Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

Getts, Daniel R.; Terry, Rachael L.; Getts, Meghann Teague; Deffrasnes, Celine; Müller, Marcus; van Vreden, Caryn; Ashhurst, Thomas M.; Chami, Belal; McCarthy, Derrick; Wu, Huiling; Ma, Jin; Martin, Aaron; Shae, Lonnie D.; Witting, Paul; Kansas, Geoffrey S.; Kühn, Joachim; Hafezi, Wali; Campbell, Iain L.; Reilly, David; Say, Jana; Brown, Louise; White, Melanie Y.; Cordwell, Stuart J.; Chadban, Steven J.; Thorp, Edward B.; Bao, Shisan; Miller, Stephen D.; King, Nicholas J. C.

doi:10.1126/scitranslmed.3007563

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

Negatively charged immune-modifying microparticles bind to the scavenger receptor MARCO on inflammatory monocytes, resulting in their apoptosis and reduced inflammatory damage in a range of diseases.