Li, Y., Miao, Y., Gao, S., Lin, F., Deng, Y., & Geng, L. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.11.032 · Cited by 237 · see citing works

A Comparison of Optical, Electrochemical, Magnetic, and Colorimetric Point-of-Care Biosensors for Infectious Disease Diagnosis

Pashchenko, O. I., Shelby, T., Banerjee, T., & Santra, S. (2018) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.8b00023 · Cited by 239 · see citing works

Biomolecular sensors for advanced physiological monitoring

Flynn, C. D., Chang, D., Mahmud, A., Yousefi, H., Das, J., Riordan, K. T., Sargent, E. H., & Kelley, S. O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00067-z · Cited by 226 · see citing works

Future cancer research priorities in the USA: a Lancet Oncology Commission

Jaffee, E. M., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., Barker, A. D., Bastani, R., Bhatia, S. N., Bluestone, J. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30698-8 · Cited by 211 · see citing works

DNA Clutch Probes for Circulating Tumor DNA Analysis

Das, J., Ivanov, I., Sargent, E. H., & Kelley, S. O. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b05679 · Cited by 206 · see citing works

Pd Nanoparticles Decorated N-Doped Graphene Quantum Dots@N-Doped Carbon Hollow Nanospheres with High Electrochemical Sensing Performance in Cancer Detection

Xi, J., Xie, C., Zhang, Y., Wang, L., Xiao, J. Z., Duan, X., Ren, J., Xiao, F., & Wang, S. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b05561 · Cited by 196 · see citing works

Surpassing the detection limit and accuracy of the electrochemical DNA sensor through the application of CRISPR Cas systems

Xu, W., Jin, T., Dai, Y., & Liu, C.-C. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112100 · Cited by 191 · see citing works

Organic Photodetectors with Gain and Broadband/Narrowband Response under Top/Bottom Illumination Conditions

Wang, W., Du, M., Zhang, M., Miao, J., Fang, Y. Z., & Zhang, F. (2018) · Advanced Optical Materials · doi:10.1002/adom.201800249 · Cited by 185 · see citing works

Tailored Graphitic Carbon Nitride Nanostructures: Synthesis, Modification, and Sensing Applications

Chen, L., & Song, J. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201702695 · Cited by 182 · see citing works

Mechanistic Challenges and Advantages of Biosensor Miniaturization into the Nanoscale

Soleymani, L., & Li, F. (2017) · ACS Sensors · doi:10.1021/acssensors.7b00069 · Cited by 177 · see citing works

Advances in biological applications of self-assembled DNA tetrahedral nanostructures

Li, S., Tian, T., Zhang, T., Cai, X., & Lin, Y. (2018) · Materials Today · doi:10.1016/j.mattod.2018.08.002 · Cited by 176 · see citing works

2D Nanomaterial-Based Surface Plasmon Resonance Sensors for Biosensing Applications

Singh, S., Singh, P. K., Umar, A., Lohia, P., Albargi, H. B., Castañeda, L., & Dwivedi, D. K. (2020) · Micromachines · doi:10.3390/mi11080779 · Cited by 176 · see citing works

Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles

Zhou, Y., Mohamadi, R. M., Poudineh, M., Kermanshah, L., Ahmed, S. U., Safaei, T. S., Stojcic, J., Nam, R. K., Sargent, E. H., & Kelley, S. O. (2015) · Small · doi:10.1002/smll.201502365 · Cited by 175 · see citing works

Fe3O4 nanoparticles on graphene oxide sheets for isolation and ultrasensitive amperometric detection of cancer biomarker proteins

Sharafeldin, M., Bishop, G. W., Bhakta, S., El‐Sawy, A. M., Suib, S. L., & Rusling, J. F. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.12.052 · Cited by 170 · see citing works

Integrated Electrochemical Microsystems for Genetic Detection of Pathogens at the Point of Care

Hsieh, K., Ferguson, B. S., Eisenstein, M. S., Plaxco, K. W., & Soh, H. T. (2015) · Accounts of Chemical Research · doi:10.1021/ar500456w · Cited by 158 · see citing works

A Highly Sensitive Narrowband Nanocomposite Photodetector with Gain

Shen, L., Fang, Y., Wei, H., Yuan, Y., & Huang, J. (2016) · Advanced Materials · doi:10.1002/adma.201503774 · Cited by 156 · see citing works

Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework

Song, P., Shen, J., Ye, D., Dong, B., Wang, F., Pei, H., Wang, J., Shi, J., Wang, L., Xue, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14664-8 · Cited by 150 · see citing works

Highly Sensitive, Fast Response Perovskite Photodetectors Demonstrated in Weak Light Detection Circuit and Visible Light Communication System

Li, C., Lu, J., Zhao, Y., Sun, L., Wang, G., Ma, Y., Zhang, S., Zhou, J., Shen, L., & Huang, W. (2019) · Small · doi:10.1002/smll.201903599 · Cited by 145 · see citing works

Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis

Zhang, P., Wu, X., Gardashova, G., Yang, Y., Zhang, Y., Xu, L., & Zeng, Y. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz2878 · Cited by 145 · see citing works

Direct DNA Analysis with Paper-Based Ion Concentration Polarization

Gong, M. M., Nosrati, R., Gabriel, M. C. S., Zini, A. S., & Sinton, D. A. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b08523 · Cited by 144 · see citing works

High‐Performance Near‐IR Photodetector Using Low‐Bandgap MA0.5FA0.5Pb0.5Sn0.5I3 Perovskite

Xu, X., Chueh, C., Jing, P., Yang, Z., Shi, X., Zhao, T., Lin, L. Y., & Jen, A. K. ‐. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201701053 · Cited by 140 · see citing works

Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes

Xia, Y., Zhang, R., Wang, Z., Tian, J., & Chen, X. S. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00675b · Cited by 136 · see citing works

Recent advances in microfluidic chip integrated electronic biosensors for multiplexed detection

Liao, Z., Wang, J., Zhang, P., Zhang, Y., Miao, Y., Gao, S., Deng, Y., & Geng, L. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.08.061 · Cited by 136 · see citing works

DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development

Ye, D., Zuo, X., & Fan, C. (2018) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061417-010007 · Cited by 134 · see citing works

Organic Photodetectors: Materials, Structures, and Challenges

Liu, J., Wang, Y., Wen, H., Bao, Q., Shen, L., & Ding, L. (2020) · Solar RRL · doi:10.1002/solr.202000139 · Cited by 134 · see citing works

Porous nanozymes: the peroxidase-mimetic activity of mesoporous iron oxide for the colorimetric and electrochemical detection of global DNA methylation

Bhattacharjee, R., Tanaka, S., Moriam, S., Masud, M. K., Lin, J., Alshehri, S. M., Ahamad, T., Salunkhe, R. R., Nguyen, N., Yamauchi, Y., et al. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01132j · Cited by 134 · see citing works

Exploring the Trans‐Cleavage Activity of CRISPR‐Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

Dai, Y., Somoza, R. A., Wang, L., Welter, J. F., Li, Y., Caplan, A. I., & Liu, C.-C. (2019) · Angewandte Chemie · doi:10.1002/ange.201910772 · Cited by 132 · see citing works

Photonic Crystal Microbubbles as Suspension Barcodes

Shang, L., Fu, F., Cheng, Y., Wang, H., Liu, Y., Zhao, Y., & Gu, Z. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b10612 · Cited by 131 · see citing works

Framework-Nucleic-Acid-Enabled Biosensor Development

Yang, F., Li, Q., Wang, L., Zhang, G., & Fan, C. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00257 · Cited by 131 · see citing works

Sensitive and Stable Tin–Lead Hybrid Perovskite Photodetectors Enabled by Double‐Sided Surface Passivation for Infrared Upconversion Detection

Zhao, Y., Li, C., Jiang, J., Wang, B., & Shen, L. (2020) · Small · doi:10.1002/smll.202001534 · Cited by 130 · see citing works

Accelerated Electron Transfer in Nanostructured Electrodes Improves the Sensitivity of Electrochemical Biosensors

Fu, K. X., Seo, J., Kesler, V., Maganzini, N., Wilson, B. D., Eisenstein, M. S., Murmann, B., & Soh, H. T. (2021) · Advanced Science · doi:10.1002/advs.202102495 · Cited by 129 · see citing works

Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine

Li, J., Baird, M. A., Davis, M. A., Tai, W., Zweifel, L. S., Waldorf, K. M. A., Gale, M., Rajagopal, L., Pierce, R. H., & Gao, X. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0082 · Cited by 130 · see citing works

SERS based point-of-care detection of food-borne pathogens

Mungroo, N. A., Oliveira, G. V., & Neethirajan, S. R. (2015) · Microchimica Acta · doi:10.1007/s00604-015-1698-y · Cited by 122 · see citing works

Mechano‐Based Transductive Sensing for Wearable Healthcare

Wang, T., Yang, H., Qi, D., Liu, Z., Cai, P., Zhang, H., & Chen, X. (2018) · Small · doi:10.1002/smll.201702933 · Cited by 121 · see citing works

High-Throughput Electrochemical Microfluidic Immunoarray for Multiplexed Detection of Cancer Biomarker Proteins

Tang, C. K., Vaze, A., Shen, M., & Rusling, J. F. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00256 · Cited by 118 · see citing works

Multifunctional Perovskite Photodetectors: From Molecular-Scale Crystal Structure Design to Micro/Nano-scale Morphology Manipulation

Zhao, Y., Yin, X., Li, P., Ren, Z., Gu, Z., Zhang, Y., & Song, Y. (2023) · Nano-Micro Letters · doi:10.1007/s40820-023-01161-y · Cited by 117 · see citing works

A Universal Strategy for Aptamer‐Based Nanopore Sensing through Host–Guest Interactions inside α‐Hemolysin

Li, T., Liu, L., Li, Y., Xie, J., & Wu, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201502047 · Cited by 115 · see citing works

Dual nanoenzyme modified microelectrode based on carbon fiber coated with AuPd alloy nanoparticles decorated graphene quantum dots assembly for electrochemical detection in clinic cancer samples

Xu, Q., Yuan, H. S., Dong, X., Zhang, Y., Asif, M., Dong, Z., He, W., Ren, J., Sun, Y., & Xiao, F. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.02.026 · Cited by 113 · see citing works

Multiplex Immunosensor Arrays for Electrochemical Detection of Cancer Biomarker Proteins

Munge, B. S., Stracensky, T. S., Kathleen, G., DiBiase, D., & Rusling, J. F. (2016) · Electroanalysis · doi:10.1002/elan.201600183 · Cited by 112 · see citing works

A Butterfly‐Inspired Hierarchical Light‐Trapping Structure towards a High‐Performance Polarization‐Sensitive Perovskite Photodetector

Zhan, Y., Wang, Y., Cheng, Q., Li, C., Li, K., Li, H., Peng, J., Lü, B., Wang, Y., Song, Y., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908743 · Cited by 112 · see citing works

Digital immunoassay for biomarker concentration quantification using solid-state nanopores

He, L., Tessier, D. R., Briggs, K., Tsangaris, M., Charron, M., McConnell, E. M., Lomovtsev, D., & Tabard‐Cossa, V. (2021) · Nature Communications · doi:10.1038/s41467-021-25566-8 · Cited by 115 · see citing works

Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis

D’Agata, R., Giuffrida, M., & Spoto, G. (2017) · Molecules · doi:10.3390/molecules22111951 · Cited by 111 · see citing works

Lossless enrichment of trace analytes in levitating droplets for multiphase and multiplex detection

Chen, X., Ding, Q., Bi, C., Ruan, J., & Yang, S. (2022) · Nature Communications · doi:10.1038/s41467-022-35495-9 · Cited by 109 · see citing works

Multicomponent magnetic nanoparticle engineering: the role of structure-property relationship in advanced applications

Díez, A. G., Rincón‐Iglesias, M., Lanceros-Méndez, S., Reguera, J., & Lizundia, E. (2022) · Materials Today Chemistry · doi:10.1016/j.mtchem.2022.101220 · Cited by 106 · see citing works

Valency‐Controlled Framework Nucleic Acid Signal Amplifiers

Liu, Q., Ge, Z., Mao, X., Zhou, G., Zuo, X., Shen, J., Shi, J., Li, J., Wang, L., Chen, X., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201802701 · Cited by 99 · see citing works

A fully-automated, six-plex single molecule immunoassay for measuring cytokines in blood

Rivnak, A. J., Rissin, D. M., Kan, C. W., Song, L., Fishburn, M. W., Piech, T., Campbell, T. G., DuPont, D. R., Gardel, M., Sullivan, S., et al. (2015) · Journal of Immunological Methods · doi:10.1016/j.jim.2015.04.017 · Cited by 98 · see citing works

Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing

Yang, F., Zuo, X., Fan, C., & Zhang, X. (2018) · National Science Review · doi:10.1093/nsr/nwx134 · Cited by 95 · see citing works

Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome

Gardner, L., Kostarelos, K., Mallick, P., Dive, C., & Hadjidemetriou, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00645-x · Cited by 96 · see citing works

Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscale

Bruno, G., Trani, N. D., Hood, R. L., Zabre, E., Filgueira, C. S., Canavese, G., Jain, P., Smith, Z. W., Demarchi, D., Hosali, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04133-8 · Cited by 92 · see citing works

Breaking the barrier to biomolecule limit-of-detection via 3D printed multi-length-scale graphene-coated electrodes

Ali, M. A., Hu, C., Yuan, B., Jahan, S., Saleh, M. S., Guo, Z., Gellman, A. J., & Panat, R. P. (2021) · Nature Communications · doi:10.1038/s41467-021-27361-x · Cited by 91 · see citing works

Synergy of Peptide–Nucleic Acid and Spherical Nucleic Acid Enabled Quantitative and Specific Detection of Tumor Exosomal MicroRNA

Liu, L., Lü, H., Shi, R., Peng, X., Xiang, Q., Wang, B., Wan, Q.-Q., Sun, Y., Yang, F., & Zhang, G. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03622 · Cited by 88 · see citing works

Development of a novel label-free impedimetric electrochemical sensor based on hydrogel/chitosan for the detection of ochratoxin A

Li, X., Falcone, N., Hossain, M. N., Kraatz, H., Chen, X., & Huang, H. (2021) · Talanta · doi:10.1016/j.talanta.2021.122183 · Cited by 89 · see citing works

Nanotechnology-Based Strategies for Early Cancer Diagnosis Using Circulating Tumor Cells as a Liquid Biopsy

Huang, Q., Wang, Y., Chen, X., Wang, Y., Li, Z., Du, S., Wang, L., & Chen, S. (2017) · Nanotheranostics · doi:10.7150/ntno.22091 · Cited by 88 · see citing works

Automated 3D-printed unibody immunoarray for chemiluminescence detection of cancer biomarker proteins

Tang, C. K., Vaze, A., & Rusling, J. F. (2017) · Lab on a Chip · doi:10.1039/c6lc01238h · Cited by 87 · see citing works

High‐Performance Nucleic Acid Sensors for Liquid Biopsy Applications

Das, J., & Kelley, S. O. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201905005 · Cited by 87 · see citing works

Infrared Photodetectors: Recent Advances and Challenges Toward Innovation for Image Sensing Applications

Saleem, M. I., Kyaw, A. K. K., & Hur, J. (2024) · Advanced Optical Materials · doi:10.1002/adom.202401625 · Cited by 90 · see citing works

High-Curvature Nanostructuring Enhances Probe Display for Biomolecular Detection

Luna, P. D., Mahshid, S. S., Das, J., Luan, B., Sargent, E. H., Kelley, S. O., & Zhou, R. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b05153 · Cited by 84 · see citing works

MXene and black phosphorus based 2D nanomaterials in bioimaging and biosensing: progress and perspectives

Huang, M., Gu, Z., Zhang, J., Zhang, D., Zhang, H., Yang, Z., & Qu, J. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00410g · Cited by 82 · see citing works

Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum

Tiambeng, T. N., Roberts, D. S., Brown, K. A., Zhu, Y., Chen, B., Wu, Z., Mitchell, S. D., Guardado-Alvarez, T. M., Jin, S., & Ge, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-17643-1 · Cited by 76 · see citing works

Combinatorial Probes for High‐Throughput Electrochemical Analysis of Circulating Nucleic Acids in Clinical Samples

Das, J., Ivanov, I., Safaei, T. S., Sargent, E. H., & Kelley, S. O. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201800455 · Cited by 77 · see citing works

Nanoporous Glass Integrated in Volumetric Bar-Chart Chip for Point-of-Care Diagnostics of Non-Small Cell Lung Cancer

Li, Y., Xuan, J., Song, Y., Qi, W., He, B., Wang, P., & Qin, L. (2015) · ACS Nano · doi:10.1021/acsnano.5b07357 · Cited by 77 · see citing works

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents

Passaes, C., Bruel, T., Decalf, J., David, A., Angin, M., Monceaux, V., Müller-Trutwin, M. C., Noël, N., Bourdic, K., Lambotte, O., et al. (2017) · Journal of Virology · doi:10.1128/jvi.02296-16 · Cited by 76 · see citing works

Automated 3D-Printed Microfluidic Array for Rapid Nanomaterial-Enhanced Detection of Multiple Proteins

Kadimisetty, K., Malla, S., Bhalerao, K. S., Mosa, I. M., Bhakta, S., Lee, N. H., & Rusling, J. F. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01198 · Cited by 75 · see citing works

Strand Displacement Strategies for Biosensor Applications

Dai, Y., Furst, A. L., & Liu, C.-C. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.10.001 · Cited by 74 · see citing works

Bubble-Mediated Ultrasensitive Multiplex Detection of Metal Ions in Three-Dimensional DNA Nanostructure-Encoded Microchannels

Qu, X., Yang, F., Chen, H., Li, J., Zhang, H., Zhang, G., Li, L., Wang, L., Song, S., Tian, Y., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03645 · Cited by 73 · see citing works

Biosensors for liquid biopsy: circulating nucleic acids to diagnose and treat cancer

Bellassai, N., & Spoto, G. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9806-3 · Cited by 71 · see citing works

The sustainability of emerging technologies for use in pharmaceutical manufacturing

Weaver, E., O’Hagan, C., & Lamprou, D. A. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2093857 · Cited by 70 · see citing works

Label-free electrochemical detection of HepG2 tumor cells with a self-assembled DNA nanostructure-based aptasensor

Sun, D., Lü, J., Chen, D., Jiang, Y., Wang, Z., Qin, W., Yu, Y., Chen, Z., & Zhang, Y. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.04.142 · Cited by 70 · see citing works

Critical Review: digital resolution biomolecular sensing for diagnostics and life science research

Huang, Q., Li, N., Zhang, H., Che, C., Sun, F., Xiong, Y., Canady, T. D., & Cunningham, B. T. (2020) · Lab on a Chip · doi:10.1039/d0lc00506a · Cited by 70 · see citing works

Homogeneous Entropy-Driven Amplified Detection of Biomolecular Interactions

Kim, D., Garner, O. B., Özcan, A., & Carlo, D. D. (2016) · ACS Nano · doi:10.1021/acsnano.6b02060 · Cited by 70 · see citing works

Disposable Microfluidic Immunoarray Device for Sensitive Breast Cancer Biomarker Detection

de Oliveira, R. A. G., Materón, E. M., Melendez, M. E., Carvalho, A. L., & Faria, R. C. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03350 · Cited by 70 · see citing works

Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray

Sharafeldin, M., Chen, T., Özkaya, G. U., Choudhary, D., Molinolo, A., Gutkind, J. S., & Rusling, J. F. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112681 · Cited by 69 · see citing works

How to Improve the Performance of Electrochemical Sensors via Minimization of Electrode Passivation

Barek, J. (2021) · Chemosensors · doi:10.3390/chemosensors9010012 · Cited by 69 · see citing works

Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders

Chen, P., Huang, N., Chung, M. T., Cornell, T. T., & Kurabayashi, K. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.005 · Cited by 68 · see citing works

Basics of Biosensors and Nanobiosensors

Bhattarai, P., & Hameed, S. (2020) · doi:10.1002/9783527345137.ch1 · Cited by 68 · see citing works

Antibody-nanoparticle conjugates to enhance the sensitivity of ELISA-based detection methods

Billingsley, M. M., Riley, R., & Day, E. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177592 · Cited by 66 · see citing works

Toward Personalized Nanomedicine: The Critical Evaluation of Micro and Nanodevices for Cancer Biomarker Analysis in Liquid Biopsy

Clack, K., Soda, N., Kasetsirikul, S., Mahmudunnabi, R. G., Nguyen, N., & Shiddiky, M. J. A. (2023) · Small · doi:10.1002/smll.202205856 · Cited by 68 · see citing works

Flexible Narrowband Ultraviolet Photodetectors with Photomultiplication Based on Wide Band Gap Conjugated Polymer and Inorganic Nanoparticles

Zhang, X., Zheng, E., Esopi, M. R., Cai, C., & Yu, Q. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b06861 · Cited by 64 · see citing works

Universal amplification-free molecular diagnostics by billion-fold hierarchical nanofluidic concentration

Ouyang, W., & Han, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904513116 · Cited by 64 · see citing works

Nanostructured biomolecular detectors: pushing performance at the nanoscale

Cederquist, K. B., & Kelley, S. O. (2012) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2012.04.011 · Cited by 36 · see citing works

Nanodevices in diagnostics

Hu, Y., Fine, D. H., Tasciotti, E., Bouamrani, A., & Mauro Ferrari, B. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.82 · Cited by 90 · see citing works

Demonstration of a digital microfluidic platform for the high throughput analysis of 12 discrete fluorimetric enzyme assays using a single newborn dried blood spot punch

Singh, R. P., Chopra, S., Graham, C., Nelson, L., Ng, R., Nuffer, M., Vadlamani, P., Norton, S. M., & Pamula, V. K. (2018) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2017.12.361 · Cited by 7 · see citing works

Improving biosensors at the nanoscale.

Moore, R. (2008) · PubMed

Micro and Nanotechnologies Enhanced Biomolecular Sensing

Wang, T. (2013) · Biosensors · doi:10.3390/bios3030283 · Cited by 4 · see citing works